Navigation Links
Targeting PTEN may prevent skin cancer
Date:7/26/2011

PHILADELPHIA Scientists believe they have identified a role for PTEN, a known tumor suppressor, in removing DNA damage derived from UVB radiation, a known risk factor for non-melanoma skin cancer, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.

Yu-Ying He, Ph.D., an assistant professor of medicine at the University of Chicago, found that laboratory mice with reduced levels of PTEN were more likely to have UVB-induced skin cancers.

"This was an unexpected finding and definitely provides a new approach for chemoprevention strategies," she said. "It's possible that if we can increase PTEN activity through nutritional supplements or some sort of pharmaceutical intervention, we may be able to prevent this common cancer."

Non-melanoma skin cancer is the most common cancer in the United States. The 1 million cases diagnosed last year accounted for 40 percent of all new diagnosed cancers. Scientists know that the major risk factor for this type of skin cancer is UVB radiation from sunlight, which leads to DNA damage.

PTEN, which was first identified in 1997, promotes genomic stability and cellular repair and can lead to a reduction in the molecular misfiring that leads to cancer and tumor progression.

In the current study, He and colleagues exposed skin cells to UVB radiation and examined the rates of DNA repair. Those with lower PTEN levels had slower rates of DNA repair, because of loss of the key DNA repair protein xeroderma pigmentosum C (XPC). Importantly, if the scientists restored the levels of XPC, then the rates of DNA repair went up as well.

"Cells without appropriate levels of PTEN were not able to repair sufficiently," said He.

He called the idea of a chemoprevention trial "promising," and said that her lab plans to assess the chemopreventive potential of restoring PTEN function.


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1

Related medicine news :

1. Targeting the Ewing sarcoma family of tumors
2. Latest data from Cedars-Sinai vaccine study supports immune targeting of brain tumors
3. Study confirms safety, cancer-targeting ability of nutrient in broccoli, other vegetables
4. NIH grant for the move toward clinical trials targeting the lysosomal storage disease MPSIIIB
5. Targeting top 911 callers can trim cost, improve patient care
6. Cancer-targeting investigational nanoparticle receives FDA IND approval for first-in-human trial
7. New program targeting whole-person health care gets major grant
8. Targeting nicotine receptors to treat cognitive impairments in schizophrenia
9. Scientists announce new advance with potential for future cancer targeting
10. Investment in CRC screening targeting pre-medicare population could cut medicare treatment costs
11. Targeting hit-and-run cancer viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2018)... ... December 06, 2018 , ... Tea infusions made from ... than the drug most commonly used against the ailment—and with no adverse side ... study’s authors, including a professor and two research associates at Worcester Polytechnic Institute ...
(Date:12/5/2018)... Tenn. and DALLAS, Texas (PRWEB) , ... December ... ... team, again proved its leading SkinPen Precision device is setting a new standard ... its record-setting Aesthetics Everything win. , Each year this award is presented at ...
(Date:12/5/2018)... ... December 05, 2018 , ... Northeast ... on January 26 at North Monroe Baptist Church, 210 Finks Hideaway Rd, Monroe, ... of the agency’s effort to educate and equip faith leaders to address substance ...
(Date:12/5/2018)... ... December 05, 2018 , ... Dr. Jessica Allen of ... and LAPIP™ protocol for ailing dental implants in the Fort Collins area. Dr. Allen ... proven to regenerate the bone and tissues lost to gum disease. , "Gum disease ...
(Date:12/5/2018)... ... December 05, 2018 , ... Definitive ... provider market, announced today that it was ranked #184 on Deloitte’s Technology Fast ... the highest growth in the fields of technology, media, telecommunications, life science, and ...
Breaking Medicine News(10 mins):
(Date:12/6/2018)... ... December 06, 2018 , ... Last year, 172 children deaths ... of those children had not gotten the vaccine. Vaccination is the first step in ... shots reduce the severity of the illness if infected. Along with getting vaccinated, people ...
(Date:12/6/2018)... ... 06, 2018 , ... Today, the Alternative to Meds Center ... of Americans and people worldwide who suffer first-hand with drug addiction or prescription ... Meds Center utilizes the tenets of neurochemistry in assessing each client. Every facet ...
(Date:12/6/2018)... WEST PALM BEACH, Fla. (PRWEB) , ... December 06, 2018 , ... ... partnering with “Speak Up for Kids Palm Beach”. The nonprofit serves 1500 children countywide ... stigma of addiction, but is also fighting against the stigma that surrounds local treatment ...
Breaking Medicine Technology: