Navigation Links
UCLA, Caltech research on immune-cell therapy could strengthen promising melanoma treatment
Date:3/22/2013

ose were not the genetically engineered T cells, and they appeared to be a byproduct of a process called 'antigen spreading' by the original engineered cells. After 90 days, those cells lost their tumor-killing ability as well."

Antigen spreading is a process by which a T cell that has been engineered to attack a particular tumor expands its immune response to other T cells in the body, which then attack the same tumor but are focused on different antigens. (Antigens are substances that trigger a response by the body's immune system.) Scientists may be able to use this process, Heath stressed, to improve T cellbased treatments for melanoma.

"Our results have led us to possible ways to improve the T cell therapy to extend its positive effect," Heath said. "We need to incorporate strategies that maintain the functional properties of the engineered T cells used for therapy. This might include modifying how we grow the T cells in the laboratory to make their tumor-killing effect last longer or make them resistant to the effects of the patient's T cells as they recover from pretreatment chemotherapy conditioning and possibly increase the antigen spreading of anti-tumor T cells."

UCLA professor of medicine Dr. Antoni Ribas was one of Heath's key collaborators on the research.

"One of the possible approaches to resolve the problem identified by this study is to use engineered blood stem cells instead of the peripheral blood used in the original trials with this therapy in the hope that the engineered blood stem cells will provide a renewable source of engineered T cells," said Ribas, a member of UCLA's Broad Stem Cell Research Center and Jonsson Cancer Center.

Caltech's Chao Ma, the study's first author, said the findings and the use of the new nanotechnology assay process hold promise for treatments of other disease as well.

"This study points to the value of these single-cell functional analyses for probi
'/>"/>

Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists from UCLA, Israels Technion uncover brains code for pronouncing vowels
2. Michigan Lupus Foundation Texas Hold 'Em Tournament Raises Thousands for Lupus Support, Education & Research
3. Frisco Institute for Reproductive Medicine Welcomes China Research Team
4. Research explores links between physical and emotional pain relief
5. Multiple sclerosis research: The thalamus moves into the spotlight
6. Dr. Roger D. Weiss earns Hazeldens Dan Anderson Research Award
7. Patient Wishes Should Guide End-of-Life Care, Researchers Say
8. Scripps Research study underlines potential of new technology to diagnose disease
9. Researchers new method may sharpen microscopic images
10. New web portal on health research in Europe
11. Researchers tackle physician challenge of correctly ordering laboratory tests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... ... July 06, 2015 , ... With a new community ... with Livonia Save Our Youth and announced a new charity campaign to raise funds ... to alcohol and drug abuse. Livonia Save Our Youth is a coalition created especially ...
(Date:7/6/2015)... ... July 06, 2015 , ... Dr. Lawrence Green is now offering the newly ... is a non-surgical method to dissolve fat cells and is the first of ... deposits under the chin, commonly known as a double chin. Dr. Green participated in ...
(Date:7/6/2015)... London, United Kingdom (PRWEB) , ... July 06, 2015 , ... ... Guide app could help. More than 29 million Americans have diabetes, the majority of ... addition, 86 million U.S. adults or more than one in three, have prediabetes (abnormally ...
(Date:7/5/2015)... ... July 06, 2015 , ... Security Life Insurance ... announce the next generation of PrimeStar Individual Dental Insurance. Beginning now, enhancements include ... network options—Maximum Allowable Charge (MAC) and usual, customary and reasonable (UCR). , ...
(Date:7/5/2015)... ... July 05, 2015 , ... World Patent ... Master, a landscaping invention that effectively removes weeds without harming man and ... Scott Cooper, CEO and Creative Director of World Patent Marketing. "It is projected ...
Breaking Medicine News(10 mins):Health News:Bowker Insurance Group and Nonprofit Livonia Save Our Youth Initiate New Charity Campaign in Livonia, MI to Provide for The Health and Safety of The Communities’ Youth 2Health News:Bowker Insurance Group and Nonprofit Livonia Save Our Youth Initiate New Charity Campaign in Livonia, MI to Provide for The Health and Safety of The Communities’ Youth 3Health News:Rockville, MD Practice Now Offering New FDA-Approved Non-Surgical Double Chin Treatment 2Health News:115 Million in the U.S. could beat diabetes with the help of a new app 2Health News:Security Life Insurance Company of America Launches the Next Generation of PrimeStar Individual Dental Insurance Plans 2Health News:8 Landscaping Tips That Can Save You Money Thanks To World Patent Marketing's Innovative Landscaping Invention 2Health News:8 Landscaping Tips That Can Save You Money Thanks To World Patent Marketing's Innovative Landscaping Invention 3Health News:8 Landscaping Tips That Can Save You Money Thanks To World Patent Marketing's Innovative Landscaping Invention 4Health News:8 Landscaping Tips That Can Save You Money Thanks To World Patent Marketing's Innovative Landscaping Invention 5
... breast cancer shows promise in fighting life-threatening fungal infections ... and patients with cancer. Some scientists suspected that tamoxifen ... of Rochester Medical Center shows that it actually kills ... "It,s still early, but if tamoxifen, or molecules like ...
... , CARY, Ill., July 20 Sage Products, Inc. ... of No. 5 on the list of the Best Medium Sized Companies ... and the Society for Human Resource Management (SHRM). Sage is a veteran-owned ... focus on prevention and solving challenges in the healthcare industry. , ...
... , , , WASHINGTON, July 20 The ... , Pro-life leaders to hold press conference discussing potential backlash -- ... to kill the innocent. , , Address: National Press ... Time and Date: 2:00 PM, Tuesday, July 21 , , ...
... , , , , ... more than 260 of the country,s brightest undergraduate students met at ... bring together program participants and help them apply their science research ... , The three-day symposium is a key component of ...
... smoking-related content, study shows, , MONDAY, July 20 (HealthDay News) ... TV shows or movies that glamorize smoking, he or she ... particularly from popular social networking sites such as MySpace and ... Pediatrics , found that the Internet is the newest ...
... , , CHICAGO, July 20 ... Corporation (NYSE: WAT ) is introducing clinical scientists to ... including a new research use only (RUO) kit for quantitative measurement ... AACC meeting, the Waters(R) MassTrak(TM) Immunosuppressants XE RUO Kit ...
Cached Medicine News:Health News:Breast cancer drug shows promise against serious infections 2Health News:Sage Products Named a Top Five Medium Sized Company to Work For In America 2Health News:Sage Products Named a Top Five Medium Sized Company to Work For In America 3Health News:Sage Products Named a Top Five Medium Sized Company to Work For In America 4Health News:Amgen Scholars Discover Their Potential During Summer Science Research Program and National Symposium 2Health News:Amgen Scholars Discover Their Potential During Summer Science Research Program and National Symposium 3Health News:Internet May Be Newest Venue for Teen Tobacco Exposure 2Health News:Internet May Be Newest Venue for Teen Tobacco Exposure 3Health News:Waters Drives Efficiency in the Clinical and Research Laboratory and Showcases New MassTrak Systems at AACC 2009 2Health News:Waters Drives Efficiency in the Clinical and Research Laboratory and Showcases New MassTrak Systems at AACC 2009 3Health News:Waters Drives Efficiency in the Clinical and Research Laboratory and Showcases New MassTrak Systems at AACC 2009 4
(Date:7/6/2015)... FRANCISCO, Calif. , July 6, 2015 ... pharmaceutical company, and Oculeve, a development-stage medical device company ... today announced that they have entered into an agreement ... transaction.  Under the terms of the agreement, Allergan will ... commercialization milestone payments related to Oculeve,s lead development program ...
(Date:7/6/2015)... , July 6, 2015 /PRNewswire/ -- China Nepstar Chain Drugstore ... a leading retail drugstore chain in China ... stores, today announced that its board of directors has ... 2015, from Simin Zhang , chairman of the ... Drugstore Holding Ltd., an investment vehicle wholly owned by ...
(Date:7/4/2015)... 4, 2015 Adding SIR-Spheres® ... with unresectable metastatic colorectal cancer in the liver ... Patients with unresectable metastatic colorectal cancer ... experienced the greatest improvement in Progression-Free Survival (PFS) ... Y-90 resin microspheres to a current first-line chemotherapy ...
Breaking Medicine Technology:Allergan to Acquire Oculeve Dry Eye Disease Development Programs 2Allergan to Acquire Oculeve Dry Eye Disease Development Programs 3Allergan to Acquire Oculeve Dry Eye Disease Development Programs 4China Nepstar Chain Drugstore Ltd. Announces Receipt of "Going Private" Proposal 2China Nepstar Chain Drugstore Ltd. Announces Receipt of "Going Private" Proposal 3China Nepstar Chain Drugstore Ltd. Announces Receipt of "Going Private" Proposal 4China Nepstar Chain Drugstore Ltd. Announces Receipt of "Going Private" Proposal 5China Nepstar Chain Drugstore Ltd. Announces Receipt of "Going Private" Proposal 6New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 2New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 3New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 4
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: