Navigation Links
UCB Announces Positive Results From Phase II Clinical Trial of Investigational Anti-Epilepsy Drug Brivaracetam
Date:12/3/2007

ATLANTA, Dec. 3 /PRNewswire/ -- UCB today announced data demonstrating that anti-epileptic drug (AED) brivaracetam, with the proposed trade name Rikelta(TM), administered as an adjunctive treatment in adults with refractory epilepsy with partial onset seizures, significantly reduced seizure frequency and had a side-effect profile comparable to placebo. The results of the two Phase IIb (Abstracts C.04 and 3.218), double-blind, randomized, parallel- group, placebo-controlled dose ranging studies were presented today as an oral platform presentation at the 61st annual meeting of the American Epilepsy Society.

"It is exciting to see the promising results that brivaracetam produced in this highly refractory population of epilepsy patients," said Jacqueline French, MD, lead study author and professor of neurology at New York University. "The development of novel anti-epilepsy drugs is vital to addressing the needs of treatment-resistant epilepsy patients. We look forward to seeing the results of our Phase III clinical research."

The two studies involved 365 patients, ages 16-65, with refractory partial onset seizures, which were uncontrolled despite treatment with one to two other AEDs. Patients in the first study (Abstract C.04) were randomized to receive 5 mg/day, 20 mg/day, 50 mg/day or placebo, administered twice-daily without titration over the seven week treatment period. The study found that brivaracetam reduced weekly seizure frequency over placebo by 9.8%, 14.9%, and 22.1% with doses of 5mg/day, 20 mg/day, and 50 mg/day, respectively, suggesting a dose response trend with brivaracetam 5 mg-50 mg/day.

An analysis of the study's secondary endpoints found that brivaracetam:

-- Reduced median seizure frequency from baseline by 29.9%, 42.6% and

53.1% for 5mg/day, 20mg/day and 50mg/day, respectively, compared with

21.7% for placebo.

-- Reduced weekly seizure frequency from baseline in 32.0%, 44.2% and


'/>"/>
SOURCE UCB, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
2. CRC Health Group Announces Acquisition of Bayside Marin Recovery Center, San Rafael
3. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
4. HEI, Inc. Announces Sale of RFID Division Assets
5. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Zyloprim(R)
6. Mettler-Toledo International Inc. Announces Webcast of Presentation at Thomas Weisel Partners 2007 Healthcare Conference
7. Z Trim Announces Revocation of Gregory Halpern Severence Agreement
8. Brooke Franchise Corporation Announces Selected July Results
9. Manor Care, Inc. Announces Record Date for Special Stockholder Meeting
10. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Adipex-P(R)
11. Planet Technologies Announces Agreement to Acquire Antigen Laboratories
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... Lifeguard Master is out with their new spider ... on the Lifeguard Master website and are in stock. The ... a quality and flexible product during their rescue efforts. According ... Spider Straps are some of the most popular items we ... heavy nylon” , The Spider Straps are rated superior to ...
(Date:4/21/2015)... The Science Museum of Virginia welcomes theoretical nuclear ... Lunch Break Science program. On Wednesday, April 29, Dr. Briceno ... from the subatomic world of quantum mechanics to astronomical scales ... of the community to grab lunch and take a bite ... delve into the nucleus and dissect the complex world of ...
(Date:4/21/2015)... 2015 On Saturday, May 2nd, 2015, ... of his team from Georgia Eye Physicians and ... Lupus Now, being held in Piedmont Park by the ... to be the largest LFA-sponsored walk in the nation, ... raise funds and awareness for lupus, an unpredictable and ...
(Date:4/21/2015)... “The warm summer season is fast approaching,” says Marta ... younger than her age? In the ongoing battle against ... Signs of premature aging are deep wrinkles and unsightly ... spent in the sun without adequate protection.” , Outward appearances ... dangers of UV rays can go deep below the surface. ...
(Date:4/20/2015)... VA (PRWEB) April 21, 2015 Using ... and CMOs Speed Production and Improve Compliance , **FDAnews ... p.m. EDT, http://www.fdanews.com/qualitybydesign , The life sciences ... forcing them to do more with less. Mergers, ... and CMOs to finds ways to speed up production ...
Breaking Medicine News(10 mins):Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 2Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 3Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 4Health News:Quarks and Forks at the Science Museum of Virginia 2Health News:9th Annual Walk to End Lupus Now 2Health News:9th Annual Walk to End Lupus Now 3Health News:Sun’s the Word this Mother’s Day Say’s SunGrubbies.com, a Leading Retailer of Sun Protection Products 2Health News:FDAnews Announces — Using Quality by Design to Improve Manufacturing: How Sponsors and CMOs Speed Production and Improve Compliance Webinar, May 7, 2015 2Health News:FDAnews Announces — Using Quality by Design to Improve Manufacturing: How Sponsors and CMOs Speed Production and Improve Compliance Webinar, May 7, 2015 3
... Health Minister Anbumani Ramadoss urged the Prime Minister Mr. ... the ban on smoking in the films and television. ... and broadcasting failing to reach consensus on modalities for ... Prime Minister Manmohan Singh to resolve the matter. ...
... able to isolates molecule that would be helpful and ... has been done independently by teams from Harvard Medical ... a master protein that shows how neurons change as ... 17) features the two studies in which the teams ...
... doctors were dismissed by the Bihar government on Wednesday ... ,The Chief Minister of Bihar Mr. Nitish Kumar ... from service, which was carried out with immediate effect. ... officers and initiated departmental proceedings against 16 doctors for ...
... the federal Government to distribute subsidized life-saving hepatitis C ... patients in Australia. // A small percentage of ... condition. If appropriate steps are not instituted at the ... the cases of liver cirrhosis and cancer. ...
... it is high time for the medicine industry to ... that would help identify fake medicines. // ... to cheat customers have been found to contain even ... enormous profit and have remained the target of crime ...
... in two Australian children, according to reports published today ... known to lead to a host of problems including ... ,Professor Cres Eastman, one among Australia’s leading endocrinologists has ... call to the authorities who seem to be very ...
Cached Medicine News:Health News:Need For Smarter Ways To Identify Fake Drugs & Internet Counterfeiting: WHO 2
(Date:4/20/2015)... 2015  Johnson & Johnson (NYSE: JNJ ) ... the investment community beginning at 8:30 a.m. (Eastern Time) ... Hotel in New Brunswick, New Jersey ... Paul Stoffels , M.D., Worldwide Chairman Pharmaceuticals, and ... Chairman, Pharmaceuticals will host the meeting. Dominic Caruso ...
(Date:4/20/2015)... , April 20, 2015 The preclinical contract ... pharmacokinetic testing of drugs and safety testing of medical devices, ... present at this week,s workshop " Drug Transporters in ADME: ... Baltimore, MD . The title of Dr. Hidalgo,s talk ... of a session entitled "Transporter Tools of the Future." ...
(Date:4/20/2015)... -- In its latest action to ensure competition in ... Cardinal Health, Inc. has agreed to resolve charges ... the sale and distribution of low-energy radiopharmaceuticals and ... for these drugs. The proposed stipulated order requires ... and represents the second largest monetary settlement the ...
Breaking Medicine Technology:Absorption Systems Chief Scientist Ismael Hidalgo to Present at International Workshop on Drug Transporters 2Cardinal Health Agrees to Pay $26.8 Million to Settle Charges It Monopolized 25 Markets for the Sale of Radiopharmaceuticals to Hospitals and Clinics, says FTC 2Cardinal Health Agrees to Pay $26.8 Million to Settle Charges It Monopolized 25 Markets for the Sale of Radiopharmaceuticals to Hospitals and Clinics, says FTC 3Cardinal Health Agrees to Pay $26.8 Million to Settle Charges It Monopolized 25 Markets for the Sale of Radiopharmaceuticals to Hospitals and Clinics, says FTC 4Cardinal Health Agrees to Pay $26.8 Million to Settle Charges It Monopolized 25 Markets for the Sale of Radiopharmaceuticals to Hospitals and Clinics, says FTC 5
... 1, 2011 Upsher-Smith Laboratories, Inc. announced today ... the Year Award for branded pharmaceutical sales under ... and Exposition (NHCE) in Las Vegas, NV held ... largest conferences of its kind, bringing together community ...
... Components, the leading supplier of disposable nitrous-oxide cylinders ... medical device manufacturers. Gas cylinders from iSi ... and/or disposable cryogenic medical devices. iSi,s newest ... and provides 23.5 grams of liquid N2O with the ...
Cached Medicine Technology:Upsher-Smith Laboratories Named Manufacturer of the Year by AmerisourceBergen Corporation 2Bring Your Cryogenic Medical Device to Life with Disposable N2O Cylinders from iSi Components 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: