Navigation Links
UCLA scientists find cell pathway driving a deadly sub-type of breast cancer
Date:11/14/2008

An intra cellular pathway not previously linked to breast cancer is driving a sub-type of the disease that is highly lethal and disproportionately over-represented in African American women.

The pathway regulates how cells identify and destroy proteins and represents a class of genes called proteasome targeting complexes. The work shows that basal cancer cells degrade the tumor suppressor gene p27 by making a new type of proteasome targeting complex. The gene p27 is one of a handful of proteins that are expressed in normal cells and act to prevent rapid cell growth, which is indicative of cancer. Beyond chemotherapy, no specific therapeutic target has been identified for this sub-type of cancer, found in between 12 to 15 percent of breast cancers in the general population and up to 25 percent of cases in African American women.

"The mortality rates in this subgroup of cancer are very high," said Tim Lane, senior author of the paper and a researcher at UCLA's Jonsson Comprehensive Cancer Center. "The possibility that this new proteasome targeting complex might provide targets for therapeutic intervention is a completely new area for breast cancer research."

The research, done in animal models and human breast cancer cell lines, is published in the Nov. 15 issue of the journal Genes and Development.

Scientists have identified five to seven different sub-types of breast cancer. Basal-like breast cancers currently are among the most difficult to treat.

Targeted therapeutics are available for several sub-types. Women with HER-2 positive breast cancers can receive Herceptin, which when paired with chemotherapy extends disease-free survival by more than 50 percent. HER-2 positive women used to have the worst prognoses before Herceptin was developed. They now have the best prognoses because the drug targets what's broken in the cancer cell that is driving the disease. Another sub-type includes women with Estrogen
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2804
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... there are only 24 hours in a day, that doesn’t seem ... time within their busy schedules for exercise and fitness. Fortunately, one ... get in shape. Here are five ways you can reach your ... Up Your Commute , Consider riding a bike or taking the ... daily routine. If you must use your car to get to ...
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, 2014 ... may be showing a genetic propensity for obesity as toddlers, ... been linked to increased body fat, but the same genes ... the researchers said. At 1 year, kids with these ... 3, however, these genes were linked to excessive weight gain, ...
(Date:10/22/2014)... HealthDay Reporter TUESDAY, Oct. ... in vitro fertilization (IVF) -- the incubation of embryos in ... device inside the vagina, new research suggests. Scientists from ... an INVOcell, might sharply cut costs for pricey IVF procedures ... accessible to those who don,t live near big-city assisted reproduction ...
(Date:10/20/2014)... Texas (PRWEB) October 20, 2014 The ... the must-have source of thousands of facts, figures and ... countries and 68 medical sector forecast categories the ... with global, regional and national views on the worldwide ... outlook. , The report gives you data for 2010-2019, ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 ASCNYC ... organization that helps New Yorkers living with HIV/AIDS ... toward health, housing, recovery and self-sufficiency. Each year, ... the local community through their tireless efforts. , ... Marc Shapses , has been selected as this ...
Breaking Medicine News(10 mins):Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 2Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 4Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 2Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 3
... , , BUENOS AIRES, ... Inc., as the recipient of its 2009 Customer Value Leadership ... has deployed an effective strategy to continuously add value to ... in the medical imaging market. , , ...
... BEIJING, Sept. 1 /PRNewswire-Asia-FirstCall/ -- China Medical Technologies,Inc. (the ... medical device,company that develops, manufactures and markets advanced,in-vitro diagnostic ... fiscal quarter ended June 30, 2009 ("1Q FY2009"). ... ("FY2009"). , , 1Q FY2009 Highlights, ...
... 1 The Global Biomarker,Market report analyzes the biomarker ... studies the major market drivers, restraints,and opportunities for the ... the macro- and micro-markets with respect to different,geographic regions. ... market data tables and in-depth TOC on biomarker,market. Early ...
... BEIJING, Sept. 1 /PRNewswire-Asia-FirstCall/ -- China Medical ... leading China-based medical device,company that develops, manufactures and markets ... for the fourth,fiscal quarter ("4Q FY2008") and the full ... 4Q FY2008 Highlights, -- ...
... 1 September: The wider use of reperfusion therapy in patients ... Europe. Effective reperfusion therapy in an AMI patient can cut ... by a sudden blockage of a coronary artery, one of ... Effective reperfusion therapy provides a timely and sustainable reopening of ...
... A therapy called cardiac resynchronization can significantly delay the progression ... in the New England Journal of Medicine . ... by 41 percent, the study found. "This shows, for the ... hospitalization for heart failure can be delayed with pacing therapy," ...
Cached Medicine News:Health News:Frost & Sullivan Recognizes Carestream Health with the 2009 Latin American Computed Radiology Customer Value Leadership Award 2Health News:Frost & Sullivan Recognizes Carestream Health with the 2009 Latin American Computed Radiology Customer Value Leadership Award 3Health News:Frost & Sullivan Recognizes Carestream Health with the 2009 Latin American Computed Radiology Customer Value Leadership Award 4Health News:China Medical Technologies Reports FY2009 First Fiscal Quarter Unaudited Financial Results 2Health News:China Medical Technologies Reports FY2009 First Fiscal Quarter Unaudited Financial Results 3Health News:China Medical Technologies Reports FY2009 First Fiscal Quarter Unaudited Financial Results 4Health News:China Medical Technologies Reports FY2009 First Fiscal Quarter Unaudited Financial Results 5Health News:China Medical Technologies Reports FY2009 First Fiscal Quarter Unaudited Financial Results 6Health News:China Medical Technologies Reports FY2009 First Fiscal Quarter Unaudited Financial Results 7Health News:China Medical Technologies Reports FY2009 First Fiscal Quarter Unaudited Financial Results 8Health News:China Medical Technologies Reports FY2009 First Fiscal Quarter Unaudited Financial Results 9Health News:China Medical Technologies Reports FY2009 First Fiscal Quarter Unaudited Financial Results 10Health News:China Medical Technologies Reports FY2009 First Fiscal Quarter Unaudited Financial Results 11Health News:China Medical Technologies Reports FY2009 First Fiscal Quarter Unaudited Financial Results 12Health News:China Medical Technologies Reports FY2009 First Fiscal Quarter Unaudited Financial Results 13Health News:MarketsandMarkets: Global Biomarker Market Worth US$ 20.5 Billion by 2014 2Health News:MarketsandMarkets: Global Biomarker Market Worth US$ 20.5 Billion by 2014 3Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 2Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 3Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 4Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 5Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 6Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 7Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 8Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 9Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 10Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 11Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 12Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 13Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 14Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 15Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 16Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 17Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 18Health News:China Medical Technologies Reports FY2008 Fourth Fiscal Quarter and Full Year Unaudited Financial Results 19
(Date:10/22/2014)... 22, 2014  Paper Pak Industries, a manufacturer ... ® Body Guard Bio, a disposable, highly ... bacteria and virus while protecting service providers and ... features a rugged, external nylon shell, watertight zipper, ... leak-proof inner chamber that contains contaminated and potentially ...
(Date:10/22/2014)... 2014  With a vision to ensure safety ... Global Pharmaceutical and Biotech manufacturer selects and implements ... solution to protect their animal health brand.  ... Photo - http://photos.prnewswire.com/prnh/20141021/153439 ... aggregated by the Xyntek and Antares solution is ...
(Date:10/22/2014)... Abaxis, Inc. (NasdaqGS: ABAX ), ... today reported financial results for the second fiscal quarter ... , Revenues of $53.9 million, up 18% over ... $0.24, up 33% over last year,s comparable quarter. ... Veterinary Reference Laboratories (AVRL) of $3.5 million, up 50% ...
Breaking Medicine Technology:New, State-Of-The-Art Body Bag Minimizes The Spread Of Bacteria And Virus 2Xyntek and Antares Serialization Solution Protects Pets Too! 2Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 2Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 3Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 4Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 5Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 6Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 7Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 8Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 9Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 10Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 11Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 12Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 13Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 14
... BOSTON, Nov. 26 Surface Logix, Inc. today announced,that ... an,update of the company,s drug development pipeline at the ... 27-29, 2007 at The,Pierre Hotel in New York City. ... 2007 at 2:50 PM EST., Surface Logix currently ...
... GAITHERSBURG, Md., Nov. 26 MedImmune, Inc. today,announced ... first Phase 1 clinical,trial of CAM- 3001, a ... of the granulocyte-macrophage colony stimulating factor,receptor (GM-CSFR). The ... of single doses of CAM-3001 in patients with ...
Cached Medicine Technology:MedImmune Initiates First Clinical Trial of Monoclonal Antibody Targeting GM-CSFR in Patients with Rheumatoid Arthritis 2
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
Inquire...
Medicine Products: