Navigation Links
Studies assess genetics, modified treatment to improve outcomes, reduce toxicity
Date:12/8/2012

toxicity from chemotherapy in African-American and Asian children with acute myeloid leukemia (AML).

AML, the second most common form of leukemia in children, is a blood cancer in which the bone marrow makes a large number of abnormal white blood cells that crowd out other healthy blood cells over time, leading to infection, anemia, or excessive bleeding. Although 60 to 70 percent of children with AML achieve long-term remission after treatment with multi-agent chemotherapy, the treatment-related mortality (TRM) associated with this intensive treatment regimen remains a major concern for this patient population. Recently, researchers have developed models that use sophisticated genome sequencing techniques to better understand how patients' genetic makeup may influence their risk of TRM.

The WT1 gene, a tumor suppressor that regulates cell growth, can be subject to "loss-of-function" mutations that lead to the development of AML. Unlike genetic mutations, single-nucleotide polymorphisms (SNPs, naturally occurring variations in the DNA that determine an individual's unique genetic makeup) are not typically thought to play a role in leukemia development or treatment response. However, researchers recently discovered that the presence of SNP rs16754 in the WT1 gene is correlated with improved outcomes in pediatric patients with AML. Based on the fact that the frequency of SNP rs16754 varies by race, researchers assessed the effect of this SNP on outcomes in specific ethnic patient groups.

To determine if the presence of SNP rs16754 affected survival, remission, relapse risk, and TRM in pediatric AML patients of different ethnicities, a team of investigators analyzed the DNA of 492 children with AML enrolled in the CCG-2961 protocol, a Phase III Children's Cancer Group trial. The intensive treatment regimen delivered to patients during CCG-2961 allowed researchers to study the effects of ethnicity on patient outcome, while minimizing non-biologica
'/>"/>

Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine news :

1. John Theurer Cancer Center to present 37 studies at the 2012 ASH Annual Meeting
2. Benefit6 Whole Body Protection, a New Product by I Do Strive LLC, Provides Increased Energy Production According to Recent Studies
3. Sharp spike in computer-related injuries predicted for medical workers, find studies
4. Analysis of conflicting fish oil studies finds that omega-3 fatty acids still matter
5. Studies from 2012 Quality Care Symposium highlight findings in improving quality of cancer care
6. New studies show effects of mammography guideline changes
7. 2 NIH studies show power of epidemiology research; Underscore need to address health disparities
8. Scripps studies show community-based diabetes programs are key to lowered costs and improved care
9. Cancer Drug Reduced Relapses in MS Patients: Studies
10. University of Houston India Studies Program presents Circuits of Empire: India as Metropole
11. Studies Show Limits, Promise of Laser Removal of Tattoos
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... Next weekend is Labor Day ... astronomically, officially ends on September 22nd this year). For IT security personnel, it should ... on which could prove far more costly than a simple headache. , Joe Caruso, ...
(Date:8/29/2015)... ... August 29, 2015 , ... ... the localized area with stretching, soft tissue manipulation. Platelet rich plasma injections also ... shown through research to improve treatment outcomes. This localized treatment seems to ...
(Date:8/28/2015)... ... August 29, 2015 , ... Rio Salado College joined nine educational ... as part of the EDUCAUSE - Next Generation Learning Challenges 2015 Breakthrough Models Incubator ... third Breakthrough Models Incubator hosted by EDUCAUSE and NGLC, which is designed ...
(Date:8/28/2015)... ... August 28, 2015 , ... Approximately 2,000 United Methodists are ... children helping children, a thank you to the many creative and generous ways ... the United Methodist initiative to end malaria deaths. , The Columbus Zoo and ...
(Date:8/28/2015)... ... 28, 2015 , ... With the goal of furthering music education programs in ... the Adams County Fairgrounds in Mendon, IL on May 30th, 2015. Backed once again ... education in the underfunded school districts of Mendon and its neighboring town of Quincy, ...
Breaking Medicine News(10 mins):Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 3Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 4Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 2Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 3Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 3Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 4Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:Best Drug Rehabilitation Interviews Country-Rock Duo Highway Run at the 2015 "Music With A Mission" Benefit Concert 2
... examined by,the same doctor during their first six ... preventive health screenings -- for lead poisoning,anemia and ... being,cared for repeatedly by the same physician, often ... important factor in the children they studied., ...
... potential diagnostic test that could help surgeons confirm or ... joints that require surgical revision has been developed by ... and Skin Diseases (NIAMS), a part of the National ... a subgroup of people who need the surgery a ...
... 3 ,Comprehensive Pharmacy Services (CPS) with the Commonwealth ... Pharmacy,Services (SOPS) are pleased to announce their new ... of-the-art pharmacy services for all,SOPS customers within participating ... its current vendor due to a number of ...
... Spine Care Centers ... of Excellence, ... Inc. have joined forces to conduct the nation,s first,comprehensive survey of ... spine centers across the nation and uncover,spine care program trends., ...
... for Medical Professionals, NEW YORK, March 3 ... practical knowledge and authority of the,American College of ... a new co-publishing agreement. Through the agreement,McGraw-Hill and ... focused on key,clinical issues and procedures, with an ...
... hosting its Fourth International Research Conference at the ... Baltimore, Md. March 17-18. The two-day conference will ... malaria research, including discussions of malaria parasite genetics ... Nearly half-a-billion people worldwide are infected with malaria. ...
Cached Medicine News:Health News:In Early Childhood, Continuous Care by One Doctor Improves Delivery of Health Screenings 2Health News:In Early Childhood, Continuous Care by One Doctor Improves Delivery of Health Screenings 3Health News:New test for joint infection could spare some patients an unnecessary procedure 2Health News:New test for joint infection could spare some patients an unnecessary procedure 3Health News:Comprehensive Pharmacy Services Awarded $80 Million Dollar Pharmacy Services Contract for the State of Massachusetts 2Health News:Comprehensive Pharmacy Services Awarded $80 Million Dollar Pharmacy Services Contract for the State of Massachusetts 3Health News:SpineMark, NeuStrategy Partner to Conduct Nation's First Spine COE Survey(TM) 2Health News:SpineMark, NeuStrategy Partner to Conduct Nation's First Spine COE Survey(TM) 3Health News:McGraw-Hill Professional Enters Partnership with American College of Physicians, the World's Largest Internal Medicine Organization 2
(Date:8/28/2015)... PITTSBURGH , Aug. 28, 2015 ... announced that its shareholders have approved Mylan,s proposed ... ; TASE) and the related issuance of Mylan ... general meeting of shareholders held today. The transaction ... the extraordinary general meeting. In addition, the transaction ...
(Date:8/28/2015)... y LONDRES, 28 de agosto de 2015 /PRNewswire/ ... hoy su participación en el  Congreso de la ... cardiológicas más recientes y novedosas, entre ellas HeartModel ... a las personas y la tecnología con los ... diagnosticar, guiar los tratamientos y permitir atención en ...
(Date:8/27/2015)... 27, 2015  The Academy of Managed Care ... Administration,s (FDA,s) draft guidance and proposed rule that ... to bear a nonproprietary name with an FDA-designated ... a decision from the FDA on the naming ... stakeholders urging the agency to use the same ...
Breaking Medicine Technology:Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 2Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 3Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 4Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 5Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 6Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 7Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 8Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 9Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 2Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 3Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 4Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 5AMCP Is Disappointed in FDA's Draft Guidance and Proposed Rule Calling for Suffix on Nonproprietary Names of Biological Products 2
... Norway, Feb. 4, 2011 Photocure (OSE: PHO), a ... today announced positive results from its consumer trial with ... skin,s appearance. The RevitAll study was ... confirm if treatment with Allumera™ improves skin appearance, when ...
... Health Corp. (Nasdaq: WBMD ) today announced that ... the UBS 21st Annual Global Healthcare Services Conference on Tuesday, ... analysts and the general public are invited to listen to ...  The broadcast can be accessed at www.wbmd.com (in ...
Cached Medicine Technology:Photocure Announces Positive Allumera™ Trial Results for Delivering Significant Skin Appearance Improvements 2Photocure Announces Positive Allumera™ Trial Results for Delivering Significant Skin Appearance Improvements 3Photocure Announces Positive Allumera™ Trial Results for Delivering Significant Skin Appearance Improvements 4
Solid lower plate with outside width 15 mm. Open serrated upper plate with inside dimensions 9 x 12 mm. Serrated handle with locking thumb screw and polished finish....
Wide 1 mm x 3 mm smooth platform. Serrated handle with polished finish. Most popular size or model....
Oval solid 15 mm wide lower plate. Open upper plate with inside dimensions 11 mm x 8 mm. Serrated handle with locking thumb screw and polished finish....
Fine 2 mm wide platform. Cross action serrated handle with metal tip guard. Polished finish....
Medicine Products: