Navigation Links
UCB Announces Positive Results From Phase II Clinical Trial of Investigational Anti-Epilepsy Drug Brivaracetam
Date:12/3/2007

ATLANTA, Dec. 3 /PRNewswire/ -- UCB today announced data demonstrating that anti-epileptic drug (AED) brivaracetam, with the proposed trade name Rikelta(TM), administered as an adjunctive treatment in adults with refractory epilepsy with partial onset seizures, significantly reduced seizure frequency and had a side-effect profile comparable to placebo. The results of the two Phase IIb (Abstracts C.04 and 3.218), double-blind, randomized, parallel- group, placebo-controlled dose ranging studies were presented today as an oral platform presentation at the 61st annual meeting of the American Epilepsy Society.

"It is exciting to see the promising results that brivaracetam produced in this highly refractory population of epilepsy patients," said Jacqueline French, MD, lead study author and professor of neurology at New York University. "The development of novel anti-epilepsy drugs is vital to addressing the needs of treatment-resistant epilepsy patients. We look forward to seeing the results of our Phase III clinical research."

The two studies involved 365 patients, ages 16-65, with refractory partial onset seizures, which were uncontrolled despite treatment with one to two other AEDs. Patients in the first study (Abstract C.04) were randomized to receive 5 mg/day, 20 mg/day, 50 mg/day or placebo, administered twice-daily without titration over the seven week treatment period. The study found that brivaracetam reduced weekly seizure frequency over placebo by 9.8%, 14.9%, and 22.1% with doses of 5mg/day, 20 mg/day, and 50 mg/day, respectively, suggesting a dose response trend with brivaracetam 5 mg-50 mg/day.

An analysis of the study's secondary endpoints found that brivaracetam:

-- Reduced median seizure frequency from baseline by 29.9%, 42.6% and

53.1% for 5mg/day, 20mg/day and 50mg/day, respectively, compared with

21.7% for placebo.

-- Reduced weekly seizure frequency from baseline in 32.0%, 44.2% and


'/>"/>
SOURCE UCB, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
2. CRC Health Group Announces Acquisition of Bayside Marin Recovery Center, San Rafael
3. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
4. HEI, Inc. Announces Sale of RFID Division Assets
5. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Zyloprim(R)
6. Mettler-Toledo International Inc. Announces Webcast of Presentation at Thomas Weisel Partners 2007 Healthcare Conference
7. Z Trim Announces Revocation of Gregory Halpern Severence Agreement
8. Brooke Franchise Corporation Announces Selected July Results
9. Manor Care, Inc. Announces Record Date for Special Stockholder Meeting
10. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Adipex-P(R)
11. Planet Technologies Announces Agreement to Acquire Antigen Laboratories
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 2014 Princeview Dental ( http://www.princeviewdental.com ), ... expert opinion on the most effective oral care for ... practices and routines that are necessary for proper oral ... Dr. Janice Mummery, Founder of Princeview Dental. “Not too ... day is still important, as is using the proper ...
(Date:8/29/2014)... 2014 A recent article brings ... overexposure to the sun are well known, and yet many ... damage often doesn’t manifest itself physically on the skin until ... Thomas Leveritt showed, even if it can’t be seen the ... camera in order to show ordinary people on the street ...
(Date:8/29/2014)... 29, 2014 In 2014, industry veterans ... merging or selling their practices. The Deloitte’s 2013 Survey ... to retire earlier than planned in the next two ... physicians are concerned about the future of their profession ... general, physicians are cynical and worried about the future ...
(Date:8/29/2014)... Pearl River, NY (PRWEB) August 29, 2014 ... happier? Create incredible value proposition and provide top ... has recently expanded his practice by partnering with ... Dr. David Greuner, and launching two new websites! ... of breast, body and face surgical procedures. Some ...
(Date:8/29/2014)... 29, 2014 In short, minimally invasive ... Scott Katzman of Orthopedic and Laser Spine Surgery ... perform repairs. Problems with the discs, nerves and ... number of treatment needs that can be offered from ... an advantageously small incision and intervention that exposes the ...
Breaking Medicine News(10 mins):Health News:Princeview Dental, One of Etobicoke’s Trusted Dental Clinics, Announces the Best Tooth Brushing Practices for Kids 2Health News:Artist Uses Ultraviolet Camera to Reveal Hidden Sun Damage 2Health News:Artist Uses Ultraviolet Camera to Reveal Hidden Sun Damage 3Health News:Planning for Retiring, Selling, or Closing Down the Practice? Help is at Hand 2Health News:Planning for Retiring, Selling, or Closing Down the Practice? Help is at Hand 3Health News:Planning for Retiring, Selling, or Closing Down the Practice? Help is at Hand 4Health News:Michael Fiorillo’s Advanced Plastic Surgery Center Expansion – New Vein Specialist and Websites Launch 2Health News:Michael Fiorillo’s Advanced Plastic Surgery Center Expansion – New Vein Specialist and Websites Launch 3Health News:Advancements in Spine Surgery Offered by this Modern Florida Surgery Group are Cutting Out Historically Demanding Recovery Times 2
... Nov. 19 2009 has been a monumental year ... "moneyvation," from QUITPLAN Services, QuitCash Challenge, helped the 31-year-old ... win The Challenge. Nearly 2,000 Minnesotans, including Doug, attempted ... to win the $5,000 grand prize. , On Thursday, ...
... , Official Statement by Teamsters General President Jim ... President Jim Hoffa issued the following statement today about the ... higher-cost health plans that will mean a huge middle-class tax ... that would impose an excise tax on insurers for higher-cost ...
... , FAIRFIELD, N.J., Nov. 19 Monogram Energy, Inc. ... completed the acquisition of Triad Therapeutics, Inc. ("Triad"), which ... the terms of the Stock Purchase and Recapitalization Agreement, ... of Triad in exchange for approximately 95% ownership to ...
... who directs the University of Southern California Center ... effort to evaluate robots as exercise coaches for adults ... elderly. The effort, entitled "Robot Motivator: Towards Adaptive ... influence of virtual social characters on people,s motivation to ...
... , New Video Educates Kids on How to Prevent ... learn the five things that they can do to prevent the ... a new music video released today by the Department of Health. ... the simple ways to prevent H1N1 flu in a manner that ...
... WASHINGTON, Nov. 19 Now that a bill has been ... of the Democratic Caucus to vote to allow debate to ... promise of quality, affordable health care for all. , "Majority ... forward," said USAction Program Director Alan Charney. "Now it,s time ...
Cached Medicine News:Health News:First-Time Father-to-Be Quits Smoking, Wins $5,000 in The QuitCash Challenge(TM) 2Health News:First-Time Father-to-Be Quits Smoking, Wins $5,000 in The QuitCash Challenge(TM) 3Health News:Monogram Energy, Inc. Acquires Triad Therapeutics, Inc. 2Health News:Pennsylvania Department of Health Releases H1N1 Flu Prevention Music Video 2Health News:60 Votes: Democratic Caucus Must Move Forward With Promise of Quality, Affordable Health Care for All With a Public Insurance Option 2
(Date:8/28/2014)... , Aug. 28, 2014 Levi & Korsinsky ... in the United States District Court for the District ... investors who purchased Galectin Therapeutics Inc. ("Galectin" or the ... July 28, 2014. For more information, click ... that during the Class Period the Company violated federal ...
(Date:8/28/2014)... , August 28, 2014 ... "DNA diagnostics Market (products, applications, techniques, end users ... Growth and Forecast, 2013 - 2020," indicates that ... billion by 2020 registering a CAGR of 9.8% ... accurate diagnosis and cost effectiveness over alternative diagnostic ...
(Date:8/28/2014)... , Aug. 28, 2014 /PRNewswire-iReach/ -- Gateway ... at the 9 th Annual Global Pharma ... , September 8-9 th . The Global Pharma ... leaders in small molecule and biologic pharmaceutical manufacturing. ... challenges that today,s manufacturers face, such as the ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Levi & Korsinsky, LLP Reminds Investors of Class Action Against Galectin Therapeutics Inc. and Its Board of Directors and a Lead Plaintiff Deadline of September 29, 2014 -- GALT 2DNA Diagnostics Market is Expected to Reach $19 Billion by 2020 - Allied Market Research 2DNA Diagnostics Market is Expected to Reach $19 Billion by 2020 - Allied Market Research 3Gateway Analytical to Promote Particulate Identification Services at the 9th Annual Global Pharma Manufacturing Summit 2Gateway Analytical to Promote Particulate Identification Services at the 9th Annual Global Pharma Manufacturing Summit 3
... Catalina Council of the Boy Scouts of America announced ... the Chemistry Merit Badge requirements through an event hosted ... Valley, Arizona. Boy Scout participants will have the chance ... under whose guidance they can participate in activities geared ...
... 18, 2012  Acclaimed trial attorney Mark Lanier , founder ... keynote address at the HarrisMartin MDL Conference on Transvaginal ... in Miami, Fla. The conference at the Four ... lawyers and includes an in-depth review of the latest in ...
Cached Medicine Technology:Catalina Council Boy Scouts Partner With Sanofi US Tucson Research Center to Host First-Ever Chemistry Merit Badge Program 2Catalina Council Boy Scouts Partner With Sanofi US Tucson Research Center to Host First-Ever Chemistry Merit Badge Program 3Attorney Mark Lanier Presenting Keynote at National Mesh Litigation Conference 2
... Profile Ergonomic Design for Neurosurgery. ... offers rigid working channel scopes ... The rigid scope body facilitates ... the target. The steerable tip ...
... Ethisorb Dura Patch is a synthetic absorbable ... and. spinalis defects. Ethisorb Dura Patch is pliable, ... cut to the desired shape, care must be ... violet dyed, PDS foil covered side is oriented ...
... patch, Duragen is a matrix for ... handles and conforms similar to normal ... matrix for dural closure. Remarkable onlay ... defects. Fully resorbed following complete tissue ...
Elmed electrosurgical systems for major surgery....
Medicine Products: