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Tomas Ganz, M.D., Ph.D., to present 2014 ASH E. Donnall Thomas Lecture
Date:7/22/2014

(WASHINGTON, July 22, 2014) The American Society of Hematology (ASH) will honor Tomas Ganz, MD, PhD, of the University of California Los Angeles with the 2014 E. Donnall Thomas Lecture for his groundbreaking research in iron homeostasis, including the discovery of the iron-regulatory hormone hepcidin and investigation of its roles in iron metabolism. This award, named after the Nobel Prize Laureate and past Society president E. Donnall Thomas, MD, recognizes pioneering research achievements in hematology that have represented a paradigm shift or significant discovery in the field.

Dr. Ganz will present his lecture, "Iron, Erythropoiesis, and Host Defense: A Mnage Trois," at 9:00 a.m. on Monday, December 8, at the 56th ASH Annual Meeting and Exposition in San Francisco. His lecture will explore the advances in understanding of homeostatic iron regulation and the iron-regulatory responses to the challenges of acute hemorrhage and acute infection. During his lecture, Dr. Ganz will discuss iron deficiency anemia and anemia of inflammation and will expand upon how their frequency may reflect an evolutionary compromise to provide sufficient iron for essential processes while avoiding the tendency of iron to promote microbial infections and cause tissue injury. He will further elucidate insights into several components of iron regulation and response and discuss how the hormone hepcidin is regulated by erythroferrone, interleukin-6, and, to a lesser extent, other cytokines in response to blood loss and infection. Dr. Ganz's lecture will also touch upon how, as understanding of systemic iron homeostasis and its disorders increases, biological targets for diagnostic and therapeutic applications will be identified.

Dr. Ganz has been the leading scientist in the effort to uncover the molecular basis of iron homeostasis and its disorders. He played a pivotal role in the discovery of hepcidin and continues to lead the way in the ongoing exploration of
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Contact: Amanda Szabo
aszabo@hematology.org
202-552-4914
American Society of Hematology
Source:Eurekalert

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