Navigation Links
St. Jude researcher receives grant to focus on cancer pharmacogenomics in children
Date:9/7/2010

With its new expansion of the Pharmacogenomics Research Network (PGRN), the National Institutes of Health (NIH) awarded St. Jude Children's Research Hospital a prestigious grant to focus on anticancer agent research in children.

The five-year, $8.6 million grant is titled "PAAR4KidsPharmacogenomics of Anticancer Agents Research in Children."

"We've been part of the PGRN for 10 years. But now, we will be the only PGRN group to focus on children, and we are partnering with NCI's Children's Oncology Group. We will be able to comprehensively study children with acute lymphoblastic leukemia, and we are moving some pharmacogenetic testing into real patient care," said Mary V. Relling, Pharm.D., Pharmaceutical Sciences chair at St. Jude.

A scientist at St. Jude since 1988, Relling's research focuses on pharmacokinetics and pharmacodynamics in children and how genome variability influences response to cancer chemotherapy.

In support of personalized medicine, the NIH has expanded the PGRN, a nationwide group of scientists focused on understanding how genes affect a person's response to medicines. The NIH estimates it will spend $161.3 million over the next five years to expand the network.

Spearheaded by the NIH's National Institute of General Medical Sciences (NIGMS) and launched in 2000, the PGRN has already identified gene variants linked to people's responses to medicines for cancer, heart disease, asthma, nicotine addiction and other conditions. The PGRN projects beginning this summer will build on this decade-old foundation and move the PGRN into several new areas: rheumatoid arthritis, bipolar disorder, and rural and underserved populations.

Along with St. Jude, the other PGRN research groups include University of California, San Francisco; University of Florida, Gainesville; University of California, San Diego; Children's Hospital Oakland Research Institute, Calif.; University of Pennsylvania, Philadelphia; University of Toronto; Brigham and Women's Hospital, Boston, Mass.; The University of Chicago, Ill.; Vanderbilt University School of Medicine, Nashville, Tenn.; The Ohio State University, Columbus; University of Maryland, Baltimore; University of Washington, Seattle; and Mayo Clinic, Rochester, Minn.

PAAR4Kids is funded by three NIH components: NIGMS, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Cancer Institute. Other NIH components funding the PGRN include the National Heart, Lung, and Blood Institute; the National Institute on Drug Abuse; the National Human Genome Research Institute; the National Institute of Mental Health; the National Institute of Arthritis and Musculoskeletal and Skin Diseases; and the Office of Research on Women's Health in the Office of the Director.

The project described was supported by Award Number U01GM092666 from the National Institute of General Medical Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of General Medical Sciences or the National Institutes of Health.


'/>"/>

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital
Source:Eurekalert

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Tiny fruit fly could offer big clues in fight against obesity, researcher says
6. Researchers create drug to keep tumor growth switched off
7. MSU researcher linking breast cancer patients with alternative therapies
8. UT researcher receives $2.4 million to research obesity, high-risk pregnancy
9. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
10. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
11. Clemson researchers develop hands-free texting application
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... The Radiology Business Management ... . The annual awards, now in their 12th year, are among the most prestigious ... , In 2016, the awards were retooled to recognize achievements in both large budget ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... financial planning, and related services to families and business owners across eastern Michigan, ... at feeding regional families struggling with financial difficulties. , The Oxford/Orion FISH Food ...
(Date:3/24/2017)... Northridge, CA (PRWEB) , ... March 24, 2017 ... ... Dr. Ramin Assili, announce that they are now offering treatments for sleep apnea ... treated at dental offices. Sleep apnea , specifically the obstructive type, is ...
(Date:3/24/2017)... ... March 24, 2017 , ... Gastro Health ... partnership to prep patients for colonoscopy at the HyGIeaCare® Center that is to ... Miami, FL. , The HyGIeaCare® Prep, cleared by the U.S. Food ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... “End Time ... the salient events will interrelate. “End Time GPS” is the creation of published ... explosives expert while working on military munitions and space-vehicle projects. Now, at age ninety-one, ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... and INDIANAPOLIS , March 23, ... LLY ) and the William Sansum Diabetes Center have ... Latino people affected by diabetes through enhanced research, education ... diabetes and cardiovascular disease bears a disproportionate weight on ... ," said David Kerr , M.D., FRCPE, director ...
(Date:3/23/2017)... SPRING, Md. , March 23, 2017  The ... to Bavencio (avelumab) for the treatment of adults and ... cell carcinoma (MCC), including those who have not received ... metastatic MCC, a rare, aggressive form of skin cancer. ... most common cancers, patients with a rare form called ...
(Date:3/23/2017)... Iowa , March 23, 2017   BioSpace ... career resource, has partnered with Indiana Biosciences Research ... organizations and educational institutions to bring the ... the first-ever BioIndiana Hotbed map, an artistic representation of ... print was presented to Vice President Mike Pence ...
Breaking Medicine Technology: