Navigation Links
UCLA, Caltech research on immune-cell therapy could strengthen promising melanoma treatment
Date:3/22/2013

A new study of genetically modified immune cells by scientists from UCLA and the California Institute of Technology could help improve a promising treatment for melanoma, an often fatal form of skin cancer.

The research, which appears March 21 in the advance online edition of the journal Cancer Discovery, was led by James Heath, a member of UCLA's Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research and UCLA's Jonsson Comprehensive Cancer Center. Heath is a professor of molecular and medical pharmacology at UCLA and also holds the Elizabeth W. Gilloon Chair in Chemistry at Caltech.

The melanoma treatment uses T cells immune cells that play a major role in fighting infection taken from patients with melanoma. The cells are then genetically modified in the laboratory so that when they are reintroduced into a patient's bloodstream, they specifically attack melanoma tumors. In early clinical trials, this treatment was shown to shrink tumors dramatically in many patients, but the positive effects were often short-lived.

The UCLA and Caltech researchers found that after the engineered T cells were returned to patients, their efficacy faded within two to three weeks. Surprisingly, however, once the engineered cells were no longer effective, a new group of non-engineered T cells arose that had a similar tumor-killing effect that lasted even longer, the scientists discovered.

Using newly developed nanotechnology chips to perform multidimensional and multiplexed immune-monitoring assays, the researchers were able to examine at high resolution single engineered T cells taken at different times from patients undergoing the therapy, each of whom had a different level of response to the treatment.

"The engineered T cells did not recover their tumor-killing effect," Heath said, "but after one month, another group of T cells appeared that did have tumor-killing effects for another 90 days. Th
'/>"/>

Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists from UCLA, Israels Technion uncover brains code for pronouncing vowels
2. Michigan Lupus Foundation Texas Hold 'Em Tournament Raises Thousands for Lupus Support, Education & Research
3. Frisco Institute for Reproductive Medicine Welcomes China Research Team
4. Research explores links between physical and emotional pain relief
5. Multiple sclerosis research: The thalamus moves into the spotlight
6. Dr. Roger D. Weiss earns Hazeldens Dan Anderson Research Award
7. Patient Wishes Should Guide End-of-Life Care, Researchers Say
8. Scripps Research study underlines potential of new technology to diagnose disease
9. Researchers new method may sharpen microscopic images
10. New web portal on health research in Europe
11. Researchers tackle physician challenge of correctly ordering laboratory tests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... Beach, FL (PRWEB) August 01, 2014 ... announced today the opening of a new K-CAPS® ... , The company announced expansion plans last year ... According to Dale Martin, General Manager, “KCAPS® are ... the world.” He added that: “Compared to other ...
(Date:8/1/2014)... South Jordan, Utah (PRWEB) August 01, 2014 ... selling company MonaVie, who completes its 500th week of ... paid since the company was founded in January 2005 ... 39 countries throughout the world. The company pays commissions ... HKD, HUF, ILS, JPY, MYR, MXN, NZD, PLN, USD, ...
(Date:8/1/2014)... (PRWEB) August 01, 2014 Transparency ... announced the addition of a comprehensive report on ... ‘Infusion System Market (Large Volume, Disposable, Syringe, Ambulatory ... Growth, Trends And Forecast, 2013 – 2019’ is ... http://www.transparencymarketresearch.com . , To begin with, the ...
(Date:8/1/2014)... Thompson HealthDay Reporter THURSDAY, ... raging in West Africa has a well-earned reputation as one ... that early and intense medical care can greatly improve a ... for Ebola, which wreaks life-threatening havoc within the body by ... doctors must fall back on the basics of "good meticulous ...
(Date:8/1/2014)... University] New research shows that people who grew ... have a 16-percent greater risk of experiencing poor health ... member sent to prison. The finding, which accounted for ... high rate of imprisonment may be independently imparting enduring ... "These people were children when this happened, and it ...
Breaking Medicine News(10 mins):Health News:MonaVie Records 500th Commission Week, Having Paid Out More Than $1.4B in Distributor Commissions 2Health News:Transparency Market Research Adds Report on Global Infusion System Market to its Repository 2Health News:Transparency Market Research Adds Report on Global Infusion System Market to its Repository 3Health News:There's No Ebola Cure, But Early Intensive Treatment Boosts Survival 2Health News:There's No Ebola Cure, But Early Intensive Treatment Boosts Survival 3Health News:Jailed family member increases risks for kids' adult health 2Health News:Jailed family member increases risks for kids' adult health 3
... program continues momentum in North ... ... nation,s largest effort to reward physicians for,delivering high-quality care, announced today that ... BCBSNC,and the North Carolina State Health Plan are collaborating in a three-year,pilot ...
... WellPoint,NextRx, the nation,s largest health plan-owned pharmacy benefits manager,(PBM) ... Idaho to serve,as the pharmacy benefits manager for their ... of Idaho, an independent licensee of the Blue,Cross Blue ... contract,will extend this agreement for an additional five years., ...
... to Provide ... for Their Families, CHICAGO, May 7 Mother,s Day is ... gatherings and gifts,and to honor those who give so much to their families ... of those mothers who,live in poverty and need the assistance of programs offered ...
... sales $50.8 million, up 25% versus year ago on operating basis ... high commodity costs - Net loss $1.2 million, includes ... 30% growth in net sales on operating basis (1), PARAMUS, ... announced its results for the first quarter ended,March 31, 2008. The ...
... activity in brain,s reward centers , , WEDNESDAY, May 7 ... that a gut hormone known for its appetite-promoting powers ... make food look more tasty and irresistible. , The ... this hormone,s so-called "hedonic effect" on the senses unfolds ...
... as Steno, has just been sequenced. The results reveal ... The research was carried out by scientists at the ... of Bristol. , Understanding the genome of this ... this particularly resistant organism. The paper will be published ...
Cached Medicine News:Health News:Blue Cross and Blue Shield of North Carolina Achieves Bridges to Excellence Certification 2Health News:Blue Cross and Blue Shield of North Carolina Achieves Bridges to Excellence Certification 3Health News:WellPoint NextRx Announces New Agreement With Blue Cross of Idaho 2Health News:Catholic Charities Calls for Increased Support of Mothers in Need: 2Health News:Smart Balance Announces 2008 First-Quarter Results 2Health News:Smart Balance Announces 2008 First-Quarter Results 3Health News:Smart Balance Announces 2008 First-Quarter Results 4Health News:Smart Balance Announces 2008 First-Quarter Results 5Health News:Smart Balance Announces 2008 First-Quarter Results 6Health News:Smart Balance Announces 2008 First-Quarter Results 7Health News:Smart Balance Announces 2008 First-Quarter Results 8Health News:Smart Balance Announces 2008 First-Quarter Results 9Health News:Smart Balance Announces 2008 First-Quarter Results 10Health News:Smart Balance Announces 2008 First-Quarter Results 11Health News:Smart Balance Announces 2008 First-Quarter Results 12Health News:Hunger Hormone Makes Food Look More Tasty 2Health News:Hunger Hormone Makes Food Look More Tasty 3Health News:Superbug genome sequenced 2
(Date:8/1/2014)... 2014 /PRNewswire-iReach/ -- DeepResearchReports.com adds "2014 Deep Research ... and "2014 Deep Research Report on Global and ... research database. Photo - ... Report on Global and China Potassium Nitrate  Industry" ... China and Global Potassium ...
(Date:7/31/2014)... July 31, 2014 STAAR Surgical Company (NASDAQ: ... marketer of implantable lenses and delivery systems for the ... July 4, 2014 of $20.0 million, a 10% increase ... 2013. On a constant currency basis, revenues grew 11% ... second quarter of 2013.  The effect of foreign currency ...
(Date:7/31/2014)... Calif., July 31, 2014 Xencor Inc. ... company developing engineered monoclonal antibodies for the treatment ... cancer, today reported financial results for the second ... of recent business highlights. "In the ... American Thoracic Society 2014 International Conference (ATS) demonstrating ...
Breaking Medicine Technology:Potassium Nitrate Market & Tricalcium Phosphate Industry Analysis for Global & China Regions 2Potassium Nitrate Market & Tricalcium Phosphate Industry Analysis for Global & China Regions 3Potassium Nitrate Market & Tricalcium Phosphate Industry Analysis for Global & China Regions 4Potassium Nitrate Market & Tricalcium Phosphate Industry Analysis for Global & China Regions 5STAAR Surgical Reports 10% Second Quarter Revenue Growth 2STAAR Surgical Reports 10% Second Quarter Revenue Growth 3STAAR Surgical Reports 10% Second Quarter Revenue Growth 4STAAR Surgical Reports 10% Second Quarter Revenue Growth 5STAAR Surgical Reports 10% Second Quarter Revenue Growth 6STAAR Surgical Reports 10% Second Quarter Revenue Growth 7STAAR Surgical Reports 10% Second Quarter Revenue Growth 8STAAR Surgical Reports 10% Second Quarter Revenue Growth 9STAAR Surgical Reports 10% Second Quarter Revenue Growth 10STAAR Surgical Reports 10% Second Quarter Revenue Growth 11STAAR Surgical Reports 10% Second Quarter Revenue Growth 12STAAR Surgical Reports 10% Second Quarter Revenue Growth 13STAAR Surgical Reports 10% Second Quarter Revenue Growth 14STAAR Surgical Reports 10% Second Quarter Revenue Growth 15STAAR Surgical Reports 10% Second Quarter Revenue Growth 16STAAR Surgical Reports 10% Second Quarter Revenue Growth 17STAAR Surgical Reports 10% Second Quarter Revenue Growth 18STAAR Surgical Reports 10% Second Quarter Revenue Growth 19STAAR Surgical Reports 10% Second Quarter Revenue Growth 20STAAR Surgical Reports 10% Second Quarter Revenue Growth 21STAAR Surgical Reports 10% Second Quarter Revenue Growth 22STAAR Surgical Reports 10% Second Quarter Revenue Growth 23STAAR Surgical Reports 10% Second Quarter Revenue Growth 24STAAR Surgical Reports 10% Second Quarter Revenue Growth 25STAAR Surgical Reports 10% Second Quarter Revenue Growth 26STAAR Surgical Reports 10% Second Quarter Revenue Growth 27STAAR Surgical Reports 10% Second Quarter Revenue Growth 28STAAR Surgical Reports 10% Second Quarter Revenue Growth 29STAAR Surgical Reports 10% Second Quarter Revenue Growth 30STAAR Surgical Reports 10% Second Quarter Revenue Growth 31Xencor Reports Second Quarter 2014 Financial Results 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: