Navigation Links
Study shows long-term efficacy of minimally invasive therapy for patients with Barrett's esophagus
Date:2/20/2013

Philadelphia - According to a new study by researchers at the Perelman School of Medicine at the University of Pennsylvania, patients with Barrett's esophagus and early or pre-cancerous cells have been shown to significantly benefit from minimally invasive therapy delivered through an endoscope a medical instrument used to look inside an organ or cavity in the body. Until recently, patients with these conditions were treated by surgery to remove the whole esophagus. Study results show that endoscope-based therapies have a high success rate; all of the damaged cells were removed in up to 95 percent of cases, greatly reducing the chances of cancer progression. Additionally, in over two-thirds of cases, patients had no biological signs of the return of disease for years. The study appears in the February issue of GIE: Gastrointestinal Endoscopy.

The esophagus is the tube that connects the mouth with the stomach. Barrett's esophagus, which can be a precursor to cancer of the esophagus, is a condition in which the cells of the lower esophagus become damaged, typically from persistent exposure to stomach acid. Barrett's esophagus affects over three million people in the United States. Men develop Barrett's esophagus twice as often as women.

"This study is one of only a few that focuses on the long-term effects of minimally invasive techniques for the treatment of Barrett's esophagus," said Gregory G. Ginsberg, MD, professor of Medicine and director of Endoscopic Services at Penn Medicine, and corresponding author on the study. "We examined patients from as far back as 1998 and had an average follow-up of nearly three years. This gives us a more complete measure of assessing the longer-term benefits of these types of intervention."

Among the therapies evaluated in the new study were radiofrequency ablation and endoscopic resection. In radiofrequency ablation, a balloon or small paddle that transmits energy is attached to the endoscope to burn away a thin layer of the esophageal mucosa, removing the damaged cells. It is a half-hour outpatient procedure performed under mild sedation.

In an endoscopic resection, an endoscope is inserted down the throat to reach the esophagus. Its light and camera enable the doctor to see and navigate, and it has tools for removal of the affected tissue. Both procedures are far less invasive and less expensive than an esophagectomy, a major surgery that removes the esophagus in patients with advanced conditions.

Approximately 10 percent of patients with long-term gastroesophageal reflux disease (GERD) will develop Barrett's esophagus. GERD is a chronic regurgitation of acid from the stomach into the lower esophagus, which often results in recurring heartburn and, less commonly, difficulty swallowing. A small percentage of patients with Barrett's esophagus will develop high grade dysplasia, a more serious condition. High grade dysplasia isn't cancer, but it is the step before cancer. The risk of developing esophageal cancer from high grade dysplasia has been examined in several studies and ranges from 20 percent to 50 percent. Overall, patients with Barrett's esophagus have a less than 1 percent risk of developing esophageal cancer over their lifetimes. Esophageal cancer is especially invidious; it has a less than 15 percent five-year survival rate.

Results of the study also show that in as many as one-third of the cases, manifestations of the disease returned. "These findings of recurrence make it clear that Barrett's esophagus patients should undergo life-long periodic endoscopic exams to watch for precancerous esophagus cells. If we find these cells, we can treat them via the endoscope to prevent esophageal cancer," said Ginsberg.

Barrett's esophagus is named after Norman Barrett (1903-1979), who described the condition in 1950.

Other study authors from Penn include Carlos Guarner-Argente, MD, PhD; Thomas Buoncristiano, Emma E. Furth, MD, and Gary W. Falk, MD, MSc.


'/>"/>

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-349-5964
University of Pennsylvania School of Medicine
Source:Eurekalert

Related medicine news :

1. Setting the record straight on Medicares overhead costs: New study
2. Pitt study examines cost-effectiveness of medicare drug plans in schizophrenia and bipolar disorder
3. Gene Mutations Benefit for Ovarian Cancer Patients May Not Last: Study
4. Human Teeth Healthier in the Stone Age Than Today: Study
5. NYUs Shedlin publishes study on the health of Colombian refugees in Ecuador
6. UCLA study suggests link between untreated depression, response to shingles vaccine
7. Study shows reduced risk of preterm birth for pregnant women vaccinated during pandemic flu
8. Too Much Coffee in Pregnancy Tied to Smaller, Later Newborns, Study Says
9. Early Exposure to Gluten May Help Babies Avoid Celiac Risk: Study
10. CWRU study examines family struggles with anger and forgiveness when relative is dying
11. Emerging SARS-Like Virus Well-Suited to Attack Humans: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... ... integration of Microsoft(R) Word(TM) Online(TM), which enables sleep physicians to create and edit ... the reporting process and provides a familiar interface that does not require additional ...
(Date:4/28/2017)... ... , ... Getting enough sleep affects much more than energy – it also has mental and ... can compromise motor reaction time, which can increase the risk of having a car accident. ... tips from the NSF to help you sleep better and feel better:, ...
(Date:4/28/2017)... Cypress, California (PRWEB) , ... April 28, 2017 ... ... LED T8 Direct Replace tubes . These lamps offer an instant energy-saving solution ... no need to rewire fixtures or disconnect ballasts. These 50,000 hour rated lamps ...
(Date:4/28/2017)... ... April 28, 2017 , ... Children and adolescents who ... experiences than children in the general population. That’s because foster care is designed ... family challenges. While no fault of their own, youth who have experienced trauma ...
(Date:4/28/2017)... ... 28, 2017 , ... Early detection and elimination of new ... minimize the cost of development. In this webinar, sponsored by Molecular Devices, an ... for cardiac toxicity using induced pluripotent stem cells (iPSCs). , In the first ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017 ... "Global Biosimilar Pipeline and Market Prospects: Addressing Production ... report to their offering. ... "Global Biosimilar Pipeline and Market Prospects: ... Design" provides an in-depth assessment of the current trends ...
(Date:4/20/2017)... 2017  CVS Pharmacy, the retail division of ... store design to enhance the retail customer experience ... products and expanded beauty selections paired with informational ... new offerings. Together with its innovative digital programs, ... customer experience at CVS Pharmacy.  ...
(Date:4/20/2017)... 20, 2017 Research and Markets has ... Market Share, Application Analysis, Regional Outlook, Growth Trends, Key Players, ... their offering. ... pharmacogenomics market was valued at US$ 7,167.6 Mn in 2015, ... expanding at a CAGR of 5.6% from 2016 to 2024. ...
Breaking Medicine Technology: