Navigation Links
Turning back the Clock in Inherited Anemias
Date:12/4/2008

ene called BCL11A. Located on chromosome 2, it encodes a transcription factor, a protein that regulates activity of other genes. This turned out to be a valuable lead.

In the new study, led by Orkin and Sankaran, the team showed that BCL11A directly suppresses HbF production. When the researchers suppressed BCL11A itself in human red-blood-cell precursors, the cells began making HbF in large amounts.

"This is one of very few instances in the gene association field where one has been able to take a candidate gene and figure out what it's doing," says Orkin, the study's senior investigator who is also a professor of pediatrics at Harvard Medical School and chair of pediatric oncology at Dana-Farber. "It's pretty clear that this gene is a silencer of fetal hemoglobin. If you could knock it down to a low level, you could turn on fetal hemoglobin."

"The discovery of a single gene that profoundly affects fetal hemoglobin levels represents a major breakthrough in the quest for effective therapies for sickle cell disease and thalassemia," notes Elizabeth G. Nabel, MD, director of the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health, which helped support the study. "Researchers can now direct their efforts at developing novel therapies aimed at a specific target that could dramatically alter the course of these often devastating blood disorders. This news should bring great hope to the millions of people worldwide affected by sickle cell disease and thalassemia."

Increasing levels of HbF would compensate for abnormal or insufficient adult hemoglobin in sickle-cell anemia or thalassemia, easing symptoms and in some cases achieving a virtual cure, the researchers say. The drug hydroxyurea, used in some patients with hemoglobin disorders, often raises HbF levels, but the increases are modest, it doesn't work in all patients, it can cause toxicity, and no one knows
'/>"/>

Source: PRWeb
Copyright©2008 Vocus, Inc.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. N.J. Hospitals, Military and Veterans Affairs Join Broad Effort to Improve Returning Vets Healthcare
2. Turning Clocks Back Increases Risk of Drowsy Driving
3. With the Economy of the United States at a Turning Point, Health Care Could Be Our Next Serious Crisis ...
4. Science Fiction Has Become Reality with Remarkable Anti-Aging Treatment Breakthrough - Turning Back the Biological Clock in Aging
5. Drinking Problems Greater Among Returning Combat Veterans
6. Turning Life Insurance to Cash
7. Karen Haney Joins The Turning Point Group as Partner and Vice President of Client Services - Healthcare
8. Growing Public Health Crisis of Domestic Violence and Suicides by Returning Veterans
9. RAI CEO: Returning Value in a Challenging Time
10. Courage Center Offers Credentialed Educational Forum on Issues of Returning Injured Employees to Work
11. Chehalis Tribes Announce Benefit to Help Returning Combat Veterans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Turning back the Clock in Inherited Anemias
(Date:9/17/2014)... New York, NY (PRWEB) September 17, 2014 ... morcellators ( http://www.drugbot.com/morcellator/ ) in laparoscopic hysterectomies and other ... LLP reports. According to figures posted on Change.org, at ... September 17th. * , According to a recent report ... one year ago by Dr. Hooman Noorchashm, after his ...
(Date:9/17/2014)... NC (PRWEB) September 17, 2014 The ... of $50,000 to the National Children’s Oral Health Foundation: ... education through NCOHF’s Orange County Oral Health Zone Program® ... Zone Program is engaging a range of local constituent ... the cycle of severe tooth decay and its devastating ...
(Date:9/17/2014)... HealthDay Reporter WEDNESDAY, Sept. 17, ... to explain why antibiotic-resistant bacteria can thrive in a hospital ... to be the culprit. They can easily enter bacteria and ... gene that makes bacteria drug-resistant, a new study finds. ... to a class of antibiotic called carbapenems," said the study,s ...
(Date:9/17/2014)... than 87,000 men, a global team of scientists says ... differences in the genetic code -- that increase a ... to be the largest of its kind, has revealed ... of ethnic groups comprising men of European, African, Japanese ... smaller studies, according to William B. Isaacs, Ph.D., a ...
(Date:9/17/2014)... September 17, 2014 CarePoint Health became ... over 150 CarePoint Health employees participated in the Ice ... ALS Association. The event took place on September ... Center. CarePoint Health donated $100 to the ALS Association ... a total of approximately $15,000. The Ice Bucket Challenge ...
Breaking Medicine News(10 mins):Health News:Power Morcellator Petition Nears 85,000 Signatures, Bernstein Liebhard LLP Reports 2Health News:Power Morcellator Petition Nears 85,000 Signatures, Bernstein Liebhard LLP Reports 3Health News:Power Morcellator Petition Nears 85,000 Signatures, Bernstein Liebhard LLP Reports 4Health News:Delta Dental Community Care Foundation Donation to America's ToothFairy Helps Deliver Critical Services 2Health News:Researchers Discover How Bacteria Resist Antibiotics in Hospitals 2Health News:Researchers Discover How Bacteria Resist Antibiotics in Hospitals 3Health News:Large study reveals new genetic variants that raise risk for prostate cancer 2Health News:CarePoint Health Accepts the Ice Bucket Challenge 2Health News:CarePoint Health Accepts the Ice Bucket Challenge 3
... at the Kimmel Cancer Center at Thomas Jefferson ... how common blood pressure medications might help prevent ... in the laboratory that one type of pressure-lowering ... cancer cell growth and causes cell death. , ...
... Researchers at St. Jude Childrens Research Hospital have discovered ... to initiate most cases of an aggressive and often-fatal ... known as "cooperating oncogenic lesions," include the deletion of ... the development of a blood stem cell into a ...
... Now Available in ... Commercial Fitness Equipment, LAKE SUCCESS, ... monitoring and fitness assessment technology, announced today,that its patented OwnCode(R) ... can now be seamlessly and cost-effectively,incorporated into commercial fitness equipment, ...
... WESTLAKE VILLAGE, Calif., April 14 ... has been recognized for,call center operation ... Power,and Associates Certified Call Center Program(SM). ... the HealthFusion call center,operations to provide ...
... Prix Galien USA 2008 Announced for September 24, ... Nobel Laureate Walter,Gilbert, Ph.D., the Carl M. ... of Biogen, has joined fellow Nobel Laureates on ... in,biopharmaceutical research. Prix Galien USA 2008,( http://www.prix-galien-usa.com ) ...
... April 14 It,s 2 a.m. on a Sunday morning, your,dog ... weekend. What do,you do?, Well, this scenario happened to pet ... Internet about what to do for his lab mix,he realized he ... He,needed to develop a comprehensive resource for pet owners everywhere to,assist ...
Cached Medicine News:Health News:Blood pressure drugs halt pancreatic cancer cell growth, Jefferson researchers find 2Health News:St. Jude discovery offers new avenues to understanding an aggressive form of leukemia 2Health News:St. Jude discovery offers new avenues to understanding an aggressive form of leukemia 3Health News:Polar Introduces Cost-Effective Solution to Reduce Heart Rate Data Cross-Talk 2Health News:J.D. Power and Associates Reports: HealthFusion Recognized for Providing an Outstanding Customer Service Experience 2Health News:J.D. Power and Associates Reports: HealthFusion Recognized for Providing an Outstanding Customer Service Experience 3Health News:Prix Galien USA Welcomes Eighth Nobel Laureate to its Prestigious Award Committee 2Health News:Prix Galien USA Welcomes Eighth Nobel Laureate to its Prestigious Award Committee 3Health News:Comprehensive Pet Care Web Site Takes New Approach in Helping Pet Owners With Their Furry Members of the Family 2
(Date:9/17/2014)... OTEMR, Inc. , ONETOUCH EMR, 2.0 has achieved ONC ... the software is capable of supporting eligible providers with ... measures required to qualify for funding under the American ... certified on July 14, 2014 by ICSA Labs ... (ONC-ACB) and is compliant in accordance with applicable criteria ...
(Date:9/17/2014)... 17, 2014  Lightbeam Health Solutions announced today ... (Physician Direct ACO) to deploy the Lightbeam population ... better care while reducing costs. Photo ... Direct Accountable Care Organization is the ACO operating ... OPNS mission is to be the premier integrated ...
(Date:9/17/2014)... --  myMatrixx, a pharmacy and ancillary medical benefit manager for workers, ... has awarded myMatrixx with a "Best Places to Work ... row. Best Places to Work is ... Best Companies Group.  The competition, which involves months of ... insurance industry companies with at least 25 employees in ...
Breaking Medicine Technology:OTEMR, Inc.'s ONETOUCH EMR Achieves ONC HIT 2014 Edition COMPLETE EHR Certification from ICSA Labs 2OTEMR, Inc.'s ONETOUCH EMR Achieves ONC HIT 2014 Edition COMPLETE EHR Certification from ICSA Labs 3Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 2Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 3myMatrixx Honored with "Best Places to Work in Insurance" Award 2
... Aug. 11, 2011 Lexicon Pharmaceuticals, Inc. ... on discovering breakthrough treatments for human disease, announced today ... president and chief executive officer, will present at the ... August 16, 2011 at 1:15 p.m. Eastern Time in ...
... Minn., Aug. 11, 2011 The City of St. Louis ... to help provide residents with some relief from the high ... the National League of Cities (NLC) – the City is ... discount cards offer city residents an average of 23 percent ...
Cached Medicine Technology:Lexicon Pharmaceuticals to Present at the Wedbush 2011 Life Sciences Management Access Conference 2St. Louis Park and the National League of Cities Bring Free Prescription Discount Card Program to Residents 2
This CDI original designed Bra Vest incorporates Velcro® adjustable side closures to provide maximum compression to the patients breast, upper abdomen, upper and lower back....
Female Mini-VEST Seamless, Front Closure...
Male Support Brief...
For Lipoplasty or surgery of abdomen, flanks and midriff...
Medicine Products: