Navigation Links
UCLA scientist uncovers biological clock able to measure age of most human tissues
Date:10/20/2013

Everyone grows older, but scientists don't really understand why. Now a UCLA study has uncovered a biological clock embedded in our genomes that may shed light on why our bodies age and how we can slow the process. Published in the Oct. 21 edition of Genome Biology, the findings could offer valuable insights into cancer and stem cell research.

While earlier clocks have been linked to saliva, hormones and telomeres, the new research is the first to identify an internal timepiece able to accurately gauge the age of diverse human organs, tissues and cell types. Unexpectedly, the clock also found that some parts of the anatomy, like a woman's breast tissue, age faster than the rest of the body.

"To fight aging, we first need an objective way of measuring it. Pinpointing a set of biomarkers that keeps time throughout the body has been a four-year challenge," explained Steve Horvath, a professor of human genetics at the David Geffen School of Medicine at UCLA and of biostatistics at the UCLA Fielding School of Public Health. "My goal in inventing this clock is to help scientists improve their understanding of what speeds up and slows down the human aging process."

To create the clock, Horvath focused on methylation, a naturally occurring process that chemically alters DNA. Horvath sifted through 121 sets of data collected previously by researchers who had studied methylation in both healthy and cancerous human tissue.

Gleaning information from nearly 8,000 samples of 51 types of tissue and cells taken from throughout the body, Horvath charted how age affects DNA methylation levels from pre-birth through 101 years. To create the clock, he zeroed in on 353 markers that change with age and are present throughout the body.

Horvath tested the clock's effectiveness by comparing a tissue's biological age to its chronological age. When the clock repeatedly proved accurate, he was thrilledand a little stunned.


'/>"/>
Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles Health Sciences
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
4. Scientists identify major source of cells defense against oxidative stress
5. Scientists tailor cell surface targeting system to hit organelle ZIP codes
6. Scientists rewrite rulebook on breast cancer in landmark global study
7. Kessler Foundation scientist awarded $554,000 for multiple sclerosis employment research
8. Warwick scientists uncover how checkpoint proteins bind chromosomes
9. NIH scientists link quickly spreading gene to Asian MRSA epidemic
10. Joslin scientists identify important mechanism that affects the aging process
11. Scripps Research scientists show how memory B cells stay in class to fight different infections
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA scientist uncovers biological clock able to measure age of most human tissues
(Date:8/20/2014)... August 20, 2014 According to an ... August 7 in the multicounty litigation (MCL) case pending ... DEPUY ASR HIP IMPLANTS LITIGATION; no. BER-L-3971-11), nearly 350 ... been dismissed without prejudice. The cases enumerated in the ... being resolved.” The Rottenstein Law Group LLP, a national ...
(Date:8/20/2014)... made it easier to predict both breast cancer ... of a unique gene. The newly found marker ... and customise a treatment regimen that is more ... scientists from A*STAR,s Institute of Molecular and Cell ... Singapore (CSI Singapore) at the National University of ...
(Date:8/20/2014)... BCC Research ( http://www.bccresearch.com ) reveals ... DETECTORS: TECHNOLOGIES AND GLOBAL MARKETS , the global ... grow to $15.2 billion by 2019, with a ... Increasing industrialization is driving significant growth across ... range of industrial applications such as military and ...
(Date:8/20/2014)... 2014 The finalists are in for ... industry trade magazine, will honor the pharmaceutical industry’s most ... given to outstanding companies, marketers and brand managers representing ... “We are proud to announce that we received our ... double the number of submissions we received last year,” ...
(Date:8/20/2014)... Mateo, CA (PRWEB) August 20, 2014 ... newest product—the Really Little Green Pouch —to meet ... to feed babies and toddlers homemade foods. , ... Little Green Pouch co-founder Maggie Crawford. She continues, ... kids, to limit exposure to things like pesticides and ...
Breaking Medicine News(10 mins):Health News:350 NJ DePuy ASR Lawsuits Dismissed Pending Settlement Talks, Notes Rottenstein Law Group LLP 2Health News:Novel gene predicts both breast cancer relapse and response to chemotherapy 2Health News:Global Market for Photonic Sensors and Detectors to Reach $15.2 Billion in 2019 2Health News:Global Market for Photonic Sensors and Detectors to Reach $15.2 Billion in 2019 3Health News:PM360 Announces 2014 Trailblazer Award Finalists 2Health News:PM360 Announces 2014 Trailblazer Award Finalists 3Health News:PM360 Announces 2014 Trailblazer Award Finalists 4Health News:PM360 Announces 2014 Trailblazer Award Finalists 5Health News:PM360 Announces 2014 Trailblazer Award Finalists 6Health News:PM360 Announces 2014 Trailblazer Award Finalists 7Health News:PM360 Announces 2014 Trailblazer Award Finalists 8Health News:Little Green Pouch Launches New Product to Help Health-conscious Parents Reduce Babies’ Eco-footprint 2
... Dec. 20 HMS Holdings Corp. (Nasdaq:,HMSY) today announced ... Conference, which will be held January 7-10, 2008 at ... http://www.newscom.com/cgi-bin/prnh/20030304/NYTU172LOGO ), Robert Holster, Chairman and CEO ... at 2:00 p.m. Pacific Time., A live broadcast ...
... to determine if treating depression improves health of ... heart ... with heart,disease are more likely to suffer from depression than those ... well understood,but it is known that depression in heart patients is ...
... THURSDAY, Dec. 20 (HealthDay News) -- Exposure to secondhand ... of developing allergies, Swedish researchers say. , A team ... by the parents of more than 4,000 families. , ... were ages two months, 12 months, 2 years and ...
... Toronto Stock Exchange Symbol: AKL, MONTREAL, Dec. ... drug development company focused on developing therapies for ... to unfavorable market,conditions, particularly in the small and ... public offering initiative. The Company is currently,contemplating other ...
... University researchers have updated their Food Guide Pyramid for ... now known as MyPyramid. The Tufts version is specifically ... and content. The Modified MyPyramid for Older Adults continues ... fluid balance, but has added additional guidance about forms ...
... WESTBROOK, Maine, Dec. 19 IDEXX Laboratories,Inc. (Nasdaq: ... the,JPMorgan 26th Annual Healthcare Conference. Jonathan W. Ayers, Chairman,President ... the Company on,Monday, January 7, 2008 at 8:00 a.m. ... Individuals can access the live audio webcast of,the presentation ...
Cached Medicine News:Health News:Blue Cross Blue Shield of Michigan Foundation Funds Study Exploring Link between Heart Disease and Depression 2Health News:Parents' Smoking Boosts Child's Allergy Risk 2Health News:Akela Pharma provides corporate update 2Health News:Tufts researchers update their food guide pyramid for older adults 2Health News:Tufts researchers update their food guide pyramid for older adults 3
(Date:8/20/2014)... NEW YORK, Aug 20, 2014 Reportlinker.com ... available in its catalogue: Global Patient ... This report analyzes the worldwide markets ... following Product Segments: Floor Scales, Infant & Baby ... report provides separate comprehensive analytics for the US, ...
(Date:8/19/2014)... Aug. 19, 2014   Lincor Inc. ... experience technology to New Jersey ... agreement, CarePoint Health will deploy Lincor,s PatientLINC technology ... Christ Hospital and Hoboken University Medical Center. ... of software solutions to help hospitals reach new ...
(Date:8/19/2014)... , Aug. 19, 2014 /PRNewswire-iReach/ -- ChemImage founder ... present a scientific poster describing an innovative diagnostic procedure ... 2014: Shedding New Light on Disease (SPEC) conference in ... Dr. Treado,s poster entitled, "Development of in vitro Diagnostics ... will be discussed during the conference poster session on ...
Breaking Medicine Technology:Global Patient Scales Industry 2Global Patient Scales Industry 3Global Patient Scales Industry 4Global Patient Scales Industry 5Global Patient Scales Industry 6Global Patient Scales Industry 7Global Patient Scales Industry 8Global Patient Scales Industry 9Global Patient Scales Industry 10Global Patient Scales Industry 11Global Patient Scales Industry 12Global Patient Scales Industry 13Global Patient Scales Industry 14Global Patient Scales Industry 15Global Patient Scales Industry 16Global Patient Scales Industry 17Global Patient Scales Industry 18Global Patient Scales Industry 19Lincor Announces Agreement With CarePoint Health For State-Of-The-Art Patient Engagement Technology 2ChemImage Scientists Present Latest Developments for in vitro Detection of Colorectal Cancer Using Raman Molecular Imaging (RMI) at International Conference Focused on Biomedical Applications of Raman Spectroscopy 2
... contamination, which causes false ... Hydrophobic, nonwicking and self-sealing ... pass through these aerosol-resistant ... to tips with absorption ...
Inquire...
... Finntip Filters are ideal ... methods, or for any work ... They are designed for pipetting ... samples, and other. For applications ...
... Finntip Filters are ideal for ... or for any work where ... are designed for pipetting DNA/RNA ... and other. For applications requiring ...
Medicine Products: