Navigation Links
UCLA scientist uncovers biological clock able to measure age of most human tissues
Date:10/20/2013

Everyone grows older, but scientists don't really understand why. Now a UCLA study has uncovered a biological clock embedded in our genomes that may shed light on why our bodies age and how we can slow the process. Published in the Oct. 21 edition of Genome Biology, the findings could offer valuable insights into cancer and stem cell research.

While earlier clocks have been linked to saliva, hormones and telomeres, the new research is the first to identify an internal timepiece able to accurately gauge the age of diverse human organs, tissues and cell types. Unexpectedly, the clock also found that some parts of the anatomy, like a woman's breast tissue, age faster than the rest of the body.

"To fight aging, we first need an objective way of measuring it. Pinpointing a set of biomarkers that keeps time throughout the body has been a four-year challenge," explained Steve Horvath, a professor of human genetics at the David Geffen School of Medicine at UCLA and of biostatistics at the UCLA Fielding School of Public Health. "My goal in inventing this clock is to help scientists improve their understanding of what speeds up and slows down the human aging process."

To create the clock, Horvath focused on methylation, a naturally occurring process that chemically alters DNA. Horvath sifted through 121 sets of data collected previously by researchers who had studied methylation in both healthy and cancerous human tissue.

Gleaning information from nearly 8,000 samples of 51 types of tissue and cells taken from throughout the body, Horvath charted how age affects DNA methylation levels from pre-birth through 101 years. To create the clock, he zeroed in on 353 markers that change with age and are present throughout the body.

Horvath tested the clock's effectiveness by comparing a tissue's biological age to its chronological age. When the clock repeatedly proved accurate, he was thrilledand a little stunned.


'/>"/>
Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles Health Sciences
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
4. Scientists identify major source of cells defense against oxidative stress
5. Scientists tailor cell surface targeting system to hit organelle ZIP codes
6. Scientists rewrite rulebook on breast cancer in landmark global study
7. Kessler Foundation scientist awarded $554,000 for multiple sclerosis employment research
8. Warwick scientists uncover how checkpoint proteins bind chromosomes
9. NIH scientists link quickly spreading gene to Asian MRSA epidemic
10. Joslin scientists identify important mechanism that affects the aging process
11. Scripps Research scientists show how memory B cells stay in class to fight different infections
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA scientist uncovers biological clock able to measure age of most human tissues
(Date:10/25/2014)... York (PRWEB) October 25, 2014 ... lawsuits ( http://www.vaginalmeshlawsuit2015.com/ ) filed against Boston ... in U.S. District Court, Southern District of West ... Judgment on Punitive Damages in a group of ... a ruling issued on October 21st, U.S. District ...
(Date:10/25/2014)... 25, 2014 Limbkeepers® announced today that ... Innovations with Ed Begley Jr, airing 1st QTR 2015 ... In this episode, Innovations will focus on Limbkeepers® non ... fragile, thinning skin on arms, hands, and legs from ... these versatile products, which help reduce injuries, allow for ...
(Date:10/25/2014)... By Steven Reinberg ... -- The virus that causes common cold sores -- herpes ... studies by Swedish researchers suggest. In fact, being a ... risk of Alzheimer,s disease, the researchers found. "The ... common dementia disorder is a breakthrough," said lead researcher Dr. ...
(Date:10/25/2014)... -- Researchers who discovered antibiotics in farmed and ... concern. The use of antibiotics in animals, ... contribute to the development of antibiotic-resistant bacteria that ... the study. Each year in the United ... and kill about 23,000, according to the Infectious ...
(Date:10/25/2014)... Current osteoporosis screening guidelines and tools fail to ... osteoporosis-related fractures, a new study says. "If ... that help us accurately predict who will suffer ... these at-risk people for preventive measures," study author ... division of general internal medicine and health services ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 4Health News:Upcoming Episode of Innovations with Ed Begley, Jr. to Feature Limbkeepers® 2Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 2Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 3Health News:Researchers Say Antibiotics in Fish a Health Concern 2Health News:Osteoporosis Screening Guidelines May Miss Younger Women at Risk 2
... home importance of awareness and,education of kidney disease, which ... Calif., Oct. 16 In a nationwide,effort to raise ... focusing on raising awareness of kidney disease among 20 ... the nation,s,largest independent dialysis provider, announced today that its ...
... A small capsule that takes snapshots of the small ... doctors spot cases of Crohns disease that had gone ... at Wake Forest University Baptist Medical Center. , Reporting ... in Philadelphia, the researchers said that of 198 video ...
... leading provider of,Business Process Integration solutions for ... filled three Director-level positions based at the,company,s ... Thompson,Director of Data Management; Darryl Means, Director ... Healthcare Operations. (Logo: http://www.newscom.com/cgi-bin/prnh/20050113/SFTH042LOGO ) ...
... ... Oct. 16 With the percentage of,overweight American children and ... milk?" Milk Mustache Campaign is recognizing 10,pediatricians across the nation ... obesity crisis into their own hands. Since 1991, the ...
... When you are healthy,purchasing disability insurance can ... financial asset: your,ability to earn a living, says ... care insurance lawyer. (Photo: http://www.newscom.com/cgi-bin/prnh/20070717/NYFNSC02 ... you want to make sure you,buy the right ...
... ROCHESTER, N.Y., Oct. 16 Many routine surgical ... dermatologists may soon be sharing,reviewing and diagnosing noninvasive ... Lucid Inc.,s VivaNet(TM) telemedicine server and its,VivaScope(R) confocal ... special microscopes to digitally,image a patient,s skin, may ...
Cached Medicine News:Health News:DaVita Volunteers Raise More than $1,000,000 for Nationwide Kidney Education and Prevention Programs 2Health News:Capsule endoscopy turning up undiagnosed cases of Crohn's disease 2Health News:Three New Director-Level Appointments at Adaptis 2Health News:Three New Director-Level Appointments at Adaptis 3Health News:Pediatricians Awarded for Innovative Approaches to Combat Childhood Obesity 2Health News:Pediatricians Awarded for Innovative Approaches to Combat Childhood Obesity 3Health News:Pediatricians Awarded for Innovative Approaches to Combat Childhood Obesity 4Health News:Why Healthy People Should Consider Individual Disability Insurance 2Health News:VivaScope(R) Confocal Imager May Eliminate Need for Routine Skin Biopsies for Dermatology Patients 2
(Date:10/22/2014)... HAMILTON, N.J. , Oct. 22, 2014 ... CLIA-certified, CAP-accredited laboratory which specializes in high ... that it is now offering new Cystic ... including next- generation DNA sequencing platforms. ... a genetically inherited multisystem disorder that affects ...
(Date:10/22/2014)... Antigen Discovery Inc. (ADi), a privately held ... the receipt of a National Institutes of Health (NIH) ... Institute of Dental and Craniofacial Research (NIDCR). The one-year ... Protein Microarray Chip, which will contain every protein in ... in the development of safe and effective vaccines and ...
(Date:10/22/2014)... -- AVACEN Medical announced today that its AVACEN 100 ... by the U.S. Food and Drug Administration. This clearance ... Internet for: the temporary relief of joint pain ... sprains . Logo - http://photos.prnewswire.com/prnh/20141021/153513 ... a sophisticated medical device incorporating over 3,000 firmware instructions ...
Breaking Medicine Technology:Medical Diagnostic Laboratories, L.L.C. Institute for Biomarker Research Announces New Prenatal Cystic Fibrosis Tests 2Biomarker Discovery Company, Antigen Discovery Inc., Awarded an NIH Phase I Small Business Innovation Research Grant to Develop a Pan-HIV Protein Microarray Chip 2AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2
... May 11, 2012  Amgen (NASDAQ: AMGN ) ... vice president of Research and Development at Amgen will ... Administration (FDA) stakeholder hearing on biosimilars. Miletich will urge members ... for biosimilars to establish approval standards that advance patient ...
... Mylan Inc. (Nasdaq: MYL ) today ... mg, 20 mg, 40 mg and 80 mg in ... has received marketing authorization from each country,s respective health ... is the generic version of Pfizer,s Lipitor® Tablets. This ...
Cached Medicine Technology:Amgen To Provide Testimony At FDA Stakeholder Hearing On Biosimilars 2Amgen To Provide Testimony At FDA Stakeholder Hearing On Biosimilars 3Amgen To Provide Testimony At FDA Stakeholder Hearing On Biosimilars 4Amgen To Provide Testimony At FDA Stakeholder Hearing On Biosimilars 5Amgen To Provide Testimony At FDA Stakeholder Hearing On Biosimilars 6Mylan Launches Generic LipitorĀ® in Five European Countries 2
Bench Top Horizontal (clean bench) Airflow Cabinet...
... chamber provides a safe, clean environment ... in accord with USP-797 requirements. HEPA ... 5) cleanliness conditions in the work ... and tilt-up front panel for easy ...
... testing at various temperatures, this chamber ... a clean heating unit to maintain ... 140F. Transparent panels allow full visibility, ... access to the work area. Includes ...
... and removes chemical fumes, allowing ... Bonded charcoal filters remove most ... safe exhaust flow speed = ... opening. Includes air speed monitor, ...
Medicine Products: