Navigation Links
Smokeless Tobacco Products Do Raise Cancer Risk
Date:7/2/2008

Snuff, chew shouldn't be viewed as a safe alternative to smoking, experts say

WEDNESDAY, July 2 (HealthDay News) -- Smokeless tobacco products (STPs), which include products such as snuff and chew tobacco, do increase the user's risk of cancer -- just not as much as smoking does.

So say researchers who examined worldwide patterns of STP use and the associated risk of cancer.

Reporting in the July issue of The Lancet Oncology, a team led by Dr. Paolo Boffeta, of the International Agency for Research on Cancer, in France, noted that STPs contain more than 30 carcinogens, including nitrosamines and metals.

Their analysis of studies from around the world found that STP users had an overall 80 percent increased risk of oral cancer and a 60 percent increased risk of esophageal cancer. They also had a similar increase in the risk of pancreatic cancer. European studies suggest no increased risk of lung cancer among STP users, but American studies suggest an 80 percent increased risk of lung cancer, the team said.

Cancer rates associated with STPs vary between countries. For example, more than 50 percent of oral cancers in India and Sudan are attributable to STPs, compared with 4 percent in the U.S.

The findings are published in a special edition of the journal devoted to lung cancer.

Overall, studies do support a strong association between STPs and cancer, said the authors, who did not recommend smokeless tobacco as a substitute for smoking.

"We do not intend to address explicitly the use of smokeless tobacco to reduce the risk from tobacco smoking -- e.g., by promoting smokers to switch to smokeless products or by introducing these products in a population where the habit is not prevalent," the researchers concluded.

"Nevertheless, several conclusions can be reached based on the available data ... the risk of cancer, especially that of oral and lung cancer, is probably lower in smokeless tobacco users in the USA and northern Europe than in smokers, and the risk of cancer is higher in smokeless tobacco users than in non-users of any form of tobacco," the team wrote. "Available data for a possible benefit of switching from smoking to smokeless tobacco come from few studies and models from the USA and Sweden."

Another article in the July issue of The Lancet Oncology suggests that DNA screening for certain biomarkers could help assess lung cancer risk in people exposed to secondhand smoke.

Many carcinogens in cigarette smoke are known to cause DNA lesions called DNA adducts and many carcinogens are known to leave unique signatures on cancer-related genes in the form of specific mutations at specific locations, noted Dr. Ahmad Besaratinia and Dr. Gerd Pfeifer, of the Beckman Research Institute of the City of Hope National Medical Center in Duarte, Calif.

They noted that a technique called DNA-lesion footprinting, in conjunction with mutagenicity analysis, is currently used to find carcinogen signatures. They proposed this technique be used in cancer-relevant genes, which are commonly mutated in smoke-related lung cancer.

In fact, this method has already been used successfully to find adducts connected with various smoke-derived carcinogens, the researchers said.

More information

The U.S. National Cancer Institute has more about smokeless tobacco and cancer.



-- Robert Preidt



The Lancet Oncology, news release, July 2, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Smokeless Tobacco: Not a Harmless Substitute
2. UGA study: Youth exposed to smokeless tobacco ads despite settlement
3. Grandmother is Inspiration for Winner of Tobacco Free Florida YouCare Contest
4. Rivalry Aside, Marlins and Rays Team Up To Fight Tobacco
5. Major Associations Band Together to Urge Congressional Action on Tobacco Legislation
6. World No Tobacco Day Sounds Urgent Call for Nations to Fight Tobacco Use, Save Lives
7. PA State Health Officials Encourage Smokers to Quit on World No Tobacco Day
8. A new way to look at lung cancer and tobacco carcinogens
9. World No Tobacco Day: Global Organizations Join Forces To Break the Tobacco Marketing Net and Help Children Grow Up Smoke-Free
10. American Lung Association Launches Online Photo Campaign to Expose Big Tobacco in Communities Nationwide
11. ClearWay Minnesota(SM) Board Approves $1.4 Million in New Grants to Reduce Tobaccos Harm
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Smokeless Tobacco Products Do Raise Cancer Risk
(Date:5/26/2016)... ... May 26, 2016 , ... May 2016 – Lips ... central to popular cosmetic improvement efforts. Record numbers of clients now ask about lip ... or pouty, says Kally Papantoniou, MD, of Advanced Dermatology P.C. , The ...
(Date:5/26/2016)... (PRWEB) , ... May 26, ... ... organization promoting quality-based imaging practices, is seeking nominations to serve on its ... diagnostic imaging. , “RadSite’s quality-benchmarking activities incorporate key process and ...
(Date:5/26/2016)... ... May 26, 2016 , ... In Madeira Beach Florida, a ... a single drawbridge, citizens formed an organization, Madeira Beach United, to oppose two development ... the small town center to a high rise urban environment. , According to the ...
(Date:5/26/2016)... ... 26, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star ... High blood pressure affects millions of people worldwide, and many patients use prescription ... heart disease, stroke, kidney disease, and hardening of the arteries. However, prescription medications ...
(Date:5/26/2016)... ... May 26, 2016 , ... With long-term experience ... President of Business Intelligence and Informatics, effective immediately. http://www.fluidedgeconsulting.com , As ... as a healthcare business and financial strategist for over 20 years. By ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016  Zymo Research ... for their new reference materials that help researchers ... sample collection to analyses. The rapid growth of ... for researchers to have standard methods to improve ... generated. Biases inherently exist at every step of ...
(Date:5/25/2016)... As illustrated by the Spring ... the numbers and momentum of cannabis in the US ... billions, more research and development push the sector forward. ... Legal Marijuana Markets Report  from from ArcView Market Research ... the increase in sector is attributed to adult use ...
(Date:5/25/2016)... , May 25, 2016 MedDay, a ... announces that an oral presentation entitled "High doses of biotin ... trial" will be given by Professor Ayman Tourbah , ... Congress of the European Academy of Neurology (EAN) in ... related disorders 3" will take place on Sunday, 29 May ...
Breaking Medicine Technology: