Navigation Links
Studies assess genetics, modified treatment to improve outcomes, reduce toxicity
Date:12/8/2012

ATRA+idarubicin (AIDA) treatment regimen. The primary study objective was event-free survival (EFS) at two years, with secondary objectives including overall survival (OS), disease-free survival (DFS), cumulative incidence of relapse (CIR) rates, molecular response, and safety.

Results suggest that the targeted ATO+ATRA therapy strategy might offer similar efficacy to the chemotherapy-based regimen. In the 154 patients who were evaluable for response, complete remission was achieved in all patients (100%) in the ATO+ATRA arm and 95 percent in the AIDA arm. EFS was observed in 97 percent in the ATO+ATRA arm, with one death and two relapses, compared to 86.7 percent in the AIDA arm, in which seven deaths and four relapses were observed. Overall survival, DFS, and CIR rates were 98.7 percent, 97 percent, and 1.6 percent, respectively, in the ATO+ATRA arm, versus 91.1 percent, 91.6 percent, and 4.3 percent, respectively, in the AIDA arm. Additionally, fewer side effects (fever, low neutrophil and platelet counts) were observed in the ATO+ATRA arm.

"This is one of the first times that we can report the success of a treatment strategy for an acute leukemia that relies solely on targeted molecular therapy," said Francesco Lo-Coco, MD, lead author and Chairman of the APL subcommittee of the Italian GIMEMA group and Professor of Hematology at University Tor Vergata in Rome, Italy. "Our results are an important step toward the further utilization of targeted therapies for other types of leukemia, as we begin to focus on improving the overall treatment experience for patients by offering new strategies that deliver the same efficacy as traditional options with considerably lower toxicity."

Dr. Lo-Coco will present this study during the Plenary Scientific Session on Sunday, December 9, at 3:45 p.m. EST at the Georgia World Congress Center in Hall B5, Level 1, Building B.


'/>"/>
Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine news :

1. John Theurer Cancer Center to present 37 studies at the 2012 ASH Annual Meeting
2. Benefit6 Whole Body Protection, a New Product by I Do Strive LLC, Provides Increased Energy Production According to Recent Studies
3. Sharp spike in computer-related injuries predicted for medical workers, find studies
4. Analysis of conflicting fish oil studies finds that omega-3 fatty acids still matter
5. Studies from 2012 Quality Care Symposium highlight findings in improving quality of cancer care
6. New studies show effects of mammography guideline changes
7. 2 NIH studies show power of epidemiology research; Underscore need to address health disparities
8. Scripps studies show community-based diabetes programs are key to lowered costs and improved care
9. Cancer Drug Reduced Relapses in MS Patients: Studies
10. University of Houston India Studies Program presents Circuits of Empire: India as Metropole
11. Studies Show Limits, Promise of Laser Removal of Tattoos
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... Plate Club you eat pretty much everything you put ... Cornell University study shows that the average adult eats 92% ... plate. "If you put it on your plate, ... of the forthcoming book, Slim by Design, Professor of Marketing ... Wansink and co-author Katherine Abowd Johnson analyzed 1179 diners and ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 As reported on ... a caller request to name her favorite beauty products, “ ... on to say that “ Botox has changed my ... the makeup chair preparing for her various, daily appearances. ... explained Ms. Ripa (see: goo.gl/shmTQM). , “I think that Kelly ...
(Date:7/22/2014)... The Beryl Institute announces its fifth ... Scholar Program. These offerings reinforce the Institute’s commitment to ... healthcare and the need for rigorous research to understand ... scholar programs are intended to encourage and support ... focusing on the patient experience before, during and after ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 The market ... the past few years, owing to novel medical indications ... BoNTs in the aging societies where physical appearance is ... by one player, current competitors, new companies and technologies ... As biosimilar BoNTs will put the price of 1st-gen ...
(Date:7/22/2014)... NJ (PRWEB) July 22, 2014 CarePoint Health ... recently elected as the President of the medical staff at ... Levine will serve as President, as voted on by the ... of the medical staff in relation to the administration at ... needs of physicians and to work to make the Medical ...
Breaking Medicine News(10 mins):Health News:Celebrity Botox: Kelly Ripa Confesses to Getting Botox Injections 2Health News:The Beryl Institute Opens Applications for 2014 Patient Experience Grant and Scholar Programs 2Health News:The Beryl Institute Opens Applications for 2014 Patient Experience Grant and Scholar Programs 3Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 2Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 3Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 4Health News:Dr. Howard Levine Elected President of the Medical Staff at Bayonne Medical Center 2
... Deficiency Foundation LAS VEGAS and TOWSON, Md., May 5 ... that threatened their lives, Terri Cerda and her two ... Combined Immune Deficiency Disease (CIDD), will be featured on ... Edition." CIDD is one of the most severe types ...
... May 5 Baxter Regional Medical Center has recently ... patient satisfaction , in the National Database after ... They have also reached number one in Arkansas, number ... Compirion Healthcare Solutions, a hospital process improvement firm from ...
... May 5 The Cosmetic Bootcamp LLC, the leading ... meeting has reached capacity for sponsorship. According to Kenneth ... our expectations, even in this economy." He credits ... meeting as well as the boutique atmosphere that fosters ...
... May 5 Medifast, Inc. (NYSE: MED ) ... Control Center in Austin, Tx. The new Medifast Weight Control ... Louis Henna Dr., Suite 120 A, Round Rock, Tx 87664. ... log onto http://www.medifastcenters.com or ...
... discovered gene known as DEAR1 is mutated in breast cancer ... early-onset breast cancer, a research team headed by scientists at ... in the journal PLoS Medicine . , "The ... women have recurrences in the breast, and cancers that do ...
... study by the division of global child health ... cautions adoptive parents not to rely solely on ... immunizations. In the study, "Predictive Value of Immunization ... Internationally Adopted Children," division chief, Anna Maria Mandalakas, ...
Cached Medicine News:Health News:ABC's 'Extreme Makeover: Home Edition' Helps Family Coping with Primary Immunodeficiency Disease 2Health News:ABC's 'Extreme Makeover: Home Edition' Helps Family Coping with Primary Immunodeficiency Disease 3Health News:Compirion Helps Baxter Regional Medical Center Achieve Patient Satisfaction Rankings in the Top 5th Percentile Nationally 2Health News:Compirion Helps Baxter Regional Medical Center Achieve Patient Satisfaction Rankings in the Top 5th Percentile Nationally 3Health News:Compirion Helps Baxter Regional Medical Center Achieve Patient Satisfaction Rankings in the Top 5th Percentile Nationally 4Health News:Compirion Helps Baxter Regional Medical Center Achieve Patient Satisfaction Rankings in the Top 5th Percentile Nationally 5Health News:Compirion Helps Baxter Regional Medical Center Achieve Patient Satisfaction Rankings in the Top 5th Percentile Nationally 6Health News:Medifast Weight Control Center Opens in Round Rock, TX 2Health News:Novel gene predicts local recurrence in early-onset breast cancer 2Health News:Novel gene predicts local recurrence in early-onset breast cancer 3Health News:Parents of internationally adopted children advised to verify children's immunization levels 2
(Date:7/22/2014)... Research and Markets  has announced the ... report to their offering. ... diagnose, monitor, and assess medical conditions, diseases, or infections ... for earlier and more targeted treatment. These tests are ... results. This kind of diagnostics provides early detection of ...
(Date:7/22/2014)... VIEW, Calif. , July 22, 2014 /PRNewswire/ ... resonance imaging (MRI) market, Frost & Sullivan recognizes ... for Product Leadership. Siemens Healthcare,s FREEZEit solution, which ... the need for robust and motion-insensitive imaging. The ... boosted the evolution of body MRI imaging in ...
(Date:7/22/2014)...  PuraMed BioScience®, Inc., (OTCBB: PMBS), a researcher, ... healthcare products, announced today that the company is ... "We are pleased to sponsor Operation Troop ... Chairman of PuraMed BioScience. "Research shows that many ... migraines much more frequently than the general population. ...
Breaking Medicine Technology:Global IVD Market 2014-2018: Key Vendors are Abbott Laboratories, Johnson & Johnson, Roche Diagnostics and Siemens Healthcare 2Global IVD Market 2014-2018: Key Vendors are Abbott Laboratories, Johnson & Johnson, Roche Diagnostics and Siemens Healthcare 3Frost & Sullivan Recognizes Siemens Healthcare with the Product Leadership Award for Innovative Techniques in Abdominal Imaging 2Frost & Sullivan Recognizes Siemens Healthcare with the Product Leadership Award for Innovative Techniques in Abdominal Imaging 3Frost & Sullivan Recognizes Siemens Healthcare with the Product Leadership Award for Innovative Techniques in Abdominal Imaging 4PuraMed BioScience Partners with Operation Troop Aid to Sponsor Care Packages 2PuraMed BioScience Partners with Operation Troop Aid to Sponsor Care Packages 3
... Kremers Urban Pharmaceuticals Inc. is pleased to announce ... litigation arising from its Abbreviated New Drug Application (ANDA) ... which Concerta® is the reference listed drug product. The ANDA ... The settlement includes a patent license and covenant, under ...
... N.J., Sept. 13, 2011 Savient Pharmaceuticals, Inc. (Nasdaq: ... Executive Officer and President of Savient will present at the ... 2011 at 9:30 a.m. Eastern Time.  The conference will be ... A live webcast of the presentation can be ...
Cached Medicine Technology:Savient Pharmaceuticals to Present at the Sixth Annual JMP Securities Healthcare Conference 2
For presumptive identification of Escherichia coli using enzyme technology. Tests: Indole, MUG...
... The innovative E.coli ... Pro-Lab offers definitive identification ... the use of a ... the possibility of cross-reactions ...
... Directigen™ Meningitis Individual Tests are ... for the direct qualitative detection ... type b, S. pneumoniae, N. ... coli K1 in cerebrospinal fluid ...
Inquire...
Medicine Products: