Navigation Links
UCLA scientist uncovers biological clock able to measure age of most human tissues
Date:10/20/2013

Everyone grows older, but scientists don't really understand why. Now a UCLA study has uncovered a biological clock embedded in our genomes that may shed light on why our bodies age and how we can slow the process. Published in the Oct. 21 edition of Genome Biology, the findings could offer valuable insights into cancer and stem cell research.

While earlier clocks have been linked to saliva, hormones and telomeres, the new research is the first to identify an internal timepiece able to accurately gauge the age of diverse human organs, tissues and cell types. Unexpectedly, the clock also found that some parts of the anatomy, like a woman's breast tissue, age faster than the rest of the body.

"To fight aging, we first need an objective way of measuring it. Pinpointing a set of biomarkers that keeps time throughout the body has been a four-year challenge," explained Steve Horvath, a professor of human genetics at the David Geffen School of Medicine at UCLA and of biostatistics at the UCLA Fielding School of Public Health. "My goal in inventing this clock is to help scientists improve their understanding of what speeds up and slows down the human aging process."

To create the clock, Horvath focused on methylation, a naturally occurring process that chemically alters DNA. Horvath sifted through 121 sets of data collected previously by researchers who had studied methylation in both healthy and cancerous human tissue.

Gleaning information from nearly 8,000 samples of 51 types of tissue and cells taken from throughout the body, Horvath charted how age affects DNA methylation levels from pre-birth through 101 years. To create the clock, he zeroed in on 353 markers that change with age and are present throughout the body.

Horvath tested the clock's effectiveness by comparing a tissue's biological age to its chronological age. When the clock repeatedly proved accurate, he was thrilledand a little stunned.


'/>"/>
Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles Health Sciences
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
4. Scientists identify major source of cells defense against oxidative stress
5. Scientists tailor cell surface targeting system to hit organelle ZIP codes
6. Scientists rewrite rulebook on breast cancer in landmark global study
7. Kessler Foundation scientist awarded $554,000 for multiple sclerosis employment research
8. Warwick scientists uncover how checkpoint proteins bind chromosomes
9. NIH scientists link quickly spreading gene to Asian MRSA epidemic
10. Joslin scientists identify important mechanism that affects the aging process
11. Scripps Research scientists show how memory B cells stay in class to fight different infections
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA scientist uncovers biological clock able to measure age of most human tissues
(Date:4/27/2015)... 27, 2015 Women may have a ... according to a new study published online in the ... brain injury (MTBI), is a common medical problem affecting ... , In most cases, patients who experience MTBI ... 15 percent of MTBI patients will continue to experience ...
(Date:4/27/2015)... Moreno Ranches, a producer of Brahman ... to announce their "This is It" educational Brahman cattle ... breeding and education was a huge success. The educational ... 2015. It brought together youth, educators, and experts ... breeding in general, and Brahman cattle breeding in particular. ...
(Date:4/27/2015)... April 27, 2015 UC Davis ... molecular basis of an inherited disorder that historically ... also arises in other populations of Semitic descent, ... series of elegant experiments, the researchers uncovered the ... leukodystrophy that is an incurable and progressively fatal ...
(Date:4/27/2015)... April 27, 2015 On May 5, people ... ask their social media friends around the world to join ... asthma. , May 5 is World Pulmonary Hypertension Day ... leader in the global PH community, will take part in ... blood pressure of the lungs. PH is an increase in ...
(Date:4/27/2015)... Array Health , a leading provider ... Lance Hood, senior director of marketing, will participate in ... Health Care Marketing Summit on April 29, 2015. ... Director of Payer Services, Leavitt Partners, LLC, will address ... a retail/e-commerce perspective – and equip attendees with the ...
Breaking Medicine News(10 mins):Health News:Women Show Persistent Memory Impairment after Concussion 2Health News:Women Show Persistent Memory Impairment after Concussion 3Health News:Leading Ranch for Brahman Cattle for Sale, Moreno Ranches, Announces Conclusion of 'This is It' Event for Brahman Juniors. 2Health News:UC Davis Makes Breakthrough in Understanding Canavan Disease 2Health News:UC Davis Makes Breakthrough in Understanding Canavan Disease 3Health News:UC Davis Makes Breakthrough in Understanding Canavan Disease 4Health News:Pulmonary Hypertension Association Marks World PH Day on May 5 with a Worldwide Lifesaving Social Media Blitz 2Health News:Pulmonary Hypertension Association Marks World PH Day on May 5 with a Worldwide Lifesaving Social Media Blitz 3Health News:Array Health’s Senior Director of Marketing to Present at The Fourth Annual Direct-to-Consumer Health Care Marketing Summit 2
... life when some students pushed him from the front bench in ... ,Qamar Irfan, a Class 5 student of Sarda Convent School in ... forcibly pushed off the bench by students in a fight over ... members, Qamar rushed into the class as soon as school opened ...
... diagnosed with stomach cancer. He was 68 years old then.// ... out that the hospital pathologist had misdiagnosed tests and Mr. ... out in October 2002 at Walsall Manor Hospital. The pathologist ... Wolverhampton trust. Royal Wolverhampton Hospitals NHS Trust owned up liability ...
... who are circumcised are less likely to contract HIV ... research presented recently at the International AIDS Conference at ... percent less likely to contract HIV than their uncircumcised ... ,Circumcision is the surgical removal of the foreskin ...
... New York shows that patients, who experience the health ... //be a lot done for its improvement, with almost ... health care. ,According to the ... Performance Health System, an astonishingly high amount of Americans, ...
... According to a new study by Duke University Medical ... the rate of treatment //for chronic hepatitis C than ... in the August issue of Gastroenterology, which is the ... (AGA), that the African American patients with hepatitis C ...
... The Health Service Executive in Ireland is all set to ... emergency overcrowding.// ,The Irish Examiner reports that hospitals may ... with the A&E crisis, where patients are made to wait ... A&E patients are not made to wait over 24 hours. ...
Cached Medicine News:Health News:Majority Of People In US Seek Essential Changes In Health Care System 2Health News:Majority Of People In US Seek Essential Changes In Health Care System 3Health News:Majority Of People In US Seek Essential Changes In Health Care System 4Health News:African-Americans Have A Reduced Response To Hepatitis C Treatment 2Health News:African-Americans Have A Reduced Response To Hepatitis C Treatment 3
(Date:4/27/2015)... April 27, 2015  Eiger BioPharmaceuticals, Incorporated today announced ... of lonafarnib in patients with chronic hepatitis delta viral ... program, enrolled at Ankara University Medical School, ... endemic. LOWR HDV - 1 (LOnafarnib ... study which randomized subjects to receive different doses of ...
(Date:4/27/2015)... 27, 2015 Kalorama Information expects the ... (EMR) to grow well past the period where ... to a recent report.  The healthcare market research ... continued efficiency improvements will grow the market seven ... five years.  The market for EMR systems continues ...
(Date:4/27/2015)... 2015  Novira Therapeutics, Inc., a privately held, clinical-stage ... chronic hepatitis B virus (HBV) infection, today announced the ... core inhibitor candidate, NVR 3-778, at the 2015 annual ... the Liver (EASL) in Vienna, Austria ... from studies performed in a humanized UPA/SCID mouse model ...
Breaking Medicine Technology:Eiger Bio Announces Interim Results of Lonafarnib in Combination with Ritonavir or Pegylated Interferon in Patients Infected with Hepatitis Delta Virus (HDV) 2Eiger Bio Announces Interim Results of Lonafarnib in Combination with Ritonavir or Pegylated Interferon in Patients Infected with Hepatitis Delta Virus (HDV) 3Kalorama: EMR Market Expected To Grow Beyond Incentives 2Kalorama: EMR Market Expected To Grow Beyond Incentives 3Novira Therapeutics Announces Presentation of Preclinical Antiviral Data for NVR 3-778 at EASL 2Novira Therapeutics Announces Presentation of Preclinical Antiviral Data for NVR 3-778 at EASL 3
... 17, 2011 Damage to the spine can happen for ... car accident, wear and tear from old age, or blunt ... past have had to deal with back braces, reduced mobility, ... Seyed M. Rezaian,s patented Spinal Fixator, patients are able to ...
... Unilife Corporation ("Unilife" or the "Company") (NASDAQ: ... Deputy Secretary of the U.S. Department of Agriculture, for a ... at its facility in York, Pennsylvania. The White ... direction of President Obama. The Winning the Future Roundtables ...
Cached Medicine Technology:Dr. Seyed M. Rezaian's Spinal Fixator a Revolutionary Invention for Healing Injuries of the Thoracolumbar Spine 2Unilife Hosts White House Business Council Meeting 2Unilife Hosts White House Business Council Meeting 3
IFA for the direct detection of Respiratory Syncytial Virus (RSV)...
... RSV Test utilizes a new, improved format that ... rapid RSV detection. The testing device employs innovative ... reagents have already been applied to the testing ... with clear-cut results shown by the appearance of ...
Latex agglutination slide test for the qualitative detection of rotavirus from fecal specimens....
ELISA for Anti-Proteinase 3 PR3 (cANCA)....
Medicine Products: