Navigation Links
Study provides surprising new clue to the roots of hunger
Date:2/7/2014

us is engineered to "infect" just one type of neuron in this case, the AgRP neurons that drive hunger. The virus moves upstream one synapse and identifies all neurons that are providing input to AgRP starter neurons. Then, using a host of different neuron-specific cre-recombinase expressing mice (a group of genetically engineered animals originally developed in the Lowell lab) the investigators were able to map inputs to just these nerve cells, and then manipulate these upstream neurons so that they could be targeted for activation by an external stimulus.

"We wanted to know, of all the millions of neurons in a mouse brain, which provided input to the AgRP neurons," explains Lowell. "And the shocking result was that there were only two sites in the brain that were involved the dorsal medial hypothalamus and the paraventricular nucleus, with the input from the paraventricular neurons shown to be extremely strong."

With this new information, the investigators now had a model to pursue. "We hypothesized that neurons in the paraventricular nucleus were communicating with and turning on the AgRP neurons. We developed mice that expressed cre-recombinase in many subsets of the paraventricular neurons and then, mapping the neurons one-by-one, we determined which was talking to which," says Lowell. Their results revealed that subsets of neurons expressing thyrotropin-releasing hormone (TRH) and pituitary adenylate cylcase-activating polypeptide (PACAP) were in on the neuronal chatter.

Finally, through a chemogenetic technique known as DREADDs Designer Receptor Exclusively Activated by Designer Drug the authors used chemicals to specifically and selectively stimulate or inhibit these upstream neurons in the animal models. The fed mice, which had already consumed their daily meal and otherwise had no interest in food, proceeded to search out and voraciously eat after DREADD stimulation. Conversely, the fasting mice which should have been hun
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... 03, 2015 Retrofit , the ... America’s leading corporations, today announces the appointment of its ... positions. CEO Mary Pigatti has recruited technology, ... employee engagement for the fast-growing company, which was recently ... for 2015. , “Retrofit is thrilled to announce ...
(Date:3/3/2015)... March 3, 2015, My Positive Perspective host was joined ... a unique one, not just because it was the first ... men who were both faced with monumental obstacles after being ... episode, Deierlein said to Collins, “I had the opportunity to ... very excited that you could join me on the set ...
(Date:3/3/2015)... 03, 2015 eMedEvents, a searchable ... medical education (CME) credit information, has officially been ... was initially launched in the United States (December ... kind in the field of healthcare conference technology ... this Denver, Colorado-based start-up company was successful as ...
(Date:3/3/2015)... FAYETTEVILLE, Ark. (PRWEB) March 03, 2015 ... , announced that Mr. William A. Breukelman has been ... has recently completed development of the first fully integrated ... is uniquely capable of analyzing the three-dimensional motion of ... and then comparing the analysis at 15,300 points to ...
(Date:3/3/2015)... York, NY (PRWEB) March 03, 2015 Ticket ... tickets for her 2015 tour. This well-known ticket ... added savings. , Arguably the biggest name in the music ... when Madonna performs on the “Rebel Heart Tour.” Madonna, fresh ... month will kick off her latest tour on August 29th ...
Breaking Medicine News(10 mins):Health News:Retrofit Signals Growth: Corporate Weight Management Company Announces Talent Acquisitions 2Health News:Retrofit Signals Growth: Corporate Weight Management Company Announces Talent Acquisitions 3Health News:Retrofit Signals Growth: Corporate Weight Management Company Announces Talent Acquisitions 4Health News:My Positive Perspective Releases Episode #200 With Car Accident and Coma Survivor Nick Collins 2Health News:eMedEvents Launches Online Medical Conference, Speaker and CME Platform in India 2Health News:William A. (Bill) Breukelman Named to CardioWise, Inc. Board of Directors 2Health News:William A. (Bill) Breukelman Named to CardioWise, Inc. Board of Directors 3Health News:Cheap Madonna Tickets: Madonna Presale Tickets in Miami, New York, Brooklyn, Chicago, San Jose, Toronto, Edmonton & Vancouver Now Available at TicketDown.com 2Health News:Cheap Madonna Tickets: Madonna Presale Tickets in Miami, New York, Brooklyn, Chicago, San Jose, Toronto, Edmonton & Vancouver Now Available at TicketDown.com 3
... more often in spinal fusions, but experts worry about costs ... A relatively new agent that stimulates the creation of new ... used in the United States, although costs and some complication ... new study reports. , The therapeutic agent, known as bone-morphogenic ...
... disease-linked factors don,t perform better than standard criteria, study ... biomarkers of cardiac risk, such as inflammation-linked C-reactive ... older, established factors such as smoking, obesity, high cholesterol ... newer blood-borne markers have been touted as a better ...
... decode the human genome and the information becomes publicly ... multiplying. Scientists at the National Institutes of Health were ... They evaluated responses to an online test among smokers ... variant associated with risk for lung cancer. The results, ...
... Study finds increased risk for postmenopausal women , ... blood pressure, elevated glucose and other components of metabolic ... cancer, a new study suggests. , Metabolic syndrome, also ... of such conditions as abdominal obesity, high blood glucose ...
... DALLAS, June 30 At the 8th Annual Spirit ... of North Texas (EFNT) recognized The Beryl Companies, the ... healthcare organizations, as the North Star 2009 Inductee. This ... example and show the importance of giving back to ...
... June 30 Every summer, the bloodsuckers send Canadians swatting ... good reason. , , More than just creatures ... and cause human flesh to swell and redden. An even ... , , While many Canadians warily use conventional ...
Cached Medicine News:Health News:Assessment of Bone Growth Stimulator Is Mixed 2Health News:Assessment of Bone Growth Stimulator Is Mixed 3Health News:Newer Blood Tests May Not Improve Heart Risk Assessment 2Health News:Newer Blood Tests May Not Improve Heart Risk Assessment 3Health News:Possible benefit from online genetic testing for lung cancer 2Health News:Metabolic Syndrome May Make Breast Cancer More Likely 2Health News:Beryl Receives Entrepreneurs Foundation of North Texas North Star Recognition 2
(Date:3/3/2015)... Today, the Partnership for Prescription Assistance ... research companies, unveiled a redesigned website ... and caregivers with faster, easier access to information ... assistance programs. Since its launch ... engage, educate and empower patients and caregivers to ...
(Date:3/3/2015)... BETHESDA, Md. , March 3, 2015 /PRNewswire/-- ViaCyte, ... stem cell-derived islet replacement therapy for the treatment of ... Dr. Eugene Brandon , Director of Strategic Relations ... annual summit showcases the latest in type 1 diabetes ... presentation are as follows: , , , ...
(Date:3/3/2015)... VIEW, Calif. , March 3, 2015 /PRNewswire/ ... enhanced drug discovery market, Frost & Sullivan recognizes ... & Sullivan Award for Technology Leadership. Neopeutics has ... clients a robust, cost-effective, and easily adaptable set ... agents that are catalogued as failing compounds in ...
Breaking Medicine Technology:Partnership for Prescription Assistance Relaunches Website with New Features for Patients and Caregivers 2ViaCyte to Present at JDRF TypeOneNation Research Summit 2Frost & Sullivan Applauds Neopeutics' Commitment to Accelerating the Delivery of New Nature-Based Pharmaceuticals and Therapeutics 2Frost & Sullivan Applauds Neopeutics' Commitment to Accelerating the Delivery of New Nature-Based Pharmaceuticals and Therapeutics 3Frost & Sullivan Applauds Neopeutics' Commitment to Accelerating the Delivery of New Nature-Based Pharmaceuticals and Therapeutics 4Frost & Sullivan Applauds Neopeutics' Commitment to Accelerating the Delivery of New Nature-Based Pharmaceuticals and Therapeutics 5
Cushing bayonet....
Straight, blunt tips....
Angled, pointed, with attached cable for Valleylab and other brands generators....
Autoclavable reusable pencil for Aaron 800 & 1200 - comes with generator or 1/box....
Medicine Products: