Navigation Links
UCLA, Caltech research on immune-cell therapy could strengthen promising melanoma treatment
Date:3/22/2013

A new study of genetically modified immune cells by scientists from UCLA and the California Institute of Technology could help improve a promising treatment for melanoma, an often fatal form of skin cancer.

The research, which appears March 21 in the advance online edition of the journal Cancer Discovery, was led by James Heath, a member of UCLA's Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research and UCLA's Jonsson Comprehensive Cancer Center. Heath is a professor of molecular and medical pharmacology at UCLA and also holds the Elizabeth W. Gilloon Chair in Chemistry at Caltech.

The melanoma treatment uses T cells immune cells that play a major role in fighting infection taken from patients with melanoma. The cells are then genetically modified in the laboratory so that when they are reintroduced into a patient's bloodstream, they specifically attack melanoma tumors. In early clinical trials, this treatment was shown to shrink tumors dramatically in many patients, but the positive effects were often short-lived.

The UCLA and Caltech researchers found that after the engineered T cells were returned to patients, their efficacy faded within two to three weeks. Surprisingly, however, once the engineered cells were no longer effective, a new group of non-engineered T cells arose that had a similar tumor-killing effect that lasted even longer, the scientists discovered.

Using newly developed nanotechnology chips to perform multidimensional and multiplexed immune-monitoring assays, the researchers were able to examine at high resolution single engineered T cells taken at different times from patients undergoing the therapy, each of whom had a different level of response to the treatment.

"The engineered T cells did not recover their tumor-killing effect," Heath said, "but after one month, another group of T cells appeared that did have tumor-killing effects for another 90 days. Th
'/>"/>

Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists from UCLA, Israels Technion uncover brains code for pronouncing vowels
2. Michigan Lupus Foundation Texas Hold 'Em Tournament Raises Thousands for Lupus Support, Education & Research
3. Frisco Institute for Reproductive Medicine Welcomes China Research Team
4. Research explores links between physical and emotional pain relief
5. Multiple sclerosis research: The thalamus moves into the spotlight
6. Dr. Roger D. Weiss earns Hazeldens Dan Anderson Research Award
7. Patient Wishes Should Guide End-of-Life Care, Researchers Say
8. Scripps Research study underlines potential of new technology to diagnose disease
9. Researchers new method may sharpen microscopic images
10. New web portal on health research in Europe
11. Researchers tackle physician challenge of correctly ordering laboratory tests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/4/2015)... ... September 04, 2015 , ... ECC announces the ... created specifically for adults with intellectual, developmental and acquired disabilities. The first community, ... 30 cottage or “pocket” homes. In this community, adults will live safely and ...
(Date:9/4/2015)... ... 2015 , ... FiltersFast.com, the online retail leader in air ... up. FiltersFast.com, will ship all orders over $50.00 for free. Use this ... advantage of this promotion now through September 8, 2015. , Filtersfast.com offers a ...
(Date:9/3/2015)... ... September 03, 2015 , ... Allied Anesthesia is proud to ... is the norm not the exception. , St. Jude was recently named one of ... Stroke Association, making it one of only 10 hospitals in the state to earn ...
(Date:9/3/2015)... ... 2015 , ... E-Volve Health, an Elliot Health System Company, ... to provide electronic medical record (EMR) consulting services to Amerinet clients running or ... pricing on E-Volve Health’s Epic EMR consulting, custom training and support services. E-Volve ...
(Date:9/3/2015)... ... , ... BedJet released a new version of its award winning personal climate ... BedJet v2 pre-order campaign blazed past the $1 million dollar mark in ... crowdfunding giant Kickstarter. , Simple to use and beautifully designed, the award winning BedJet ...
Breaking Medicine News(10 mins):Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 2Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 3Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 4Health News:FiltersFast.com Wows with a Long Labor Day Weekend Shipping Offer 2Health News:Allied Anesthesia Physicians Announce Partnership with St. Jude 2Health News:Allied Anesthesia Physicians Announce Partnership with St. Jude 3Health News:E-Volve Health to Offer EMR Consulting Solutions to Amerinet Members 2Health News:BedJet Hits $1 million in Sales in 28 Days on Kickstarter after Shark Tank Rejection 2Health News:BedJet Hits $1 million in Sales in 28 Days on Kickstarter after Shark Tank Rejection 3
... insights about how a bacterium uses different receptors to sense ... in environments of the order of 0.1%, approximating to a ... ,New Cornell research, highlighted on the cover of ... that receptors assemble into a kind of cooperative lattice on ...
... had suffered pneumonia eight times and experienced recurring pass-outs, had ... sense of the symptoms and providing answers. When the X-rays ... Kirchen that the symptoms may be signs of lung cancer. ... a respiratory physician, stumbled upon a nut, safely ensconced in ...
... of a nap, which follows after eating (traditionally called European ... due to changes in glucose levels//. ,Brain cells ... well as in animals become switched off after eating, and ... researchers at Manchester University finds. ,A tiny protein ...
... adult and two children have been diagnosed with the E.coli 0157 ... there have been three linked cases of E.coli 0157 within the ... a link with J&H Cairns, a butcher in the village. ... yet that J&H Cairns is the source of the outbreak, they ...
... (FGM) are significantly more likely to experience difficulties during childbirth ... result of the gruesome practice, a new United Nations study ... clear evidence of the harmful effects for women and children, ... million women worldwide., ,The serious complications during childbirth it ...
... admitted in a private hospital here in a serious condition, ... , today showed signs of improvement with all his vital ... conditon. His oxygen level and blood pressure are normal,' said ... in the wee hours., ,The doctors are also going ...
Cached Medicine News:Health News:Study Highlights How Bacteria Respond To Changes In Environment 2Health News:Diagnosis On a Fourth Patient Confirmed To Be E.Coli 2
(Date:9/3/2015)... 2015 About artificial organs ... are implanted or integrated into individuals to ... artificial heart, kidney, pancreas, and cochlear implants. ... and porous polypropylene), biologics, ceramics, and metals ... organs are incorporated with different technologies like ...
(Date:9/3/2015)...  WellCare Health Plans, Inc. (NYSE: WCG ) ... president and chief financial officer, is scheduled to present ... Wednesday, September 9, 2015, at 9:25 a.m. Eastern time. ... addition, a replay of the webcast will be available ... live broadcast and the replay will be available on ...
(Date:9/3/2015)... DUBLIN , Sep. 03, 2015 ... ) has announced the addition of the ... report to their offering. The clinical ... to its wide application and good efficacy especially ... slowing down ageing in recent years. Progesterone, ...
Breaking Medicine Technology:Global Artificial Organ Market 2015-2019 2China Progesterone Market Investigation Report 2015-2019 2
... Oral Presentation by Dr. Robert Figlin Highlights Phase 2 Data Showing ... Perifosine, Used as a Single Agent and Phase 1 Data ... Toxicity ... Biopharmaceuticals,Inc. today announced positive phase 1 & 2 data of perifosine ...
... MRSA School Scare Every day brings new reports ... -- of MRSA (methicillin-resistant staphylococcus aureus),a potentially lethal form ... and colleges. The most prominent symptoms,include skin abscesses and/or ... care facilities and attacks,those with low immune systems, children ...
Cached Medicine Technology:Phase 1 & 2 Data of Perifosine (KRX-0401) in Patients with Advanced Renal Cell Carcinoma Presented Today at the 25th Annual Chemotherapy Foundation Symposium 2Phase 1 & 2 Data of Perifosine (KRX-0401) in Patients with Advanced Renal Cell Carcinoma Presented Today at the 25th Annual Chemotherapy Foundation Symposium 3Phase 1 & 2 Data of Perifosine (KRX-0401) in Patients with Advanced Renal Cell Carcinoma Presented Today at the 25th Annual Chemotherapy Foundation Symposium 4Phase 1 & 2 Data of Perifosine (KRX-0401) in Patients with Advanced Renal Cell Carcinoma Presented Today at the 25th Annual Chemotherapy Foundation Symposium 5Phase 1 & 2 Data of Perifosine (KRX-0401) in Patients with Advanced Renal Cell Carcinoma Presented Today at the 25th Annual Chemotherapy Foundation Symposium 6Phase 1 & 2 Data of Perifosine (KRX-0401) in Patients with Advanced Renal Cell Carcinoma Presented Today at the 25th Annual Chemotherapy Foundation Symposium 7An Open Letter to Parents, Students, School Administrators, & Health Care Officials from Soapopular(R) 2An Open Letter to Parents, Students, School Administrators, & Health Care Officials from Soapopular(R) 3
... Advantage delivers higher magnification for advanced surgical ... image, even at the highest magnification. 3.5x, ... and precise color rendition is ideal for ... anti-reflective coating produce a superior image. The ...
... up of doublet objective and high power ... and 3.0x. The true benefit of this ... maintaining focal clarity is made possible due ... ultra lightweight aluminum bar and individual interpupillary ...
Used for maintaining and forming the anterior chamber by the injection and removal of fluids, air miotics, and viscoeastic substances, as well as keeping the cornea moist during surgery. 4 mm from be...
23 gauge cannula (E4969 L) with 0.33 mm aspiration port, curved shaft and polished finish. Includes Teflon irrigating sleeve (E4969 SL). Uses 60 cm (23.6 inches) of silicone tubing (N5941 5). Overall...
Medicine Products: