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Thomson Scientific Publishes its Third Quarter Issue of the Ones to Watch Reviewing the Most Promising Drugs in the Pharmaceutical Pipeline
Date:11/30/2007

Novartis Leads the Drug List With its Alzheimer's Disease Treatment Exelon

TDS

PHILADELPHIA, Nov. 30 /PRNewswire-FirstCall/ -- Thomson Scientific, part of The Thomson Corporation (NYSE: TOC; TSX: TOC) and leading provider of information solutions to the worldwide research and business communities, has issued its quarterly The Ones-to-Watch report. It provides expert insight into the five most promising drugs entering each new phase of clinical development between July and September 2007.

"Bookending this quarter's list are three potential treatments for Alzheimer's disease, two of which are just entering clinical trials and one that has already received FDA approval," said Peter Robins, editorial and content manager, Thomson Scientific. "This quarter's The Ones to Watch report showcases the ongoing drive to find therapies for diseases that impact on ageing and sedentary populations."

Which are the Ones-to-Watch this Quarter?

Topping this quarter's approval list is Exelon TDS, a new transdermal patch formulation of rivastigmine, which looks like a winner for Novartis. In the seven years since its launch, the oral formulation of rivastigmine has seen year-on-year US dollar growth as a treatment of Alzheimer's disease - and Parkinson's disease- associated dementia. The FDA approved Exelon TDS for mild to moderate dementia in July 2007. The EU approval followed two months later. The U.S. launch is expected imminently.

Second on the list is AZOR, which was developed by Daiichi Sankyo for the treatment of hypertension and includes a combination of two component drugs. In previous Phase III trials, all doses of the combination produced greater mean reductio
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