Navigation Links
U-M scientists slow development of Alzheimer's trademark cell-killing plaques
Date:3/17/2014

ANN ARBORUniversity of Michigan researchers have learned how to fix a cellular structure called the Golgi that mysteriously becomes fragmented in all Alzheimer's patients and appears to be a major cause of the disease.

They say that understanding this mechanism helps decode amyloid plaque formation in the brains of Alzheimer's patientsplaques that kills cells and contributes to memory loss and other Alzheimer's symptoms.

The researchers discovered the molecular process behind Golgi fragmentation, and also developed two techniques to 'rescue' the Golgi structure.

"We plan to use this as a strategy to delay the disease development," said Yanzhuang Wang, U-M associate professor of molecular, cellular and developmental biology. "We have a better understanding of why plaque forms fast in Alzheimer's and found a way to slow down plaque formation."

The paper appears in an upcoming edition of the Proceedings of the National Academy of Sciences. Gunjan Joshi, a research fellow in Wang's lab, is the lead author.

Wang said scientists have long recognized that the Golgi becomes fragmented in the neurons of Alzheimer's patients, but until now they didn't know how or why this fragmentation occurred.

The Golgi structure has the important role of sending molecules to the right places in order to make functional cells, Wang said. The Golgi is analogous to a post office of the cell, and when the Golgi becomes fragmented, it's like a post office gone haywire, sending packages to the wrong places or not sending them at all.

U-M researchers found that the accumulation of the Abeta peptidethe primary culprit in forming plaques that kill cells in Alzheimer's brainstriggers Golgi fragmentation by activating an enzyme called cdk5 that modifies Golgi structural proteins such as GRASP65.

Wang and colleagues rescued the Golgi structure in two ways: they either inhibited cdk5 or expressed a mutant of G
'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientists identify major source of cells defense against oxidative stress
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists rewrite rulebook on breast cancer in landmark global study
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. NIH scientists link quickly spreading gene to Asian MRSA epidemic
8. Joslin scientists identify important mechanism that affects the aging process
9. Scripps Research scientists show how memory B cells stay in class to fight different infections
10. Scientists Map Melanomas Genome
11. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... 26, 2015 Doctors Scott Sullivan and ... Breast Surgery (CRBS) and the St. Charles ... to announce that board certified Surgical Oncologist Dr. William ... surgeons. Ordoyne joins fellow breast surgical oncologist Alan Stolier, ... Frank DellaCroce, M.D., FACS; Scott Sullivan, M.D., FACS; Chris ...
(Date:3/26/2015)... MALVERN, PA (PRWEB) March 26, 2015 ... leading providers of continuing medical education, the ... for Culinary Medicine at Tulane University are ... in Culinary Medicine. The interdisciplinary program ... Specialist (CCMS) credential, is designed for physicians, nurse ...
(Date:3/26/2015)... 2015 Visiting Nurse Association of ... annual gala fundraiser, Lighting the Way, Brightening the Day, ... The Madison Hotel in Morristown, NJ. , Guests ... renowned musician Rio Clemente, delightful cuisine, an extensive silent ... Hertzel. Additionally, two prestigious awards will be presented to ...
(Date:3/26/2015)... CA (PRWEB) March 26, 2015 Dr. ... are proud to announce expanded offerings for Bay Area ... Francisco Dental Implant Center has long been a top-rated ... expanded its offerings to meet the strong demand by ... our reputation as a top-rated dental implant facility in ...
(Date:3/26/2015)... Innovative research and additional funding ... often fatal ruptures, says The Bee Foundation, a ... of brain aneurysms and funding innovative research that ... attention with the death of longtime WABC-TV ... Friday after suffering a ruptured brain aneurysm. (Source: ...
Breaking Medicine News(10 mins):Health News:Surgical Oncologist Joins Center for Restorative Breast Surgery and St. Charles Surgical Hospital 2Health News:Surgical Oncologist Joins Center for Restorative Breast Surgery and St. Charles Surgical Hospital 3Health News:Certified Culinary Medicine Specialist Program Jointly Launched by Goldring Center for Culinary Medicine at Tulane University and Cardiometabolic Risk Summit 2Health News:Certified Culinary Medicine Specialist Program Jointly Launched by Goldring Center for Culinary Medicine at Tulane University and Cardiometabolic Risk Summit 3Health News:Morristown VNA Fundraiser to Honor Distinguished Community Members 2Health News:Bay Area Dental Implant Specialist, Dr. Alex Rabinovich Announces Regional Educational Strategy 2Health News:Bay Area Dental Implant Specialist, Dr. Alex Rabinovich Announces Regional Educational Strategy 3Health News:Research and Funding Are Keys to Raising Awareness and Ultimately Preventing Fatal Brain Aneurysm Ruptures 2Health News:Research and Funding Are Keys to Raising Awareness and Ultimately Preventing Fatal Brain Aneurysm Ruptures 3
... Desperate Housewives, Star Joins The Wellness Community as National Spokesperson for ... PHILADELPHIA, Sept. 14 /PRNewswire-USNewswire/ -- Ricardo Antonio ... found himself in a role he hoped never to play again ... in late 2008 left Chavira shocked and overwhelmed with old memories ...
... , , , , ... new survey released today, 90 percent of plan sponsors believe that ... such as diabetes and heart disease are at the root of ... the greatest impact on controlling these escalating costs, nearly 60 percent ...
... a major public health problem. Affecting almost 1% of ... social toll in addition to the distress, dysfunction, disability ... of the disease are present from birth, other aspects ... expressed in early adulthood with long-lasting implications for most ...
... , , ... "The Dr. Oz Show," a high octane, multi-topic hour-long series ... Dr. Mehmet Oz, premieres in syndication today (check local listings). ... recently announced "Core Team Oz" guest contributors, fashion and style expert ...
... NEW YORK, Sept. 14 To educate healthcare professionals ... and care, Minority Health Care Communications (MHCC) will hold the National ... York Academy of Medicine in New York. , , ... New York, and the location is significant, says conference Director K. ...
... ... partners with AiRISTA to provide Wi-Fi-based RFID solutions. , ... Sparks, Maryland (PRWEB) September 14, ... Corporation (DCC) to promote, distribute, implement and support AiRISTA,s solutions and technologies ( ...
Cached Medicine News:Health News:Ricardo Antonio Chavira Uses Celebrity to Support Breast Cancer Caregivers 2Health News:Ricardo Antonio Chavira Uses Celebrity to Support Breast Cancer Caregivers 3Health News:Ricardo Antonio Chavira Uses Celebrity to Support Breast Cancer Caregivers 4Health News:Economic Conditions Signal Long-Term Shift in Rx Benefit Approach 2Health News:Economic Conditions Signal Long-Term Shift in Rx Benefit Approach 3Health News:Economic Conditions Signal Long-Term Shift in Rx Benefit Approach 4Health News:The future of schizophrenia 2Health News:The future of schizophrenia 3Health News:The future of schizophrenia 4Health News:The future of schizophrenia 5Health News:'The Dr. Oz Show' Premieres Today Nationwide 2Health News:'The Dr. Oz Show' Premieres Today Nationwide 3Health News:'The Dr. Oz Show' Premieres Today Nationwide 4Health News:'The Dr. Oz Show' Premieres Today Nationwide 5Health News:Latino HIV/AIDS Crisis Demands Attention - Health Care Professionals from Across the United States Gather in New York City for National Conference on Latinos and AIDS to Address Concerns 2Health News:Latino HIV/AIDS Crisis Demands Attention - Health Care Professionals from Across the United States Gather in New York City for National Conference on Latinos and AIDS to Address Concerns 3Health News:AiRISTA's Unified Visibility Solutions Bringing Together Wi-Fi RTLS, And Telemetry Offer Enormous Business Opportunities To Systems Integrators 2
(Date:3/26/2015)... , March 26, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: ... received a patent acceptance notice from the Israeli patent ... to prevent or reduce tissue damage caused by an ... when cardiac vessels are opened after a blockage causing ... stroke victims. Damage can be caused to ...
(Date:3/26/2015)... March 26, 2015 InfuSystem Holdings, Inc. (NYSE MKT: ... services for the healthcare industry in the United ... today it has secured a new $45.0 million credit facility ... $36.5 million credit facility with its prior lender group.  ... the new five-year senior secured credit agreement comprised of a ...
(Date:3/26/2015)... 2015  Oxis Biotech, Inc. (OXIS), a ... [OTC: OXIS] and [Euronext Paris: OXI.PA] announced ... agreement with the University of Pittsburgh related ... Xiang-Qun Xie , Associate Dean for ... of Pharmacy.  These patents/intellectual properties relate to ...
Breaking Medicine Technology:RegeneRx Receives Israeli Patent Acceptance Notice for the Use of TB4 To Prevent Tissue Damage Associated with Heart Attack and Stroke Treatments 2RegeneRx Receives Israeli Patent Acceptance Notice for the Use of TB4 To Prevent Tissue Damage Associated with Heart Attack and Stroke Treatments 3InfuSystem Announces New $45 Million Credit Facility At Substantially Lower Rates 2InfuSystem Announces New $45 Million Credit Facility At Substantially Lower Rates 3InfuSystem Announces New $45 Million Credit Facility At Substantially Lower Rates 4Oxis Biotech Executes Option Agreement to Certain Patents/Intellectual Properties Owned by the University of Pittsburgh 2Oxis Biotech Executes Option Agreement to Certain Patents/Intellectual Properties Owned by the University of Pittsburgh 3
... 2010 Omnicell, Inc ., (Nasdaq: ... to acute healthcare facilities, will display its latest innovations ... (ASHP) Midyear Clinical Meeting and Exhibition from December ... previewed include the new Omnicell Savvy™ mobile medication system; ...
... is natural that all customers using the services of online ... for them and getting their order within the shortest possible ... and well-taken. This site assures new and regular clients with ... security. It uses the most updated methods to make every ...
Cached Medicine Technology:Omnicell to Showcase Latest Product Innovations at ASHP 2Omnicell to Showcase Latest Product Innovations at ASHP 3Omnicell to Showcase Latest Product Innovations at ASHP 4Omnicell to Showcase Latest Product Innovations at ASHP 5A New Online Pharmacy rxbuys.com by RX Corp Offers its Services to International Clients 2
... System consists of a sterile Hemostatic ... Compression System.,Both devices work together to ... achieves topical hemostasis by facilitating clotting ... Femoral Compression System provides external compression ...
... WaveScan WaveFront System is an ophthalmic diagnostic ... wavefront aberrations of the human eye using ... be used to determine regular (sphero-cylindrical) refractive ... or blurry vision in the human eye. ...
... LADARWave® device gives you ... measure and display the ... individual eye. This capability ... a better understanding of ...
... eye drops quickly remove redness ... other pollutants and provide protection ... and the sun. This unique ... LIQUIFILM®, to soothe, cool and ...
Medicine Products: