Navigation Links
Studies assess genetics, modified treatment to improve outcomes, reduce toxicity
Date:12/8/2012

ATRA+idarubicin (AIDA) treatment regimen. The primary study objective was event-free survival (EFS) at two years, with secondary objectives including overall survival (OS), disease-free survival (DFS), cumulative incidence of relapse (CIR) rates, molecular response, and safety.

Results suggest that the targeted ATO+ATRA therapy strategy might offer similar efficacy to the chemotherapy-based regimen. In the 154 patients who were evaluable for response, complete remission was achieved in all patients (100%) in the ATO+ATRA arm and 95 percent in the AIDA arm. EFS was observed in 97 percent in the ATO+ATRA arm, with one death and two relapses, compared to 86.7 percent in the AIDA arm, in which seven deaths and four relapses were observed. Overall survival, DFS, and CIR rates were 98.7 percent, 97 percent, and 1.6 percent, respectively, in the ATO+ATRA arm, versus 91.1 percent, 91.6 percent, and 4.3 percent, respectively, in the AIDA arm. Additionally, fewer side effects (fever, low neutrophil and platelet counts) were observed in the ATO+ATRA arm.

"This is one of the first times that we can report the success of a treatment strategy for an acute leukemia that relies solely on targeted molecular therapy," said Francesco Lo-Coco, MD, lead author and Chairman of the APL subcommittee of the Italian GIMEMA group and Professor of Hematology at University Tor Vergata in Rome, Italy. "Our results are an important step toward the further utilization of targeted therapies for other types of leukemia, as we begin to focus on improving the overall treatment experience for patients by offering new strategies that deliver the same efficacy as traditional options with considerably lower toxicity."

Dr. Lo-Coco will present this study during the Plenary Scientific Session on Sunday, December 9, at 3:45 p.m. EST at the Georgia World Congress Center in Hall B5, Level 1, Building B.


'/>"/>
Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine news :

1. John Theurer Cancer Center to present 37 studies at the 2012 ASH Annual Meeting
2. Benefit6 Whole Body Protection, a New Product by I Do Strive LLC, Provides Increased Energy Production According to Recent Studies
3. Sharp spike in computer-related injuries predicted for medical workers, find studies
4. Analysis of conflicting fish oil studies finds that omega-3 fatty acids still matter
5. Studies from 2012 Quality Care Symposium highlight findings in improving quality of cancer care
6. New studies show effects of mammography guideline changes
7. 2 NIH studies show power of epidemiology research; Underscore need to address health disparities
8. Scripps studies show community-based diabetes programs are key to lowered costs and improved care
9. Cancer Drug Reduced Relapses in MS Patients: Studies
10. University of Houston India Studies Program presents Circuits of Empire: India as Metropole
11. Studies Show Limits, Promise of Laser Removal of Tattoos
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2014)... A low-cost empowerment program for adolescent girls ... harassment of these girls, who live in an ... frequently attacked, a large new study shows. , ... School of Medicine, Lucile Packard Children,s Hospital Stanford ... validated the program,s effectiveness in combating an appallingly ...
(Date:4/11/2014)... Fresh insights into the processes that control brain cell ... cancer and other brain-related disorders. , Scientists have gained ... molecule that controls how and when nerve and brain ... brain to develop and keeps it healthy. Their findings ... out of control, which is a fundamental characteristic of ...
(Date:4/11/2014)... is still open for the fifteenth annual European League ... 14 June 2014 in Paris, France. , A large ... members of the press, the majority of which are ... des Congrs de Paris. Hotel reservations are made on ... room today to avoid disappointment! , Press registration is ...
(Date:4/11/2014)... MAYWOOD, Il. (April 11, 2014) A Loyola University ... a link between overuse injury rates in young athletes ... injuries in athletes who come from families that can ... rate in lower-income athletes who are on public insurance ... privately insured young athletes are twice as likely as ...
(Date:4/9/2014)... paracetamol toxicity is the most common cause of ALF ... 150 to 200 deaths and 15 to 20 LTs occur ... Wales. LT is the definitive treatment for ALF patients ... of selection for LT (the King,s College Criteria) are not ... time or quantify the mortality risk for individual patients. ...
Breaking Medicine News(10 mins):Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 3Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 4Health News:Young athletes from higher income families more likely to suffer serious overuse injuries 2Health News:Young athletes from higher income families more likely to suffer serious overuse injuries 3Health News:New prediction model to improve patient survival after paracetamol-related liver failure 2
... advocacy organization in the State of Pennsylvania, is ... the House Dennis M. O,Brien in,their denouncement of ... for vote today. The bill requires insurance companies ... individuals less than 21 years,old, but was gutted ...
... and random environmental factors, according to findings from ... in the scientific journal Archives of Sexual ... Biological and Chemical Sciences, and Karolinska Institutet in ... are specific to an individual, and may include ...
... for anybody who cares about Lung Cancer, the Number One Cancer Killer ... Lung Cancer. For the first time, in the last four decades, Lung ... and the tireless work over the last five years of Laurie Fenton, ... ...
... process does not provide our veterans with the services ... those who so dutifully served us., JAMAICA, N.Y., ... W. Meeks (D-NY) of the Sixth Congressional,District, announced that ... to suspend the Capital Asset Realignment for Enhanced Services,(CARES) ...
... how to be footloose and injury-free , , SATURDAY, June ... simple pleasures of summer, but some who doff their shoes ... In some cases, those injuries develop infections that require surgery. ... tips from the American College of Foot and Ankle Surgeons: ...
... Incontinence and Personal Care product line by Birchwood ... mild anal incontinence and for everyday personal care. ... rectal, vaginal, and perineal cleanliness while relieving irritation ... help decrease anxiety while improving quality of life ...
Cached Medicine News:Health News:AutismLink, Autism Center of Pittsburgh Denounce Senate Autism Bill 2Health News:Homosexual behavior due to genetics and environmental factors 2Health News:Senators Chuck Hagel and Dianne Feinstein Make Lung Cancer Matter 2Health News:Senators Chuck Hagel and Dianne Feinstein Make Lung Cancer Matter 3Health News:Senators Chuck Hagel and Dianne Feinstein Make Lung Cancer Matter 4Health News:Congressman Gregory W. Meeks to Ask for Suspension of CARES Process at the St. Albans Veteran Campus 2Health News:Barefoot Lifestyle Has Its Dangers 2Health News:Birchwood Laboratories Expands B-SURE™ Incontinence and Personal Care Product Line™; Three New Products Added Including B-SURE Fresh 'n Go™, B-SURE Bottom Balm™ and B-SURE Traveler™ 2
(Date:1/15/2014)...  Celsion Corporation (the "Company") (NASDAQ: ... commitments from institutional investors to purchase an aggregate ... stock in an at-the-market registered direct offering, led ... The Company entered into definitive purchase agreements with ... to sell an aggregate of 3,603,603 shares of ...
(Date:1/15/2014)... , Jan. 15, 2014  Manufacturers, ... and technologies must be able to protect ... (IP). (Logo: http://photos.prnewswire.com/prnh/20130716/CL46586LOGO ... nature of the Medical Device Industry, it ... industry sectors of cases involving IP infringement. ...
(Date:1/15/2014)... , Jan. 15, 2014 The Cadence ... a Medical Fitness Center by the Medical Fitness ... and fitness centers to achieve their full potential. ... only certified fitness center in the western suburbs ... "The certification means the Cadence Fitness & Health ...
Breaking Medicine Technology:Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3Intellectual Property Insurance for Medical-related Products and Services 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3
... 16 Reportlinker.com announces that a ... in its catalogue. , ... Market Outlook To 2014: Policy environment, ... , http://www.reportlinker.com/p0155347/Reportlinker-Adds-The-Middle-Eastern-Pharmaceutical-Market-Outlook-To-2014-Policy-environment-market-structure-competitive-landscape-growth-opportunities.html ...
... Oct. 16 Oxygen Biotherapeutics, Inc. (OTC Bulletin Board: OXBO) ... meeting at 1:30 p.m. eastern time on Oct. 19, 2009. ... the management presentation which will follow. During that presentation, management ... , The webcast can be accessed via a link on ...
Cached Medicine Technology:Reportlinker Adds The Middle Eastern Pharmaceutical Market Outlook To 2014: Policy environment, market structure, competitive landscape, growth opportunities 2Reportlinker Adds The Middle Eastern Pharmaceutical Market Outlook To 2014: Policy environment, market structure, competitive landscape, growth opportunities 3Reportlinker Adds The Middle Eastern Pharmaceutical Market Outlook To 2014: Policy environment, market structure, competitive landscape, growth opportunities 4Reportlinker Adds The Middle Eastern Pharmaceutical Market Outlook To 2014: Policy environment, market structure, competitive landscape, growth opportunities 5Reportlinker Adds The Middle Eastern Pharmaceutical Market Outlook To 2014: Policy environment, market structure, competitive landscape, growth opportunities 6Reportlinker Adds The Middle Eastern Pharmaceutical Market Outlook To 2014: Policy environment, market structure, competitive landscape, growth opportunities 7Reportlinker Adds The Middle Eastern Pharmaceutical Market Outlook To 2014: Policy environment, market structure, competitive landscape, growth opportunities 8Reportlinker Adds The Middle Eastern Pharmaceutical Market Outlook To 2014: Policy environment, market structure, competitive landscape, growth opportunities 9Reportlinker Adds The Middle Eastern Pharmaceutical Market Outlook To 2014: Policy environment, market structure, competitive landscape, growth opportunities 10Reportlinker Adds The Middle Eastern Pharmaceutical Market Outlook To 2014: Policy environment, market structure, competitive landscape, growth opportunities 11
... Shoulder Instrument Systems offer the ... and mini-open shoulder repairs, such ... repair. Smith & Nephew shoulder ... facilitate an easier and more ...
Suture Cutter, straight...
Suture Cutter, 15 Up Curve...
Suture scissor...
Medicine Products: