Navigation Links
Study identifies protein to repair damaged brain tissue in MS
Date:2/7/2014

Vittorio Gallo, PhD, Director of the Center for Neuroscience Research at Children's National Health System, and other researchers have found a "potentially novel therapeutic target" to reduce the rate of deterioration and to promote growth of brain cells damaged by multiple sclerosis (MS). Current therapies can be effective in patients with relapsing MS, but have little impact in promoting tissue growth.

The brain produces new cells to repair the damage from MS years after symptoms appear. However, in most cases the cells are unable to complete the repair, as unknown factors limit this process. In MS patients, brain inflammation in random patches, or lesions, leads to destruction of myelin, the fatty covering that insulates nerve cell fibers called axons in the brain, and aids in transmission of signals to other neurons.

In yesterday's publication of Neuron, Gallo, who also is a professor of pediatrics at the George Washington University School of Medicine and Health Sciences (SMHS), reported identifying a small protein that can be targeted to promote repair of damaged tissue, with therapeutic potential. The molecule, Endothelin-1 (ET-1), is shown to inhibit repair of myelin. Myelin damage is a hallmark characteristic of MS. The study demonstrates that blocking ET-1 pharmacologically or using a genetic approach could promote myelin repair.

Repair of damaged MS plaques is carried out by endogenous oliogdendrocytle progenitor cells (OPCs) in a process called remyelination. Current MS therapy can be effective in patients with relapsing and remitting MS, but "have little impact in promoting remyelination in tissue," Gallo said. Several studies have shown that OPCs fail to differentiate in chronic MS lesions.

Targeting ET-1 is a process that involves identifying signals in cells that could promote lesion repair. "We demonstrate that ET-1 drastically reduces the rate of remyelination," Gallo said. As such, ET-1 is "potentially a therapeutic target to promote lesion repair in deymyelinated tissue." It could play a "crucial role in preventing normal myelination in MS and in other demyelinating diseases," Gallo said.


'/>"/>
Contact: Joe Cantlupe
jcantlupe@childrensnational.org
202-476-4500
Children's National Medical Center
Source:Eurekalert

Related medicine news :

1. Ice ages arctic tundra lush with wildflowers for woolly mammoths, study finds
2. Director of Womens Guild Lung Institute awarded grant to study treatment for lung disease
3. Columbia study finds hospitals dont follow infection prevention rules
4. Penn study reveals genetics impact risk of early menopause among some female smokers
5. New study finds feeling in control can help you live longer
6. Population Council launches study testing interventions to improve girls lives in Kenya
7. Study finds dramatic rise in skin cancer among middle-aged adults
8. New study shows core factors and strategies to turn primary care practices into PCMHs
9. Study finds high Rx burden for bipolar patients
10. Using susceptibility-weighted imaging to study concussion in college ice hockey players
11. New study explores contributors to excess infant mortality in the US South
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2017)... ... June 22, 2017 , ... Plastic Surgery Associates is ... Top Doctor for 2017. Each year, research and information firm, Castle Connolly, releases their ... title in 2015, this marks the 3rd time that Dr. Canales has ...
(Date:6/22/2017)... ... 22, 2017 , ... Children’s National Health System ... to launch a Rheumatic Heart Disease Center, with the goal of developing innovative ... disease (RHD) in high-risk, financially disadvantaged countries and low-income communities across the United ...
(Date:6/22/2017)... ... June 22, 2017 , ... ... that it has received certification for ANSI/ASIS PSC.1-2012. The company’s work in countries ... where the rule of law has been degraded. The PSC.1 standard was created ...
(Date:6/20/2017)... Murfreesboro, Tennessee (PRWEB) , ... June 20, 2017 ... ... chronic care services, announced today that Claritas Capital, a Nashville-based private equity firm, ... to accelerate our expansion plans for some time, and Claritas Capital offers the ...
(Date:6/20/2017)... ... , ... After months of negotiations, FaceCradle USA is proud to announce the debut of ... “Introducing our product on QVC is something we all worked hard to achieve for many ... than 90 million homes in the United States,” said FaceCradle USA President Dylan Doherty. “We ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... June 16, 2017  Exactly 50 years ago today, the ... later became known as the San Francisco "Summer of Love."  ... unveiling two radical innovations in strategic market research portals that ... marks the beginning of Northern Light,s "Summer of Love (For ... ...
(Date:6/13/2017)... Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), a global ... and Drug Administration (FDA) has notified the Company that the ... Zhejiang, China manufacturing facility has been closed ... of the Warning Letter related to our ... the progress we have made in our ongoing quality and ...
(Date:6/9/2017)... 2017 AirXpanders, Inc. (ASX: AXP) (AirXpanders or ... manufacture, sale and distribution of the AeroForm® Tissue Expander ... its commercial roll-out in the United States ... one hundred (100) medical institutions and health systems, located ... needle-free alternative for women who choose reconstructive surgery following ...
Breaking Medicine Technology: