Date:9/7/2010

-Eluting Stents: The ISAR TEST-4 trial will feature angiographic and clinical 2 year results from a randomized comparison of everolimus-eluting stents versus sirolimus-eluting stents. The study will shed important light on comparative outcomes of the leading first- and second generation drug-eluting stents as well as provide direct insight into the relative late performance characteristics of both devices.

Drug-Eluting Stents: The DES-BTK trial is a prospective, double-blind randomized trial comparing a polymer-free sirolimus-eluting stent with a bare-metal stent in patients with infrapopliteal disease.

Venous Thromboembolism: TORPEDO is the first prospective randomized controlled trial of the efficacy of percutaneous endovenous intervention in the reduction of venous thromboembolism and post-thrombotic syndrome, 2 common complications of deep venous thrombosis.

Restenosis Therapy: The BLAST study will provide important insights on the safety and effectiveness of LABR-312 as a systemic anti-restenosis therapy after vascular intervention in patients with coronary stenoses. The novel use of this monocyte-specific inhibitor and the quantitative correlation of angiographic and clinical effects along a biological continuum of cellular modulation may change the paradigm of concomitant drug therapy to prevent restenosis.

SATURDAY, SEPTEMBER 25

• Drug-Eluting Stents: ISAR-TEST-5 is a prospective, randomized trial of the polymer-free sirolimus/probucol-eluting stents compared to zotarolimus-eluting stents in patients with coronary artery disease stents after 1 year.

• Pharmaceutical Therapy; Drug-Eluting Stents: HORIZONS-AMI is the largest completed randomized trial of different pharmacologic regimens and stent types in heart attack patients. At 1 year, bivalirudin alone compared to heparin plus glycoprotein IIb/IIIa inhibitors resulted in significantly reduced rates of major bleeding and mo
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Contact: Judy Romero jromero@crf.org Cardiovascular Research Foundation Source:Eurekalert

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