Navigation Links
Study: HIV Infection Does Not Adversely Affect Outcomes of Liver Transplantation for Hepatocellular Carcinoma
Date:5/10/2013

Durham, NC (PRWEB) May 10, 2013

Liver transplantation for hepatocellular carcinoma (HCC) is feasible for HIV-infected patients, with no differences in post-transplant survival or HCC recurrence rates compared with liver transplantation for HCC in HIV-uninfected patients. The study, published in The Oncologist, was led by Dr. Fabrizio Di Benedetto, MD, PhD, Associate Professor of Surgery, University of Modena and Reggio Emilia, Modena, Italy, and represents the largest multicenter study of liver transplant for HCC in HIV-infected patients to date.

Patients infected with HIV experience a more aggressive course of HCC, in part due to the tumor-enhancing effects of HIV proteins, including increased growth signaling and diminished antitumor immune response. Moreover, as highly active antiretroviral therapy (HAART) prolongs the life expectancy of HIV-infected patients, the progression of underlying liver disease toward HCC is increasingly a major cause of morbidity and mortality in this patient population. Liver transplantation for HCC in HIV-infected patients is a recent indication, and its viability as a treatment option has been a matter of debate.

In the current study, researchers evaluated post-transplant outcomes in 30 HIV-positive patients and 125 HIV-uninfected patients who underwent liver transplantation for HCC at three transplantation centers in northern Italy between 2004 and 2009. Two patients in the HIV-positive cohort (6.7%) and 18 uninfected patients (14.4%) experienced a recurrence of HCC during the follow-up period of approximately 32 months (p = .15). Overall survival was similar for HIV-infected and -uninfected patients at 1 year (77% vs. 86.4%) and 3 years (65% vs. 70%), respectively, after liver transplantation (p = .32).

“The key message of this study is that liver transplantation is a valid option for HCC treatment in HIV-infected patients,” Dr. Di Benedetto and colleagues wrote. “We suggest that HIV-infected patients must be offered the same liver transplant options for HCC treatment currently provided to HIV-uninfected subjects.”

All HIV-infected patients were given HAART until liver transplantation, and antiviral therapy was discontinued only until liver function stabilized. No patients developed AIDS-defining events during the follow-up period, which the study authors attributed to early HAART resumption following transplantation. In particular, ritonavir-boosted protease inhibitor (PI) therapy appeared to induce more rapid increases in immunosuppressive drug serum levels than unboosted PI therapy, and is the preferred HAART regimen. In the future, new options for antiviral therapy may further improve HIV control and post-transplantation outcomes in HIV-infected patients undergoing liver transplantation for HCC.

The transplantation centers used a multidisciplinary approach to patient care that included input from oncologists, radiologists, gastroenterologists, liver surgeons, and infectious disease specialists. Dr. Di Benedetto and colleagues urged clinicians to adopt a similar collaborative approach to optimize outcomes for HIV-infected patients undergoing liver transplantation for HCC.

###

The full article, titled “Multicenter Italian Experience in Liver Transplantation for Hepatocellular Carcinoma in HIV-Infected Patients,” can be accessed at http://www.TheOncologist.com.

About The Oncologist
Established by oncologists to help physicians better manage their practices in an ever-changing environment, The Oncologist® is the official journal of the Society for Translational Oncology (STO). Now in its 18th year, this internationally peer-reviewed journal focuses on clear and concise interpretation addressing the multimodality diagnosis, treatment, and quality of life of the cancer patient. Each issue is meant to impact the practice of oncology and to facilitate significant communication in the introduction of new medical treatments and technologies. For more information, visit http://www.TheOncologist.com.

About AlphaMed Press: Established in 1983, AlphaMed Press, with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes three internationally renowned peer-reviewed journals with globally recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines. STEM CELLS® (http://www.StemCells.com), which celebrated its 31st year in 2013, is the world's first journal devoted to this fast paced field of research. THE ONCOLOGIST® (http://www.TheOncologist.com), entering its 18th year, is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. STEM CELLS TRANSLATIONAL MEDICINE® (http://www.StemCellsTM.com), in its second year, is dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices.

Read the full story at http://www.prweb.com/releases/2013/5/prweb10722333.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Penn pilot study: Group of Bradford Co, Pa. residents concerned about health effects of hydrofracking
2. Great HealthWorks, Inc., makers of Omega XL, Report New Independent Study: Omega-3 DHA Protects Against Liver Disease
3. New IU study: How often is more important than why when describing breakups
4. Study: Physicians less likely to bond with overweight patients
5. The doctor wont see you now? Study: US facing a neurologist shortage
6. Study: Dental bib clips can harbor oral and skin bacteria even after disinfection
7. Doctors Health Press Reports on Study: Apples, Pears, Leafy Green Vegetables Lower Risk of Stroke
8. Bel Marra Health Reports on a New Harvard Study: Abuse of Prescription Drugs and Alcohol on the Steady Upswing
9. Study: Hospital infections in cancer patients climbed, deaths declined
10. Cedars-Sinai study: Obesity may be linked to microorganisms living in the gut
11. Study: Research reveals protective properties of influenza vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... With the exception of restorative dentistry, to date there has been ... the recent approval by the FDA, there is a now a new protocol in stopping ... is very simple and quick to apply. The application is as simple as drying ...
(Date:2/11/2016)... Alpharetta, Georgia (PRWEB) , ... February 11, 2016 ... ... Physicians Group (DMPG) will use the action analytics leader’s population health solutions, ... analytics and clinical support to the Atlanta-area healthcare system. Details of the contract ...
(Date:2/11/2016)... ... ... The Journal of Pain Research has seen a significant increase ... taken from the Scopus database (Elsevier B.V.) and is a measure of a journal's ... over a three year period and also the importance of the journals where the ...
(Date:2/11/2016)... ... February 11, 2016 , ... Pediatric cardiovascular surgeons, cardiologists and ... making data on heart procedures public and easily understandable for families and patients ... of Pediatric and Congenital Heart Disease Outcomes will bring hundreds of pediatric heart ...
(Date:2/11/2016)... ... February 11, 2016 , ... The Commission for ... the Board of Commissioners. Individuals interested in volunteer board service are encouraged to ... clinical practice settings and across allied health to contribute to its mission and ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016 Scientists ... cell-isolation method that opens the door to genetic ... now have been impossible to isolate with 100 ... isolate specific tumor types in various stages of ... variants of these cells that are clinically relevant, ...
(Date:2/11/2016)... 11, 2016  Aytu BioScience, Inc. (OTCQX: AYTU), a ... and related conditions, announced today that the Company will ... of 2016 on Tuesday, February 16, 2016, at 4:30 ... provide an overview of its business and growth strategy, ... ended December 31, 2015. --> ...
(Date:2/11/2016)... CARLSBAD, Calif. , Feb.11, 2016  Ionis Pharmaceuticals, Inc. ... a live webcast on Thursday, February 25 at 11:30 a.m. ... on pipeline and business progress. www.ionispharma.com . ... at the same address. --> www.ionispharma.com . A ... the same address. --> Interested parties may listen ...
Breaking Medicine Technology: