Navigation Links
Turning a painkiller into a cancer killer
Date:6/14/2010

LA JOLLA, Calif., June 15, 2010 Without knowing exactly why, scientists have long observed that people who regularly take non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin have lower incidences of certain types of cancer. Now, in a study appearing in Cancer Cell on June 15, investigators at Sanford-Burnham Medical Research Institute (Sanford-Burnham) and their colleagues have figured out how one NSAID, called Sulindac, inhibits tumor growth. The study reveals that Sulindac shuts down cancer cell growth and initiates cell death by binding to nuclear receptor RXRα, a protein that receives a signal and carries it into the nucleus to turn genes on or off.

"Nuclear receptors are excellent targets for drug development," explained Xiao-kun Zhang, Ph.D., professor at Sanford-Burnham and senior author of the study. "Thirteen percent of existing drugs target nuclear receptors, even though the mechanism of action is not always clear."

RXRα normally suppresses tumors, but many types of cancer cells produce a truncated form of this nuclear receptor that does just the opposite. This study showed that shortened RXRα enhances tumor growth by stimulating other proteins that help cancer cells survive. Luckily, the researchers also found that Sulindac can be used to combat this deviant RXRα by switching off its pro-survival function and turning on apoptosis, a process that tells cells to self-destruct.

Sulindac is currently prescribed for the treatment of pain and fever, and to help relieve symptoms of arthritis. The current study demonstrates a new application for Sulindac as a potential anti-cancer treatment that targets truncated RXRα protein in tumors. However, some NSAIDs have gotten a lot of bad press for their potentially dangerous cardiovascular side effects. To overcome this limitation, the researchers tweaked Sulindac, creating a new version of the drug now called K-80003 that both decreases negativ
'/>"/>

Contact: Josh Baxt
jbaxt@sanfordburnham.org
858-795-5236
Sanford-Burnham Medical Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Holistic Management and Allan Savory Win the 2010 Buckminster Fuller Award for Turning Deserts into Thriving Grasslands and Combating Climate Change.
2. Parents of Autistic Children Turning to Alternative Treatments
3. New iVillage Study Reveals That Majority of Women 18-34 Go Online First With Health Questions - Before Turning to Their Doctor or Other Family Members
4. Doctors Turning to Cardiac Catheterization Too Quickly
5. Turning metal black more than just a novelty
6. Acupuncture May Trigger Natural Painkiller
7. New Form of Painkiller May Fight Colon Cancer
8. Another perk of painkillers? Decreased hormone levels may reduce cancer risk
9. Painkillers Lower Estrogen Levels, May Explain Cancer Reduction Risk
10. Overdoses From Prescription Painkillers on the Rise
11. Makers of Powerful Painkillers Present Safety Plans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2015)... The Classic Denture Center , located in ... Throughout all of March patients can receive $25 off ... can help overall mouth health and give patients ... certain symptoms that suggest the denture teeth are in ... 1.    Pain, clicking, and popping in the joints, 2.    Pain behind ...
(Date:2/28/2015)... 2015 Indosoft Inc , developers ... Asterisk, are pleased to announce the development of Q-Suite ... 5.8 versions of Q-Suite, this new version will include ... of new features to the leading edge call center ... 5.9 will add features to enhance security and protection. ...
(Date:2/28/2015)... Pioneer Millworks reclaimed USA wood will ... Construction Materials Show, an annual, premier sustainable building event ... and top manufacturers of the latest building products, services ... sourced and manufactured by Pioneer Millworks from their Oregon ... at restaurants, hotels, retailers, and corporate offices. Nichibi ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 A case ... testosterone lawsuits that have been filed by law firms ... second week in March, the Firm notes. , ... parties involved in the federal litigation will meet on ... related to prescription therapy treatments designed to raise levels ...
(Date:2/28/2015)... The noted Friedman Dental Group of South Florida ... their website. The new version of the site is ... section about their team members. Potential and current patients ... each Friedman Dental Group team member including new staff. ... provide our patients with the opportunity to get to ...
Breaking Medicine News(10 mins):Health News:Classic Denture Center in Portland Oregon is Offering March Discount 2Health News:Indosoft Proudly Announces Q-Suite 5.9 Call Center Software for Asterisk 2Health News:US Reclaimed Wood from Pioneer Millworks to be Featured at Architecture & Construction Materials Show in Tokyo. 2Health News:Bernstein Liebhard LLP Notes Approaching Conference in Federal Litigation that Includes Numerous Testosterone Lawsuits Filed by the Firm 2Health News:Bernstein Liebhard LLP Notes Approaching Conference in Federal Litigation that Includes Numerous Testosterone Lawsuits Filed by the Firm 3Health News:Bernstein Liebhard LLP Notes Approaching Conference in Federal Litigation that Includes Numerous Testosterone Lawsuits Filed by the Firm 4Health News:Friedman Dental Group Announces Their Updated Website 2
... ... pesticide use must be eliminated to stop the terrible human suffering and environmental toll ... a huge difference. , ... (PRWEB) June 15, 2010 -- Adrian Desbarats, owner of an organic clothing ...
... ... Dr. Joshua M. Hurwitz has been appointed Division ... of Obstetrics, Gynecology and Reproductive Sciences of Danbury Hospital. Dr. ... for patient care and teaching. He practices with Reproductive Medicine ...
... ... glamour icons from Hollywood to New York—and now it’s available locally at an innovative White ... treatment to come out of Brazil since the Brazilian Wax. , ... White Rock, BC (PRWEB) June 15, 2010 -- It’s ...
... PTSD symptoms may be key to treating anger among Iraq/Afghanistan ... at Chapel Hill and Veterans Affairs researchers. "Most ... aggressiveness, but for the small subset who do, this study ... lead author of the study, an assistant professor of psychiatry ...
... Scientists have long known that certain types of bacteria ... researchers have discovered how bacteria perform this essential task. ... report their discovery in a featured article in the ... Immunology, now available online. Knight is professor and ...
... prevent 100,000 deaths worldwide each year, study suggests , ... commonly used to prevent excess bleeding in surgeries could ... trauma, a new study suggests. , The drug, tranexamic ... and easily administered, experts said. It works by significantly ...
Cached Medicine News:Health News:Organic Clothing – Is Your Clothing Delivering Death in Small Doses? 2Health News:Organic Clothing – Is Your Clothing Delivering Death in Small Doses? 3Health News:Infertility Specialist Dr. Joshua Hurwitz Appointed to Lead Division of Reproductive Endocrinology and Infertility at Danbury Hospital 2Health News:Infertility Specialist Dr. Joshua Hurwitz Appointed to Lead Division of Reproductive Endocrinology and Infertility at Danbury Hospital 3Health News:“Brazilian Blowout” Blows into Local Salon 2Health News:Study: Specific PTSD symptoms related to anger and aggressiveness among Iraq/Afghanistan veterans 2Health News:How bacteria boost the immune system 2Health News:Drug That Stops Bleeding Could Save Lives 2Health News:Drug That Stops Bleeding Could Save Lives 3
(Date:2/27/2015)... MISSISSAUGA, ON , Feb. 27, 2015 /CNW/ - Covalon ... advanced medical technologies company, today announced financial results for ... For the three months ended December 31, 2014, ... for the quarter was $229,820 or $0.02 per share.  ... Pedlar , said "I am very pleased with the ...
(Date:2/27/2015)...  Uroplasty, Inc. (NASDAQ: UPI ), a medical ... products to treat voiding dysfunctions, today announced that it ... Tuesday, March 10, 2015. Rob Kill , President ... Officer, will present at 4:00 p.m. Pacific Time and ... at the Ritz Carlton in Laguna Niguel, ...
(Date:2/26/2015)...  Finesse expands office in Leicester, United ... expansion of its operations in Leicester ... access for customers is expected shortly afterward. ... to the current office, the new premises will double ... allow Finesse to bring on more service personnel. The ...
Breaking Medicine Technology:Covalon Announces First Quarter Financial Results 2Covalon Announces First Quarter Financial Results 3Uroplasty to Participate in the 27th Annual ROTH Conference 2New Finesse Office in United Kingdom 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: