Navigation Links
Shingles symptoms may be caused by neuronal short circuit
Date:9/10/2013

ogy and a member of the Princeton Neuroscience Institute.

The first of these two proteins is called glycoprotein B, a fusion protein that drills the holes in the axon wall. A second protein, called Us9, acts as a shuttle that sends glycoprotein B into axons, according to the researchers. "The localization of glycoprotein B is crucial," Granstedt said. "If glycoprotein B is present but not in the axons, the synchronized flashing won't happen."

The researchers succeeded in stopping the short circuit from occurring in engineered viruses that lacked the gene for either glycoprotein B or Us9. Such genetically altered viruses are important as research tools, Enquist said.

Finding a way to block the activity of the proteins could be a useful strategy for treating the pain and itching associated with herpes viral diseases, Enquist said. "If you could block fusion pore formation, you could stop the generation of the signal that is causing pain and discomfort," he said.

Granstedt conducted the experiments with Jens-Bernhard Bosse, a postdoctoral research associate in molecular biology. Assistance with 2-photon microscopy was provided by Stephan Thiberge, director of the Bezos Center for Neural Circuit Dynamics at the Princeton Neuroscience Institute.

The team previously observed the synchronized firing in laboratory-grown neurons (PLoS Pathogens, 2009), but the new study expands on the previous work by observing the process in live mice and including the contribution of Us9, Granstedt said.

Shingles, which is caused by the virus herpes zoster and results in a painful rash, will afflict almost one out of three people in the United States over their lifetime. Genital herpes, which is caused by herpes simplex virus-2, affects about one out of six people ages 14 to 49 years in the United States, according the Centers for Disease Control and Prevention.


'/>"/>

Contact: Catherine Zandonella
czandone@princeton.edu
Princeton University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Shingles Vaccine Safe, Underutilized, Study Says
2. Treatment with anti-TNFs can increase the risk of shingles by up to 75 percent
3. Shingles Not Linked to Increased Cancer Risk, Study States
4. No increased risk of cancer for people with shingles
5. Doctors Encourage Treatment for Shingles to Be Started When the Pain Kicks in – VyGone Introduces Shingles Vaccine
6. Study suggests link between untreated depression and response to shingles vaccine
7. Untreated Depression May Cut Shingles Vaccine Effectiveness
8. UCLA study suggests link between untreated depression, response to shingles vaccine
9. Shingles Treatment
10. How “How To Cure Shingles” Helps People Get Rid Of Shingles Quickly – Health Review Center
11. Newer Rheumatoid Arthritis Drugs Dont Seem to Increase Risk of Shingles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... May 22, 2015 Pioneer Millworks, the ... the forefront of designing with reclaimed wood, introducing their ... Los Angeles, California. Their newest offerings, Vat 35, ... surface and color to America's largest design event. , ... at each show, anxious to see and feel the ...
(Date:5/22/2015)... 22, 2015 Following yesterday’s announcement that ... with US-based health brand Nature’s Way, Marc St-Onge has ... of Ascenta Skin is an integral part of the ... this opportunity to further develop Ascenta Skin into a ... Skin is a breakthrough, anti-aging skincare supplement featuring 6 ...
(Date:5/22/2015)... Family, friends, students, colleagues, mentors and fellow ... LaSalle D. Leffall, on Monday, May 18, with an ... Rounds in the hospital’s Tower Auditorium. Leffall’s younger sister, ... trying to keep the secret. “I’d like to go ... he’ll know something is up,” she said. , After ...
(Date:5/22/2015)... Power Systems is proud to announce the sponsorship of Elite ... in his second year of racing in the professional division ... Department in Missoula, MT. He entered the triathlon scene in ... he has had 15 1st Place finishes. In his first ... all seven of his 2014 races, including two 2nd Place ...
(Date:5/22/2015)... 22, 2015 Gateway Building Concepts is ... The services the company specialize in include decks, additions, ... pool houses and much more. , The redesigned ... owner of the company. It includes two geometrical lines ... was thought out to be used with many things ...
Breaking Medicine News(10 mins):Health News:Pioneer Millworks to Reveal New Design Trends with Reclaimed Wood at Dwell on Design in LA 2Health News:Pioneer Millworks to Reveal New Design Trends with Reclaimed Wood at Dwell on Design in LA 3Health News:Ascenta Skin President Announces Plans to Grow Brand 2Health News:Colleagues Surprise Dr. LaSalle Leffall with 85th Birthday Celebration 2
... PITTSBURGH, Oct. 13 Today,s autism research draws ... functional magnetic,resonance imaging (fMRI) to neural development. At ... Systems in Autism," 16 of,the world,s most prominent ... the disorder and discuss the direction of future,study ...
... system ,can,t remember anything, study says , , MONDAY, Oct. ... more than help guide your daily sleep/wake cycle -- ... and memory, say Stanford University researchers. , In tests ... is critical to the rodents, ability to memorize what ...
... WINTER WITH THE VIPER RESPONDER LE SPECIAL ... VEHICLE SECURITY & REMOTE START SYSTEM, VISTA, Calif., Oct. ... (Nasdaq: DEIX ), has joined,the fight against breast cancer ... & Remote Start systems from Viper,supporting Susan G. Komen for ...
... to Get Tested, LOS ANGELES, Oct. 13 , ... of all newly diagnosed HIV/AIDS cases,reported in Los Angeles ... week of activities aimed at raising awareness and encouraging ... Awareness Day,observed on October 15., -- October 14, ...
... interruption to shipments or service to new or ... Cardiac Science,Corporation (Nasdaq: CSCX ) announced today ... action of certain automated external,defibrillators (AEDs) manufactured between ... this time frame may have a component whose ...
... than ever before, study finds , , MONDAY, Oct. 13 ... treated for high blood pressure, say researchers from the ... major factor in the dramatic increase in the number ... the obesity epidemic rife in the United States, they ...
Cached Medicine News:Health News:Carnegie Mellon International Autism Symposium to Feature Groundbreaking Research, Oct. 17-18 2Health News:Circadian Rhythm Plays Role in Memory 2Health News:Supporting Susan G. Komen for the Cure(R) During National Breast Cancer Awareness Month 2Health News:Supporting Susan G. Komen for the Cure(R) During National Breast Cancer Awareness Month 3Health News:Nearly Half of Newly Diagnosed HIV/AIDS Cases in Los Angeles County Are Among Latinos 2Health News:Cardiac Science Initiates Voluntary Field Corrective Action of Certain AEDs 2Health News:Cardiac Science Initiates Voluntary Field Corrective Action of Certain AEDs 3Health News:Blood Pressure on the Rise in America 2Health News:Blood Pressure on the Rise in America 3
(Date:5/22/2015)... ORLANDO, Fla. , May 22, 2015 ... Copay Assistance Program. This program provides financial assistance for ... "We are pleased to announce the addition of the ... programs," stated Mark McGreevy , executive director. "With ... mission and vision of a world where no one ...
(Date:5/22/2015)... WORTH, Texas , May 22, 2015 ... $58.4 million in 2014 and is estimated to reach $90.7 ... to 2019. Browse through the TOC of North ... and segments, with the help of various tables and figures. ... will receive 10% customization on this report.   ...
(Date:5/22/2015)... and KING OF PRUSSIA, Pa. , ... (NHF) has awarded CSL Behring its 2015 Corporate ... commitment to advancing science and improving the care of the ... Perreault , CEO and Managing Director, CSL Limited, during the ... on May 21. "The National Hemophilia ...
Breaking Medicine Technology:The Assistance Fund Adds Melanoma Assistance Program 2North America Dental Lasers Market is Expected to Reach $90.7 Million by 2019, at a CAGR of 9.2% From 2014 to 2019 2North America Dental Lasers Market is Expected to Reach $90.7 Million by 2019, at a CAGR of 9.2% From 2014 to 2019 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 2National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 4
... one of the tools used to prevent deep ... fitted, putting patients at,risk for potentially-deadly blood clots, ... Their findings appear in the September issue of ... at increased risk for blood clots after surgery,because ...
... Pharmaxis (ASX: PXS; Nasdaq: PXSL) today announced,that the ... safety of,Bronchitol in subjects with bronchiectasis has concluded ... following 12 months of treatment., A total ... Bronchitol twice,per day and 99 subjects completed the ...
Cached Medicine Technology:Dallas Researchers Find Compression Stockings Improperly Used 212 Month Phase 3 Trial Finds Bronchitol Safe in Bronchiectasis 212 Month Phase 3 Trial Finds Bronchitol Safe in Bronchiectasis 3
The Capio CL Transvaginal Suture Capturing Device allows for a transvaginal suture fixation to Cooper's Ligament for sling procedures...
... urinary stress incontinence (SUI) with a minimally ... SP) or a transobturator (BioArc™ TO) approach. ... combining synthetic and biologic materials. It is ... BioArc utilizes a polypropylene mesh for fixation ...
... a minimally invasive treatment for female stress ... be performed at the same time. This ... sling, the In-Fast Ultra inserter is used ... into the posterior aspect of the pubic ...
... architecture of the Uretex® polypropylene ... integrity for tension-free sling placement. ... securely to surrounding tissue without ... fixation devices, minimizing risk of ...
Medicine Products: