Navigation Links
Targeting PTEN may prevent skin cancer
Date:7/26/2011

PHILADELPHIA Scientists believe they have identified a role for PTEN, a known tumor suppressor, in removing DNA damage derived from UVB radiation, a known risk factor for non-melanoma skin cancer, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.

Yu-Ying He, Ph.D., an assistant professor of medicine at the University of Chicago, found that laboratory mice with reduced levels of PTEN were more likely to have UVB-induced skin cancers.

"This was an unexpected finding and definitely provides a new approach for chemoprevention strategies," she said. "It's possible that if we can increase PTEN activity through nutritional supplements or some sort of pharmaceutical intervention, we may be able to prevent this common cancer."

Non-melanoma skin cancer is the most common cancer in the United States. The 1 million cases diagnosed last year accounted for 40 percent of all new diagnosed cancers. Scientists know that the major risk factor for this type of skin cancer is UVB radiation from sunlight, which leads to DNA damage.

PTEN, which was first identified in 1997, promotes genomic stability and cellular repair and can lead to a reduction in the molecular misfiring that leads to cancer and tumor progression.

In the current study, He and colleagues exposed skin cells to UVB radiation and examined the rates of DNA repair. Those with lower PTEN levels had slower rates of DNA repair, because of loss of the key DNA repair protein xeroderma pigmentosum C (XPC). Importantly, if the scientists restored the levels of XPC, then the rates of DNA repair went up as well.

"Cells without appropriate levels of PTEN were not able to repair sufficiently," said He.

He called the idea of a chemoprevention trial "promising," and said that her lab plans to assess the chemopreventive potential of restoring PTEN function.


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1

Related medicine news :

1. Targeting the Ewing sarcoma family of tumors
2. Latest data from Cedars-Sinai vaccine study supports immune targeting of brain tumors
3. Study confirms safety, cancer-targeting ability of nutrient in broccoli, other vegetables
4. NIH grant for the move toward clinical trials targeting the lysosomal storage disease MPSIIIB
5. Targeting top 911 callers can trim cost, improve patient care
6. Cancer-targeting investigational nanoparticle receives FDA IND approval for first-in-human trial
7. New program targeting whole-person health care gets major grant
8. Targeting nicotine receptors to treat cognitive impairments in schizophrenia
9. Scientists announce new advance with potential for future cancer targeting
10. Investment in CRC screening targeting pre-medicare population could cut medicare treatment costs
11. Targeting hit-and-run cancer viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2018)... ... October 16, 2018 , ... ... mission to provide simple, easy-to-use software for biopharma companies. By pairing the InTime ... answer those crucial resourcing questions without spending millions of dollars implementing a complicated ...
(Date:10/16/2018)... (PRWEB) , ... October 15, 2018 , ... ... product line, VALIDATE® Body Fluids, Order Number 205bf, for easier linearity and calibration ... in the documentation of linearity, calibration verification and verification of the reportable range ...
(Date:10/13/2018)... ... 12, 2018 , ... At HEI Health, we believe tomorrow’s healthcare can be ... year’s National Healthcare CXO Fall Summit by Marcus Evans. HEI will be hosting an ... Experience challenges with leading healthcare providers. , Marcus Evans National Healthcare CXO Summit ...
(Date:10/13/2018)... WASHINGTON (PRWEB) , ... October 13, 2018 , ... ... President’s Council on Sports, Fitness & Nutrition, has announced LaRhonda Burley as its ... Foundation was congressionally chartered in 2010 to support and strengthen the mission of ...
(Date:10/11/2018)... ... October 11, 2018 , ... Four weeks before ... manipulation,” warns former U.S. Department of Homeland Security deputy assistant secretary Paul Rosenzweig ... We Can Stop it. , Pointing to the ability of Russian hackers to ...
Breaking Medicine News(10 mins):
(Date:10/13/2018)... ... October 12, 2018 , ... In the ... is open and has hotel availability for anyone in need, and the Pensacola ... through Northwest Florida. In the aftermath, Pensacola is open and has hotel availability ...
(Date:10/13/2018)... Manchester, UK (PRWEB) , ... October 13, 2018 , ... ... will reach 14.4 per cent over the next five years, from $3200 million in ... a key driver and could even help drive this growth further. This news comes ...
(Date:10/11/2018)... (PRWEB) , ... October 11, 2018 , ... ... and e-discovery software for corporate law departments and law firms, today announced it ... Attendees should visit booth 110 to learn how corporate legal departments are using ...
Breaking Medicine Technology: