Navigation Links
Targeted investigational therapy potential to overcome crizotinib resistance in lung cancers
Date:10/20/2013

in patients with lung cancer. They then showed that PF-06463922 inhibited the growth of tumors harboring three of the crizotinib-resistant ALK mutants, including the most resistant ALK mutant, G1202R, in mice.

Further analysis indicated that PF-06463922 readily entered the brains of mice, rats, and dogs. In mice, levels of PF-06463922 in the brain were 20-30 percent of levels of PF-06463922 in the blood. This is potentially clinically relevant because a significant number of lung cancer patients will develop brain metastasis during the course of their disease, according to Smeal, although he noted that it will be important to see if these results in animals hold true in humans.

Smeal and colleagues also found that PF-06463922 potently inhibited the protein ROS1, a close relative of ALK recently implicated in a number of cancer types, including some lung and brain cancers. Further, PF-06463922 had antitumor effects in two mouse models of cancers driven by ROS1 gene abnormalities, leading the researchers to suggest that PF-06463922 has potential as a treatment for this subgroup of cancers, in addition to its promise as a new treatment for ALK-driven cancers.


'/>"/>

Contact: Lauren Riley
lauren.riley@aacr.org
215-446-7155
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeted therapeutics for colon cancer to be presented at AACR meeting
2. First targeted nanomedicine to enter human clinical studies
3. Highly targeted irradiation as good as whole breast radiotherapy in early stage cancer
4. Dana-Farber: Study reports first success of targeted therapy in type of non-small cell lung cancer
5. Inflammatory pathway spurs cancer stem cells to resist HER2-targeted breast cancer treatment
6. Killer infections targeted by hospital study
7. Lower risk of serious side-effects in trials of new targeted drugs
8. Treating drug resistant cancer through targeted inhibition of sphingosine kinase
9. Pitt: Targeted oxidation-blocker prevents secondary damage after traumatic brain injury
10. Deadly witch hunts targeted by grassroots womens groups
11. Large lung cancer study shows potential for more targeted therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... March 27, 2015 The federal court ... allege the statin medication increases the risk that a ... Inc.’s Motion to Dismiss four individual cases that had ... Management Order issued in the U.S. District Court, District ... that the dismissals were warranted because the plaintiffs in ...
(Date:3/27/2015)... NY (PRWEB) March 27, 2015 Top ... plastic surgery patients travel to the Dominican Republic to ... plastic surgery clinic is turning the medical tourism industry ... surgery patients — with trustworthy services becoming the central ... selecting a plastic surgeon. Patients are not only attracted ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 Ticket Down is a ... in 2015. After a phenomenal and highly successful live ... will be going out on tour again in 2015 and they ... gets underway on April 29th in New York City at the ... the Comerica Theatre on May 10th. , Fans of the hit ...
(Date:3/27/2015)... Ticket Down is a reputable source of authentic ... Nebraska on Friday, May 8th and Saturday, May 9th. ... added in Omaha as Garth has done in other markets ... World Tour is continuing its run throughout the United States ... Trisha Yearwood will bring their act to Omaha, NE at ...
(Date:3/27/2015)... Michigan (PRWEB) March 27, 2015 ... LiveToBeSober.org, along with former Detroit Lions wide receiver ... luncheon and educational presentation on substance abuse, treatment ... Among those who attended were pastors, ministers and ... leaders and other distinguished guests. , “Our ‘Fighting ...
Breaking Medicine News(10 mins):Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 2Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 3Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 2Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 3Health News:Nashville Live in Concert Tickets in New York, Boston, Washington, DC, Chicago, Minneapolis, San Francisco, Los Angeles and Phoenix Now On Sale at TicketDown.com 2Health News:Cheap Garth Brooks Tickets for CenturyLink Center in Omaha: Ticket Down Slashes Garth Brooks Concert Tickets in Omaha, NE at the CenturyLink Center 2Health News:Cheap Garth Brooks Tickets for CenturyLink Center in Omaha: Ticket Down Slashes Garth Brooks Concert Tickets in Omaha, NE at the CenturyLink Center 3Health News:LiveToBeSober.org Hosts Conference on Substance Abuse Treatment and Recovery at Ford Field 2
... the world , including India, must face the challenges ... all their citizens get access to effective healthcare // ... catastrophic medical expenses, a new World Bank report said. ... struggling to cope with sharply rising costs even while ...
... Ashok Bhatt, Gujarat Health minister was admitted to UN Mehta’s civil hospital on Thursday morning. Hospital authorities said, he was ... ... ... ...
... jobs on the NHS worsened today after Oxford Radcliffe Hospitals said ... budget.// The Trust operates four hospitals in Oxford and Banbury. ... although it currently has 600 vacancies. Campaign group Health Emergency said ... health sector and this number could only double by the end ...
... persons, including the Managing Director of a pharmaceutical ... of Ephedrine tablets, a controlled substance notified under ... 1985. ,According to Directorate of Revenue ... remanded to judicial custody by the Metropolitan Sessions ...
... are not comfortable talking on HIV/AIDS and sexual and ... the city's adolescents have problems related to sex, according ... as 50 per cent adolescents studying from classes IX ... at least comes emotional disturbances and social adjustment with ...
... to a Norwegian research it was found that Invitro ... pregnancy. According to the statistics it is found// that ... in women who have IFV. Placenta praevia is the ... this the placenta covers part or the entire cervix, ...
Cached Medicine News:
(Date:3/27/2015)... Vein & Surgery Clinic is the only clinic offering laser ... Victoria, Texas . The clinic specializes in the ... for a variety of medical and cosmetic conditions. High-end vein ... for their patients. Since adding laser tattoo removal, Victoria Vein ... residents get rid of their unwanted ink. "Our ...
(Date:3/27/2015)... 27, 2015   Cypher Genomics, Inc., ... data showing that, compared to a panel of ... highly equivalent interpretations of whether certain genetic abnormalities ... in a fraction of the time. Cypher,s Mantis ... comprehensive genetic analysis in non-invasive prenatal testing (NIPT) ...
(Date:3/27/2015)... Holdings, Inc. (NYSE and SIX: ZMH) is celebrating a key milestone in ... Knee System. ,   ... introduced the NexGen knee system, with its innovative design and ... of the NexGen knee have taken place worldwide. ... the importance of design innovation and component quality for surgeons and patients ...
Breaking Medicine Technology:Victoria Vein And Surgery Clinic Uses Advanced Astanza Duality Tattoo Removal Technology 2New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 2New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 3Zimmer Celebrates Key Milestones For NexGen Complete Knee System 2
... As obesity rates and the cost of healthcare continue ... in Washington D.C. is bringing together industry thought leaders, ... address pressing public health issues utilizing mobile health technology. ... wearable body monitoring systems, recently announced the findings from ...
... 9, 2010 HeartWare International, Inc. (Nasdaq: ... invasive, miniaturized circulatory support technologies that are revolutionizing the ... Aaronson, MD, MS, will present data from the ADVANCE ... American Heart Association (AHA) Scientific Sessions 2010 at McCormick ...
Cached Medicine Technology:Results of Two New Clinical Studies Show Promise of Emerging Mobile Health Technology to Combat Obesity Epidemic 2Results of Two New Clinical Studies Show Promise of Emerging Mobile Health Technology to Combat Obesity Epidemic 3HeartWare Bridge-to-Transplant Data Featured as Late Breaking Clinical Trial at American Heart Association Scientific Sessions 2010 2
... Eppendorf Reference Series 2000 Pipette is a ... a compact and robust design, and superior ... used to operate the measuring stroke and ... Product features: Eppendorf "pipette/tip" system ...
... samples of moderate viscosity and density. Proven ergonomic design reduces hand fatigue, ... Volume Range (ul) ... 1.2~4 Imprecision(%) ... 0.1 ...
... The new Finnpipette Focus from Thermo ... with uncompromising performance. Advanced features such ... .01ul fine volume adjustment on microvolumes help ... in single channel pipettes. The new interchangeable ...
... The Finnpipette Digital offers improved ergonomics ... rounded handle, modified grippy finger rest ... operator comfort and efficiency. Finnpipette Digitals ... power-boosted gearing mechanism (pat. pend.) and ...
Medicine Products: