Navigation Links
Turning back the Clock in Inherited Anemias
Date:12/4/2008

how it works.

"While it's been demonstrated that increased levels of HbF ameliorate the severity of sickle cell disease and beta-thalassemia, no direct strategies have yet been developed to increase HbF in these diseases," says Sankaran. "By reducing BCL11A expression or activity, we may be able to develop targeted therapies."

Hemoglobin is the protein in red blood cells that carries oxygen to the body's tissues. In sickle- cell disease, hemoglobin is abnormal, forming long chains that make red blood cells stiff and sickle-shaped. In thalassemia, the body's ability to produce hemoglobin is severely compromised. The hallmark of both disorders is anemia that can range from mild to life-threatening. Sickle-cell disease can cause severe pain and eventual organ damage as the abnormal, sickle-shaped cells block blood vessels, robbing tissues of their blood supply; beta-thalassemia requires frequent blood transfusions and then chelation therapy to rid the blood of excess iron that also leads to organ failure.

At birth, HbF comprises between 50 to 95 percent of a child's hemoglobin before the switch to adult hemoglobin production. The fetal form is thought to be an adaptation to the low oxygen in the fetal environment. Fetal hemoglobin has a higher affinity for oxygen, enabling it to pull oxygen more easily from the mother's circulation.

Are there potential side effects from boosting fetal hemoglobin levels? No, the researchers say. "Some people with rare genetic deletions have 100 percent fetal hemoglobin, and they're perfectly normal," says Orkin.

Orkin and Sankaran are conducting further studies to figure out how the switch from fetal to adult hemoglobin production occurs and how to target BCL11A therapeutically. "Improved understanding will permit the design of therapies for reactivation of HbF in patients with sickle-cell disease or thalassemia," says Orkin.

This study was
'/>"/>

Source: PRWeb
Copyright©2008 Vocus, Inc.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. N.J. Hospitals, Military and Veterans Affairs Join Broad Effort to Improve Returning Vets Healthcare
2. Turning Clocks Back Increases Risk of Drowsy Driving
3. With the Economy of the United States at a Turning Point, Health Care Could Be Our Next Serious Crisis ...
4. Science Fiction Has Become Reality with Remarkable Anti-Aging Treatment Breakthrough - Turning Back the Biological Clock in Aging
5. Drinking Problems Greater Among Returning Combat Veterans
6. Turning Life Insurance to Cash
7. Karen Haney Joins The Turning Point Group as Partner and Vice President of Client Services - Healthcare
8. Growing Public Health Crisis of Domestic Violence and Suicides by Returning Veterans
9. RAI CEO: Returning Value in a Challenging Time
10. Courage Center Offers Credentialed Educational Forum on Issues of Returning Injured Employees to Work
11. Chehalis Tribes Announce Benefit to Help Returning Combat Veterans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Turning back the Clock in Inherited Anemias
(Date:9/19/2014)... Frankfurt, Germany (PRWEB) September 19, 2014 ... today that its new ND® Infusion Catheter ... University of Frankfurt. , The study commenced on September ... Cardiology. The use of the new catheter demonstrated a ... commonly known as stem cells. “We are at the ...
(Date:9/19/2014)... QueenBeeTickets.com has the largest ticket inventory that ... tour set to begin on January 21 of 2015, discount ... the secure website. , Click Here to view ... QueenBeeTickets.com. , The Plain Spoken Tour has recently been announced, ... for a show coming to their local area. Presales have ...
(Date:9/19/2014)... and other adult family members living without minors in ... with young children or adolescents to eat family meals ... research suggests. , The study is the first large-scale ... a substantial amount of research has focused on health ... eating patterns have not been widely studied in adult-only ...
(Date:9/19/2014)... 2014 A McLean County ... (case 14-L-1175), following a failed hip replacement using a ... DePuy Orthopaedics Inc. and Johnson & Johnson over allegations ... Group, a nationally known personal injury law firm, represents ... in litigation involving defective hips. , According to the ...
(Date:9/19/2014)... 19, 2014 VogueQueen.com has ... that will make ladies more beautiful at their weddings. ... everyone can afford. The company’s new products are made ... offering great savings for all the global clients. ... extremely beautiful. I have ordered several items on its ...
Breaking Medicine News(10 mins):Health News:First-in-man procedure utilizes a new method of stem cell delivery 2Health News:First-in-man procedure utilizes a new method of stem cell delivery 3Health News:John Mellencamp Plain Spoken Tour Tickets: QueenBeeTickets.com Delights Customers with Discount Tickets for Mellencamp’s 80-City 2015 Concert Tour with Carlene Carter 2Health News:Even without kids, couples eat frequent family meals 2Health News:Even without kids, couples eat frequent family meals 3Health News:Even without kids, couples eat frequent family meals 4Health News:Flood Law Group Comments on Recent Hip Replacement Lawsuit 2Health News:VogueQueen.com’s New Line Of Cheap Wedding Dresses Aims To Attract Chic Ladies 2
... the World Federation for Mental Health reveals that patients ... life suffers because of their disease. ,Bipolar disorder ... elation and depression. Also known as manic-depressive illness that ... population. This is a chronic condition and most of ...
... been around now for almost 40 years for treatment ... it maybe useful in treating cancer as it has been ... This was reported by international team of scientists. Leslie Wilson, ... Santa Barbara, The results are published in online edition of ...
... Researchers have found that teenage girls living in temperate countries ... in life if they took supplements of Vitamin D in ... is low. The sun is important for formation of the ... ,The vitamin supplement would help to strengthen bones for later ...
... Losing one kilo of weight may be equivalent to losing ... from osteoarthritis of the knee. ,Researchers from the Wake ... of exercise and weight loss on the osteoarthritis of the ... 5% of the body weight in obese elderly patients can ...
... cancer is the most common and deadly cancer worldwide. About ... out of which // 85% will die before 2010. Habit ... is fastly increasing in low and middle income countries. The ... smoking related disease causes 5 million deaths a year. ...
... to a recent study researchers say the drug orlistat ... least a year without // major side effects in ... the intestines to absorb fat by up to 30 ... taking orlistat passes through the body without being digested ...
Cached Medicine News:Health News:Vitamin D Supplement in Teenage Girls essential in Winter months 2Health News:Aggressive Tobacco taxation policy can reduce cigarette smoking, 2
(Date:9/18/2014)... 2014 MiMedx Group, Inc. (NASDAQ: ... marketer of patent protected regenerative biomaterials and bioimplants ... it has entered into a distribution agreement with ... its dehydrated human amnion/chorion membrane ("dHACM") allograft products ... a private label basis. The MiMedx ...
(Date:9/18/2014)... 2014  Zacks.com announces the list of stocks featured ... Research analysts discuss the latest news and events impacting ... the blog include the Avanir Pharmaceuticals (Nasdaq: AVNR - ... Free Report ), Orexigen (Nasdaq: OREX - Free ... ) and Gilead (Nasdaq: GILD - Free Report ...
(Date:9/18/2014)... YORK and PLAINSBORO, N.J. ... announced today its support of the National Hemophilia ... Care , which provides support to people with ... physical and psychosocial challenges that can impede disease ... six modules, Communication With Your Provider About ...
Breaking Medicine Technology:MiMedx Signs Distribution Agreement With Zimmer 2MiMedx Signs Distribution Agreement With Zimmer 3The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 2The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 3The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 4The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 5The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 6Novo Nordisk Supports National Hemophilia Foundation Initiative for "Collaborating in Care" Disease Management Program 2Novo Nordisk Supports National Hemophilia Foundation Initiative for "Collaborating in Care" Disease Management Program 3
... level of blood oxygenation can be an essential ... in the clinical setting is often desirable. In ... technology into easily used point-of-care devices, recent products ... values., ,HemoCue, Inc., Lake Forest, Calif., says that ...
... the context of many clinical laboratories, automated production in ... years. In automobile assembly, for example, automated lines fabricate ... The result has been vastly improved products, far fewer ... These days, only a handful of luxury and sports ...
Cached Medicine Technology:Hemoglobin Testing at the Point of Care 2Hemoglobin Testing at the Point of Care 3Lab Automation Networks Proliferating 2Lab Automation Networks Proliferating 3Lab Automation Networks Proliferating 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: