Navigation Links
Studies challenge standards to improve treatment outcomes for patients with clotting disorders
Date:12/8/2012

re liberal approach (keeping hematocrit levels between 45 and 50%), investigators from Italy conducted a study comparing the two strategies among 365 patients with newly diagnosed PV. Patients in Arm A were treated aggressively to maintain hematocrit levels at less than 45 percent, while the patients in Arm B were treated to maintain levels between 45 and 50 percent. The primary composite endpoint was major clots, including stroke, heart attack, transient ischemic attacks ("mini strokes"), clots in the veins in the abdomen, DVT or PE, and cardiovascular death.

The investigators observed that the risk of developing major clots was four times higher in those patients whose hematocrit levels were kept between 45 and 50 percent than in patients whose levels were kept below 45 percent. With the more intensive regimen in Arm A, 1.1 percent of the patients had a major clot versus 4.4 percent in the less aggressive regimen in Arm B. The median hematocrit levels during follow-up were 44 percent and 48 percent, respectively. Treatment with phlebotomy, anti-clotting drugs, and hydroxyurea were comparable.

There was no difference in the safety profile between the regimens. Six patients in Arm A and one patient in Arm B developed myelofibrosis, a blood disorder that causes the bone marrow to be replaced by scar tissue. Researchers observed no statistical difference in the frequency of acute leukemias that occurred in three patients in Arm A and one patient in Arm B.

"These data validate the notion that it is important to keep hematocrit levels below 45 percent for this population of patients who are at a high risk of developing clotting complications," said Tiziano Barbui, MD, lead author and Professor of Hematology and Scientific Director of the Research Foundation at Ospedali Riuniti di Bergamo in Italy. "The results from our study will be especially important in the development of new drugs for polycythemia vera, as we look to maintain these leve
'/>"/>

Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Studies assess genetics, modified treatment to improve outcomes, reduce toxicity
2. John Theurer Cancer Center to present 37 studies at the 2012 ASH Annual Meeting
3. Benefit6 Whole Body Protection, a New Product by I Do Strive LLC, Provides Increased Energy Production According to Recent Studies
4. Sharp spike in computer-related injuries predicted for medical workers, find studies
5. Analysis of conflicting fish oil studies finds that omega-3 fatty acids still matter
6. Studies from 2012 Quality Care Symposium highlight findings in improving quality of cancer care
7. New studies show effects of mammography guideline changes
8. 2 NIH studies show power of epidemiology research; Underscore need to address health disparities
9. Scripps studies show community-based diabetes programs are key to lowered costs and improved care
10. Cancer Drug Reduced Relapses in MS Patients: Studies
11. University of Houston India Studies Program presents Circuits of Empire: India as Metropole
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2015)... Optimity Advisors ( Optimity ) ... of care for healthcare organizations worldwide – today ... help operationalize contracting and engagement models. As part ... series of seven “ OrangePapers” that provide ... is a strategy, operations and information technology advisory ...
(Date:5/28/2015)... what your racquet can do for you but what kind ... the launch of their new digital campaign, HEAD introduces trick ... unique skill to HEAD Pro Players and consumers around the ... demonstrates how to gain more control over the racquet and ... tennis enthusiasts everywhere to join the show. , The digital ...
(Date:5/28/2015)... 2015 Although many people have resigned ... their slow metabolism for life, never being able to ... true. There are methods to jump start the metabolism. ... low-carbohydrate, low-fat and no-fat foods, cleverly worded to lure ... times the foods contain hidden ingredients and hidden ...
(Date:5/28/2015)... Aureus Medical Group (web: aureuslocumtenens.com), a national leader ... that it will participate as an exhibitor at the ... be held June 9-14, 2015 in New Orleans, Louisiana. ... and exhibits with products and services. , Representatives ... be available to speak with attendees about its full ...
(Date:5/28/2015)... 28, 2015 JJ Mowder-Tinney, PT, PhD, NCS, ... New York Physical Therapy Association (NYPTA) by the Delegation at ... member of the NYPTA. At the National level, she ... Section Research Committee and an abstract reviewer for the Neurology ... been a member of the Program committee since 2010 and ...
Breaking Medicine News(10 mins):Health News:Optimity Advisors Now Offers Outcomes Based Contracting Services to Support Engagement Model For New Healthcare Innovative Models of Care 2Health News:Tennis Artist Baffles Novak Djokovic - HEAD Launches Trick Shot Campaign “Frame & Play” 2Health News:As Part of their Comprehensive Weight Loss Program, Diet Doc Now Teaches Patients how to Identify Hidden Carbohydrates for Safe, Fast and Long Term Weight Loss Success 2Health News:As Part of their Comprehensive Weight Loss Program, Diet Doc Now Teaches Patients how to Identify Hidden Carbohydrates for Safe, Fast and Long Term Weight Loss Success 3Health News:As Part of their Comprehensive Weight Loss Program, Diet Doc Now Teaches Patients how to Identify Hidden Carbohydrates for Safe, Fast and Long Term Weight Loss Success 4Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the American Association of Nurse Practitioners’ 2015 National Conference 2
... 2 Responding to increased attention about clinical productivity ... Centric, Inc. ( www.usercentric.com ) - a ... a new service for the healthcare industry called ... providers. Among the technologies targeted for these service ...
... of a naturally fluorescent molecule found in all living ... according to bioengineers. , NADH, or nicotinamide adenine dinucleotide, ... for the functioning of an enzyme -- found mostly ... or mitochondria. It fuels a series of biochemical reactions ...
... Acquisition of BiotelCONSHOHOCKEN, Pa., April 2 CardioNet, Inc. ... technology company with an initial focus on the diagnosis ... into the cardiac clinical research services business and the ... The two companies entered into a binding definitive merger ...
... WASHINGTON, April 2 The following is a statement from ... (TFAH) in response to the release of the new report ... by the Robert Wood Johnson Foundation Commission to Build a ... healthy as he or she can be. And every ...
... of the Country,s Largest e-Prescribing Initiatives Drives Industry-leading Prescriber ... you recently went to your doctor and received a ... the rule. That,s right, in New Jersey more and ... pad in favor of e-prescribing technology that is improving ...
... PHILADELPHIA, April 2 John K. Davis, II has ... at the American Board of Internal Medicine (ABIM), effective ... will work closely with senior management and the Board ... operational oversight for the development and implementation of information ...
Cached Medicine News:Health News:User Centric Offers New Service, Usability Diagnostics, to Measure HIT Usability 2Health News:User Centric Offers New Service, Usability Diagnostics, to Measure HIT Usability 3Health News:Naturally fluorescent molecules may serve as cancer biomarker 2Health News:Naturally fluorescent molecules may serve as cancer biomarker 3Health News:CardioNet Expands Product Offering and Launches Clinical Research Services 2Health News:CardioNet Expands Product Offering and Launches Clinical Research Services 3Health News:CardioNet Expands Product Offering and Launches Clinical Research Services 4Health News:CardioNet Expands Product Offering and Launches Clinical Research Services 5Health News:CardioNet Expands Product Offering and Launches Clinical Research Services 6Health News:Trust for America's Health Supports Recommendations from Robert Wood Johnson Foundation Commission to Build a Healthier America 2Health News:Trust for America's Health Supports Recommendations from Robert Wood Johnson Foundation Commission to Build a Healthier America 3Health News:Horizon Blue Cross Blue Shield of New Jersey and CVS Caremark Reach 5.5 Million e-Prescriptions 2Health News:Horizon Blue Cross Blue Shield of New Jersey and CVS Caremark Reach 5.5 Million e-Prescriptions 3Health News:Horizon Blue Cross Blue Shield of New Jersey and CVS Caremark Reach 5.5 Million e-Prescriptions 4Health News:John K. Davis, II to Join the American Board of Internal Medicine as Chief Information Officer 2
(Date:5/28/2015)...   Clementia Pharmaceuticals, Inc. today announced ... part (Part B) of its natural history study ... rare, severely disabling congenital myopathy characterized by painful, ... result in the formation of new, abnormal (heterotopic) ... The multi-center, non-interventional, two-part longitudinal study is ...
(Date:5/28/2015)... 2015 MabVax Therapeutics Holdings, Inc. (OTCQB: MBVX), ... that its President and Chief Executive Officer, David ... Invitational Investor Conference being held at the Luxe ... on June 1-3, 2015. Mr. Hansen ... significant progress made in the last year and plans ...
(Date:5/28/2015)... , May 28, 2015  Caris Life Sciences®, ... promise of precision medicine, today announced the presentation ... demonstrate the utility of Caris Molecular Intelligence®, the ... mechanisms of drug resistance and pathway alterations in ... in poster sessions at the annual meeting of ...
Breaking Medicine Technology:Clementia Advances Natural History Study of Patients with Fibrodysplasia Ossificans Progressiva 2Clementia Advances Natural History Study of Patients with Fibrodysplasia Ossificans Progressiva 3MabVax Therapeutics Holdings to Present at the 2015 LD Micro Invitational Investor Conference on June 2nd at 4:30 PM EDT 2MabVax Therapeutics Holdings to Present at the 2015 LD Micro Invitational Investor Conference on June 2nd at 4:30 PM EDT 3MabVax Therapeutics Holdings to Present at the 2015 LD Micro Invitational Investor Conference on June 2nd at 4:30 PM EDT 4Caris Life Sciences Presents Large Cohort Biomarker Analyses that Characterizes Drug Resistances and Pathway Aberrations to Inform Targeted Anticancer Treatment Strategies 2Caris Life Sciences Presents Large Cohort Biomarker Analyses that Characterizes Drug Resistances and Pathway Aberrations to Inform Targeted Anticancer Treatment Strategies 3Caris Life Sciences Presents Large Cohort Biomarker Analyses that Characterizes Drug Resistances and Pathway Aberrations to Inform Targeted Anticancer Treatment Strategies 4Caris Life Sciences Presents Large Cohort Biomarker Analyses that Characterizes Drug Resistances and Pathway Aberrations to Inform Targeted Anticancer Treatment Strategies 5
... estimate that nearly one-third of cases of melanoma ... diagnosed in women during their childbearing years. Since many women ... with the fact that melanoma is the most common form ... could be faced with developing melanoma before or during pregnancy.At ...
... Up To $55 Million in Near Term Payments ... today announced that the company has entered into ... European rights to develop and commercialize the investigational ... syndrome with constipation (IBS-C) and other gastrointestinal conditions. ...
Cached Medicine Technology:Melanoma and Pregnancy: What Every Woman Needs to Know About the Risks, Prognosis 2Melanoma and Pregnancy: What Every Woman Needs to Know About the Risks, Prognosis 3Melanoma and Pregnancy: What Every Woman Needs to Know About the Risks, Prognosis 4Melanoma and Pregnancy: What Every Woman Needs to Know About the Risks, Prognosis 5Ironwood Announces Linaclotide European Licensing Agreement with Almirall 2Ironwood Announces Linaclotide European Licensing Agreement with Almirall 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: