Navigation Links
Studies assess genetics, modified treatment to improve outcomes, reduce toxicity
Date:12/8/2012

a treatment associated with both short- and long-term toxicities.

ALL, the most common form of leukemia in children, is a fast-growing cancer of the white blood cells in which the bone marrow makes a large number of abnormal white blood cells that are unable to develop and fight infection. Important developments over the past 20 years have led to seminal insights about ALL in children, and today nearly 90 percent of children diagnosed with standard-risk ALL are cured. Some treatment regimens for standard-risk ALL include initial infusions of daunorubicin, a type of anthracycline. While effective, continual use of this therapy is associated with potential long-term heart damage, leading researchers to assess whether eliminating or reducing the dosage of daunorubicin during the initial one-month induction therapy period might provide the same level of efficacy as the standard treatment protocol with reduced long-term risk.

In order to assess the efficacy of ALL treatment without daunorubicin during induction therapy, a team of researchers from 20 centers across France and one center in Belgium initiated a multicenter Phase III clinical trial in which 1,128 pediatric patients with standard-risk B-cell ALL were randomized into two treatment arms. Arm A included 560 patients who received a standard dose of daunorubicin during induction therapy, while Arm B included 568 patients who did not receive initial therapy with daunorubicin. Both groups received doxorubicin during delayed intensification (last treatment phase before reaching maintenance) and a standard protocol of 24-month maintenance therapy from December 2000 to June 2010, during which five-year event-free survival (EFS) and overall survival (OS) were assessed.

For those patients treated with daunorubicin, the five-year EFS rate was 92.9 percent, compared to 93.3 percent in the non-daunorubicin arm. Overall survival rates were 97.2 percent and 98.2 percent in the daunorubicin and n
'/>"/>

Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine news :

1. John Theurer Cancer Center to present 37 studies at the 2012 ASH Annual Meeting
2. Benefit6 Whole Body Protection, a New Product by I Do Strive LLC, Provides Increased Energy Production According to Recent Studies
3. Sharp spike in computer-related injuries predicted for medical workers, find studies
4. Analysis of conflicting fish oil studies finds that omega-3 fatty acids still matter
5. Studies from 2012 Quality Care Symposium highlight findings in improving quality of cancer care
6. New studies show effects of mammography guideline changes
7. 2 NIH studies show power of epidemiology research; Underscore need to address health disparities
8. Scripps studies show community-based diabetes programs are key to lowered costs and improved care
9. Cancer Drug Reduced Relapses in MS Patients: Studies
10. University of Houston India Studies Program presents Circuits of Empire: India as Metropole
11. Studies Show Limits, Promise of Laser Removal of Tattoos
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... (HealthDay News) -- Roaming the high Alps more than ... as the "Ice Man" no doubt had a very tough ... not have shielded the Ice Man, nicknamed Otzi, from a ... for atherosclerosis, or "hardening of the arteries," appears to be ... a new study finds. "Our ancestors going back ...
(Date:8/1/2014)... , Parkinson,s disease affects ... activity ceases and the cells die. Researchers at the Max ... supplying D-lactate or glycolate, two products of the gene DJ-1, ... to cultured HeLa cells and to cells of the nematode ... prevented the degeneration of neurons. They also showed that the ...
(Date:8/1/2014)... 01, 2014 The North America Sports Drink ... North America, with analysis and forecast of revenue. The Sports ... around $5,021.9 million in 2012 to $6,243 million by 2018, ... Browse through the TOC of the North America Sports Drink ... provided. This also provides a glimpse of the segmentation in ...
(Date:8/1/2014)... Gerontological Society of America (GSA) ... field of aging has chosen Madonna Harrington ... PhD, of the University of Luxembourg; and Philipp ... The London School of Economics and Political Science ... Innovative Publication Awards. , These distinguished honors recognize ...
(Date:8/1/2014)... According to Forrester Research, more than 90 ... in search of information, and thanks to the launching of ... information and resources on insurance specifically for the state of ... this next step in the growth of our business,” Doug ... - Commercial Insurance Resources office. “We recognize that the web ...
Breaking Medicine News(10 mins):Health News:'Ice Man' Mummy May Have Been at Risk of Heart Disease 2Health News:Potential treatment and prevention of Parkinson's disease 2Health News:North America Sports Drinks Market is Expected to Reach $6,243 Million in 2018 - New Report by MicroMarket Monitor 2Health News:North America Sports Drinks Market is Expected to Reach $6,243 Million in 2018 - New Report by MicroMarket Monitor 3Health News:North America Sports Drinks Market is Expected to Reach $6,243 Million in 2018 - New Report by MicroMarket Monitor 4Health News:Harrington Meyer, Leist, Hessel, Avendano to receive GSA's 2014 Kalish awards 2Health News:DCInsurers Agent Doug King Launches a New Website 2Health News:DCInsurers Agent Doug King Launches a New Website 3
... HealthDay Reporter , TUESDAY, Sept. 13 (HealthDay News) -- ... aortic valve live in fear of sudden death, but a ... complication called aortic dissection. However, these people are at ... or bulge in the wall of the aorta, researchers report. ...
... children with autism spectrum disorder (ASD), routine medical procedures ... difficult. Communication and social interaction deficits and reliance on ... the significant factors to be considered when preparing a ... effort to help families and medical providers make necessary ...
... of Boston,s elderly homeless population is emerging from a ... Hebrew SeniorLife, an affiliate of Harvard Medical School. The ... rates of geriatric syndromes, including functional decline, falls, frailty ... that many of these conditions may be easily treated ...
... a widely prescribed class of drugs used to lower cholesterol, ... in people who,ve had strokes, new research finds. Statins ... caused by blocked blood flow to the brain, to reduce ... raised concerns that statins might also raise the risk of ...
... Health and Sanford-Burnham Medical Research Institute (Sanford-Burnham) have ... laboratory scientists uncovering new approaches for treating cancer ... Basic medical research often struggles to achieve ... into medical practice. The field of translational medicine ...
... that taking the anti-inflammatory drug celecoxib can reduce the ... at the cost of increasing the risk of heart ... Researchers at Winship Cancer Institute of Emory University ... cells into suicide, separately from its known effects. The ...
Cached Medicine News:Health News:Heart Defect Seems to Pose Low Risk of Aorta Tear 2Health News:Autism Speaks launches 'blood draw' tool kit -- practical guidance for parents and providers 2Health News:Autism Speaks launches 'blood draw' tool kit -- practical guidance for parents and providers 3Health News:Institute for Aging Research study finds Boston's elderly homeless sicker than others 2Health News:Statins Don't Raise Risk of Brain Bleeds After Stroke: Study 2Health News:Scripps Health and Sanford-Burnham to collaborate to advance new cancer treatments 2Health News:Separating a cancer prevention drug from heart disease risk 2
(Date:8/1/2014)... Aug. 1, 2014 Research and ... "Global Medical Biosensors Market 2014-2018" report ... http://photos.prnewswire.com/prnh/20130307/600769 Medical biosensors are used ... physicochemical detectors. These biosensors monitor health status, disease ... non-invasive methods. They are cost-effective and user-friendly devices. ...
(Date:8/1/2014)... PALO ALTO, Calif. , Aug. 1, 2014 ... today announced a partnership to expand awareness of proper ... the CFChef Shares program. CFChef Shares will run from ... AbbVie,s CFChef program – an online resource for CF ... a healthy diet by submitting recipes to the ...
(Date:8/1/2014)... -- According to the new research ... infective), Basic (Films, Cleansing), Advanced (Hydrogels, Hydrocolloids, Alginate, ... Relief Devices, NPWT) - Global Forecast to 2019" ... expected to reach $18.3 Billion by 2019 from ... of 3.2% from 2014 to 2019. ...
Breaking Medicine Technology:Global Medical Biosensors Market 2014-2018: Key Vendors are Abbott, Bayer, LifeScan and F. Hoffmann-La Roche 2AbbVie and Cystic Fibrosis Research, Inc. (CFRI) Team Up to Raise Awareness of the Nutritional Needs of CF Patients through the CFChef Shares Program 2AbbVie and Cystic Fibrosis Research, Inc. (CFRI) Team Up to Raise Awareness of the Nutritional Needs of CF Patients through the CFChef Shares Program 3Wound Care Market Worth $18.3 Billion by 2019 2Wound Care Market Worth $18.3 Billion by 2019 3
... Stiefel, a GSK company, today announced the launch of the ... the United States. The launch will occur in the technical ... New Orleans. Indicated for the treatment of acne, Stiefel will ...   PanOxyl ® Acne Creamy Wash will be available in ...
... MEDfx Corporation today announced a Direct Project pilot that ... of the standards and protocols supported by the Direct ... in, and is a contributor to, the nationally-sponsored Direct ... Health IT.  The MEDfx Direct pilot will be demonstrated ...
Cached Medicine Technology:Stiefel Launches Most-Prescribed BPO Wash Formulations Over-the-Counter 2MEDfx to Harmonize the Direct Project With CONNECT 2MEDfx to Harmonize the Direct Project With CONNECT 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: