Navigation Links
Smell and eye tests show potential to detect Alzheimer's early
Date:7/13/2014

Biomarkers Lifestyle Study of Aging (AIBL).

Amyloid Detected in the Lens of the Eye Strongly Correlates to Amyloid Levels Detected in the Brain

At AAIC 2014, Paul D. Hartung, M.S, President and CEO of Cognoptix, Inc. and colleagues reported the results of a study of a novel fluorescent ligand eye scanning (FLES) system that detects beta-amyloid in the lens of the eye using a topically-applied ointment that binds to amyloid and a laser scanner.

The researchers studied 20 people with probable Alzheimer's disease, including mild cases, and 20 age-matched healthy volunteers; all participants' Alzheimer's status was masked from the observers. The ointment was applied to the inside of participants' lower eyelids the day before measurement. Laser scanning detected beta-amyloid in the eye by the presence of a specific fluorescent signature. Brain amyloid positron emission tomography (PET) scanning was performed on all participants to estimate amyloid plaque density in the brain.

Using results from the fluorescent imaging, researchers were able to differentiate people with Alzheimer's from healthy controls with high sensitivity (85 percent) and specificity (95 percent). In addition, amyloid levels based on the eye lens test correlated significantly with results obtained through PET brain imaging. No serious adverse events were reported, according to the scientists.

"There is a critical need for a fast, dependable, low-cost and readily available test for the early diagnosis and management of Alzheimer's disease," said Pierre N. Tariot, M.D., Director of the Banner Alzheimer's Institute in Phoenix, and a principal investigator in the study.

"The results of this small Phase 2 feasibility study validate our previously reported results and demonstrate the ability of the FLES system to reproduce the findings of clinical diagnosis of Alzheimer's with high sensitivity and specificity," said Hartung. "This system shows p
'/>"/>

Contact: Alzheimer's Association Media Line
media@alz.org
312-335-4078
Alzheimer's Association
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Why does bacon smell so good? (video)
2. Claim that raw milk reduces lactose intolerance doesnt pass smell test, study finds
3. Detecting sickness by smell
4. Smells BeGone Air Freshening Aerosol Sprays on Sale at SmellsBeGone.com
5. Mosquitoes smell you better at night, study finds
6. Smells BeGone Launches New Pinterest Page
7. Age-related smelling loss significantly worse in African-Americans
8. Black, Stinky, Smelly Sludge In Pond?
9. Do Latex Mattresses Smell? SleepJunkie.org Clears the Air with Latest Article
10. Foul-smelling gas shows health benefits in reducing joint swelling
11. Smell and taste experts to discuss new discoveries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... The Louis W. Sullivan ... to distribute health information technology innovation to transform ... the development of six key guiding principles of ... healthcare. These are an expansion of the Institute ... that is respectful of and responsive to individual ...
(Date:10/22/2014)... 22, 2014 With the Affordable Care Act ... by the American Institutes for Research (AIR) finds that three ... use health insurance, but 42 percent say they are not ... before signing up for coverage. , The AIR survey found ... percent able to calculate correctly how much they owe for ...
(Date:10/22/2014)... 22, 2014 Best Cheap Hosting USA ... world. The site has recently announced that iPower ( ... for people from around the world. , “iPower is ... today and is providing various kinds of useful products ... insists on offering excellent customer service and a number ...
(Date:10/22/2014)... Losing Weight Your Body’s Way , In a world where ... it certainly can be difficult to choose the right weight ... by doing it the healthy way? Set aside the fads ... body, exercise regularly, and choose foods with the most nutritional ... need to exercise more and eat less. Despite the number ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Lintelus, Inc., ... Sr. Vice President of Sales, will be speaking on ... Meetings Technology Expo on October 28, at the Holiday ... hosting a booth as well as a Tech Demo ... Meeting can create a more engaging event experience. , ...
Breaking Medicine News(10 mins):Health News:The Sullivan Institute for Healthcare Innovation Announces Release of Guiding Principles for Patient Experience-Centered Care 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:Best Cheap Hosting USA Has Recently Announced The Best Cheap Web Hosting Companies In 2014 2Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2
... WASHINGTON, Nov. 8 Speaker Nancy Pelosi and Democratic leaders held ... Affordable Health Care for America Act. The bill passed by ... opening remarks: , "I and some of my colleagues just ... Obama, congratulating us on a great victory for the American people. ...
... ... Company’s Mississauga, Ontario facility. , ... Toronto, ON (PRWEB) November 8, 2009 -- Thomas Wellner, President and ... a commercial scale pharmaceutical grade freeze dryer and expects to make commercial scale freeze ...
... does not mean the battle is won," said Dr. Charmaine ... of 240-194, the Stupak-Ellsworth-Pitts-Kaptur-Dahlkemper-Lipinski-Smith Amendment to prohibit abortion mandates and ... Americans United for Life Action President and CEO Dr. Charmaine ... for the pro-life Americans across this country who have flooded ...
... of H.R. 3961 to Secure the Stability of Medicare ... Rohack, M.D., President, American Medical Association. , (Logo: ... of the House health reform bill, which will help improve ... swift passage of H.R. 3961 to secure the stability of ...
... Care Reform Bill , Critical legislation would ... BALTIMORE, Nov. 7 SUMMARY: Tonight the ... reform legislation that would strengthen Medicare for seniors and ... Americans out of affordable health coverage. , The Affordable ...
... The American Medical Association (AMA) today awarded its 2009 Benjamin ... Kraff, M.D., an ophthalmologist from Chicago, IL. The award recognizes ... of duty to make an outstanding public service contribution to ... the opening session of the 2009 Interim Meeting of the ...
Cached Medicine News:Health News:Therapure Biopharma Inc. Announces Delivery of its First Commercial-Scale Lyophilizer 2Health News:Americans United for Life Action Comments on Passage of Pro-Life Amendment: Bipartisan Pro-life Majority Reflects the Will of the American People 2Health News:AMA Hails House Passage of Health Reform Bill (H.R. 3962) 2Health News:AARP Maryland Key Vote News Alert 2Health News:AARP Maryland Key Vote News Alert 3Health News:AMA Honors IL Ophthalmologist Manus C. Kraff M.D. for Volunteer Eye Care for Military Members 2
(Date:10/22/2014)... Oct. 22, 2014   Reproductive Medicine Associates ... in the field of infertility, presents new clinical ... screening. The research abstract, released during the 70 ... (ASRM) meeting in Honolulu, Hawaii ... gene defect (SGD) pre-implantation genetic diagnosis (PGD). ...
(Date:10/22/2014)... , October 22, 2014 A ... Gloves Market (Product type, Form, End user, Application and ... Insights, Analysis, Research, Report, Opportunities, Segmentation and Forecast, 2013 ... gloves market. Based on key trends tracked, it is ... at $7.9 billion by 2020, registering a CAGR of ...
(Date:10/22/2014)... 2014   BioNano Genomics , the genome ... centers to purchase an Irys™ System . Among ... Institute (NCI), NIH Intramural Sequencing Center (NISC) and Genoscope ... a comprehensive view of a genome was a ... not deliver the scalability or reliability to detect ...
Breaking Medicine Technology:New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3
... Corporation (Nasdaq: THOR ), a world leader in ... failing hearts, said today it will be participating in the ... Wednesday, May 11. David V. Smith, executive vice ... the company, beginning at 8:40 a.m., Pacific Daylight Time (11:40 ...
... CINCINNATI, May 6, 2011 Kendle (Nasdaq: ... today announced the Company is postponing its Annual Meeting ... Research, LLC.  The annual meeting had been scheduled for ... 4, 2011, that it has signed a merger agreement ...
Cached Medicine Technology:Kendle Announces Postponement of 2011 Annual Meeting 2Kendle Announces Postponement of 2011 Annual Meeting 3Kendle Announces Postponement of 2011 Annual Meeting 4
Multispot HIV-1/HIV-2 is a rapid indirect EIA using recombinant and peptide antigens for simultaneous detection and differentiation of anti-HIV-1 and anti-HIV-2 antibodies in human serum or plasma....
Bio-Rad's Genetic Systems™ HBsAg EIA 3.0 screening and confirmatory assays offer outstanding sensitivity and early detection of HBV infection, helping to meet your testing criteria....
The most compact revolutionary innovation in hematology. 3 Part DIFF + CRP measurement on whole blood....
... Evolis™ is a self contained microplate ... based EIA assays. The system is dedicated ... encountered in todays busy laboratory. The system ... of EIA assays that satisfy their microplate ...
Medicine Products: