Navigation Links
Treating eye diseases with anti-VEGF therapies may have side effects
Date:1/11/2013

Rockville, MD A new Investigative Ophthalmology & Visual Science (IOVS) article reveals that increasingly aggressive therapies that block VEGF could cause damage in treating eye diseases. Scientists discovered inhibiting anti-VEGF might have a harmful effect on the tissue responsible for producing the fluid that bathes the eye, medically termed the ciliary body.

"Very little is known about the factors that regulate the integrity and function of this tissue [the ciliary body] in the adult," said author Patricia A. D'Amore, PhD, of Schepens Eye Research Institute/Massachusetts Eye and Ear. "Our finding indicates that VEGF-A is at least one of the molecules that play a role in keeping the ciliary body healthy and functioning properly."

In the study, Expression and role of VEGF-A in the Ciliary Body, investigators simulated the VEGF-A activity in adult mice and found that blocking the protein decreased the intraocular pressure, an unexpected side effect that impaired the ciliary body.

Several anti-VEGF-A therapies are currently being widely and successfully used for the treatment of eye diseases like wet macular degeneration, diabetic macular edema and retinopathy of prematurity. D'Amore agrees that there is no evidence to indicate that the manner in which these drugs are being administered interferes with the ciliary body. "However, there is a move toward developing methods to continuously deliver anti-VEGF to the eye and to have drugs that are more potent inhibitors of VEGF," she said. "I would be concerned that more aggressive VEGF inhibition in the eye would have deleterious effects on the ciliary body."

The research team's investigation of anti-VEGF-A on the ciliary body was the result of prior studies that found blocking VEGF can lead to the degeneration of capillary beds, particularly capillaries that have specializations called fenestrations like the ones found in the ciliary body. These include whole body VEGF bl
'/>"/>

Contact: Katrina Norfleet
knorfleet@arvo.org
240-221-2924
Association for Research in Vision and Ophthalmology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study Suggests Treating Dyslexia Before Kids Learn to Read
2. New standards for treating traumatic shoulder injuries to improve patient care
3. Treating childhood obesity: A family affair
4. Unique physiology key to diagnosing and treating diabetes in Asian populations
5. Studies See Advances in Detecting, Treating Pancreatic Cancer
6. 1 size doesnt fit all when treating blood pressure in people with diabetes, VA/U-M study suggests
7. Nanomedicines promise fewer side effects in treating cancer
8. Mount Sinai researchers develop a multi-target approach to treating tumors
9. A non-antibiotic approach for treating urinary tract infections
10. UT Southwestern study shows treating diabetes early, intensively is best strategy
11. Researchers report success in treating autism spectrum disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/4/2015)... ... September 04, 2015 , ... ... Association (CHPA) joint meeting of its Product, Quality and Manufacturers, Dietary Supplements and ... rules constantly evolving in the consumer goods industry, it can be difficult for ...
(Date:9/4/2015)... ... September 04, 2015 , ... San ... available at CitiDent. CEREC is a newer method for creating restorations through innovative ... patients by eliminating the need for multiple appointments, CEREC produces restorations with total ...
(Date:9/4/2015)... ... September 04, 2015 , ... Bio-Logic Aqua® Research, a fresh ... its only mission and research focus: Water Life Science®. In the current warming ... evaporation is becoming dangerously accelerated. As a result of the global fresh water, ...
(Date:9/4/2015)... ... September 04, 2015 , ... ECC announces ... neighborhood created specifically for adults with intellectual, developmental and acquired disabilities. The first ... feature 30 cottage or “pocket” homes. In this community, adults will live safely ...
(Date:9/4/2015)... ... 2015 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has written an ... Pope’s upcoming trip to the United States. , Yisrayl lays out what he says is ... and society is. Yisrayl also provides the meaning of his own name and describes what ...
Breaking Medicine News(10 mins):Health News:Inmar Experts To Address OTC Manufacturers’ Session on Hazardous Waste and Handling at CHPA Meeting 2Health News:Inmar Experts To Address OTC Manufacturers’ Session on Hazardous Waste and Handling at CHPA Meeting 3Health News:San Francisco Dentist, Dr. Ben Amini, is Now Offering CEREC Technology at CitiDent 2Health News:Bio-Logic Aqua® Research Announces Water Life Science and Body Water Evaporation as Research Focus and Mission 2Health News:Bio-Logic Aqua® Research Announces Water Life Science and Body Water Evaporation as Research Focus and Mission 3Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 2Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 3Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 4Health News:Yisrayl Hawkins Writes Open Letter to Pope Francis In Light of Approaching U.S. Visit 2
... Vermont have uncovered the possible causes for brain disorders ... were// published November 1, 2006 in the prestigious journal ... for signaling regional blood flow changes in the brain. ... uninterrupted supply of oxygen and glucose, which is provided ...
... alcohol heavily over a short period of time or drink ... to face more depression than men, says a study.// ... Of Medicine and Health Sciences and other researchers studied the ... history of depression, according to the online edition of BBC ...
... Scientists have now uncovered graphic evidence that suggests a ... occurrence of herpes simplex infection//. The journal, Neurobiology of ... older individuals, the same gene is implicated in causing ... interest to the scientific world. It raises the possibility ...
... A compound derived from the bark of a tree could help ... new study.// ,The new molecule tazopsine was isolated ... science portal SciDev Net. ,Madagascar is an island ... It is the fourth largest island in the world and is ...
... before and for 24 hours after stent placement or ... any significant// treatment effect compared to placebo, according to ... had shown promise in preliminary studies. ,Acute ST-elevation ... following a heart attack) is a major public health ...
... issue of the Journal of the National Cancer Institute, the ... 2005 was $2.3// billion in the first year after diagnosis. ... of cancer care, but few have attempted to include a ... traveling to and from care, waiting for appointments, and receiving ...
Cached Medicine News:Health News:Potential Key to Brain Blood-Flow Disorders Explored by Scientists 2Health News:Potential Key to Brain Blood-Flow Disorders Explored by Scientists 3Health News:Potential Key to Brain Blood-Flow Disorders Explored by Scientists 4Health News:Herpes Simplex and Alzheimer’s Disease Linked to Single Gen 2Health News:Herpes Simplex and Alzheimer’s Disease Linked to Single Gen 3Health News:Herpes Simplex and Alzheimer’s Disease Linked to Single Gen 4Health News:Drug Therapy Offers Little Benefit for Some Patients Undergoing Angioplasty or Stent Procedure 2Health News:Cancer Care-Patient's Time Costs Studied 2
(Date:9/3/2015)... NEW YORK , Sept. 3, 2015 /PRNewswire/ ... disease is a condition that involves narrowing or ... due to heart rhythm problems, smoking, high cholesterol, ... infarction, peripheral arterial disease, atherosclerosis, and heart failure ... contraction or obstruction of blood vessels, especially coronary ...
(Date:9/3/2015)... About dry eye syndrome Dry eye ... deficient tear production or quick tear evaporation or deviation ... aqueous tear deficient dry eye and evaporative dry eye. ... not produce enough tears, whereas meibomian gland dysfunction results ... slow tear evaporation and maintain tear stability. The symptoms ...
(Date:9/3/2015)... Fla. , Sept. 3, 2015  WellCare Health ... Drew Asher , senior vice president and chief ... Fargo Securities 2015 Healthcare Conference on Wednesday, September 9, ... presentation will be webcast live. In addition, a replay ... of the live broadcast. Both the live broadcast and ...
Breaking Medicine Technology:Global Cardiovascular Implants Market 2015-2019 2Global Dry Eye Syndrome Market 2015-2019 2
... Fla., May 5, 2011 Dyadic International, Inc. ... focused on the discovery, development, manufacture and sale ... industrial enzyme and biopharmaceutical industries, today announced financial ... The financial information contained in this press release ...
... AmbiCom Holdings, Inc. (OTCQB:ABHI), a leader ... suppliers, today announced that it has retained Hayden IR, ... develop and implement a strategic investor relations program to ... investment community. "Wireless medical devices are ...
Cached Medicine Technology:Dyadic International Reports 2011 First Quarter Financial Results 2Dyadic International Reports 2011 First Quarter Financial Results 3Dyadic International Reports 2011 First Quarter Financial Results 4Dyadic International Reports 2011 First Quarter Financial Results 5AmbiCom Retains Hayden IR to Develop Strategic Investor Relations Program 2AmbiCom Retains Hayden IR to Develop Strategic Investor Relations Program 3
... The Biomet Ankle ... ideally suited for,tibiotalocalcaneal ... second-generation nail affords ... fixation that incorporates ...
... clinical and economic issues of cerclage wiring, ... to maximize tension control while minimizing invasion ... efficient instrumentation with a simple technique. , ... indicated for general orthopaedic trauma surgery involving: ...
OmniAccess&trade Hip Retractor System sets a new standard in hip exposure. It provides constant, absolute exposure of the acetabulum during total hip arthroplasty and revision procedures....
... of DePuy's aggressive innovations have become the ... be equalled. The AML Total Hip ... efficiently address and effectively meet the needs ... With greater than 15 years of ...
Medicine Products: