Navigation Links
Topical treatment for cold sores achieves efficacy of oral drugs; represents paradigm shift
Date:10/28/2008

WASHINGTON, D.C. (October 28, 2008) Scientists at NanoBio Corporation have demonstrated for the first time in humans that a novel topical treatment for cold sores (herpes labialis), NB-001, speeds healing of lesions as effectively as the leading oral systemic drugs but without safety or toxicity concerns.

The new data provide the first proof of principle that a topical agent can attain equivalent efficacy rates to oral systemic drugs, according to the NanoBio scientists. Topical treatments are widely considered inferior to oral systemic treatments because they fail to penetrate to the site of infection with adequate drug levels required to subdue infections.

In the study of 482 patients, NB-001 healed lesions 1.3 days faster than placebo as measured by investigators (P=0.006). Results of the randomized, double-blind, placebo-controlled, phase 2b trial are being presented at the 48th annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)/Infectious Diseases Society of America (IDSA) 46th annual meeting in Washington, D.C.

NB-001 was well tolerated, without safety concerns or adverse events, and was not systemically absorbed. "NB-001 challenges the conventional wisdom that topical therapies are less effective, because NB-001 directly accesses the site of infection in the dermis and epidermis instead of remaining on top of the skin," said James R. Baker, Jr., M.D., founder and chairman of NanoBio Corp. "NB-001 employs a physical mode of action to disrupt the outer membranes of pathogens and prompt viral lysis, essentially killing on contact."

The study also suggests that the physical mode of action of NB-001 significantly reduces the likelihood that pathogens will develop resistance to the biocidal effect of the topical lotion.

"These characteristics make NB-001 an ideal candidate for first-line treatment with the potential for widespread use across a broad range of patients," said Mary Fla
'/>"/>

Contact: Becky Levine
blevine@medthink.com
919-786-4918
MedThink Communications
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Perrigo Company Announces FDA Approval for Ciclopirox Topical Solution
2. Perrigo Company Announces FDA Approval for Ciclopirox Topical Solution
3. Voltaren(R) Gel Receives US Regulatory Approval as the First Approved Topical Prescription Treatment for Pain Associated with Osteoarthritis
4. Warner Chilcott and NexMed Sign U.S. Collaboration for Topical Alprostadil Treatment for Erectile Dysfunction
5. Topical treatment for age spots, from Harvard Womens Health Watch
6. Summit VetPharm Introduces New Feline Topicals Vectra(TM) for Cats & Kittens and Vectra(TM) for Cats
7. International Federation of Sports Medicine Selects Celadrin(R) Topical Cream as its First and Only Official Joint and Muscle Topical Cream
8. ZARS Pharma Announces Worldwide License Agreement With Galderma Pharma S.A. for Pliaglis(TM), a Topical Local Anesthetic
9. Topical Cream Treats Precancerous Lesions of Vulva
10. ImQuest Presents New Anti-HIV Drug and Topical Microbicide Development Results on Lead Pyrimidinedione Products IQP-0410 and IQP-0528
11. Fougera First-to-Market With Calcipotriene Topical Solution 0.005% (Rx) (Scalp Solution)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... of scientists led by a researcher from the Cancer ... University of Singapore has identified the cancer specific stem ... the possibility of developing new drugs for the treatment ... The research group, led by Dr Chan Shing Leng, ... first time that a cancer-specific variant of a cell ...
(Date:4/23/2014)... known as Ritalin, may prevent the depletion of self-control, ... a journal of the Association for Psychological Science. , ... or trying to focus attention on a boring textbook ... potential explanation for this difficulty: Exerting self-control for a ... self-control effectively on subsequent tasks. , "It is as ...
(Date:4/22/2014)... Jersey Institute of Technology (NJIT) today to join ... of the New Jersey Innovation Institute (NJII), an ... business innovation through the leveraging of industry, government, ... Cory Booker, Panasonic Corp. of North America Chairman ... Kim Guadagno, New Jersey Secretary of Higher Education ...
(Date:4/22/2014)... at UT Southwestern Medical Center are making breakthroughs that ... A team of physician-scientists at UT Southwestern has ... with natural anti-depressant properties) works inside the brain. Simultaneously, ... depression in the form of a neuroprotective drug known ... in April,s issue of Molecular Psychiatry, is ...
(Date:4/22/2014)... Washington, DC (April 22, 2014) The International ... May 22-26 in Seattle, Washington. The theme of ... life" means in a networked and digital society. ... and attended by over 2,200 Communication scholars representing ... largest scholarly international communication conference in the world. ...
Breaking Medicine News(10 mins):Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 3Health News:ADHD drug may help preserve our self-control resources 2Health News:Government and industry leaders herald launch of NJIT's New Jersey Innovation Institute 2Health News:Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches 2Health News:Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches 3Health News:International Communication Association to hold Annual Conference in Seattle, Washington 2
... 26 The National Quality,Improvement Center on Non-Resident ... the four projects that have been selected to,receive ... in the,U.S. Department of Health and Human Services ... is the experimentation of a model intervention and,evaluation ...
... Bulletin Board: HFIT), a leading employee health improvement company,will ... ending,December 31, 2007, on Wednesday, March 5, 2008, after ... hold a conference call to discuss the,results the same ... Lehman,president and chief executive officer, and Wes Winnekins, chief ...
... They had more data but were less likely to get ... Feb. 26 (HealthDay News) -- Men considering prostate cancer screening ... the disease and were less likely to choose screening than ... study concludes. , Researchers from the University of California, Los ...
... used to develop more effective treatments for,pediatric patients, ... Andel,Institute (VAI) has entered into a multi-year licensing ... for use of its,XenoBase software and database system., ... created by,scientists at Van Andel Research Institute (VARI) ...
... told U.S. lawmakers that small businesses struggle under a,health ... and little or no coverage for millions of Americans ... act., Speaking before the U.S. House of Representatives ... the health care crisis is a,national problem. However, in ...
... Hospira, Inc.,(NYSE: HSP ), a leading ... national agreement with HealthTrust Purchasing Group, LP ... organizations with,access, on a non-exclusive basis, to ... disposables, along with intravenous,(I.V.) solutions, nutritionals and ...
Cached Medicine News:Health News:Non-Resident Fathers Project Selects Four National Sites for Funding to Increase Father Involvement and Improve Outcomes in Child Welfare 2Health News:Non-Resident Fathers Project Selects Four National Sites for Funding to Increase Father Involvement and Improve Outcomes in Child Welfare 3Health News:Non-Resident Fathers Project Selects Four National Sites for Funding to Increase Father Involvement and Improve Outcomes in Child Welfare 4Health News:Non-Resident Fathers Project Selects Four National Sites for Funding to Increase Father Involvement and Improve Outcomes in Child Welfare 5Health News:Health Fitness Corp. to Report Fourth Quarter and Year End 2007 Financial Results on March 5, 2008 2Health News:Web Tool Aids Men in Prostate Decisions 2Health News:Van Andel Institute and Children's Memorial Research Center of Chicago Form a Partnership to Facilitate Pediatric Research 2Health News:Governor Rendell Tells Congress 'Prescription for Pennsylvania' Will Improve Health Care Climate for Small Businesses 2Health News:Governor Rendell Tells Congress 'Prescription for Pennsylvania' Will Improve Health Care Climate for Small Businesses 3Health News:Governor Rendell Tells Congress 'Prescription for Pennsylvania' Will Improve Health Care Climate for Small Businesses 4Health News:Governor Rendell Tells Congress 'Prescription for Pennsylvania' Will Improve Health Care Climate for Small Businesses 5Health News:Hospira Announces New Contract With HealthTrust Purchasing Group for Infusion Devices, Solutions and Equipment 2Health News:Hospira Announces New Contract With HealthTrust Purchasing Group for Infusion Devices, Solutions and Equipment 3
(Date:1/15/2014)... Jan. 15, 2014  In an unprecedented effort to curb the spread ... and other transport vehicles, an advanced and portable UV germicidal lamp ... the first time. In order to prevent EMS ... pathogens, West Palm Beach Fire Rescue is ...
(Date:1/15/2014)... The Cadence Fitness & Health Center has been certified ... Association, a non-profit organization assisting medically integrated health and ... Fitness & Health Center is the only certified fitness ... Chicagoland area. "The certification means the Cadence ...
(Date:1/15/2014)... Pharmaceuticals International, Inc. (NYSE: VRX and ... the Hart-Scott-Rodino Antitrust Improvements Act of 1976 ("HSR") with ... indirect wholly-owned subsidiary, Sapphire Subsidiary Corp. ("Purchaser"), for all ... Medical, Inc. (NASDAQ: SLTM ) ("Solta") at ...
Breaking Medicine Technology:Superbugs No Longer Ride In Rescue Vehicles 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
... Tianyin Pharmaceutical Co., Inc. (NYSE Amex: TPI ... modernized traditional Chinese medicine, branded generics and other pharmaceuticals ... to the 26th floor, Conference Room E of 100 ... will be admitted beginning at 9:30 am. ...
... A recently issued patent extends protection of the ... selling medical thermometer brand, the TemporalScanner™ Temporal Artery ... Patent No. 7,787,938, entitled, "Temporal Artery Temperature Detector" ... to the already extensive Exergen portfolio of valuable ...
Cached Medicine Technology:TPI 2010 Shareholder Annual Meeting on 3/21/11 to Be Held at 100 Wall Street, near NYSE 2Exergen Granted New Patent for Temporal Artery Thermometers 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: