Navigation Links
Turning back the Clock in Inherited Anemias
Date:12/4/2008

ene called BCL11A. Located on chromosome 2, it encodes a transcription factor, a protein that regulates activity of other genes. This turned out to be a valuable lead.

In the new study, led by Orkin and Sankaran, the team showed that BCL11A directly suppresses HbF production. When the researchers suppressed BCL11A itself in human red-blood-cell precursors, the cells began making HbF in large amounts.

"This is one of very few instances in the gene association field where one has been able to take a candidate gene and figure out what it's doing," says Orkin, the study's senior investigator who is also a professor of pediatrics at Harvard Medical School and chair of pediatric oncology at Dana-Farber. "It's pretty clear that this gene is a silencer of fetal hemoglobin. If you could knock it down to a low level, you could turn on fetal hemoglobin."

"The discovery of a single gene that profoundly affects fetal hemoglobin levels represents a major breakthrough in the quest for effective therapies for sickle cell disease and thalassemia," notes Elizabeth G. Nabel, MD, director of the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health, which helped support the study. "Researchers can now direct their efforts at developing novel therapies aimed at a specific target that could dramatically alter the course of these often devastating blood disorders. This news should bring great hope to the millions of people worldwide affected by sickle cell disease and thalassemia."

Increasing levels of HbF would compensate for abnormal or insufficient adult hemoglobin in sickle-cell anemia or thalassemia, easing symptoms and in some cases achieving a virtual cure, the researchers say. The drug hydroxyurea, used in some patients with hemoglobin disorders, often raises HbF levels, but the increases are modest, it doesn't work in all patients, it can cause toxicity, and no one knows
'/>"/>

Source: PRWeb
Copyright©2008 Vocus, Inc.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. N.J. Hospitals, Military and Veterans Affairs Join Broad Effort to Improve Returning Vets Healthcare
2. Turning Clocks Back Increases Risk of Drowsy Driving
3. With the Economy of the United States at a Turning Point, Health Care Could Be Our Next Serious Crisis ...
4. Science Fiction Has Become Reality with Remarkable Anti-Aging Treatment Breakthrough - Turning Back the Biological Clock in Aging
5. Drinking Problems Greater Among Returning Combat Veterans
6. Turning Life Insurance to Cash
7. Karen Haney Joins The Turning Point Group as Partner and Vice President of Client Services - Healthcare
8. Growing Public Health Crisis of Domestic Violence and Suicides by Returning Veterans
9. RAI CEO: Returning Value in a Challenging Time
10. Courage Center Offers Credentialed Educational Forum on Issues of Returning Injured Employees to Work
11. Chehalis Tribes Announce Benefit to Help Returning Combat Veterans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Turning back the Clock in Inherited Anemias
(Date:7/29/2015)... New Port Richey, FL (PRWEB) , ... July ... ... across the nation have become increasingly aware of the impact drinking and substance ... morale, and increased illness. Financial loss is tagged in the billions per year. ...
(Date:7/29/2015)... ... , ... " Core Organizer ” was featured on NewsWatch as part of ... the market for iOS, Android, and Windows. Joe Toohey, the host of AppWatch and ... help anyone get organized. , Wouldn’t it be great if everyone could be a ...
(Date:7/29/2015)... ... 29, 2015 , ... More than 28,000 students in Pennsylvania ... living with autism will converge upon Penn State to share the latest updates ... Autism Conference will be held Aug. 3-6 at the Penn Stater Conference Center ...
(Date:7/29/2015)... ... July 29, 2015 , ... According to The Spirits Business ... is directly responsible for stimulating and perpetuating alcohol use disorders. Humans have the same ... of the National academy of Sciences, and has given researchers inklings to explore Rsu1 ...
(Date:7/29/2015)... ... 29, 2015 , ... With a new community program in ... Cancer Support Services and announced a new charity campaign to raise funds to ... groups, workshops and educational programs at no charge. Scott Campbell Agency initiates ...
Breaking Medicine News(10 mins):Health News:Workplace Trouble: Survey Reveals Sharp Escalation in Restaurant/Food Service Employee Drug Abuse 2Health News:Workplace Trouble: Survey Reveals Sharp Escalation in Restaurant/Food Service Employee Drug Abuse 3Health News:Get More Organized with the Core Organizer App 2Health News:Penn State Conference to Address Instruction, Success for Children with Autism 2Health News:Study Reveals Potential for Gene Manipulation to Stop Alcohol Addiction 2Health News:Study Reveals Potential for Gene Manipulation to Stop Alcohol Addiction 3Health News:Scott Campbell Agency and Nonprofit Stillwaters Cancer Support Services Initiate New Charity Campaign in Waukesha, WI to Provide Help for People Touched by Cancer 2Health News:Scott Campbell Agency and Nonprofit Stillwaters Cancer Support Services Initiate New Charity Campaign in Waukesha, WI to Provide Help for People Touched by Cancer 3
... Statement of Michael Bender, Plaintiff, WASHINGTON, June 5 ... Administration has finally agreed to comply with the law,and ... substance that poses a,health risk to pregnant women and ... this week, our lawsuit, Moms,Against Mercury et al. v. ...
... four-week and seventeen-week periods ended May 29,2008., ... Periods ended May 29, 2008 ... Month Year to Date (Dollars in millions) ... weeks), Total retail drug store sales ...
... Medical Corp.,(Nasdaq Capital Market: ESMC) announced today that ... Scientific, Inc. ("Drew") acquired JAS,Diagnostics, Inc. ("JAS"). JAS ... in vitro diagnostics ("IVD") reagents that markets its ... the,world. JAS, based in Miami, Florida, generates annual ...
... Health Magazine, SEATTLE, June 5 Kagome, one ... Mango Orchard natural 100 percent juice,blend have been named ... With the help of top health experts, Health ... fitness to the ultimate test,and unveiled a total of ...
... a lower cost tool than MRI for evaluating new ... News) -- Researchers say they can cheaply and easily ... off a tumor,s blood supply by using the same ... a technique called bioluminescence imaging (BLI), the University of ...
... Massachusetts School of,Professional Psychology, WEST ROXBURY, Mass., ... about the ,invisible wounds of war, - the ... and post traumatic,stress disorder (PTSD) - which raise ... suicide. We need to begin focusing on their,recuperation ...
Cached Medicine News:Health News:US FDA Admits Risks of Mercury Dental Fillings, Settles Lawsuit 2Health News:Longs Reports Preliminary May Retail Drug Store Sales 2Health News:Escalon(R) Enhances Position Within IVD Reagent Market with Strategic Acquisition of JAS Diagnostics 2Health News:Escalon(R) Enhances Position Within IVD Reagent Market with Strategic Acquisition of JAS Diagnostics 3Health News:Kagome's Yellow Mango Orchard Blended Juice Named One of America's Healthiest Buys 2Health News:Kagome's Yellow Mango Orchard Blended Juice Named One of America's Healthiest Buys 3Health News:Tracking Cancer Drug's Effectiveness 2Health News:Growing Public Health Crisis of Domestic Violence and Suicides by Returning Veterans 2
(Date:7/29/2015)... -- STAAR Surgical Company (NASDAQ: STAA ), a leading developer, ... the eye today reported financial results for the second quarter ... , Net Sales of $18.7 Million Down 7% from ... $2.1 Million from the Weakening Euro and Yen , ... , APAC Sales Down 1% Including Korea - Up ...
(Date:7/29/2015)... 29, 2015  Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: ... the second quarter ended June 30, 2015. ... HETLIOZ and Fanapt" said Mihael H. Polymeropoulos M.D., Vanda,s ... life cycle management of our products set the stage ... Financial Highlights , Total net product ...
(Date:7/29/2015)... NEWARK, Calif. , July 29, 2015 /PRNewswire/ ... "Company") today announced that its Board of Directors, ... its independent financial and legal advisors, has unanimously ... non-binding proposal from Horizon Pharma plc (NASDAQ: ... outstanding shares of Depomed in an all-stock transaction ...
Breaking Medicine Technology:STAAR Surgical Reports Second Quarter 2015 Results 2STAAR Surgical Reports Second Quarter 2015 Results 3STAAR Surgical Reports Second Quarter 2015 Results 4STAAR Surgical Reports Second Quarter 2015 Results 5STAAR Surgical Reports Second Quarter 2015 Results 6STAAR Surgical Reports Second Quarter 2015 Results 7STAAR Surgical Reports Second Quarter 2015 Results 8STAAR Surgical Reports Second Quarter 2015 Results 9STAAR Surgical Reports Second Quarter 2015 Results 10STAAR Surgical Reports Second Quarter 2015 Results 11STAAR Surgical Reports Second Quarter 2015 Results 12STAAR Surgical Reports Second Quarter 2015 Results 13STAAR Surgical Reports Second Quarter 2015 Results 14STAAR Surgical Reports Second Quarter 2015 Results 15STAAR Surgical Reports Second Quarter 2015 Results 16STAAR Surgical Reports Second Quarter 2015 Results 17STAAR Surgical Reports Second Quarter 2015 Results 18STAAR Surgical Reports Second Quarter 2015 Results 19STAAR Surgical Reports Second Quarter 2015 Results 20STAAR Surgical Reports Second Quarter 2015 Results 21STAAR Surgical Reports Second Quarter 2015 Results 22STAAR Surgical Reports Second Quarter 2015 Results 23STAAR Surgical Reports Second Quarter 2015 Results 24Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 2Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 3Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 4Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 5Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 6Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 7Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 8Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 9Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 10Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 11Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 12Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 13
... PARK, Calif., March 22, 2011 Telome Health, Inc. ... property portfolio. THI will provide telomere length data from ... health monitoring. THI leverages the predictive ... protective caps at the ends of chromosomes, to assess ...
... MOUNT PROSPECT, Ill., March 22, 2011 The National Association ... the prescription monitoring programs (PMPs) of North Dakota , ... agreements to participate in the PMP Interconnect ™ system, ... United States to be linked, providing a more effective means ...
Cached Medicine Technology:Telome Health, Inc. Launches With Exclusive IP Portfolio 2Telome Health, Inc. Launches With Exclusive IP Portfolio 3Three States Sign on to Participate in NABP's Interconnected Prescription Monitoring System 2Three States Sign on to Participate in NABP's Interconnected Prescription Monitoring System 3
Anti-Tg and Anti-TPO are two major autoantibodies implicated in autoimmune related thyroiditis and aid in the differential diagnosis of Hashimoto's thyroiditis and Graves' disease....
... is an automated, turbidimetric, whole- blood assay ... the ability of activated platelets to bind ... of the VerifyNow IIb/IIIa assay device contains ... this analysis. Within the well is an ...
... The Company's first commercial product is ... with single-use, disposable assay devices . The ... products are direct use of a vacuum-type ... a result in minutes. VerifyNow IIb/IIIa, the ...
... ComboMap system provides both pressure and ... singly or in a combined screen ... SmartWire and Volcano's unique Doppler FloWire. ... valuable tools to assess ambiguous or ...
Medicine Products: