Navigation Links
Study identifies protein to repair damaged brain tissue in MS
Date:2/7/2014

Vittorio Gallo, PhD, Director of the Center for Neuroscience Research at Children's National Health System, and other researchers have found a "potentially novel therapeutic target" to reduce the rate of deterioration and to promote growth of brain cells damaged by multiple sclerosis (MS). Current therapies can be effective in patients with relapsing MS, but have little impact in promoting tissue growth.

The brain produces new cells to repair the damage from MS years after symptoms appear. However, in most cases the cells are unable to complete the repair, as unknown factors limit this process. In MS patients, brain inflammation in random patches, or lesions, leads to destruction of myelin, the fatty covering that insulates nerve cell fibers called axons in the brain, and aids in transmission of signals to other neurons.

In yesterday's publication of Neuron, Gallo, who also is a professor of pediatrics at the George Washington University School of Medicine and Health Sciences (SMHS), reported identifying a small protein that can be targeted to promote repair of damaged tissue, with therapeutic potential. The molecule, Endothelin-1 (ET-1), is shown to inhibit repair of myelin. Myelin damage is a hallmark characteristic of MS. The study demonstrates that blocking ET-1 pharmacologically or using a genetic approach could promote myelin repair.

Repair of damaged MS plaques is carried out by endogenous oliogdendrocytle progenitor cells (OPCs) in a process called remyelination. Current MS therapy can be effective in patients with relapsing and remitting MS, but "have little impact in promoting remyelination in tissue," Gallo said. Several studies have shown that OPCs fail to differentiate in chronic MS lesions.

Targeting ET-1 is a process that involves identifying signals in cells that could promote lesion repair. "We demonstrate that ET-1 drastically reduces the rate of remyelination," Gallo said. As such, ET-1 is "pote
'/>"/>

Contact: Joe Cantlupe
jcantlupe@childrensnational.org
202-476-4500
Children's National Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Ice ages arctic tundra lush with wildflowers for woolly mammoths, study finds
2. Director of Womens Guild Lung Institute awarded grant to study treatment for lung disease
3. Columbia study finds hospitals dont follow infection prevention rules
4. Penn study reveals genetics impact risk of early menopause among some female smokers
5. New study finds feeling in control can help you live longer
6. Population Council launches study testing interventions to improve girls lives in Kenya
7. Study finds dramatic rise in skin cancer among middle-aged adults
8. New study shows core factors and strategies to turn primary care practices into PCMHs
9. Study finds high Rx burden for bipolar patients
10. Using susceptibility-weighted imaging to study concussion in college ice hockey players
11. New study explores contributors to excess infant mortality in the US South
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 2014 Women’s health specialist, Dr. Amber ... Gynecology of Columbus, Inc., A Division of MaternOhio Clinical ... more than 100,000 patients annually. Dr. Murphy will provide ... stages of a women’s life. She is accepting new ... Westerville and Dublin. , Dr. Murphy offers a wide ...
(Date:10/20/2014)... Zereana Jess-Huff, a 34-year-old mother, corporate executive and ovarian cancer ... think outside the bra. She doesn’t try to hide her ... about women’s other lady parts. , "We have won the ... pink and everybody knows what you’re talking about,” Jess-Huff points ... not been won when it comes to gynecologic cancers. It ...
(Date:10/20/2014)... Principle Business Enterprises, a family owned ... top-of-the-line absorbent products. The company has recently made ... brand, Tranquility® Premium Protection absorbent products. The company ... its packaging a new look, and is currently working ... the public. , The new website, developed with Thread ...
(Date:10/20/2014)... October 20, 2014 Rockynol Retirement ... Center on Oct. 14. The $11 million project will ... and a cooked-to-order kitchen with full-service restaurant style dining. ... choice for first class Assisted Living apartments,” said Kara ... deserve the highest quality of care and this investment ...
(Date:10/20/2014)... National Teen Driver Safety Week is October 19-25, 2014 ... (Ohio AAP, http://www.ohioaap.org ) is joining the National Highway ... to talk to their teens and always set the rules ... the leading cause of death for U.S. teens. In 2012, ... 859 (42%) of those teen drivers were killed in crashes. ...
Breaking Medicine News(10 mins):Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 2Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 3Health News:Tranquility® Premium Protection Incontinence Products Releases New Logo and Website 2Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Ohio AAP Promotes National Teen Driver Safety Week 2
... Brands Donate $500,000 To Help Americans Live Heart-Healthy, ... North America Inc. today announced that it is ... heart health and encouraging healthy habits among Americans. ... the American Heart Association to address the dangers ...
... Office Expands with Appointment of New Strategic Talent -WEST ... strategic interactive marketing agency serving the healthcare industry, today ... the addition of four key new hires. Three of ... Group,s Manhattan offices which were established in 2007."We,re excited ...
... Practicing Clinicians Exchange (PCE) has formed a partnership ... to provide immunization continuing education programs to nurse practitioners ... In recognition of these vital healthcare providers, expanding role ... Updates throughout the year as part of the PCE ...
... generously during 2008 holiday shopping seasonFORT WORTH, Texas, Feb. ... its customers, raised nearly $1.5 million for the fifth-annual ... and fundraising initiative for St. Jude Children,s Research Hospital ... , Customers who shopped at RadioShack stores had ...
... Hospice By The Bay,s eight-week group provides teens, ages 13-17, who are ... to be with other young people who are grieving. , ... Larkspur, ... adults. Hospice By The Bay ,s eight-week group provides teens, ages ...
... Direct, Inc., a leading online retailer of contact lenses in the United ... from dry winter eyes can be easily prevented. , ... Bellevue, WA ... online retailer of contact lenses in the United States wants ...
Cached Medicine News:Health News:Leading Spring Water Brands From Nestle Waters Team Up With the American Heart Association START! Initiative 2Health News:Leading Spring Water Brands From Nestle Waters Team Up With the American Heart Association START! Initiative 3Health News:Cadient Group Continues Growth Trend with Key New Hires 2Health News:Practicing Clinicians Exchange Forms Partnership with CDC 2Health News:RadioShack Helps Raise $1.5 Million for St. Jude Children's Research Hospital(R) Fifth-Annual Thanks and Giving(R) Campaign 2Health News:RadioShack Helps Raise $1.5 Million for St. Jude Children's Research Hospital(R) Fifth-Annual Thanks and Giving(R) Campaign 3Health News:Hospice By The Bay Teen Grief Group Offers Support for Ages 13-17 2Health News:Contact Lens Wearers Should Blink More Often During Winter - Tips from VisionDirect.com to Keep Eyes Moist During Dry Winter Months 2Health News:Contact Lens Wearers Should Blink More Often During Winter - Tips from VisionDirect.com to Keep Eyes Moist During Dry Winter Months 3
(Date:10/20/2014)... -- Indianapolis interventional medical device maker NICO Corporation ... visualization leader Synaptive Medical announced today ... that they have joined forces to integrate their ... the first of its kind and will make ... BrainPath® interventional access technology and Synaptive,s BrightMatter™ real-time ...
(Date:10/20/2014)...  AnaptysBio, Inc., a leader in the discovery ... appointment of Marco Londei , M.D. as ... preclinical and clinical development of AnaptysBio,s proprietary antibody ... welcome Dr. Londei to AnaptysBio,s executive leadership team," ... Executive Officer of AnaptysBio. "Dr. Londei,s extensive expertise ...
(Date:10/20/2014)... -- Norgine B.V. today announced that the ... preparation, NER1006, presented at the 79 th Annual ... Philadelphia, PA , has met its ... endpoint of cleansing success. The study demonstrated high quality ... in screening colonoscopy patients. [1] (Logo: ...
Breaking Medicine Technology:Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 2Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 3Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 4Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 5AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2Positive Results from Phase II Data Show NER1006 Achieves High Quality Bowel Cleansing Efficacy 2
... 2011 The Radiosurgery Society™ (RSS), a non-profit organization ... clinical practice of stereotactic body radiotherapy (SBRT) and radiosurgery ... at the La Costa Resort in Carlsbad, Calif.   ... Radiosurgery Society has been expanded to serve as a ...
... To reward loyal shoppers, CVS/pharmacy today ... multiple free gift cards just by shopping for essentials ... began on Sunday October 16 and will go through ... can earn $10 gift cards to Macy,s, Gap, Applebee,s, ...
Cached Medicine Technology:Announcing The Radiosurgery Society™ And Its 2012 SRS/SBRT Scientific Meeting 2Announcing The Radiosurgery Society™ And Its 2012 SRS/SBRT Scientific Meeting 3Save Big This Fall with CVS/pharmacy's Free Gift Cards Promotion 2Save Big This Fall with CVS/pharmacy's Free Gift Cards Promotion 3
... The 0.1mm Pierce Tip Opening Is ... Without The Need For A Separate Cystotome. The ... Positions Without Elevating The Incision.,The Distal Jaws Have ... Help To Prevent Inadvertent Pick Up Of Iris. ...
2.5V Halogen source, fiber-optic delivery, 3X magnification, pocket-sized....
... line offer patented Sensomatic® handles ... picked up and switch off ... delivery of light from 2.5V ... illumination of examination area. ...
... fiber-optically delivered light provides ... 2.5V halogen source. ... ejected using the SpecEject® ... magnification, swivellable lens allowing ...
Medicine Products: