Navigation Links
UCLA scientists find cell pathway driving a deadly sub-type of breast cancer
Date:11/14/2008

An intra cellular pathway not previously linked to breast cancer is driving a sub-type of the disease that is highly lethal and disproportionately over-represented in African American women.

The pathway regulates how cells identify and destroy proteins and represents a class of genes called proteasome targeting complexes. The work shows that basal cancer cells degrade the tumor suppressor gene p27 by making a new type of proteasome targeting complex. The gene p27 is one of a handful of proteins that are expressed in normal cells and act to prevent rapid cell growth, which is indicative of cancer. Beyond chemotherapy, no specific therapeutic target has been identified for this sub-type of cancer, found in between 12 to 15 percent of breast cancers in the general population and up to 25 percent of cases in African American women.

"The mortality rates in this subgroup of cancer are very high," said Tim Lane, senior author of the paper and a researcher at UCLA's Jonsson Comprehensive Cancer Center. "The possibility that this new proteasome targeting complex might provide targets for therapeutic intervention is a completely new area for breast cancer research."

The research, done in animal models and human breast cancer cell lines, is published in the Nov. 15 issue of the journal Genes and Development.

Scientists have identified five to seven different sub-types of breast cancer. Basal-like breast cancers currently are among the most difficult to treat.

Targeted therapeutics are available for several sub-types. Women with HER-2 positive breast cancers can receive Herceptin, which when paired with chemotherapy extends disease-free survival by more than 50 percent. HER-2 positive women used to have the worst prognoses before Herceptin was developed. They now have the best prognoses because the drug targets what's broken in the cancer cell that is driving the disease. Another sub-type includes women with Estrogen
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2804
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... 31, 2015 , ... Wyoming Medical Center, an acute care ... Clinical Documentation Improvement (CDI) and medical coding needs. Based on a proprietary Natural ... is an enterprise-level coding solution that combines CDI, Coding, Quality and Compliance Auditing ...
(Date:8/31/2015)... CA (PRWEB) , ... August 31, 2015 , ... Castle ... to the practice. Dr. Pedram Ghasri is a graduate of the University of California, ... and continued his studies at the University of California, Irvine Medical School. As a ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... “My mother ... said an inventor, from Hagerhill, Ky. “I thought there could be a comfortable way ... Protector. , The Nasal Cannula Ear Protector offers a more secure way to anchor ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... A year ... the team is preparing to release a new issue commemorating the successful first year. ... information they need for a potentially difficult time in their lives,” says Melissa Wolfert, ...
(Date:8/31/2015)... Los Angeles, ACA (PRWEB) , ... August 31, 2015 , ... ... filling a growing niche in the digital healthcare industry. , Consumer driven health ... the field: one in an advisory and strategic role to the company, and another ...
Breaking Medicine News(10 mins):Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 2Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 3Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 4Health News:Castle Dermatology Institute Now Welcomes Dr. Pedram Ghasri to the Practice 2Health News:InventHelp® Inventor Designs Nasal Cannula Ear Protector (AVZ-1217) 2Health News:Seniors Guide Magazine Celebrates Its First Year in Columbus With A Special Anniversary Issue 2Health News:Seniors Guide Magazine Celebrates Its First Year in Columbus With A Special Anniversary Issue 3Health News:ZendyHealth Adds Two Prestigious Consumer Driven Health Plan (CDHP) Experts 2Health News:ZendyHealth Adds Two Prestigious Consumer Driven Health Plan (CDHP) Experts 3
... beating heart transplant for a 58-year-old man and says the ... Bruce Rosengard, at Papworth Hospital in Cambridge, led the team ... be kept warm as to body temperature and beating before ... removed organs are usually placed on ice and transferred to ...
... a Canadian National research project children’s blood here are ... PCBs to flame retardants//. ,A report by Toronto-based ... with even higher levels than their parents., ,On ... in the blood and urine samples of subjects. Some ...
... second highest success rate in heart surgeries, ensuring that 99.6 ... stories, the group's chairman Prathap C Reddy said here today. ... he said while the hospital that had the highest success ... cost effective as it charged less than 4,000 dollars. ...
... Osteoporosis (IOF WCO), the world's largest Scientific congress devoted ... June 2, in Toronto, Canada//. ,Professor Rene ... that this year's congress attracted 720 abstracts, more than ... 2004 in Rio de Janeiro, Brazil. ,On ...
... sex during the final weeks of pregnancy is not a trigger ... popular myth, that has deterred many couples enjoy physical pleasure during ... a relief., ,A study was conducted among 93 women, ... of their pregnancy. The finding revealed that women, who enjoyed the ...
... emerged victorious in a historic Supreme Court case around a ... with the ruling providing expanded access to private care//. ... from any (private) coverage. It’s a violation of the judgment. ... and eventually to die,' Chaoulli said. ,In a ...
Cached Medicine News:
(Date:8/31/2015)... 2015  Asterias Biotherapeutics, Inc. (NYSE MKT: AST), ... of regenerative medicine, today announced that the third ... -based Rush University Medical Center in a ... doses of AST-OPC1 (oligodendrocyte progenitor cells) in newly ... spinal cord injury (SCI). This represents the final ...
(Date:8/31/2015)... , Aug. 31, 2015 Bionomics Limited (ASX:BNO, ... development of innovative therapeutics for the treatment of diseases ... announced that its BNC101 IND submission has passed review ... plans to initiate a Phase 1 clinical trial in ... metastatic pancreatic cancer prior to 31 December 2015. ...
(Date:8/30/2015)... y LONDRES, August 30, 2015 ... visión holística de l cuidado al ... trayecto   Royal Philips  ... debut europeo de IntelliSpace Cardiovascular , un sistema ... sofisticadas herramientas para acceder, analizar y compartir imágenes cardiovasculares ...
Breaking Medicine Technology:Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 4Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 5Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 6Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 2Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 3Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 4Philips presenta IntelliSpace Cardiovascular en el Congreso ESC 2015 2Philips presenta IntelliSpace Cardiovascular en el Congreso ESC 2015 3
... 25, 2011 Imagenetix, Inc. (OTC Bulletin Board: IAGX ... December 31, 2010. Net sales decreased 4% for the third quarter ... period of last year. A loss of $1,202,000, $0.10 per share, ... to a net loss of $294,000, $.03 per share, for the ...
... Accuray Incorporated (Nasdaq: ARAY ), a ... its Senior Vice President, General Counsel and Corporate Secretary, ... Company" by the Silicon Valley/San Jose Business Journal ... of their ,Best Bay Area Corporate Counsel Awards,. This annual ...
Cached Medicine Technology:Imagenetix, Inc. Reports Third Quarter 2011 Results 2Imagenetix, Inc. Reports Third Quarter 2011 Results 3Accuray's General Counsel Wins Best Bay Area Corporate Counsel Award 2Accuray's General Counsel Wins Best Bay Area Corporate Counsel Award 3Accuray's General Counsel Wins Best Bay Area Corporate Counsel Award 4
... new generation of posterior stabilized knee ... the following: Patellar flange mates with ... machined condyles assure precise, repeatable kinematics ... and patella to reduce wear. Constant ...
... total knee prosthesis stems from many years ... and manufacturing technologies have been used in ... well as a favorable pressure distribution pattern ... wear to a minimum. The inherent design ...
The Balanced Knee System provides instrumentation designed to achieve proper tissue balancing and alignment with user-friendly instrumentation that provides reproducible results....
... Knee System provides anatomical replacement of all ... preserving the stabilizing Anterior and Posterior Ligaments, ... of the knee. All the components in ... and are equally proportioned and contoured to ...
Medicine Products: