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Study Finds No Tie Between Acne Drug Accutane and Crohn's, Colitis
Date:2/20/2013

WEDNESDAY, Feb. 20 (HealthDay News) -- A new study counters the notion that the prescription acne drug Accutane raises the risk of Crohn's disease or colitis in women.

The study of more than 45,000 women found no such link between Accutane (isotretinoin) use and these illnesses, which are collectively known as inflammatory bowel disease (IBD).

One expert not connected to the study called it a "welcome review."

"There has been a lot of speculation and even litigation that Accutane causes inflammatory bowel disease," said Dr. Michele Green, a dermatologist at Lenox Hill Hospital in New York City.

"Dermatologists have been discouraged from using Accutane and the makers of Accutane have discontinued their production due to countless lawsuits," she noted, but "this study once again highlights the safety of Accutane."

Ulcerative colitis and Crohn's disease are the most common forms of IBD, a group of disorders in which the intestines become inflamed. Symptoms include abdominal pain, diarrhea, loss of appetite, unexplained weight loss, bleeding from the rectum, fever, joint pain and skin problems.

In this study, published in the February issue of JAMA Dermatology, researchers compared almost 2,200 women of reproductive age who had IBD against another group of more than 43,000 women without IBD.

Only 10 (0.46 percent) of the IBD patients and 191 (0.44 percent) of those in the control group had used Accutane -- so there was essentially no difference.

The findings "do not suggest an increase in risk" for IBD among those who use Accutane, concluded Mahyar Etminan, of the University of British Columbia in Canada, and colleagues.

Severe acne can cause serious emotional distress for children and teens. The study results show that concerns about IBD should not prevent doctors should not prevent from prescribing Accutane to these patients, the researchers concluded in a journal news release.<
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