Navigation Links
UCLA, Caltech research on immune-cell therapy could strengthen promising melanoma treatment
Date:3/22/2013

ose were not the genetically engineered T cells, and they appeared to be a byproduct of a process called 'antigen spreading' by the original engineered cells. After 90 days, those cells lost their tumor-killing ability as well."

Antigen spreading is a process by which a T cell that has been engineered to attack a particular tumor expands its immune response to other T cells in the body, which then attack the same tumor but are focused on different antigens. (Antigens are substances that trigger a response by the body's immune system.) Scientists may be able to use this process, Heath stressed, to improve T cellbased treatments for melanoma.

"Our results have led us to possible ways to improve the T cell therapy to extend its positive effect," Heath said. "We need to incorporate strategies that maintain the functional properties of the engineered T cells used for therapy. This might include modifying how we grow the T cells in the laboratory to make their tumor-killing effect last longer or make them resistant to the effects of the patient's T cells as they recover from pretreatment chemotherapy conditioning and possibly increase the antigen spreading of anti-tumor T cells."

UCLA professor of medicine Dr. Antoni Ribas was one of Heath's key collaborators on the research.

"One of the possible approaches to resolve the problem identified by this study is to use engineered blood stem cells instead of the peripheral blood used in the original trials with this therapy in the hope that the engineered blood stem cells will provide a renewable source of engineered T cells," said Ribas, a member of UCLA's Broad Stem Cell Research Center and Jonsson Cancer Center.

Caltech's Chao Ma, the study's first author, said the findings and the use of the new nanotechnology assay process hold promise for treatments of other disease as well.

"This study points to the value of these single-cell functional analyses for probi
'/>"/>

Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists from UCLA, Israels Technion uncover brains code for pronouncing vowels
2. Michigan Lupus Foundation Texas Hold 'Em Tournament Raises Thousands for Lupus Support, Education & Research
3. Frisco Institute for Reproductive Medicine Welcomes China Research Team
4. Research explores links between physical and emotional pain relief
5. Multiple sclerosis research: The thalamus moves into the spotlight
6. Dr. Roger D. Weiss earns Hazeldens Dan Anderson Research Award
7. Patient Wishes Should Guide End-of-Life Care, Researchers Say
8. Scripps Research study underlines potential of new technology to diagnose disease
9. Researchers new method may sharpen microscopic images
10. New web portal on health research in Europe
11. Researchers tackle physician challenge of correctly ordering laboratory tests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/4/2015)... ... September 04, 2015 , ... A Union ... Project. Core Compassion Project is a non-profit organization dedicated to offering Pilates ... effects of cancer treatments and recover their mobility, strength, and range of motion ...
(Date:9/4/2015)... ... 2015 , ... Mike Day, a former Navy SEAL who was shot 27 ... Championships in Kona on October 10th. , Mike is running the race to raise ... and the cutting-edge treatments that restore their quality of life. More than ...
(Date:9/4/2015)... (PRWEB) , ... September 04, 2015 , ... Having access ... This has led to an increasing amount of unnecessary emergency room visits which affects ... and taxes the country’s health bill. Fortunately, a solution to alleviate this problem has ...
(Date:9/4/2015)... ... ... and Overseer at The House of Yahweh, has written an open letter to Pope Francis ... United States. , Yisrayl lays out what he says is the true meaning of the ... provides the meaning of his own name and describes what bible prophecy says about his ...
(Date:9/3/2015)... , ... September 03, 2015 , ... While bariatric surgeon ... the best practices when preparing for a bariatric procedure, some patients have been recently ... from the basic instructions typical for many types of surgery that should be followed ...
Breaking Medicine News(10 mins):Health News:Girl’s Night Out to Benefit Core Compassion Project, Located at the Beautiful, Morning Glory Farm 2Health News:Navy SEAL Shot 27 Times Competes in Ironman World Championship in Kona to Raise Money for Veteran's Suffering from TBI and PTSD 2Health News:Telemedicine Platform DocChat Announces Launch Offering a Way for Patients to Consult Doctors and Receive Prescriptions 24/7 2Health News:Telemedicine Platform DocChat Announces Launch Offering a Way for Patients to Consult Doctors and Receive Prescriptions 24/7 3Health News:Yisrayl Hawkins Writes Open Letter to Pope Francis In Light of Approaching U.S. Visit 2Health News:Dr. Feiz and Associates Answer August's ‘Patient Submitted Question of the Month’: “How Can I Prepare for Weight Loss Surgery” 2
... year wind up in ER during major U.S. holidays, researchers ... kids are injured during the holidays, it,s not too many ... most damage, a new study shows. , Rather, it is ... to fall prey to, the researchers from Nationwide Children,s Hospital ...
... ... ... (TNI) announced a new quarter of a million dollar challenge to all superfruit companies in ... up to Tahitian Noni Bioactive Beverages., , , , ,Tahitian Noni International will pay $250,000 ...
... ... CFO magazine, won an Excellence in Financial Journalism Award from the New York State Society ... ... Myers, contributing editor of CFO magazine , won an Excellence in Financial Journalism Award ...
... ... announced a collaboration with SkillSoft Asia Pacific to provide SkillSoft’s full ... with SkillSoft to provide SkillSoft’s content to our clients” said Lyle ... provision of our technology enabled learning needs. Our clients have an ...
... ... patient education content for urgent care websites. These customizable pages inform prospective patients about ... this content helps the urgent care clinics attract patients who would otherwise go to a ... ...
... disabilities related to mobility increased significantly from 1997 to 2007, ... among Americans ages 65 and over, according to a new ... Researchers found a rise in the proportion of Americans ... need for help in daily personal care activities such as ...
Cached Medicine News:Health News:Most Holiday Injuries to Kids Spurred by Everyday Mishaps 2Health News:Quarter of a Million Dollar Superfruit Challenge Announced 2Health News:CFO magazine Wins Excellence in Financial Journalism Award 2Health News:PeopleStreme Collaborates with SkillSoft for Learning Management Content 2Health News:WebForDoctors' Medical Content Pages Direct Patients to Urgent Care Centers as Alternatives to Emergency Rooms 2Health News:WebForDoctors' Medical Content Pages Direct Patients to Urgent Care Centers as Alternatives to Emergency Rooms 3Health News:Middle-aged Americans reporting more mobility related disabilities, study finds 2Health News:Middle-aged Americans reporting more mobility related disabilities, study finds 3
(Date:9/3/2015)... 2015 Report Details ... Market, its R&D and Sales Potentials ... cancer-treating medicines? Visiongain,s new report gives you revenue predictions for ... discover financial data, R&D trends, opportunities, interviews and revenue forecasts. ... you see forecasted sales to 2025 at overall world market, ...
(Date:9/3/2015)... Sept. 3,  2015 About artificial ... devices, which are implanted or integrated into ... These include artificial heart, kidney, pancreas, and ... (polyurethane, polysulfone, and porous polypropylene), biologics, ceramics, ... organs. These organs are incorporated with different ...
(Date:9/3/2015)... , Sept. 3, 2015 Nevro Corp. ... that is providing innovative evidence-based solutions for the treatment ... be presenting at the Morgan Stanley Global Healthcare Conference ... Nevro management is scheduled to present ... via a live audio webcast, accessible in the "Investors" ...
Breaking Medicine Technology:World Cancer-Treating Drugs Industry and Market: Companies, Therapies, R&D and Forecasts 2015-2025 2World Cancer-Treating Drugs Industry and Market: Companies, Therapies, R&D and Forecasts 2015-2025 3World Cancer-Treating Drugs Industry and Market: Companies, Therapies, R&D and Forecasts 2015-2025 4World Cancer-Treating Drugs Industry and Market: Companies, Therapies, R&D and Forecasts 2015-2025 5World Cancer-Treating Drugs Industry and Market: Companies, Therapies, R&D and Forecasts 2015-2025 6World Cancer-Treating Drugs Industry and Market: Companies, Therapies, R&D and Forecasts 2015-2025 7Global Artificial Organ Market 2015-2019 2
...
30 Pre-formed and razor sharp...
Stab incision blades color coded for simple and accurate identification...
Open wire loops decrease the chance of interfering with instruments, Designed to retract the eyelid during ophthalmic microsurgery or minor office procedures...
Medicine Products: