Navigation Links
U-M sibling study discovers genetic region linked to control of key blood-clotting protein
Date:1/8/2013

moking, were minimized, giving the scientists a better chance of uncovering genetic causes.

The researchers report that the first part of their analysis, called a genome-wide association study, confirmed the two major genes already known to explain a small part of the differences in von Willebrand factor.

The researchers also looked at which parts of the genome were shared between siblings and how this related to von Willebrand factor levels. They identified a section of chromosome 2 that contains a gene that significantly regulates von Willebrand factor but had not previously been detected in studies of unrelated individuals.

The next step will be to determine the identity of the exact gene on chromosome 2, how it differs among people, and how these differences alter the level of von Willebrand factor and the associated risk for bleeding and blood clotting. Understanding how this gene affects von Willebrand factor may lead to improved diagnosis for bleeding and blood-clotting disorders, as well as new approaches to treatment.

The researchers plan to apply a similar analysis to other traits in blood clotting, says Dr. Karl Desch, assistant professor in the pediatrics department at the U-M Medical School and first author of the study.

"Using the sibling structure in this study, we will hopefully discover more novel loci that determine the variation in these other traits," he said.


'/>"/>

Contact: Jim Erickson
ericksn@umich.edu
734-647-1842
University of Michigan
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Not Fair! How Sibling Fights May Lead to Later Mood Problems
2. Sibling squabbles can lead to depression, anxiety
3. Developmental Woes Common in Siblings of Children With Autism
4. Study of half siblings provides genetic clues to autism
5. Brief class on easy-to-miss precancerous polyps ups detection, Mayo study shows
6. Study finds flame retardant pollutants at far-flung locations
7. Recession Drove Down Doctor Visits, Study Says
8. Black and Hispanic patients less likely to complete substance abuse treatment, Penn study shows
9. People with diabetes in Ontario getting fewer government-funded eye exams, new study finds
10. Menopause Can Bring Lapses in Memory, Thinking, Study Finds
11. Meds May Spur Compulsive Behaviors in Some Parkinsons Patients: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... at the University of York reveals that a process ... the nervous system may also play a pivotal role ... team, led by Dr Will Brackenbury, a Medical Research ... has studied how voltage-gated sodium channels assist in the ... the membranes of excitable cells, such as neurons, where ...
(Date:4/23/2014)... stool from healthy, unrelated donors was safe and ... caused by Clostridium difficile , according to ... Infectious Diseases and available online. Known as ... whether given via a colonoscope or a nasogastric ... this promising treatment more readily available to patients. ...
(Date:4/23/2014)... researchers say clinical trials for a new experimental ... very promising. Patients treated with CPX-351, a combination ... showing better responses than patients treated with the ... myeloid leukemia is an aggressive blood cancer with ... older patients," explained Jeffrey Lancet, M.D., senior member ...
(Date:4/23/2014)... M.D., scientific director at the National Institute of Arthritis ... the 2014 recipient of the Ross Prize in Molecular ... Molecular Medicine . The award will be given ... Sciences in Manhattan, followed by scientific presentations by Dr. ... the National Institutes of Health. , The award, which ...
(Date:4/23/2014)... 2014 The American Society for Radiation Oncology (ASTRO) ... Postoperative Radiation Therapy for Endometrial Cancer: An ASTRO ... radiation therapy in the treatment of endometrial cancer. ... May-June 2014 issue of Practical Radiation Oncology ... ASTRO. The full-length guideline is available as an ...
Breaking Medicine News(10 mins):Health News:Breast cancer replicates brain development process 2Health News:Pilot study suggests ways to widen access to fecal transplants for C. diff infections 2Health News:Moffitt Cancer Center's phase 3 study may be game-changer for acute myeloid leukemia 2Health News:NIH scientist to receive Ross Prize in Molecular Medicine 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 3
... To reduce mortality and improve patient care in the ... Care Societies Collaborative (CCSC), in conjunction with the US ... that research in the field become less fragmented and ... critical illness. The CCSC comprises the ...
... a popular activity in nursing homes, senior centers ... beyond socializing. Researchers found high-contrast, large bingo cards ... cognitive difficulties and visual perception problems produced by ... "The general finding of improved performance across healthy ...
... Michigan State University researchers one working at a medieval ... in East Lansing have shown how modern science can ... the first to confirm the existence of brucellosis, an infectious ... The findings, which appear in the American Journal of ...
... best cigarette is no cigarette, but for the millions ... researchers from Cornell University may have found a way ... antioxidant extracts in cigarette filters, the researchers were able ... reduced the amount of cancer-causing free radicals passing through ...
... suggests that there may be a positive relationship between ... to a report in the January issue of ... the JAMA/Archives journals. Amika Singh, Ph.D., of the ... and Care Research, Amsterdam, the Netherlands, and colleagues reviewed ...
... , SUNDAY, Jan. 1 (HealthDay News) -- Losing weight is ... long-held behaviors is a skill in itself, a medical expert ... people have to be ready to face some setbacks and ... and medical weight-loss specialist at Gottlieb Memorial Hospital, part of ...
Cached Medicine News:Health News:ATS issues joint statement on key issues and recommendations for critical care research 2Health News:ATS issues joint statement on key issues and recommendations for critical care research 3Health News:'BINGO!' game helps researchers study perception deficits 2Health News:Scientists crack medieval bone code 2Health News:Physical activity, school performance may be linked 2Health News:Persistence Is Key to Losing Weight and Keeping It Off 2Health News:Persistence Is Key to Losing Weight and Keeping It Off 3
(Date:1/15/2014)... January 15, 2014 Shire plc (LSE: SHP, NASDAQ: ... of Fair Trading (OFT) approval condition to the announced tender offer ...   As a result of the waiver, the transaction ... complete the tender offer on January 24, 2014 following the currently ...
(Date:1/15/2014)...  In an unprecedented effort to curb the spread of "superbugs" such ... vehicles, an advanced and portable UV germicidal lamp manufactured by MRSA-UV ... In order to prevent EMS paramedics and transport ... West Palm Beach Fire Rescue is the first in ...
(Date:1/15/2014)... 2014 The Cadence Fitness & Health Center has ... Medical Fitness Association, a non-profit organization assisting medically integrated ... The Cadence Fitness & Health Center is the only ... in the Chicagoland area. "The certification means ...
Breaking Medicine Technology:Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Superbugs No Longer Ride In Rescue Vehicles 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3
... MEDomics, LLC provides NextGen sequence-based DNA diagnostic ... era and is transforming diagnostic testing for mitochondrial ... capital investment from our partner, SpaGus Ventures LLC. ... used by MEDomics to fuel the continued growth ...
... FLORHAM PARK, N.J., April 7, 2011 Shionogi Inc., ... today announced the U.S. commercial availability of CUVPOSA™ (glycopyrrolate) ... reduce chronic severe drooling in patients aged 3 to ... as cerebral palsy. "Shionogi is proud ...
Cached Medicine Technology:MEDomics Announces a Growth Capital Investment from SpaGus Ventures LLC and Gary Augusta Joins MEDomics as Chief Operating Officer 2Shionogi Announces Commercial Availability of CUVPOSA™ (Glycopyrrolate) Oral Solution for Pediatric Chronic Severe Drooling Associated With Neurologic Conditions 2Shionogi Announces Commercial Availability of CUVPOSA™ (Glycopyrrolate) Oral Solution for Pediatric Chronic Severe Drooling Associated With Neurologic Conditions 3Shionogi Announces Commercial Availability of CUVPOSA™ (Glycopyrrolate) Oral Solution for Pediatric Chronic Severe Drooling Associated With Neurologic Conditions 4Shionogi Announces Commercial Availability of CUVPOSA™ (Glycopyrrolate) Oral Solution for Pediatric Chronic Severe Drooling Associated With Neurologic Conditions 5
... The Vitros ECi brings true ... to immunodiagnostic testing. Highly sensitive assays ... oncology and bone metabolism testing are ... under development. The Vitros ECi can ...
... is a flexible system that ... environments small hospitals, backup ... satellite locations. The Vitros 250 ... can be automated or placed ...
... an effort to improve on the ... toxicology, abused drugs, and immunosuppressants tests, ... which incorporates random access capabilities. Although ... undergone several important changes in the ...
The IMx system is an automated analyzer designed to perform microparticle enzyme immunoassay (MEIA), fluorescence polarization immunoassay (FPIA) and ion capture technologies....
Medicine Products: