Navigation Links
Studies assess genetics, modified treatment to improve outcomes, reduce toxicity
Date:12/8/2012

, leading to a shortage of normal white and red blood cells and platelets in the blood, which is associated with clotting defects that can cause serious bleeding. Without prompt diagnosis and treatment, APL can be fatal in a matter of hours or days.

Early treatment regimens for APL relied heavily on anthracycline-based chemotherapy with daunorubicin or idarubicin. In the early 1990s, research supported the addition of a non-chemotherapeutic agent, all-trans-retinoic acid (ATRA, a vitamin A derivative developed from ancient Chinese herbal medicine), to standard regimens. ATRA causes cancer cells to develop fully into mature blood cells, which progress through full differentiation and eventually die (unlike leukemia cells that are unable to fully mature). The combination regimen of chemotherapy and ATRA dramatically improved the survival outlook for those with APL and made the disease curable in up to 80 percent of patients. More recently, another natural compound, arsenic trioxide (ATO), was integrated into APL treatment, showing higher efficacy and better tolerability when compared with conventional chemotherapy. Today, as investigators continue to report the success of targeted cancer therapies (best exemplified by imatinib for chronic myeloid leukemia), researchers have questioned whether traditional toxic chemotherapy is still necessary to achieve high cure rates for patients with APL.

To investigate whether a combination of ATO+ATRA could provide the same therapeutic benefit as conventional treatment including chemotherapy, researchers from the Italian-German cooperative teams Gruppo Italiano Malattie EMatologiche dell'Adulto (GIMEMA), Study Alliance Leukemia (SAL) group, and German-Austrian AML Study Group (AMSLG) designed a multicenter, international Phase III trial in which 162 patients with standard-risk APL were divided into two treatment arms. Patients in Arm A received a regimen of ATO+ATRA, while patients in Arm B received the standard
'/>"/>

Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine news :

1. John Theurer Cancer Center to present 37 studies at the 2012 ASH Annual Meeting
2. Benefit6 Whole Body Protection, a New Product by I Do Strive LLC, Provides Increased Energy Production According to Recent Studies
3. Sharp spike in computer-related injuries predicted for medical workers, find studies
4. Analysis of conflicting fish oil studies finds that omega-3 fatty acids still matter
5. Studies from 2012 Quality Care Symposium highlight findings in improving quality of cancer care
6. New studies show effects of mammography guideline changes
7. 2 NIH studies show power of epidemiology research; Underscore need to address health disparities
8. Scripps studies show community-based diabetes programs are key to lowered costs and improved care
9. Cancer Drug Reduced Relapses in MS Patients: Studies
10. University of Houston India Studies Program presents Circuits of Empire: India as Metropole
11. Studies Show Limits, Promise of Laser Removal of Tattoos
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... the Trance(TM) 8 Performance Running ... ... Leading performance running,company Brooks Sports, Inc. today announced that BioMoGo, ... new Trance(TM),8 premium support shoe. Brooks designed BioMoGo to biodegrade 50 ...
... ROYAL, Va., July 24 Steven Mosher,president of the ... problem of sex discrimination, but a form of discrimination ... video, Mosher decries the practice, common in,East and South ... this practice has already claimed the lives of over ...
... awareness campaign,with ,Better Fats Sisters, DALLAS, July 24 ... fats (monounsaturated and polyunsaturated) can help,reduce their risk of ... Heart Association., "Heart disease remains the No. 1 ... ,bad, fats lately and what not to eat. That,s ...
... A new alliance of animal,lovers is attacking one of ... pet owners., America is struggling with a weight ... million children. Unfortunately, our pets -- they really,do look ... The Campaign to End Obesity, a public/private partnership ...
... Consulting firm CPEhr, and Junior Achievement, a non-profit organization, hosted a ... School. The day included HR topics such as labor law, ... ... (PRWEB) July 24, 2008 -- Los Angeles HR Consulting ...
... to availability of more natural, longer lasting, ,cost-effective treatment for deep ... ... Minn. (PRWEB) July 24, 2008 -- Gel-Del Technologies , a ... concluded clinical trials of CosmetaLife, a dermal filler injection that company ...
Cached Medicine News:Health News:Brooks(R) Sports Launches BioMoGo Biodegradable Shoe 2Health News:Brooks(R) Sports Launches BioMoGo Biodegradable Shoe 3Health News:PRI: Pro-Life Leader Blames Feminist Groups for Slaughter of Girls 2Health News:Most Americans Don't Know 'Better Fats' Benefit Heart Health 2Health News:Most Americans Don't Know 'Better Fats' Benefit Heart Health 3Health News:PetFit Challenge Helps Keep Pets - and Pet Owners - Healthy 2Health News:CPEhr and Junior Achievement Prepare High-School Students For the Workforce 2Health News:CPEhr and Junior Achievement Prepare High-School Students For the Workforce 3Health News:Clinical Trial Concluded For New Wrinkle Treatment 2Health News:Clinical Trial Concluded For New Wrinkle Treatment 3
(Date:12/15/2014)... 12, 2014 Research and Markets ... the "MEMS Gyroscopes Analog Devices ADIS16136 Precision ... to their offering. ... grade applications made a lot of progress in ... They are now accepted in high-reliability environments, and ...
(Date:12/15/2014)... and Markets ( http://www.researchandmarkets.com/research/32cmct/inferior_vena ) has announced ... Filters - Global Trends, Estimates and Forecasts, 2012-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 Global Inferior Vena Cava (IVC) ... 2016. The North America accounts ... Europe claims approximately 27% (2018). ...
(Date:12/15/2014)... , December 15, 2014 ... drugs for aggressive drug resistant cancers, today announces that ... a private placing from new and existing investors. ... to support the development of its pipeline of innovative ... for its lead drug candidate, BGB324, a first-in-class selective ...
Breaking Medicine Technology:MEMS Gyroscopes Analog Devices ADIS16136 Precision Angular Rate Sensor Reverse Costing Analysis 2Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 2Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 3Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 4BerGenBio Completes NOK90 Million Fundraising 2
... Reportlinker.com announces that a new market research report ... and Market of Xylose in China ... and the global financial crisis in Q4 2008, Chinese ... manufacturers suspended or even stopped production due to declining ...
... 19 Contact lenses improve vision-related quality of life ... of appearance and athletics, according to data drawn from ... and contact lenses on the self-perception of nearsighted children ... that the biggest improvement may be more considerable after ...
Cached Medicine Technology:Reportlinker Adds Production and Market of Xylose in China 2Reportlinker Adds Production and Market of Xylose in China 3Children Report Better Vision-Related Quality of Life with Contact Lenses vs. Glasses 2
This book includes orthopedic, reproductive, renal, cardiovascular, GI, and respiratory problems; and other common conditions....
... enable all those involved with healthcare decisions ... very latest evidence in their field of ... each year as the volume of evidence ... delivering the best single source available for ...
Over 10,000 entries. This dictionary is both a home medical guide and as an aid for all those working in the medical and allied professions. The entries are laid out and jargon-free....
... for PDA is a combination of the Medical ... Dictionary pocket for PDA. The first part of ... overview of the Spanish language, i.e. pronunciation, common ... of anatomy and medical terminology. The second part ...
Medicine Products: