Navigation Links
Topical treatment for cold sores achieves efficacy of oral drugs; represents paradigm shift
Date:10/28/2008

WASHINGTON, D.C. (October 28, 2008) Scientists at NanoBio Corporation have demonstrated for the first time in humans that a novel topical treatment for cold sores (herpes labialis), NB-001, speeds healing of lesions as effectively as the leading oral systemic drugs but without safety or toxicity concerns.

The new data provide the first proof of principle that a topical agent can attain equivalent efficacy rates to oral systemic drugs, according to the NanoBio scientists. Topical treatments are widely considered inferior to oral systemic treatments because they fail to penetrate to the site of infection with adequate drug levels required to subdue infections.

In the study of 482 patients, NB-001 healed lesions 1.3 days faster than placebo as measured by investigators (P=0.006). Results of the randomized, double-blind, placebo-controlled, phase 2b trial are being presented at the 48th annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)/Infectious Diseases Society of America (IDSA) 46th annual meeting in Washington, D.C.

NB-001 was well tolerated, without safety concerns or adverse events, and was not systemically absorbed. "NB-001 challenges the conventional wisdom that topical therapies are less effective, because NB-001 directly accesses the site of infection in the dermis and epidermis instead of remaining on top of the skin," said James R. Baker, Jr., M.D., founder and chairman of NanoBio Corp. "NB-001 employs a physical mode of action to disrupt the outer membranes of pathogens and prompt viral lysis, essentially killing on contact."

The study also suggests that the physical mode of action of NB-001 significantly reduces the likelihood that pathogens will develop resistance to the biocidal effect of the topical lotion.

"These characteristics make NB-001 an ideal candidate for first-line treatment with the potential for widespread use across a broad range of patients," said Mary Fla
'/>"/>

Contact: Becky Levine
blevine@medthink.com
919-786-4918
MedThink Communications
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Perrigo Company Announces FDA Approval for Ciclopirox Topical Solution
2. Perrigo Company Announces FDA Approval for Ciclopirox Topical Solution
3. Voltaren(R) Gel Receives US Regulatory Approval as the First Approved Topical Prescription Treatment for Pain Associated with Osteoarthritis
4. Warner Chilcott and NexMed Sign U.S. Collaboration for Topical Alprostadil Treatment for Erectile Dysfunction
5. Topical treatment for age spots, from Harvard Womens Health Watch
6. Summit VetPharm Introduces New Feline Topicals Vectra(TM) for Cats & Kittens and Vectra(TM) for Cats
7. International Federation of Sports Medicine Selects Celadrin(R) Topical Cream as its First and Only Official Joint and Muscle Topical Cream
8. ZARS Pharma Announces Worldwide License Agreement With Galderma Pharma S.A. for Pliaglis(TM), a Topical Local Anesthetic
9. Topical Cream Treats Precancerous Lesions of Vulva
10. ImQuest Presents New Anti-HIV Drug and Topical Microbicide Development Results on Lead Pyrimidinedione Products IQP-0410 and IQP-0528
11. Fougera First-to-Market With Calcipotriene Topical Solution 0.005% (Rx) (Scalp Solution)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... July 31, 2014 Ticket Down ... Cup Finals tickets at the Sun Life Stadium in ... Champions Cup is now underway. Residents and diehard soccer fans ... to watch the Guinness International Champions Cup final in person ... competing in the tournament have been split into two groups ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Ce-Classes.com ... continues to help healthcare agencies to pass inspections ... and agencies meet their accreditation and state ... based training. , Healthcare administrators can monitor ... clicks of the mouse. Courses can be developed ...
(Date:7/31/2014)... Zensah®, a leading Miami based compression apparel company, ... , designed to help target tennis elbow, elbow tendonitis, ... for summer. The compression elbow sleeve is now available ... Zensah® fabric, the elbow sleeve is made ... no-slip cuff to ensure it stays in place, even ...
(Date:7/31/2014)... To further educate the public, The Rothenberg ... safety information regarding leaving children in hot vehicles: , ... consequences. Because a child’s body can heat up three ... children alone in a hot vehicle puts them at ... Statistics of Children Left Alone in a Car , ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Most mommy ... journals. Mommylish’s main purpose is to attract all mothers ... targeted to a particular group; whether its high fashion ... she realized that everything on the Internet was so ... information on a particular topic and then search Google ...
Breaking Medicine News(10 mins):Health News:Guinness International Champions Cup Finals Tickets in Miami, FL Available at Ticket Down 2Health News:Guinness International Champions Cup Finals Tickets in Miami, FL Available at Ticket Down 3Health News:Company Helps Healthcare Agencies to Pass Inspections and Audits 2Health News:Company Helps Healthcare Agencies to Pass Inspections and Audits 3Health News:Compression Elbow Sleeve Provides Relief From Elbow Pain to Golfers and Tennis Players 2Health News:Compression Elbow Sleeve Provides Relief From Elbow Pain to Golfers and Tennis Players 3Health News:The Rothenberg Law Firm LLP Teams Up with Local Philadelphia TV Stations to Promote Awareness of the Dangers of Leaving Children Unattended in a Hot Vehicle 2Health News:The Rothenberg Law Firm LLP Teams Up with Local Philadelphia TV Stations to Promote Awareness of the Dangers of Leaving Children Unattended in a Hot Vehicle 3Health News:Mommylish Launches Its Website 2
... VANCOUVER, May 15 /PRNewswire-FirstCall/ - CRH Medical Corporation,(CRM:TSX-V) announced ... in Bay Shore, Long Island. This Center is the ... many new markets that CRH has targeted for,expansion. The ... in 2008 bringing the Company,s total number of Centers ...
... N.Y., May 15 Two nutrients found in,certain fruits ... are lutein and zeaxanthin and they are found in ... show that lutein and zeaxanthin not only help prevent ... healthy eyes. For,example, they can improve photostress recovery under ...
... of Global Unified Worklist ... SEATTLE, May 15 Compressus, leaders in ... APC, of,Seattle, announced today an agreement to implement ... data management systems.,The implementation, which will include eight ...
... in mouse model hint of new treatment strategies for the ... polyunsaturated fat, the kind often found in baked and fried ... , The finding by University of California, Los Angeles, scientists ... a mouse model that closely mimics human cancer. , The ...
... PRO-DEX, INC. (Nasdaq:,PDEX) invites shareholders and investors to listen ... quarter financial results, and a discussion,of the outlook for ... be broadcast live over the Internet on,Thursday, May 15, ... accessed by,visiting the Company,s website at http://www.pro-dex.com . ...
... 15 ev3 Inc. (Nasdaq:,EVVV) today announced that Pat ... to present at the 2008 FBR Capital Markets,Spring Investor ... Eastern,Time (1:20 p.m. Central Time and 11:20 a.m. Pacific ... be held at the Grand Hyatt,Hotel, located at 109 ...
Cached Medicine News:Health News:CRH Medical Corporation opens Center in New York 2Health News:Lutein and Zeaxanthin Improve Sports Vision for Athletes 2Health News:Compressus Announces Seattle Radiologists Interoperability Implementation 2Health News:Compressus Announces Seattle Radiologists Interoperability Implementation 3Health News:Lowering Dietary Fat May Help Prevent Prostate Cancer 2Health News:Pro-Dex, Inc. Announces Fiscal 2008 Third Quarter Financial Results Conference Call and Webcast 2
(Date:7/31/2014)... , July 31, 2014 AFFiRiS AG ... York results of AFF008, a Phase I clinical ... the first therapy against the protein alpha-synuclein, a promising Parkinson,s ... J. Fox Foundation for Parkinson,s Research (MJFF) supported the study ... press conference on the impact a disease-modifying therapy would have ...
(Date:7/31/2014)... July 31, 2014 For the first time, ... the implantation of the SynCardia temporary Total Artificial Heart ... video posted on the Journal of Visualized Experiments website. ... the paper on the SynCardia Total Artificial Heart implantation ... accompanies "Implantation of the SynCardia Total Artificial Heart," a ...
(Date:7/31/2014)... NEW YORK , July 31, 2014 ... developing better, faster and affordable treatments for tuberculosis (TB), ... Senior Vice President, Market Access. Ms. Robertson joins the ... the company,s business in Sub-Saharan Africa and ... will oversee the TB Alliance,s efforts to ensure beneficial ...
Breaking Medicine Technology:First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 2First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 3First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 4How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video 2How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video 3TB Alliance Names Elana Robertson Senior Vice President, Market Access 2TB Alliance Names Elana Robertson Senior Vice President, Market Access 3
... Rapid Fire Marketing (Pink Sheets: RFMK ) announced ... Manufacturer to begin the development of the Pocket Puffer and the ... all specifications are met, the manufacturing facility will set up the ... a patent of the new device once complete and approved. ...
...  Ameritox, the national leader in pain medication monitoring, ... against San Diego-based Millennium Laboratories seeking damages, injunctive ... and unfair trade practices.  The Ameritox filing alleges ... in violations of the Lanham Act, unfair competition ...
Cached Medicine Technology:Rapid Fire Marketing Funds Development of Second Generation Vapor Inhaler 2Ameritox Files Amended Complaint Against Millennium Laboratories For Injunctive Relief, Declaratory Relief and Damages 2Ameritox Files Amended Complaint Against Millennium Laboratories For Injunctive Relief, Declaratory Relief and Damages 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: