Navigation Links
Study identifies protein to repair damaged brain tissue in MS
Date:2/7/2014

Vittorio Gallo, PhD, Director of the Center for Neuroscience Research at Children's National Health System, and other researchers have found a "potentially novel therapeutic target" to reduce the rate of deterioration and to promote growth of brain cells damaged by multiple sclerosis (MS). Current therapies can be effective in patients with relapsing MS, but have little impact in promoting tissue growth.

The brain produces new cells to repair the damage from MS years after symptoms appear. However, in most cases the cells are unable to complete the repair, as unknown factors limit this process. In MS patients, brain inflammation in random patches, or lesions, leads to destruction of myelin, the fatty covering that insulates nerve cell fibers called axons in the brain, and aids in transmission of signals to other neurons.

In yesterday's publication of Neuron, Gallo, who also is a professor of pediatrics at the George Washington University School of Medicine and Health Sciences (SMHS), reported identifying a small protein that can be targeted to promote repair of damaged tissue, with therapeutic potential. The molecule, Endothelin-1 (ET-1), is shown to inhibit repair of myelin. Myelin damage is a hallmark characteristic of MS. The study demonstrates that blocking ET-1 pharmacologically or using a genetic approach could promote myelin repair.

Repair of damaged MS plaques is carried out by endogenous oliogdendrocytle progenitor cells (OPCs) in a process called remyelination. Current MS therapy can be effective in patients with relapsing and remitting MS, but "have little impact in promoting remyelination in tissue," Gallo said. Several studies have shown that OPCs fail to differentiate in chronic MS lesions.

Targeting ET-1 is a process that involves identifying signals in cells that could promote lesion repair. "We demonstrate that ET-1 drastically reduces the rate of remyelination," Gallo said. As such, ET-1 is "pote
'/>"/>

Contact: Joe Cantlupe
jcantlupe@childrensnational.org
202-476-4500
Children's National Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Ice ages arctic tundra lush with wildflowers for woolly mammoths, study finds
2. Director of Womens Guild Lung Institute awarded grant to study treatment for lung disease
3. Columbia study finds hospitals dont follow infection prevention rules
4. Penn study reveals genetics impact risk of early menopause among some female smokers
5. New study finds feeling in control can help you live longer
6. Population Council launches study testing interventions to improve girls lives in Kenya
7. Study finds dramatic rise in skin cancer among middle-aged adults
8. New study shows core factors and strategies to turn primary care practices into PCMHs
9. Study finds high Rx burden for bipolar patients
10. Using susceptibility-weighted imaging to study concussion in college ice hockey players
11. New study explores contributors to excess infant mortality in the US South
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... 23, 2014 Throughout the month of July, ... plenty of new items. Also, it is hosting a couple ... its collection of short summer beach wedding dresses for ... popular styles in it. Additionally, these outfits are now offered ... , “As one of the world’s leading suppliers, LunaDress is ...
(Date:7/23/2014)... Being overweight is no longer a mere cosmetic ... a diet high in processed and sugar-laden foods significantly ... a host of diseases and weight related conditions, including ... , The body makes cholesterol, as well as ... hard plaque to build up, clogging the arteries and ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 Princeview Dental ... is announcing the importance of having a complete oral ... a dentist to ensure oral health care, as there ... says Dr. Janice Mummery, founder of Princeview Dental. “Dentists ... not able to see. Just by observing the inside ...
(Date:7/23/2014)... QC (PRWEB) July 23, 2014 ... the features and benefits of the company’s latest ... ASEPTIX² Dual UV Disinfection System uses a primary ... high-touch surfaces with ultraviolet ‘C’ energy controlling (6 ... C. diff. in less than 10 minutes in ...
(Date:7/23/2014)... Denver, CO (PRWEB) July 23, 2014 Daily ... released a cheaper and safer alternative to Botox called ... Facial Serum is an anti-aging product used to help people ... Technology Facial Serum can be used as a safe alternative ... does not have any toxins or health risks as opposed ...
Breaking Medicine News(10 mins):Health News:LunaDress Continues To Enrich Product Line By Offering Short Summer Beach Wedding Dresses 2Health News:Diet Doc’s Medical Weight Loss Programs Introduce Specialized Cholesterol Diet Plans that Deliver Fast Weight Loss and Reduce the Risk for Heart Attack and Stroke 2Health News:Diet Doc’s Medical Weight Loss Programs Introduce Specialized Cholesterol Diet Plans that Deliver Fast Weight Loss and Reduce the Risk for Heart Attack and Stroke 3Health News:Princeview Dental, One of Etobicoke’s Trusted Dental Clinics, Addresses the Need to Have Complete Oral Exams 2Health News:Sanuvox Produces ASEPTIX² Movie Showcasing the Feature Benefits of the Company’s Latest Flagship Hospital Surface Disinfection System 2Health News:Local Denver Skin Care Company Releases Safer Alternative to Botox 2
... who have higher testosterone levels may be at greater ... syndrome compared to women with lower testosterone levels, according ... Endocrine Society,s Journal of Clinical Endocrinology & Metabolism ... say researchers, in understanding the role that hormones play ...
... ... Correct On Mandatory Sleep Apnea Testing And "Successful Treatment", It Is ... Because More Than 60% Of Sleep Apnea Patients Can Not Tolerate ... Of Commercial Pilots And Drivers May Forever Lose Their Pilot,s Or ...
... , ... announced the successful rollout of the first international patients to receive the Spinal Kinetics M6-L ... American patients received M6-L implants, one single level, two double level, and one three level ... ...
... MELBOURNE, Australia, Nov. 3 The scientific and medical community ... Emeritus Professor James Boyer Brown AM, MSc (NZ), PhD (Edin), ... Society of Australia, Life Member Endocrine Society of Australia, who ... Born 7 October 1919 in New ...
... Allied World Assurance,Company, Ltd, a member company of Allied ... that Eugene Raitt, Senior Vice President, Accident,& Health and Chief ... the Direct Marketing Association for 2010. Mr. Raitt served as ... Direct Marketing Association (DMA) is a global trade association, with,over ...
... Nov. 3 Robbins & Myers, Inc. (NYSE: RBN ... Annual Industrial Conference on November 11, 2009. Representing the ... Officer, and Christopher M. Hix, Vice President and Chief Financial ... from 8:20-8:50 a.m., CT, at the Four Seasons Hotel in ...
Cached Medicine News:Health News:Postmenopausal women with higher testosterone levels 2Health News:SleepApneaUSA.net Announced An Alternative Sleep Apnea Solution For Commercial Pilots After NTSB Recommended Mandatory Sleep Apnea Certification For Testing And 'Successful Treatment' 2Health News:SleepApneaUSA.net Announced An Alternative Sleep Apnea Solution For Commercial Pilots After NTSB Recommended Mandatory Sleep Apnea Certification For Testing And 'Successful Treatment' 3Health News:SleepApneaUSA.net Announced An Alternative Sleep Apnea Solution For Commercial Pilots After NTSB Recommended Mandatory Sleep Apnea Certification For Testing And 'Successful Treatment' 4Health News:SleepApneaUSA.net Announced An Alternative Sleep Apnea Solution For Commercial Pilots After NTSB Recommended Mandatory Sleep Apnea Certification For Testing And 'Successful Treatment' 5Health News:Stenum Hospital Kicks off International Rollout of M6 Artificial Lumbar Disc Replacement Surgery 2Health News:Stenum Hospital Kicks off International Rollout of M6 Artificial Lumbar Disc Replacement Surgery 3Health News:Obituary: Professor James Boyer Brown 2Health News:Obituary: Professor James Boyer Brown 3Health News:Obituary: Professor James Boyer Brown 4Health News:Obituary: Professor James Boyer Brown 5Health News:Allied World's Eugene Raitt Elected 2010 Chairman of the Board for the Direct Marketing Association 2Health News:Allied World's Eugene Raitt Elected 2010 Chairman of the Board for the Direct Marketing Association 3
(Date:7/23/2014)... 23, 2014  ACON Equity Partners III, L.P., a ... ("ACON") announced it has completed the purchase of Injured ... Group and Parthenon Capital Partners. IWP is a leading ... Compensation, Automobile Personal Injury Protection and Personal Injury pharmacy ... As part of this transaction, ACON ...
(Date:7/23/2014)... , July 23, 2014 Sinovac Biotech Ltd. (NASDAQ: ... in China , announced today that it ... and Prevention ("Beijing CDC") to be a supplier of the ... for 2014. The Beijing CDC plans ... seasonal flu vaccine this year from four domestic vaccine manufacturers ...
(Date:7/22/2014)... 2014 /PRNewswire-iReach/ -- The global digital X-ray market ... portability, product, end user, price, and geography. The ... growth rate in the digital X-ray market by ... is attributed to technological advancements and the rising ... the largest share of the digital X-ray market, ...
Breaking Medicine Technology:ACON Investments Acquires Injured Workers Pharmacy 2ACON Investments Acquires Injured Workers Pharmacy 3Sinovac Receives Beijing CDC Tender to Supply Seasonal Flu Vaccine Anflu 2Global Digital X-Ray Market 2018 Analysis and Forecast In New Research Report Available at RnRMarketResearch.com 2Global Digital X-Ray Market 2018 Analysis and Forecast In New Research Report Available at RnRMarketResearch.com 3Global Digital X-Ray Market 2018 Analysis and Forecast In New Research Report Available at RnRMarketResearch.com 4Global Digital X-Ray Market 2018 Analysis and Forecast In New Research Report Available at RnRMarketResearch.com 5
... 2011 OncoSec Medical Incorporated (OTCBB: ONCS), which ... treat solid tumor cancers, announced today clinical study ... The Future of Ablation Therapies conference in Las ... poster titled, "OMS ElectroChemotherapy: Targeted Ablation of Solid ...
... NEW YORK, Sept. 26, 2011 ... research report is available in its ... Market in China - Forecast to ... By 2013 ...
Cached Medicine Technology:OncoSec Announces Positive Results from Head & Neck and Breast Cancer Trials 2OncoSec Announces Positive Results from Head & Neck and Breast Cancer Trials 3OncoSec Announces Positive Results from Head & Neck and Breast Cancer Trials 4Emerging Pharmaceutical Market in China - Forecast to Become The World's Third-Largest Pharmaceutical Market By 2013 2Emerging Pharmaceutical Market in China - Forecast to Become The World's Third-Largest Pharmaceutical Market By 2013 3Emerging Pharmaceutical Market in China - Forecast to Become The World's Third-Largest Pharmaceutical Market By 2013 4Emerging Pharmaceutical Market in China - Forecast to Become The World's Third-Largest Pharmaceutical Market By 2013 5Emerging Pharmaceutical Market in China - Forecast to Become The World's Third-Largest Pharmaceutical Market By 2013 6Emerging Pharmaceutical Market in China - Forecast to Become The World's Third-Largest Pharmaceutical Market By 2013 7
... utilizes allele-specific primer combinations in the PCR ... that only primers whose sequence is completely ... converted by the polymerase into PCR products. ... product. Using the Biotest SSP Kit Systems, ...
... The freezer is constructed with built-in bags ... the plasma bags are placed without contacting the ... and heavy inserts. This device ensures easy handling ... immersed plasma bags so that the relatively hot ...
Designed to complement Blood Bank Refrigerators, it freezers offer outstanding features, including programmable defrost times....
... 8624 is UL Listed, CSA ... Plasma Freezers safely store single ... cryoprecipitate. Recorders are standard. Cold ... (12.7cm) of foamed-inplace polyurethane insulation ...
Medicine Products: