Navigation Links
Stroke therapy window might be extended past nine hours for some
Date:2/9/2009

OAK BROOK, Ill. (Feb. 9, 2009) Some patients who suffer a stroke as a result of a blockage in an artery in the brain may benefit from a clot-busting drug nine or more hours after the onset of symptoms. The findings are published in the online edition of Radiology.

"Stroke is the third leading cause of death in the U.S.," said the study's lead author, William A. Copen, M.D., Director of Advanced Magnetic Resonance Neuroimaging at Massachusetts General Hospital (MGH) in Boston. "Every hour that we can add to the treatment window would allow vastly more stroke patients to be treated with potentially life-saving therapy."

The most common type of stroke is called ischemic stroke. These strokes occur when a blood clot blocks a blood vessel supplying blood to the brain. Some ischemic strokes can be treated with thrombolytic, or clot-busting, therapy using tissue plasminogen activator (t-PA), which helps dissolve the blockage. However, the window of opportunity to safely administer the medication is generally considered to be just three hours. Because few patients get to the hospital to be diagnosed and treated within that time frame, fewer than seven percent of patients receive the drug.

In this retrospective study, researchers analyzed the test results of 109 ischemic stroke patients at MGH. The testing methods included two different MRI scanning techniques: perfusion MRI, which measures blood flow in the brain, and diffusion MRI, which measures the movement of water molecules in tissue.

"Comparing the lesions that we see in these two MR images reveals which areas of the brain are threatened by a lack of blood flow, but could still be salvageable," Dr. Copen said. "A mismatch between the lesions suggests that a patient might still benefit from thrombolytic therapy."

In the study, most patients with blockage in a proximal artery, close to the base of the brain, continued to demonstrate a diffusion-perfusion mismatch between nine and 24 hours after the onset of their strokes.

"Patients who have a mismatch have been successfully treated up to nine hours after stroke onset, which is already much longer than the guidelines allow, Dr. Copen said. "Our findings suggest a need for a clinical trial to measure the effectiveness of thrombolytic therapy more than nine hours after the onset of an ischemic stroke."


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. High alcohol consumption increases stroke risk among Chinese men
3. Heavy Drinking Boosts Stroke Risk for Chinese Men
4. High alcohol consumption increases stroke risk, Tulane study says
5. Broad-based group of physicians calls for improvement in stroke treatment
6. Continued Statin Use Boosts Post-Stroke Outcomes
7. U.S. Initiative Seeks to Boost Hispanic Stroke Awareness
8. Stopping Statins After Stroke Doubles Death Risk
9. Can brain-injured, partially-blind stroke patients regain some of their lost vision?
10. REACH Registry Highlights That Patients With Peripheral Arterial Disease (PAD) Suffer High Rates of Heart Attack, Stroke, Hospitalization, and Death
11. Link Between Air Pollution, Stroke Gets Clearer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... , ... September 22, 2017 , ... “Letters From Home”: ... people, even the lost, have value to God. “Letters From Home” is the creation ... a member of the President’s Cabinet of Jerry Savelle Ministries International, who has traveled ...
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... ... Lyme and other tick-borne diseases through research, education and awareness, today announced the ... A noted immunologist and microbiologist, Dr. Sellati has more than 20 years of ...
(Date:9/21/2017)... ... September 21, 2017 , ... Process Capability Indices ... – 3:00 p.m. ET, http://www.fdanews.com/processcapabilityindices      , Quality in ... afoul of The Quality System Regulation (§820.250), and Devicemakers find themselves staring at ...
(Date:9/21/2017)... Church, VA (PRWEB) , ... September 21, 2017 ... ... Policy , **An FDAnews Management Report**, http://www.fdanews.com/products/54818-promotional-communication      , In the competitive ... edge they can get while staying in compliance with FDA rules. , The ...
(Date:9/21/2017)... ... September 21, 2017 , ... Bill Howe Plumbing’s mission ... customers, and give back to the community. For over 37 years, they have operated ... companies serving plumbing in San Diego. They were chosen as the Best ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... 2017 ... coming to Washington DC ... Tuesday, September 12 th – Monday, September 18 th .The Brain ... MRI brain scans to the public.Where:  BTF,s Mobile ... 501 K Street NW, Washington, D.C.What:BTF brings its nationwide initiative, the Road ...
(Date:9/7/2017)... Texas , Sept. 7, 2017 ... science focused on fulfilling the promise of precision ... further validate the benefits of its molecular profiling ... study utilized comprehensive genomic profiling plus (CGP+) with ... individual patient,s tumor on a molecular level, leading ...
(Date:9/6/2017)... Sept. 6, 2017  Medical professionals are ... skills while treating their patients. Medical simulations ... without involving patients. Simulation provides a safe ... carry out procedures, refine techniques and build ... of new technology, such as augmented reality, ...
Breaking Medicine Technology: