Navigation Links
Turning a painkiller into a cancer killer
Date:6/14/2010

LA JOLLA, Calif., June 15, 2010 Without knowing exactly why, scientists have long observed that people who regularly take non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin have lower incidences of certain types of cancer. Now, in a study appearing in Cancer Cell on June 15, investigators at Sanford-Burnham Medical Research Institute (Sanford-Burnham) and their colleagues have figured out how one NSAID, called Sulindac, inhibits tumor growth. The study reveals that Sulindac shuts down cancer cell growth and initiates cell death by binding to nuclear receptor RXRα, a protein that receives a signal and carries it into the nucleus to turn genes on or off.

"Nuclear receptors are excellent targets for drug development," explained Xiao-kun Zhang, Ph.D., professor at Sanford-Burnham and senior author of the study. "Thirteen percent of existing drugs target nuclear receptors, even though the mechanism of action is not always clear."

RXRα normally suppresses tumors, but many types of cancer cells produce a truncated form of this nuclear receptor that does just the opposite. This study showed that shortened RXRα enhances tumor growth by stimulating other proteins that help cancer cells survive. Luckily, the researchers also found that Sulindac can be used to combat this deviant RXRα by switching off its pro-survival function and turning on apoptosis, a process that tells cells to self-destruct.

Sulindac is currently prescribed for the treatment of pain and fever, and to help relieve symptoms of arthritis. The current study demonstrates a new application for Sulindac as a potential anti-cancer treatment that targets truncated RXRα protein in tumors. However, some NSAIDs have gotten a lot of bad press for their potentially dangerous cardiovascular side effects. To overcome this limitation, the researchers tweaked Sulindac, creating a new version of the drug now called K-80003 that both decreases negativ
'/>"/>

Contact: Josh Baxt
jbaxt@sanfordburnham.org
858-795-5236
Sanford-Burnham Medical Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Holistic Management and Allan Savory Win the 2010 Buckminster Fuller Award for Turning Deserts into Thriving Grasslands and Combating Climate Change.
2. Parents of Autistic Children Turning to Alternative Treatments
3. New iVillage Study Reveals That Majority of Women 18-34 Go Online First With Health Questions - Before Turning to Their Doctor or Other Family Members
4. Doctors Turning to Cardiac Catheterization Too Quickly
5. Turning metal black more than just a novelty
6. Acupuncture May Trigger Natural Painkiller
7. New Form of Painkiller May Fight Colon Cancer
8. Another perk of painkillers? Decreased hormone levels may reduce cancer risk
9. Painkillers Lower Estrogen Levels, May Explain Cancer Reduction Risk
10. Overdoses From Prescription Painkillers on the Rise
11. Makers of Powerful Painkillers Present Safety Plans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... May 22, 2015 Memorial Day weekend is ... Insurance is offering some tips to help promote safe ... there will be 383 traffic fatalities this Memorial Day weekend. ... National Highway Traffic Safety Association: , , ... vehicle is wearing a seatbelt, whether they’re driving or riding ...
(Date:5/22/2015)... MOUNTAIN VIEW, California (PRWEB) May 22, 2015 ... Breakers, has set a RecordSetter.com World Record at the 104th ... Coco Libre coconut water ice luge served 315 people in ... Zappos.com Bay to Breakers race is so true to the ... that we felt bringing an ice luge to the finish ...
(Date:5/22/2015)... 22, 2015 The dentist ... announces that they are now offering complimentary consultations ... dental treatments. At consultations, patients can discuss their ... what certain treatments can achieve and whether alternative ... this initial appointment. If treatments are chosen, patients ...
(Date:5/22/2015)... sweetFrog Enterprises, LLC. is pleased to announce the ... now the 16th sweetFrog store located in the Lone Star ... on the Inc. 500 list of fastest growing companies in ... East Texas for 20 years and love the natural beauty ... and nearby Palestine, sweetFrog locations. “We are really excited about ...
(Date:5/22/2015)... May 22, 2015 DMG Productions announces ... scheduled to broadcast on Friday, May 29, 2015 at ... Channel. , In this episode Innovations will explore Interstate ... to business quickly through disaster recovery and restoration. , ... that works collaboratively to develop and deliver training and ...
Breaking Medicine News(10 mins):Health News:Amica Has 4 Road Safety Tips for Memorial Day Weekend 2Health News:Coco Libre Ice Luge Sets New World Record at Bay to Breakers 2Health News:West Hollywood Dental Office, Sunset Plaza Dental is Now Offering Complimentary Consultations 2Health News:sweetFrog Opens New Location in Jacksonville, Texas 2Health News:New Episode of Innovations Airing Friday, May 29, 2015 Via Discovery Channel 2
... GORDONSVILLE, Va., May 28 PBM Holdings, Inc., ... announced today that,its Chinese affiliate company, PBM (Guangzhou) ... of the China earthquake. PBM is,partnering with the ... Red,Cross, an affiliate of the Red Cross Society ...
... in helping ... and stay on therapy, DENVER, May 28 Nearly all ... their commitment to,managing their disease in every way possible is their ... survey of people with,MS, results of which were released today at ...
... Study estimates savings of more than $60 million over 11 ... use of air bags and seat belts significantly reduces injuries ... crash and also lowers in-hospital death rates, injury severity and ... , It also suggests that optimal use of air bags ...
... published in the May 2008 (volume 8, issue 25) ... (pic-noj-en-all), an antioxidant plant extract from the bark of ... type II diabetes patients, allows people to lower ... factors. The study, conducted at the University of Arizona, ...
... The old,saying, "beauty is in the eye ... study in a recent issue of Plastic and ... Society of Plastic,Surgeons (ASPS), found that variations in ... your facial expressions, and,subsequent mood, are perceived by ...
... China Sky One,Medical, Inc. (Amex: CSY ) ... and distributor of pharmaceutical, medicinal and,diagnostic products in ... Public Accountants and Advisors LLP (,Moore Stephens,) as ... terminated its,contract with Sherb & Co., LLP that ...
Cached Medicine News:Health News:PBM Companies Partner with the Red Cross to Donate Infant Formula to China Earthquake Victims 2Health News:Significant Barriers Prevent People with MS from Fully Committing to Treatment Regimen, New Survey Reveals 2Health News:Significant Barriers Prevent People with MS from Fully Committing to Treatment Regimen, New Survey Reveals 3Health News:Significant Barriers Prevent People with MS from Fully Committing to Treatment Regimen, New Survey Reveals 4Health News:Significant Barriers Prevent People with MS from Fully Committing to Treatment Regimen, New Survey Reveals 5Health News:Significant Barriers Prevent People with MS from Fully Committing to Treatment Regimen, New Survey Reveals 6Health News:Air Bags-Seat Belts Cut Injuries, Deaths, Costs 2Health News:Study shows pine bark naturally reduces cardiovascular risk factors in diabetics 2Health News:Study shows pine bark naturally reduces cardiovascular risk factors in diabetics 3Health News:Looking Tired or Angry May Have More to do With Facial Aesthetics Than How You Feel, ASPS Study Reveals 2Health News:Looking Tired or Angry May Have More to do With Facial Aesthetics Than How You Feel, ASPS Study Reveals 3Health News:China Sky One Medical, Inc. Engages Moore Stephens as New Independent Auditor 2Health News:China Sky One Medical, Inc. Engages Moore Stephens as New Independent Auditor 3
(Date:5/22/2015)... 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX), a clinical-stage ... regeneration, today announced that J.J. Finkelstein , chief ... corporate overview at two upcoming investor conferences. ... th Annual Microcap Conference on Thursday May 28, ... at 11:00 am EDT.  A webcast will be available ...
(Date:5/22/2015)... 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ("the ... of the results of the Company,s 72-patient, placebo-controlled ... drops) for the treatment of dry eye patients ... ) model.  The exploratory study was completed in ... disseminated by the Company in a press release, ...
(Date:5/22/2015)... May 20, 2015 Research and Markets( ... "Guide to Prepare Application Dossiers for Oversea ... Edition) " report to their offering. ... of segment market of the most growth potentiality, ... device manufacturers and producers to penetrate such market. ...
Breaking Medicine Technology:RegeneRx to Present at 2 Investor Conferences 2RegeneRx to Present at 2 Investor Conferences 3Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 2Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 3Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 4China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 2China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 3
... Device Designed for Type-2 Diabetes Patients Who Are Overweight ... to Current Oral Anti-Diabetic Treatments Device ... NEW YORK, March 28 New York-Presbyterian Hospital/Weill,Cornell Medical ... of an investigational implantable device designed to help,those with ...
... Preclinical Data Indicates MSI-1436 Does Not Alter Rate of Dopamine ... ... 28 Genaera,Corporation (Nasdaq: GENR ) announced that preclinical data was ... Roitman, Ph.D., a Genaera collaborator and investigator with the,University of Illinois at ...
Cached Medicine Technology:New York-Presbyterian/Weill Cornell is First New York Medical Center to Offer Tantalus Clinical Trial to Diabetes Patients 2Genaera Corporation Announces MSI-1436 Data Presented at Society of Neuroscience Meeting 2Genaera Corporation Announces MSI-1436 Data Presented at Society of Neuroscience Meeting 3Genaera Corporation Announces MSI-1436 Data Presented at Society of Neuroscience Meeting 4
Provides a combination of concentrated cold / hot and compression for the knee...
Provides a combination of concentrated cold / hot and compression for the wrist...
Provides compression, support, immobilization for the knee in addition to cold / hot therapy...
... One-Piece™ Collar is completely injected molded from ... our patented chin support. , ,Our ... efficiently managed where space is limited. Color-coded ... of sizes., ,Either in a supine ...
Medicine Products: