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TCT 2010 late breaking trials to have impact on practice of interventional cardiology
Date:9/7/2010

patients with severe aortic stenosis.

  • Drug-Eluting Stents and Diabetes: SPIRIT IV is the largest randomized trial to date comparing two drug-eluting stents. The two-year outcomes from this trial will provide important insights into the absolute and relative long-term safety and efficacy outcomes of everolimus-eluting and paclitaxel-eluting stents in a complex patient population, including 1,185 randomized patients with diabetes.

  • Drug-Eluting Stents: The COMPARE trial compares the outcomes of the everolimus-eluting stent versus the paclitaxel-eluting stent in an all-comer population after 2 years.

  • Pharmaceutical Therapy: The LANCELOT ACS study evaluates the safety and efficacy of a reversible PAR-1 thrombin receptor antagonist in patients with Acute Coronary Syndrome.

  • Drug-Coated Catheter: The LEVANT 1 trial assesses the safety and efficacy of a novel drug-coated angioplasty balloon catheter for the treatment of femoropopliteal disease after 6 months.

  • Drug-Eluting Catheter: The PERfECT STENT study evaluates whether treatment with a drug-eluting stent and a paclitaxel-eluting balloon catheter is superior to treatment with the drug-eluting stent alone.

    FRIDAY, SEPTEMBER 24

    • Stenting in the Femoral Artery: The ZILVER PTX trial examines the first drug-eluting stent approved (currently CE marked, investigational in the U.S.) for the superficial femoral artery (SFA). This study compares the safety and effectiveness of the Zilver PTX drug-eluting peripheral stent to balloon angioplasty (PTA) and bare-metal stenting (BMS) after 12 months.

    • Drug-Eluting Stents: The SORT OUT-4 trial compares the safety and efficacy of the sirolimus-eluting stent, which has demonstrated the least amount of late lumen loss among previously released drug-eluting stents, with a next-generation everolimus-eluting stent in patients with coronary artery disease after 9 months.

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    Contact: Judy Romero
    jromero@crf.org
    Cardiovascular Research Foundation
    Source:Eurekalert

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