Navigation Links
UCB Announces Positive Results From Phase II Clinical Trial of Investigational Anti-Epilepsy Drug Brivaracetam
Date:12/3/2007

ATLANTA, Dec. 3 /PRNewswire/ -- UCB today announced data demonstrating that anti-epileptic drug (AED) brivaracetam, with the proposed trade name Rikelta(TM), administered as an adjunctive treatment in adults with refractory epilepsy with partial onset seizures, significantly reduced seizure frequency and had a side-effect profile comparable to placebo. The results of the two Phase IIb (Abstracts C.04 and 3.218), double-blind, randomized, parallel- group, placebo-controlled dose ranging studies were presented today as an oral platform presentation at the 61st annual meeting of the American Epilepsy Society.

"It is exciting to see the promising results that brivaracetam produced in this highly refractory population of epilepsy patients," said Jacqueline French, MD, lead study author and professor of neurology at New York University. "The development of novel anti-epilepsy drugs is vital to addressing the needs of treatment-resistant epilepsy patients. We look forward to seeing the results of our Phase III clinical research."

The two studies involved 365 patients, ages 16-65, with refractory partial onset seizures, which were uncontrolled despite treatment with one to two other AEDs. Patients in the first study (Abstract C.04) were randomized to receive 5 mg/day, 20 mg/day, 50 mg/day or placebo, administered twice-daily without titration over the seven week treatment period. The study found that brivaracetam reduced weekly seizure frequency over placebo by 9.8%, 14.9%, and 22.1% with doses of 5mg/day, 20 mg/day, and 50 mg/day, respectively, suggesting a dose response trend with brivaracetam 5 mg-50 mg/day.

An analysis of the study's secondary endpoints found that brivaracetam:

-- Reduced median seizure frequency from baseline by 29.9%, 42.6% and

53.1% for 5mg/day, 20mg/day and 50mg/day, respectively, compared with

21.7% for placebo.

-- Reduced weekly seizure frequency from baseline in 32.0%, 44.2% and


'/>"/>
SOURCE UCB, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
2. CRC Health Group Announces Acquisition of Bayside Marin Recovery Center, San Rafael
3. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
4. HEI, Inc. Announces Sale of RFID Division Assets
5. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Zyloprim(R)
6. Mettler-Toledo International Inc. Announces Webcast of Presentation at Thomas Weisel Partners 2007 Healthcare Conference
7. Z Trim Announces Revocation of Gregory Halpern Severence Agreement
8. Brooke Franchise Corporation Announces Selected July Results
9. Manor Care, Inc. Announces Record Date for Special Stockholder Meeting
10. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Adipex-P(R)
11. Planet Technologies Announces Agreement to Acquire Antigen Laboratories
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... HealthDay Reporter TUESDAY, Dec. 16, 2014 (HealthDay ... new study reveals that states that routinely perform randomized traffic ... their roads. The finding suggests that states that enforce ... inebriated revelers from getting behind the wheel in the first ... drinking and driving," said study lead author James Fell, a ...
(Date:12/15/2014)... Cancer researchers have just published an important ... deadly malignant pleural mesothelioma. Surviving Mesothelioma has just posted ... Click here to read it now. , Doctors ... and New York’s Langone Medical Center performed complete genetic ... in an effort to pinpoint the genes that are ...
(Date:12/15/2014)... SIMpalm, a leading mobile app ... iPhone for its client, which allows users to keep ... specialized in finding the right wine. At the ... combined sensory, chemistry and wine information. All this information ... fingerprint.” Those wines that are close counterparts to one ...
(Date:12/15/2014)... 2014 (HealthDay News) -- Expert pilots process visual information ... they make better decisions during landings, a new study ... techniques for pilots to master, and 36 percent of ... occur during final approach and landing. Researchers monitored ... moderately experienced pilots while they were at the controls ...
(Date:12/15/2014)... In support of high-quality independent peer ... state laws that may have unintended consequences through ... of public health policy. , The position paper, ... Independent Review, contends that state legislation that restricts ... determinations can result in subpar outcomes for both ...
Breaking Medicine News(10 mins):Health News:Enforcement of Drunk Driving Laws Makes Roads Safer, Study Finds 2Health News:Enforcement of Drunk Driving Laws Makes Roads Safer, Study Finds 3Health News:New Study Reveals Genetic Mutations That May Trigger Mesothelioma, According to Surviving Mesothelioma 2Health News:Use WinMatch Connect App to Keep Track of Wines You Like 2Health News:Study Shows Why Expert Pilots Are Experts 2Health News:NAIRO Calls for Higher Quality Independent Peer Review By Ending Restrictive State Laws 2
... Minister George Smitherman is tongue tied when questioned about ... working poor in Ontario. ,A letter ... Dentist in Toronto, with a proposal to consider dental ... Minister has not given an answer to this proposal ...
... Mukesh Haikerwal, said today the AMA is seeking a total ... ,“The lower price of duty-free tobacco encourages travellers ... purchased, the tendency is to smoke them more rapidly,” Dr ... through the imposition of tax is an important deterrent to ...
... be the latest in technology to detect even early stages ... colorimetric sensor developed by Dr. Peter Mazzone and his team from ... dots that change color when a person with lung cancer exhales ... this is quite simple, though the technology is not. ...
... bird flu since November// 2005. ,Test samples sent to ... after officials suspected a case of bird flu, in ... , The immediate measures taken were the closure of the ... well as falcon farms and bird clinics. Export and import of ...
... better your heart health. But a man’s heart and ... among cholesterol levels,// psychological function, and neurologic disorders are ... Men’s Health Watch. ,There are two ... Vascular dementia results when blood vessel damage deprives the ...
... A man from a south Kolkata neighbourhood tested positive for ... to show symptoms of the disease after a few days, ... resident of Prince Ghulam Mohammad Shah Road in the Lake ... Bhagirathi Neotia Women and Child Care Centre on Feb 19 ...
Cached Medicine News:Health News:Simple Breath Test may Detect Lung Cancer 2
(Date:12/15/2014)... and BRIDGEWATER, N.J. , Dec. 15, ... Sanofi US (EURONEXT: SAN and NYSE: SNY) are collaborating ... launch Cholesterol Counts , an awareness program that ... numbers, and the risks associated with high LDL-C (bad ... CholesterolCounts .com to take a brief poll and ...
(Date:12/15/2014)... SAN MARCOS, Texas , Dec. 15, 2014 /PRNewswire/ ... quantum dot manufacturer Quantum Materials Corp (OTCQB:QTMM), ... Rice Center for Quantum Materials (RCQM) on December 16th, ... the exploration of exotic nanomaterials in attracting top faculty ... to Rice to collaborate on research. ...
(Date:12/14/2014)... , Dec. 14, 2014  ChartSpan, a consumer ... most downloaded iPhone and iPad medical app in ... - http://photos.prnewswire.com/prnh/20141214/164317 ChartSpan is ... ability to request, manage and send electronic healthcare records. ... entrepreneurs who grew tired of waiting for the healthcare ...
Breaking Medicine Technology:Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 2Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 3Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 4Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 5Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 6Quantum Materials CEO Stephen Squires to Speak at Rice Center for Quantum Materials Launch 2Quantum Materials CEO Stephen Squires to Speak at Rice Center for Quantum Materials Launch 3ChartSpan Becomes The Most Downloaded Medical App in America 2ChartSpan Becomes The Most Downloaded Medical App in America 3
...
... A Platform for Pure ... the second platform in our ProSound ... Pure Harmonic Detection technology provides distortion-free ... Echo image quality. This technology is ...
... family of products allows you to tailor ... feature proprietary Energy Synchronous Processing Technology. The ... and voltage in all operational modes. Advanced ... sample current and voltage over 450,000 times ...
... of specially engineered gelatin granules and topical ... for haemostasis, clinically proven to control bleeding ... is indicated in surgical procedures as an ... by ligature or conventional procedures is ineffective ...
Medicine Products: