Navigation Links
UCLA scientists find cell pathway driving a deadly sub-type of breast cancer
Date:11/14/2008

An intra cellular pathway not previously linked to breast cancer is driving a sub-type of the disease that is highly lethal and disproportionately over-represented in African American women.

The pathway regulates how cells identify and destroy proteins and represents a class of genes called proteasome targeting complexes. The work shows that basal cancer cells degrade the tumor suppressor gene p27 by making a new type of proteasome targeting complex. The gene p27 is one of a handful of proteins that are expressed in normal cells and act to prevent rapid cell growth, which is indicative of cancer. Beyond chemotherapy, no specific therapeutic target has been identified for this sub-type of cancer, found in between 12 to 15 percent of breast cancers in the general population and up to 25 percent of cases in African American women.

"The mortality rates in this subgroup of cancer are very high," said Tim Lane, senior author of the paper and a researcher at UCLA's Jonsson Comprehensive Cancer Center. "The possibility that this new proteasome targeting complex might provide targets for therapeutic intervention is a completely new area for breast cancer research."

The research, done in animal models and human breast cancer cell lines, is published in the Nov. 15 issue of the journal Genes and Development.

Scientists have identified five to seven different sub-types of breast cancer. Basal-like breast cancers currently are among the most difficult to treat.

Targeted therapeutics are available for several sub-types. Women with HER-2 positive breast cancers can receive Herceptin, which when paired with chemotherapy extends disease-free survival by more than 50 percent. HER-2 positive women used to have the worst prognoses before Herceptin was developed. They now have the best prognoses because the drug targets what's broken in the cancer cell that is driving the disease. Another sub-type includes women with Estrogen
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2804
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... "I have had many hospital stays, including ... many other surgeries in my lifetime, as I am a ... stays, I was unable to move freely in order to ... freely had to physically rotate me every 30 minutes to ... and pulled the sheets. This was jarring and caused me ...
(Date:8/29/2014)... Scientists from four European countries say they have ... overall survival of mesothelioma. Surviving Mesothelioma has just posted ... to read it now. , Doctors from France, ... 523 mesothelioma patients who were part of ... at 18 weeks after treatment] was strongly correlated and ...
(Date:8/29/2014)... August 29, 2014 A recent article ... dangers of overexposure to the sun are well known, and ... should. Sun damage often doesn’t manifest itself physically on the ... by artist Thomas Leveritt showed, even if it can’t be ... special ultraviolet camera in order to show ordinary people on ...
(Date:8/29/2014)... According to these recent findings, there has been a ... in the last few years. Medical expert and Herpes researcher, ... and the symptoms that make it hard for patients to ... aren't aware of the exact symptoms of these ailments, others ... in the number of cases over the years has been ...
(Date:8/29/2014)... Penn. (PRWEB) August 29, 2014 According ... Cancer Intelligence Network (NCIN) conference held in Birmingham, England ... patients will have their disease recur”. This only goes ... for those who are struggling to fight its grueling ... story of one woman’s journey through breast cancer is ...
Breaking Medicine News(10 mins):Health News:InventHelp® Client Develops Equipment for Surgical and Bedridden Patients (HCD-279) 2Health News:European Study Says Disease Progression Predicts Mesothelioma Survival Better Than Treatment Response, According to Surviving Mesothelioma 2Health News:Artist Uses Ultraviolet Camera to Reveal Hidden Sun Damage 2Health News:Artist Uses Ultraviolet Camera to Reveal Hidden Sun Damage 3Health News:It was reported that the Number on PositiveSingles.dating increased about 20% in 2014 2Health News:Lisa Grimaldi Shares Her Fashionable Journey through Breast Cancer 2
... in German . The Deutsche Forschungsgemeinschaft ... Centres (CRCs) by 1 July 2012. This decision was taken ... The new CRCs will receive funding totalling 176 million euros ... for the initial 4-year funding period. The newly established ...
... -- Researchers led by Regenstrief Institute investigator Neale ... of Excellence on Implementing Evidence-Based Practice at the ... developed STeleR, a home telerehabilitation program that they ... stroke. Participating in STeleR also increased the likelihood ...
... D deficiency is not healthy. However, new research from the ... of the essential vitamin is not good either. The study ... have just been published in the reputed scientific Journal ... instrumental in helping calcium reach our bones, thus lessening the ...
... Reporter , TUESDAY, May 29 (HealthDay News) -- Joann Becenti awoke with ... a moving car. Fortunately, she was able to guide the ... hurt. But Becenti,s sleepless nights could have cost her her life. ... Gallup, N.M. "I knew I,d been tired a lot. I could fall ...
... Hormone Therapy Recommendations Evidence of significant ... to issue recommendations against using estrogen plus progestin in ... conditions. To update its recommendations, the Task Force conducted ... determine the effectiveness of HRT in reducing risks for ...
... postexposure treatment for suspected HIV is critical, pre-exposure preventive ... for people in high-risk groups, states a review of ... ). "Although postexposure prophylaxis has a long history ... earlier treatment in the course of infection ("treatment as ...
Cached Medicine News:Health News:DFG establishes 20 new Collaborative Research Centres 2Health News:DFG establishes 20 new Collaborative Research Centres 3Health News:DFG establishes 20 new Collaborative Research Centres 4Health News:DFG establishes 20 new Collaborative Research Centres 5Health News:DFG establishes 20 new Collaborative Research Centres 6Health News:STeleR study: Telerehab improves functioning after stroke 2Health News:Too much vitamin D can be as unhealthy as too little 2Health News:'CPAP Machine Changed My Life' 2Health News:Embargoed news from Annals of Internal Medicine 2Health News:Antiretroviral treatment for preventing HIV infection: an evidence review for physicians 2
(Date:8/28/2014)... Reportlinker.com announces that a new market ... Germany Aesthetic Lasers and Energy Devices Market ... Germany Aesthetic Lasers and Energy ... GlobalData,s new report, "Germany Aesthetic Lasers and Energy ... data on the Germany Aesthetic Lasers and Energy ...
(Date:8/28/2014)... , Aug. 28, 2014  Decision Resources Group ... will grow strongly through 2022 at a compound ... will be largely supported by strong population growth ... demand for imaging procedures. The Indian government,s greater ... facilities to purchase or upgrade diagnostic imaging equipment. ...
(Date:8/28/2014)... 28, 2014 /PRNewswire-iReach/ -- CountryFocus: Healthcare, Regulatory and ... (Photo - http://photos.prnewswire.com/prnh/20140828/140879 ) ... and Reimbursement Landscape Poland " an essential source ... the healthcare market and provides insights into the ... importantly, the report provides valuable insights into the ...
Breaking Medicine Technology:Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 2Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 3Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 4Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 5Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 6Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 7Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 8Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 9Indian Diagnostic Imaging System Market Will Grow at 6 Percent Annually Through 2022 2Indian Diagnostic Imaging System Market Will Grow at 6 Percent Annually Through 2022 3Poland & Turkey Pharmaceutical Market worth $15 billion & $21.5 billion Respectively by 2020 2Poland & Turkey Pharmaceutical Market worth $15 billion & $21.5 billion Respectively by 2020 3Poland & Turkey Pharmaceutical Market worth $15 billion & $21.5 billion Respectively by 2020 4Poland & Turkey Pharmaceutical Market worth $15 billion & $21.5 billion Respectively by 2020 5
... Life Extension Foundation of Fort Lauderdale, Fla., ... anti-aging research and integrative health therapies, has announced ... effectiveness of the dietary supplement, Cognitex® ... middle-aged to elderly subjects with subjective memory complaints. ...
... May 8, 2012  Neuralstem, Inc. (NYSE Amex: CUR ... the return of three patients from earlier cohorts in its ... (ALS or Lou Gehrig,s disease) with its spinal cord stem ... the trial for second treatments as the next cohort of ...
Cached Medicine Technology:Life Extension Foundation® study finds Cognitex® with NeuroProtection Complex may provide a positive impact on cognitive performance 2Life Extension Foundation® study finds Cognitex® with NeuroProtection Complex may provide a positive impact on cognitive performance 3Neuralstem Updates ALS Stem Cell Trial Progress 2Neuralstem Updates ALS Stem Cell Trial Progress 3Neuralstem Updates ALS Stem Cell Trial Progress 4Neuralstem Updates ALS Stem Cell Trial Progress 5
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: