Navigation Links
U-M scientists slow development of Alzheimer's trademark cell-killing plaques
Date:3/17/2014

ANN ARBORUniversity of Michigan researchers have learned how to fix a cellular structure called the Golgi that mysteriously becomes fragmented in all Alzheimer's patients and appears to be a major cause of the disease.

They say that understanding this mechanism helps decode amyloid plaque formation in the brains of Alzheimer's patientsplaques that kills cells and contributes to memory loss and other Alzheimer's symptoms.

The researchers discovered the molecular process behind Golgi fragmentation, and also developed two techniques to 'rescue' the Golgi structure.

"We plan to use this as a strategy to delay the disease development," said Yanzhuang Wang, U-M associate professor of molecular, cellular and developmental biology. "We have a better understanding of why plaque forms fast in Alzheimer's and found a way to slow down plaque formation."

The paper appears in an upcoming edition of the Proceedings of the National Academy of Sciences. Gunjan Joshi, a research fellow in Wang's lab, is the lead author.

Wang said scientists have long recognized that the Golgi becomes fragmented in the neurons of Alzheimer's patients, but until now they didn't know how or why this fragmentation occurred.

The Golgi structure has the important role of sending molecules to the right places in order to make functional cells, Wang said. The Golgi is analogous to a post office of the cell, and when the Golgi becomes fragmented, it's like a post office gone haywire, sending packages to the wrong places or not sending them at all.

U-M researchers found that the accumulation of the Abeta peptidethe primary culprit in forming plaques that kill cells in Alzheimer's brainstriggers Golgi fragmentation by activating an enzyme called cdk5 that modifies Golgi structural proteins such as GRASP65.

Wang and colleagues rescued the Golgi structure in two ways: they either inhibited cdk5 or expressed a mutant of G
'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientists identify major source of cells defense against oxidative stress
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists rewrite rulebook on breast cancer in landmark global study
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. NIH scientists link quickly spreading gene to Asian MRSA epidemic
8. Joslin scientists identify important mechanism that affects the aging process
9. Scripps Research scientists show how memory B cells stay in class to fight different infections
10. Scientists Map Melanomas Genome
11. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... within a large teaching hospital in Ireland has shown than ... in place to minimise the risk of entrapment. The report, ... therefore emphasises the need for careful selection of patients for ... need for monitoring and maintenance of hospital bed systems. , ... falling from bed. However, although the risk for any individual ...
(Date:7/30/2014)... 2014 4DSP’s new CES720 (Compact Embedded ... designed to provide a complete and generic processing platform ... is housed in an enclosure measuring five inches per ... a low-power x86 CPU tightly coupled to a high-performance ... – VITA 57.1). The Kintex-7 410T FPGA ...
(Date:7/30/2014)... According to the American Cancer Society, an estimated ... United States in 2014. (1) NTC , a ... and financial industry, has long been a proponent of advancing ... company has further demonstrated its commitment by participating in its ... Springs event to increase awareness and fundraising efforts to benefit ...
(Date:7/30/2014)... HealthDay Reporter TUESDAY, July 29, ... are vital to good health and a long life, but ... of fruits and vegetables each day, additional daily servings don,t ... The human body may only be able to effectively process ... its ability to absorb important nutrients from extra helpings, said ...
(Date:7/30/2014)... 2014 Sagacious Consultants, the premier full-service ... to a group of charities supporting veterans—Wounded Warrior Project, ... Grider Foundation. This donation is part of Sagacious Consultants’ ... contribute a donation every year to a charity of ... surrounding communities. , “We are thrilled to make this ...
Breaking Medicine News(10 mins):Health News:High frequency of potential entrapment gaps in hospital beds 2Health News:4DSP Introduces a Compact Platform for UAVs with Embedded Processing and Flexible IO 2Health News:4DSP Introduces a Compact Platform for UAVs with Embedded Processing and Flexible IO 3Health News:4DSP Introduces a Compact Platform for UAVs with Embedded Processing and Flexible IO 4Health News:NTC Takes Action Against Cancer With 5th Consecutive Relay For Life of Palm Harbor & Tarpon Springs, Raises Over $12,000 for Cancer Research 2Health News:NTC Takes Action Against Cancer With 5th Consecutive Relay For Life of Palm Harbor & Tarpon Springs, Raises Over $12,000 for Cancer Research 3Health News:NTC Takes Action Against Cancer With 5th Consecutive Relay For Life of Palm Harbor & Tarpon Springs, Raises Over $12,000 for Cancer Research 4Health News:Fruits, Veggies May Have Their Limits in Boosting Lifespan 2Health News:Fruits, Veggies May Have Their Limits in Boosting Lifespan 3Health News:Sagacious Consultants Supports Veterans Charities With $10,000 Donation 2
... help combat an increased risk for life-threatening cardiovascular diseases, ... be well // advised to monitor their blood sugar ... to a new study. ,Researchers conducted a meta-analysis ... relationship between blood sugar levels and cardiovascular disease. Results ...
... study says that Man's best friend might be able to ... dogs can smell odors from malignant tumors in urine samples. ... trained over seven months to discriminate between urine from patients ... dog was then given samples of urine from six control ...
... study researchers say the antidepressant duloxetine, also known ... fibromyalgia in women . Duloxetine works by stopping ... of the brain’s neurotransmitters that are linked to ... that is characterized by body pain, muscle tenderness, ...
... were treated for depression responded better if they had ... ,An increasing amount of research is looking at ... specifics have not been understood. Researchers conducted a study ... the treatment of depression. ,The study included 115 ...
... new study confirms the recommendation by the American Heart ... beneficial to your heart. ,A number of studies ... the reduction of heart disease. In the current study, ... dietary fiber intake and the risk of coronary heart ...
... previously held belief that infants' brains don't divide into ... the brain's left hemisphere plays the leading role in ... ,Researchers are using functional magnetic resonance imaging, or ... speech. They say this is the first time fMRI ...
Cached Medicine News:Health News:High Fiber Diet Found To Protect The Heart 2Health News:fMRI Offers Insight Into An Infants Brain 2
(Date:7/30/2014)... , July 30, 2014  Packaging Coordinators, Inc. ... definitive agreement to acquire Penn Pharmaceutical Services Limited (Penn ... in the United Kingdom ... Hope, Pennsylvania and Tokyo ... services, including Clinical and Commercial dosage form manufacturing, as ...
(Date:7/30/2014)... 30, 2014   Medical Equipment Solutions, Corp. ... a Department of Defense (US Army) contract valued at ... mobile MRI diagnostic machine and technical support staffing. As ... the Small Business Administration (SBA), Medical Equipment is proud ... the latest medical diagnostic equipment. The SBA 8-A certification ...
(Date:7/30/2014)... 2014 Die Apex Medical Corporation ... Bereich Atemtherapie- und Druckzonenprodukte, gibt bekannt, dass ... Deutschland anfechten werden. Dieses hat entschieden, dass ... von ResMed verletze. Apex weist darauf hin, ... verschiedene Patente von ResMed Anfechtungen wegen Nichtigkeit ...
Breaking Medicine Technology:PCI Announces Definitive Agreement to Acquire Penn Pharma 2PCI Announces Definitive Agreement to Acquire Penn Pharma 3PCI Announces Definitive Agreement to Acquire Penn Pharma 4PCI Announces Definitive Agreement to Acquire Penn Pharma 5Medical Equipment Solutions Corp. Awarded $2 Million contract To Service DoD 2Apex setzt seinen Kampf gegen Patente für einen freien Wettbewerb fort 2Apex setzt seinen Kampf gegen Patente für einen freien Wettbewerb fort 3
... The DNA Engine instrument is ... Unprecedented thermal uniformity and ... and block-to-block. This rugged ... cycler, it's a platform for new ...
... Start up kit. Includes configured Laptop PC ... 1 MultiBlock satellite thermal Cycler (non-robotic). ... User friendly software. Store/track run data. ... lid. Outstanding uniformity. Advanced control ...
0.2ml Gradient Block MBSR. Robot compatible block ejection mechanism. Stackable. (96 well block - holds 1 plate 0.2ml x 96 well plate)...
96 well format, Gradient features tests 12 PCR annealing temperatures in 1 run...
Medicine Products: