Navigation Links
Studies assess genetics, modified treatment to improve outcomes, reduce toxicity
Date:12/8/2012

l influences such as access to care or oral medication compliance. Of the 492 patients, 138 (28%) had the SNP rs16754 (SNP+). After stratifying the patients by ethnicity, the investigators found that the presence of SNP rs16754 varied by race, with 53 percent of Asians, 34 percent of Hispanics, 25 percent of Caucasians, and 21 percent of African Americans carrying the genetic variation. The SNP+ patients had higher five-year overall survival rates than those without the variation (SNP-) (61% vs. 44%). Within each racial subgroup, the five-year overall survival rate was higher in the SNP+ patients.

Although survival improvements in leukemia clinical trials are often attributed to increased remission rates or decreased relapse, remission and relapse rates did not differ significantly between SNP+ and SNP- patients in this study. The investigators examined whether the SNP had any association with TRM and found that TRM rates did not differ by SNP rs16754 genotype when all ethnicities were considered together. However, TRM rates in SNP+ African-American and Asian patients, when taken together, were significantly lower than in SNP- patients of those two ethnicities. African-American and Asian patients without SNP rs16754 had significantly higher rates of treatment-related toxic death compared to SNP+ patients (African-American: 25% vs. 0%; Asian: 43% vs. 0%). These results suggest that the protective effect of the presence of SNP rs16754 in reducing chemotherapy-related toxicity in pediatric AML patients is more pronounced in those of African-American and Asian descent.

"Identifying the patient-specific factors that can affect responses to treatment in different patients with the same disease brings us closer to our goal of designing personalized treatments that provide the most therapeutic benefit with the least amount of toxicity to these children," said Phoenix Ho, MD, lead author and Attending Physician at Seattle Children's Hospital in the Divisi
'/>"/>

Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine news :

1. John Theurer Cancer Center to present 37 studies at the 2012 ASH Annual Meeting
2. Benefit6 Whole Body Protection, a New Product by I Do Strive LLC, Provides Increased Energy Production According to Recent Studies
3. Sharp spike in computer-related injuries predicted for medical workers, find studies
4. Analysis of conflicting fish oil studies finds that omega-3 fatty acids still matter
5. Studies from 2012 Quality Care Symposium highlight findings in improving quality of cancer care
6. New studies show effects of mammography guideline changes
7. 2 NIH studies show power of epidemiology research; Underscore need to address health disparities
8. Scripps studies show community-based diabetes programs are key to lowered costs and improved care
9. Cancer Drug Reduced Relapses in MS Patients: Studies
10. University of Houston India Studies Program presents Circuits of Empire: India as Metropole
11. Studies Show Limits, Promise of Laser Removal of Tattoos
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/19/2014)... 2014 The leading review website, ... ) and GreenGeeks are the best Dedicated Server ... those who want to buy high quality hosting ... The IT manager of Top10BestSEOHosting.com says, “We believe ... suppliers for everyone. A lot of the global ...
(Date:10/19/2014)... working in the garment industry for decades, LunaDress’ dress specialists ... one of the company’s top designers, many ladies like prom ... add beauty to them. Chiffon floor length outfits are also ... selection of 2014 long prom dresses. , As a ... in over 20 popular designs. The company intends to meet ...
(Date:10/19/2014)... Visual Impact Frequency Training - ... released to the public generating a frenzied buzz ... fitness community. The commotion surrounding the program's launch ... prompting an investigative review. , "Many gym-goers are ... commonly known as a training 'plateau' where they ...
(Date:10/19/2014)... Government has initiated a major effort to prevent ... a workgroup of nearly 40 Alzheimer,s researchers and ... Government,s National Plan to Address Alzheimer,s Disease must ... adequately funded in order to successfully achieve this ... to enlarge and strengthen the Plan are published ...
(Date:10/19/2014)... DENVER (October 20, 2014) - As Alaska and ... outright legalization of recreational marijuana for adults, Ryan Fox ... those states and elsewhere in America: make sure your ... , Fox is founder and CEO of The Grass ... recreational dispensaries. , The Grass Station also gets ...
Breaking Medicine News(10 mins):Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2Health News:Visual Impact Frequency Training Review: Rusty Moore's Latest Fitness Guide Released 2Health News:Scientists say national Alzheimer's plan milestones must be strengthened to meet goal by 2025 2Health News:Scientists say national Alzheimer's plan milestones must be strengthened to meet goal by 2025 3Health News:Scientists say national Alzheimer's plan milestones must be strengthened to meet goal by 2025 4Health News:Scientists say national Alzheimer's plan milestones must be strengthened to meet goal by 2025 5Health News:Scientists say national Alzheimer's plan milestones must be strengthened to meet goal by 2025 6Health News:Cannabis CEO Warns Those States Considering a Legal Marijuana Market to Do Their Homework First 2Health News:Cannabis CEO Warns Those States Considering a Legal Marijuana Market to Do Their Homework First 3
... Center to Provide Increased High-Performance ... to Korean Industry and Academia, SOUTHPOINTE, Pa., ... a global innovator of simulation software and technologies,designed ... Korean Institute of Science and Technology Information (KISTI), ...
... Enhance Body, Mind & Spirit, VAIL, Colo., ... to healthcare, Next Step(R) Institute of Integrative,Medicine, Inc., ... has recently announced its 2008 series of life-changing,Wellness ... Step(R) Institute Wellness Weeks are six-night, five-day programs,that ...
... Wildly popular among,30-somethings who don,t want to ... popular,with 50- somethings who,d like to look 40 ... singled out as the only,"great" beauty serum for ... in a just published "beauty serum" ranking., ...
... Feb. 26 Two emergency care training,organizations acquired by ... a newly created parent company at the helm -- ... community., The Riverside Company, which purchased the American ... a little over a year,ago, recently created parent company, ...
... on Extending Customers and ... Revenue of Private Insurance Corporations, OAKLAND, Calif., Feb. ... call today organized by the California,Nurses Association/National Nurses Organizing ... Reggie Cervantes, a,9/11 rescue worker; Donna Smith, who has ...
... NEW YORK and DALLAS, Feb. 26 HealthpointCapital, ... Stephen H.,Hochschuler as Clinical Advisor to the Firm. ... exclusively focused on,orthopedic and dental device companies. Dr. ... Chairman of Texas Back Institute Holdings and,Chairman of ...
Cached Medicine News:Health News:KISTI Selects ANSYS as a Key Supplier in Engineering Simulation 2Health News:KISTI Selects ANSYS as a Key Supplier in Engineering Simulation 3Health News:KISTI Selects ANSYS as a Key Supplier in Engineering Simulation 4Health News:Next Step(R) Institute of Integrative Medicine, Inc. Takes Wellness to a New Level With 2008 Series of Wellness Weeks 2Health News:Next Step(R) Institute of Integrative Medicine, Inc. Takes Wellness to a New Level With 2008 Series of Wellness Weeks 3Health News:Next Step(R) Institute of Integrative Medicine, Inc. Takes Wellness to a New Level With 2008 Series of Wellness Weeks 4Health News:America's StriVectin the Only 'Great' Serum for Mature, Aging Complexions, Says Leading British Newspaper 2Health News:New Health & Safety Institute Creates Extensive, Centralized Resource for Emergency Care Training 2Health News:Michael Moore Defends 9/11 Rescue Workers and Criticizes Insurance Industry on California Nurses Association Press Call 2Health News:HealthpointCapital, LLC Appoints Stephen H. Hochschuler, M.D. as Clinical Advisor 2
(Date:10/16/2014)... (Nasdaq: CPHD ) today reported revenues for ... growth of 15% from $100.1 million for the third ... of 2014 was $(7.2) million, or $(0.10) per share, ... $(0.02) per share, in the third quarter of 2013.  ... debt discount and transaction costs, and amortization of purchased ...
(Date:10/16/2014)... 2014 Eight finalists, all representing outstanding innovation ... their proposals for a chance to compete for one ... Zayed Institute Second Annual Pediatric Surgical Innovation Symposium ... Friday, Oct. 24, 2014. Selected from a ... US and internationally, the finalists are: ...
(Date:10/16/2014)... , Oct. 16, 2014 Curtis & Coulter ... 3 weeks away from hosting their co-located Bioequivalence: ... Oral Drug Formulation Innovations Summit taking place on ... Diego, CA. November,s events are ... in streamlining the bioequivalence testing process, as well as ...
Breaking Medicine Technology:Cepheid Reports 2014 Third Quarter Results 2Cepheid Reports 2014 Third Quarter Results 3Cepheid Reports 2014 Third Quarter Results 4Cepheid Reports 2014 Third Quarter Results 5Cepheid Reports 2014 Third Quarter Results 6Cepheid Reports 2014 Third Quarter Results 7Cepheid Reports 2014 Third Quarter Results 8Cepheid Reports 2014 Third Quarter Results 9Cepheid Reports 2014 Third Quarter Results 10Cepheid Reports 2014 Third Quarter Results 11Cepheid Reports 2014 Third Quarter Results 12Cepheid Reports 2014 Third Quarter Results 13Cepheid Reports 2014 Third Quarter Results 14Cepheid Reports 2014 Third Quarter Results 15Cepheid Reports 2014 Third Quarter Results 16Cepheid Reports 2014 Third Quarter Results 17Finalists for Children's National Health System pediatric medical device competition announced 2Finalists for Children's National Health System pediatric medical device competition announced 3Finalists for Children's National Health System pediatric medical device competition announced 4Simplifying the Bioequivalence Testing Process and Optimizing Oral Formulation Development via Unifying the Global Life Science Community this November in San Diego 2
... PORTSMOUTH, N.H., Aug. 4, 2011 Novocure, a ... it has entered into a long-term supply agreement ... engineering and manufacturing conglomerate ITT Corporation (NYSE: ITT). ... ceramic components used to manufacture the disposable electrodes ...
... Texas, Aug. 4, 2011 Healthpoint Biotherapeutics today ... clinical trial investigating the efficacy of HP802-247 in ... living cell suspension containing keratinocytes and fibroblasts. The ... of two cell concentrations and two dosing frequencies ...
Cached Medicine Technology:Novocure Announces Long-Term Supply Agreement With ITT Corporation for Ceramic Sensor Technology 2Novocure Announces Long-Term Supply Agreement With ITT Corporation for Ceramic Sensor Technology 3Positive Results for Phase IIb Trial of Unique Cell-Based Therapy in Venous Leg Ulcers 2Positive Results for Phase IIb Trial of Unique Cell-Based Therapy in Venous Leg Ulcers 3Positive Results for Phase IIb Trial of Unique Cell-Based Therapy in Venous Leg Ulcers 4
... This functional brace is designed for the ... and fibula. The preformed design provides post ... removal of internal or external fixation. The ... and below the fracture site, increasing vascularity ...
... Brace features a multi-axial hinge that duplicates ... altering kinematics. The infinite degree of adjustment ... and extension control of the knee. , ... tibia in correct anatomical alignment. The precision ...
... is a revolutionary cast replacement system for ... leg and foot. , ,A self-adjusting ... and in conjunction with a rigid lattice ... time of fracture or rupture healing can ...
... the constant demands of mobilizing patients quickly. ... necessary to fit bilateral KAFO's.,The complete kit ... knee joints , 4 Copolymer thigh support ... bands , Ortho-wick™ Padding for thigh , ...
Medicine Products: