Navigation Links
UCB Announces Positive Results From Phase II Clinical Trial of Investigational Anti-Epilepsy Drug Brivaracetam
Date:12/3/2007

55.8% of patients, for 5mg/day, 20mg/day and 50mg/day, respectively,

compared to 16.7% for placebo.

-- Produced seizure freedom rates of 7.7% for 20 mg-50 mg/day, 8% for

5mg/day and 1.9% for placebo over the treatment period.

Patients in the second study (Abstract 3.218) were randomized to receive 50 mg/day, 150 mg/day, or placebo, administered twice-daily without titration over the 12 week treatment period. The findings for the study's primary endpoint-reduction in weekly seizure frequency over placebo-were not statistically significant. However, an analysis of the study's secondary endpoints demonstrated a clear difference between placebo and the 50 mg/day dose:
-- The median difference versus placebo for the percent reduction from

baseline in seizure frequency per week was 22.5%.

-- There was at least a 50% reduction in weekly seizure frequency from

baseline in 39.6% of patients, compared with 23.1% for placebo.

-- Seizure freedom rates of 9.4% were seen for 50mg/day, compared with

1.9% for placebo.

Retention rates in both studies were high and similar to placebo, with up to 98% of patients in the treatment group completing the studies. The most commonly reported adverse events were nausea, vomiting, fatigue, nasopharyngitis, anorexia, convulsion, dizziness, headache, somnolence, and insomnia. A dose-response relationship was not observed for the majority of adverse events analyzed in the studies.

Phase III clinical trials of brivaracetam as adjunctive therapy in patients with refractory partial onset epilepsy are already underway. Nearly 1,300 epilepsy patients, ages 16-70, will take part in three multicenter, multinational phase III trials. Two randomized, double-blind, placebo- controlled studies are designed to evaluate the efficacy and safety of brivaracetam (5, 20 and 50 mg/day or 20, 50 and 100 mg/day) over 12 weeks in patients with partial onset epilepsy, no
'/>"/>

SOURCE UCB, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
2. CRC Health Group Announces Acquisition of Bayside Marin Recovery Center, San Rafael
3. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
4. HEI, Inc. Announces Sale of RFID Division Assets
5. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Zyloprim(R)
6. Mettler-Toledo International Inc. Announces Webcast of Presentation at Thomas Weisel Partners 2007 Healthcare Conference
7. Z Trim Announces Revocation of Gregory Halpern Severence Agreement
8. Brooke Franchise Corporation Announces Selected July Results
9. Manor Care, Inc. Announces Record Date for Special Stockholder Meeting
10. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Adipex-P(R)
11. Planet Technologies Announces Agreement to Acquire Antigen Laboratories
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... 2015 A Bakersfield, Calif. state court jury ... trial awarding the plaintiff Coleen M. Perry a total of ... a TVT-Abbrevo pelvic mesh sling device, manufactured by Ethicon, Inc., ... , a partner at Wagstaff & Cartmell in ... plaintiff, along with Rich Freese and Tim Goss of ...
(Date:3/5/2015)... New York, NY (PRWEB) March 05, 2015 ... to move forward in a Pennsylvania mass tort ... Common Pleas, where a jury has begun hearing ... allegations that the atypical antipsychotic medication can cause ... documents, the case in question was filed on ...
(Date:3/5/2015)... 05, 2015 Central Nebraska Imaging (CNI) ... including the brand’s new logo and optimized website. ... practice’s modern approach to expert diagnostic imaging, centered on ... be built to be a resource for Nebraska patients ... automated forms, communication and referral functionality, video content and ...
(Date:3/5/2015)... HomeCEUConnection.com is proud to ... savings on their nutrition CEUs. To raise ... nutrition, HomeCEUConnection.com is offering 10% off selected ... NUTRITION2015 . , High Quality Continuing ... provides high-quality continuing education courses for Physical ...
(Date:3/5/2015)... 2015 On March 2, 2015, NBC ... on the Rise, Plastic Surgeons Say,” that comments on ... for Aesthetic Plastic Surgery and the American ... a year-over-year doubling of surgical butt augmentations performed in ... the article, this increase can be attributed to the ...
Breaking Medicine News(10 mins):Health News:Client Wins $5.7 Million in TVT-Abbrevo Verdict against Johnson & Johnson in California State Court 2Health News:Risperdal Lawsuits Move Forward in Pennsylvania, as Bernstein Liebhard LLP Comments on Start of Second Gynecomastia Trial 2Health News:Risperdal Lawsuits Move Forward in Pennsylvania, as Bernstein Liebhard LLP Comments on Start of Second Gynecomastia Trial 3Health News:Central Nebraska Imaging Center Gets Rebranding 2Health News:HomeCEUConnection.com Offers Nutrition CEUs this March to Celebrate Nutrition Month 2Health News:The Kim Kardashian and Jennifer Lopez Effect: Butt Augmentations Double from 2013 to 2014 2
... reverse the health threats, experts say , , THURSDAY, Sept. 20 ... to control their weight by watching their cholesterol by cutting ... total calories and physical activity. And guess what happened to ... an end run around the issue of health maintenance," said ...
... scientific researchers: SNM invites you to present your ... molecular imaging techniques and agents -- at the ... New Orleans, La. SNM, the worlds largest society ... showcase these studies in a new scientific investigation ...
... 20, 2007 Defects on cell-surface sugars may promote ... the central nervous system of multiple sclerosis patients, according ... also suggest that a dietary supplement similar to glucosamine ... these defects and to treat both the short-term and ...
... is challenging conventional thinking on how the cholesterol-reducing drugs ... investigate her findings. , Dr Sarah Calaghan from the ... from Heart Research UK to progress her preliminary evidence ... , For a long time the cardiovascular ...
... RFID-based inventory management solution is installed ... track critical medical supplies., BOXBOROUGH, Mass., Sept. 20 ... highest level of care, UMass Memorial Medical Center,located in ... Massachusetts, has installed WaveMark CIMS(TM), an RFID-based,inventory management solution ...
... Makes ,House Call, to New Mexico, Urges Residents to Also Press ... ... Sept. 20 The American,Medical Association (AMA) National House Call campaign ... stop scheduled Medicare,cuts. Unless Congress intervenes, Medicare will slash physician payments ...
Cached Medicine News:Health News:Childhood Obesity Epidemic a Long-Term Challenge 2Health News:Childhood Obesity Epidemic a Long-Term Challenge 3Health News:SNM seeks novel approaches to molecular imaging to showcase at annual meeting 2Health News:Cell-surface sugar defects may trigger nerve damage in multiple sclerosis patients 2Health News:Research to shed new light on how statins benefit heart patients 2Health News:WaveMark, Inc. is Chosen by UMass Memorial Medical Center 2Health News:AMA Urges Congress to Stop Medicare Cuts 2
(Date:3/5/2015)...  Pfenex Inc. (NYSE MKT: PFNX), a clinical-stage ... therapeutics including high value and difficult to manufacture ... full year 2014 financial results will be released ... opens for trading.  At 9:00 am Eastern Time, ... discuss the financial results and provide a business ...
(Date:3/5/2015)... and TÜBINGEN, Germany ... & Melinda Gates Foundation and CureVac today announced ... invest $52 million (€46 million) in CureVac, a ... technologies. As part of the agreement, the foundation ... to develop prophylactic vaccines based on CureVac,s proprietary ...
(Date:3/5/2015)... 5, 2015  Sanomedics, Inc. (OTC: SIMH, SIMHD) ("Sanomedics" ... on developing, manufacturing, and acquiring cutting-edge technology, products and ... will be exhibiting at booth # 709 at the ... (NAPNAP) taking place on March 11-13, 2015 at Caesars ... The 36 th annual NAPNAP ...
Breaking Medicine Technology:Pfenex To Report Fourth Quarter and Full Year 2014 Results and Provide Business Update 2The Bill & Melinda Gates Foundation and CureVac Collaborate to Accelerate the Development of Transformative Vaccine Technology 2The Bill & Melinda Gates Foundation and CureVac Collaborate to Accelerate the Development of Transformative Vaccine Technology 3The Bill & Melinda Gates Foundation and CureVac Collaborate to Accelerate the Development of Transformative Vaccine Technology 4Sanomedics to Showcase the Caregiver at National Association of Pediatric Nurse Practitioners Conference 2Sanomedics to Showcase the Caregiver at National Association of Pediatric Nurse Practitioners Conference 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: