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Secondhand smoke damages lungs, MRIs show
Date:11/26/2007

Its not a smoking gun, but its smoking-related, and its there in bright medical images: evidence of microscopic structural damage deep in the lungs, caused by secondhand cigarette smoke. For the first time, researchers have identified lung injury to nonsmokers that was long suspected, but not previously detectable with medical imaging tools.

The researchers suggest that their findings may strengthen public health efforts to restrict secondhand smoke.

We used a special type of magnetic resonance imaging to find these structural changes in the lungs, said study leader Chengbo Wang, Ph.D., a magnetic resonance physicist in the Department of Radiology at The Childrens Hospital of Philadelphia. Almost one-third of nonsmokers who had been exposed to secondhand cigarette smoke for a long time developed these structural changes. Formerly at the University of Virginia, Wang collaborated with radiology researchers at that institution, where they acquired the MRIs from adult smokers and nonsmokers.

Wang presented the teams findings in Chicago at the annual meeting of the Radiological Society of North America. Although the participants in the research study were adults, Wang said the results have implications for the 35 percent of American children who live in homes where regular smoking occurs.

The researchers studied 60 adults between ages 41 and 79, 45 of whom had never smoked. The 45 non-smokers were divided into groups with low and high exposure to secondhand smoke; the high-exposure subjects had lived with a smoker for at least 10 years, often during childhood. The 15 current or former smokers formed a positive control group.

The research team prepared an isotope of helium called helium-3 by polarizing it to make it more visible in the MRI. Researchers diluted the helium in nitrogen and had research subjects inhale the mixture. Unlike ordinary MRIs, this MRI machine measured diffusion, the movement of helium atoms
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Contact: Rachel Salis-Silverman
Salis@email.chop.edu
267-426-6063
Children's Hospital of Philadelphia  
Source:Eurekalert

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