Navigation Links
U-M sibling study discovers genetic region linked to control of key blood-clotting protein
Date:1/8/2013

ANN ARBORIn 2006, the lab of Dr. David Ginsburg at the Life Sciences Institute put a call out for siblings attending the University of Michigan to donate blood for a study of blood-clotting disorders.

The samples were collected over three years and have now enabled the researchers to identify the specific parts of the genome responsible for levels of a key substance for blood clotting. The findings were reported online Dec. 24 in the Proceedings of the National Academy of Sciences.

Von Willebrand disease is the most common hereditary blood-clotting disorderit's more common, but usually milder, than hemophilia. The disease is caused by lower-than-normal levels of von Willebrand factor, a substance that circulates in blood and serves as the "glue" to help blood platelets stick where they're needed to stop bleeding.

While a low level of von Willebrand factor may cause uncontrolled bleeding, high levels can contribute to blood clots, heart attacks and strokes. Age and environmental factors can lead to increased von Willebrand factor, and understanding how the body regulates the substance can help researchers develop treatments for diseases caused by excessive clotting.

Previous studies pinpointed two major genes that partially regulated levels of von Willebrand factor in the blood. However, these two genes only explained a small part of the inherited differences in von Willebrand factor levels between people. Studying siblings in college provided some clues to those differences.

A team of researchers led by Ginsburg, who is a faculty member at the Life Sciences Institute, a professor of internal medicine, human genetics and pediatrics at the U-M Medical School and a Howard Hughes Medical Institute investigator, performed a genetic analysis in two young and healthy cohorts. Because the blood donors were in their early 20s, the effect of other factors known to cause an excess of von Willebrand factor, like age and s
'/>"/>

Contact: Jim Erickson
ericksn@umich.edu
734-647-1842
University of Michigan
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Not Fair! How Sibling Fights May Lead to Later Mood Problems
2. Sibling squabbles can lead to depression, anxiety
3. Developmental Woes Common in Siblings of Children With Autism
4. Study of half siblings provides genetic clues to autism
5. Brief class on easy-to-miss precancerous polyps ups detection, Mayo study shows
6. Study finds flame retardant pollutants at far-flung locations
7. Recession Drove Down Doctor Visits, Study Says
8. Black and Hispanic patients less likely to complete substance abuse treatment, Penn study shows
9. People with diabetes in Ontario getting fewer government-funded eye exams, new study finds
10. Menopause Can Bring Lapses in Memory, Thinking, Study Finds
11. Meds May Spur Compulsive Behaviors in Some Parkinsons Patients: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... Olaparib functions as a chemical of the compound ... the first PARP inhibitors. Sufferers with BRCA1/2 strains may ... and are often immune to other types of melanoma ... exclusive weaknesses, as the tissues of melanoma have improved ... them to proceed splitting. This implies that medication which ...
(Date:11/24/2014)... SWAccessControl.com has recently released a new collection ... the company is a leading online supplier in the international ... available at discounted prices, up to 30% off. , “We ... This time, all of our items are offered at low ... so I have confidence in our fresh assortment. You will ...
(Date:11/24/2014)... 2014 SafeHandles™ announced that they will ... Ed Begley Jr, airing via Discovery Channel. Dates and ... a passive, non-invasive, replaceable, and affordable germ protective device. ... shrinkable sleeves and adhesives to promote hand hygiene in ... core of SafeHandles is the desire to make a ...
(Date:11/24/2014)... California (PRWEB) November 24, 2014 Dr. ... Diego Fertility Center, recently appeared on NBC to discuss egg ... Egg freezing has been trending in the news recently, with ... expensive procedure for women. , “[The companies] see ... who are on a career hot path.” Says Dr. Kettel. ...
(Date:11/23/2014)... 24, 2014 iFitDress.com, a well-known wedding dress ... evening gowns . They are now offered at deeply ... will last from now to Dec. 15. The main purpose ... All the company’s high quality items are ideal options for ... large sum of money. All its new mint cocktail dresses ...
Breaking Medicine News(10 mins):Health News:Olaparib Industry (CAS 763113-22-0) 2009-2019 Global and China Research Reports is Now Available at RnRMarketResearch.com 2Health News:Olaparib Industry (CAS 763113-22-0) 2009-2019 Global and China Research Reports is Now Available at RnRMarketResearch.com 3Health News:Olaparib Industry (CAS 763113-22-0) 2009-2019 Global and China Research Reports is Now Available at RnRMarketResearch.com 4Health News:SWAccessControl.com Is Happy To Release New Range Of Magnetic Locks 2Health News:New Episode of Innovations TV Series to Feature SafeHandles™ 2Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 2Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 3Health News:Trendy Long Black Evening Gowns Now Provided By iFitDress.com 2
... effective for inoperable liver cancer. It is a year since TheraSphere was ... ... either reducing tumour size or the number of tumours. Till date, it ... cannot be treated by any other means. ,TheraSphere involves injecting ...
... given to babies with low birth weight can significantly ... die from infectious diseases. The research involved 1,154 full-term ... India, most weighing 5 1/2 pounds or less. Mothers ... months. Fifteen of the 20 who died had not ...
... starting the day with a heavy breakfast and a steaming cup ... that women who eat fried food each morning are at ... oesophageal, cancer.The best way to reduce the incidence of cancer is ... or fruit. ,Cancer of the oesophagus - the food ...
... An enzyme involved in hormone production may help explain why ... their waist have such a high risk of heart disease ... approaches to treat obesity and its complications. // ... health problems such as heart disease and diabetes, but where ...
... who use stimulants like Ritalin are not at risk ... rats suggests that stimulant treatment in childhood may blunt ... ,Many children and teens with ADHD are treated ... appear to focus patients' attention and calm behavior. But ...
... than men to suffer brain cell damage from long-term use ... be reversed if they stop taking the drug. Studies have ... MDMA, can damage nerve endings that release serotonin, a brain ... also appears to damage brain cells that transmit nerve signals. ...
Cached Medicine News:Health News:Cut down on fries 2
(Date:11/24/2014)... , 24 novembre 2014  Surgical Theater ... tecnologia sarà esposta durante l,apertura in data ... d,Europa, ossia la Fondazione IRCCS Istituto Neurologico ... Planner (SRP) (strumento di pianificazione chirurgica) e ... navigazione chirurgica avanzata) saranno presentati in occasione ...
(Date:11/23/2014)...  Aurobindo Pharma USA is ... mg 100-count bottles to the consumer level. The product ... Empty capsules could result in missed dose(s) ... range from no effect, short term reduction in efficacy, ... seizures) that could be life-threatening. Aurobindo Pharma ...
(Date:11/22/2014)... , 21 de noviembre de 2014  BioClinica®, ... clínicos externalizados y tecnologías eClinical, ha indicado un ... ,seguimiento inteligente, para el seguimiento basado en el ... amplía el concepto del seguimiento basado en el ... las visitas de seguimiento o cambio de los ...
Breaking Medicine Technology:La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 2La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 3La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 4Aurobindo Pharma USA, Inc. Issues Voluntary Nationwide Recall of Northstar Label Gabapentin Capsules, USP 300 mg Due to Complaints of Empty Capsules 2El 'seguimiento inteligente' consigue un excelente momento 2El 'seguimiento inteligente' consigue un excelente momento 3
... ... Reportlinker.com announces that a new market research ... Fibrillation - Drug Pipeline Analysis and Market Forecasts to ... - Drug Pipeline Analysis and Market Forecasts to 2016 ...
... , , FRANKLIN, Mass. , ... Board: ECTE), a company developing the needle-free Symphony™ tCGM System ... and the Prelude™ SkinPrep System for transdermal drug delivery, announced ... Chairman and CEO, will be interviewed on " Steve Crowley ...
Cached Medicine Technology:Reportlinker Adds Atrial Fibrillation - Drug Pipeline Analysis and Market Forecasts to 2016 2Reportlinker Adds Atrial Fibrillation - Drug Pipeline Analysis and Market Forecasts to 2016 3Reportlinker Adds Atrial Fibrillation - Drug Pipeline Analysis and Market Forecasts to 2016 4Reportlinker Adds Atrial Fibrillation - Drug Pipeline Analysis and Market Forecasts to 2016 5Reportlinker Adds Atrial Fibrillation - Drug Pipeline Analysis and Market Forecasts to 2016 6Reportlinker Adds Atrial Fibrillation - Drug Pipeline Analysis and Market Forecasts to 2016 7Reportlinker Adds Atrial Fibrillation - Drug Pipeline Analysis and Market Forecasts to 2016 8Echo Therapeutics Chairman and CEO to be Interviewed on Steve Crowley's American Scene Radio Program and Featured on Money Channel Inc. 2Echo Therapeutics Chairman and CEO to be Interviewed on Steve Crowley's American Scene Radio Program and Featured on Money Channel Inc. 3Echo Therapeutics Chairman and CEO to be Interviewed on Steve Crowley's American Scene Radio Program and Featured on Money Channel Inc. 4
... Stainless steel spiral reinforced. X-ray opaque . ... Flange: The flange can be adjusted along ... of the cervical soft tissue. The lock ... is tightly connected to the shaft. Maximum ...
Fome-Cuf® tubes can breathe with the patient to provide a safe, effective, and low pressure seal throughout the ventilatory cycle....
... tracheostomy tubes are available in both neonatal and ... an uncuffed tube, but it has a cuff. ... shaft of the tube. , ,TTS™ (tight-to-shaft) ... with the insurance of a cuff, if and ...
Indications For Usage: ,Bypass upper airway obstructions, provide long term ventilation, support and/or manage tracheal/bronchial secretions....
Medicine Products: