"Understanding how messenger RNA length is regulated will allow researchers to begin to develop new strategies aimed at interfering with the process that causes unusual messenger RNA shortening during the formation of tumors," Wagner said.
Additional preclinical tests are needed before the strategy can be evaluated in humans.
"The work described in the Nature paper by Drs. Wagner and Shyu stems from a high-risk/high-impact Cancer Prevention & Research Institute of Texas (CPRIT) proposal they submitted together and received several years ago," said Rod Kellems, Ph.D., professor and chairman of the Department of Biochemistry and Molecular Biology at the UTHealth Medical School.
"Their research is of fundamental biological importance in that it seeks to understand the role of messenger RNA length regulation in gene expression," Kellems said. "Using a sophisticated combination of biochemistry, genetics and bioinformatics, their research uncovered an important role for a specific protein that is linked to glioblastoma tumor suppression."
Other UTHealth contributors include postdoctoral fellow Chioniso P. Masamha, Ph.D.; research associate Todd R. Albrecht; and neurosurgery associate professor Min Li, Ph.D., along with a postdoctoral fellow in his lab, Jingxuan Yang, Ph.D.
"Grade IV astrocytomas (GBM) are the most frequent and malignant form of brain tumor, with a median survival time of only 14.6 months. The mechanisms underlying gliomagenesis remain largely unknown, and limited choices are available for patients with GBM," said Min Li, director of the Cancer Research Program in the Vivian L. Smith Department of Neurosurgery at UTHealth and a member of the Mischer Neuroscience Institute at
|Contact: Robert Cahill|
University of Texas Health Science Center at Houston