Navigation Links
Scientists slow brain tumor growth in mice
Date:5/13/2014

itical to keeping messenger RNA long in healthy cells and that its reduction promotes tumor growth. The key research finding in this study was that restoring CFIm25 levels in brain tumors dramatically reduced their growth.

"Understanding how messenger RNA length is regulated will allow researchers to begin to develop new strategies aimed at interfering with the process that causes unusual messenger RNA shortening during the formation of tumors," Wagner said.

Additional preclinical tests are needed before the strategy can be evaluated in humans.

"The work described in the Nature paper by Drs. Wagner and Shyu stems from a high-risk/high-impact Cancer Prevention & Research Institute of Texas (CPRIT) proposal they submitted together and received several years ago," said Rod Kellems, Ph.D., professor and chairman of the Department of Biochemistry and Molecular Biology at the UTHealth Medical School.

"Their research is of fundamental biological importance in that it seeks to understand the role of messenger RNA length regulation in gene expression," Kellems said. "Using a sophisticated combination of biochemistry, genetics and bioinformatics, their research uncovered an important role for a specific protein that is linked to glioblastoma tumor suppression."

Other UTHealth contributors include postdoctoral fellow Chioniso P. Masamha, Ph.D.; research associate Todd R. Albrecht; and neurosurgery associate professor Min Li, Ph.D., along with a postdoctoral fellow in his lab, Jingxuan Yang, Ph.D.

"Grade IV astrocytomas (GBM) are the most frequent and malignant form of brain tumor, with a median survival time of only 14.6 months. The mechanisms underlying gliomagenesis remain largely unknown, and limited choices are available for patients with GBM," said Min Li, director of the Cancer Research Program in the Vivian L. Smith Department of Neurosurgery at UTHealth and a member of the Mischer Neuroscience Institute at
'/>"/>

Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. UBC scientists find new way to mobilize immune system against viruses
2. Dartmouth scientists identify genetic blueprint for cancerous tumors of the appendix
3. Scientists decode epigenetic mechanisms distinguishing stem cell function and blood cancer
4. Scientists identify new protein in the neurological disorder dystonia
5. Scientists awarded grant to develop diagnostics for cancer, rheumatoid arthritis, colitis
6. Norwegian neuroscientists elected to National Academy of Sciences
7. NIH scientists establish monkey model of hantavirus disease
8. Stanford scientists create circuit board modeled on the human brain
9. A civil war inside our cells: Scientists show how our bodies fight off jumping genes
10. Scientists find way to target cells resistant to chemo
11. Scientists identify cancer specific cell for potential treatment of gastric cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists slow brain tumor growth in mice
(Date:4/1/2015)... April 01, 2015 EB Medicine, ... Pediatric Emergency Medicine Practice, and Hospital Medicine Practice, ... with AgileMD to provide the content from its ... a mobile application format available on iPhones, iPads ... collaboration with AgileMD to develop mobile applications for ...
(Date:4/1/2015)... 2015 The U.S. Department of Health ... 123,000 patients who are waiting for a lifesaving organ ... surprising statistic. , In the “Play Through ... a PGA TOUR golfer and two-time heart transplant recipient, ... become organ donors. He inspires viewers by reminding ...
(Date:4/1/2015)... Pricing Healthcare has added facilities to its ... to a third of all US states. The new ... Iowa, and the first dedicated eye center in the country in ... also added. , In addition, the site reached a milestone of ... the platform continue to grow across the country. , 1. ...
(Date:4/1/2015)... Amercanex Corporation, today announced that Native Roots ... and will conduct its wholesale business thru Amercanex proprietary ... as one of the oldest and largest dispensaries in ... in 9 locations with plans of expansion to other ... to have Native Roots join Amercanex as they are ...
(Date:4/1/2015)... April 01, 2015 The term “420” is ... p.m.) when a group of California teenagers would regularly get ... started, 420 has since become a short-hand term for cannabis ... something of a national holiday for the marijuana culture. , ... rapidly-growing group of websites that help bring cannabis businesses and ...
Breaking Medicine News(10 mins):Health News:EB Medicine Partners With AgileMD on Mobile Application for Emergency Medicine Clinicians 2Health News:EB Medicine Partners With AgileMD on Mobile Application for Emergency Medicine Clinicians 3Health News:Donate Life America and Genentech have Partnered to Develop the “Play Through with Erik Compton to Donate Life" Public Service Announcement 2Health News:PricingHealthcare.com Adds Facilities in 5 States, Hits 10,000 Monthly Users Milestone 2Health News:PricingHealthcare.com Adds Facilities in 5 States, Hits 10,000 Monthly Users Milestone 3Health News:Amercanex, Native Roots form Exclusive Relationship to facilitate Wholesale Business 2Health News:Amercanex, Native Roots form Exclusive Relationship to facilitate Wholesale Business 3Health News:The WeedLife Network Marks the Marijuana Culture’s 420 Celebrations by Offering Steep Advertising Discounts 2Health News:The WeedLife Network Marks the Marijuana Culture’s 420 Celebrations by Offering Steep Advertising Discounts 3
... PAT System, Tied Directly ... to Increased Production Efficiency, NEW ORLEANS, March ... challenges that couldn,t previously be,solved, Waters Corporation (NYSE: WAT ... on Analytical Chemistry and,Applied Spectroscopy, March 2 - 6, 2008 ...
... Barras of Nederland,Texas, along with her husband and ... because she has developed mesothelioma from,washing and handling ... are represented by Dallas-based Baron & Budd, P.C., ... refinery worker at the,Beaumont DuPont facility between 1957 ...
... Institute of Diabetes and Digestive and Kidney Diseases ... information to raise awareness about diabetes, digestive diseases, ... yet diagnosed with these illnesses. The NIDDK developed ... fairs, workplace health forums, family reunions, and other ...
... 2008) New high-throughput methods are revolutionizing our ... Cold Spring Harbor Protocols ( www.cshprotocols.org/TOCs/toc3_08.dtl ) ... genes on and off. Both methods are freely ... Harbor Protocols ( www.cshprotocols.org ). , Our knowledge ...
... 3 Park Dental, a Twin Cities area,group ... the Minnesota Dental,community for 40-years, announced today that ... separating its practice from its Boston, Massachusetts-based,administrative services ... is the result of the settlement of a ...
... United,States has been fortifying some foods with folic acid (the ... public health effort to prevent neural,tube defects in newborns. The ... down by 30%. But there,s also evidence that the added ... issue of,Harvard Women,s Health Watch., In the early years ...
Cached Medicine News:Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 2Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 3Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 4Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 5Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 6Health News:Woman Sues DuPont and Asbestos Manufacturers After Developing Mesothelioma From Exposure to Asbestos in Husband's Work Clothes 2Health News:Cold Spring Harbor Protocols features high-throughput methods for analyzing gene activity 2Health News:Park Dental Announces Separation From Its Administrative Service Provider 2Health News:Park Dental Announces Separation From Its Administrative Service Provider 3Health News:Folic Acid in the Food Supply Reduces Birth Defects, but May Cause Extra Cancers, Reports the Harvard Women's Health Watch 2
(Date:4/1/2015)... April 1, 2015 International Isotopes Inc. (OTCQB: ... year ended December 31, 2014.  The Company reports a ... loss, and positive cash flow for the year ended ... in 2014 was approximately $7.5 million compared to approximately ... approximately 10%.  With the exception of the radiological services ...
(Date:4/1/2015)... 2015 LifeScienceIndustryResearch.com announces ... Industry and 2015 Deep Research Report on ... Pharmaceutical category in its database.  ... basic information, including definition, classification, application, industry ... news analysis, etc. Azithromycin Key Manufacturers Analysis ...
(Date:4/1/2015)... -- Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ... on the development of oral drug delivery systems, announced ... Glucose Clamp Study. The study will be performed at ... San Antonio and University Health System,s ... Ralph DeFronzo . The glucose clamp is ...
Breaking Medicine Technology:International Isotopes Inc. Announces 2014 Year End Financial Results 2International Isotopes Inc. Announces 2014 Year End Financial Results 3International Isotopes Inc. Announces 2014 Year End Financial Results 4International Isotopes Inc. Announces 2014 Year End Financial Results 5International Isotopes Inc. Announces 2014 Year End Financial Results 6International Isotopes Inc. Announces 2014 Year End Financial Results 7Azithromycin Market & Polypeptide Drug Industry - Global Research Reports 2Azithromycin Market & Polypeptide Drug Industry - Global Research Reports 3Azithromycin Market & Polypeptide Drug Industry - Global Research Reports 4Azithromycin Market & Polypeptide Drug Industry - Global Research Reports 5Oramed Enrolls First Patient in its Glucose Clamp Study for Oral Insulin 2Oramed Enrolls First Patient in its Glucose Clamp Study for Oral Insulin 3
... Reportlinker.com announces that a new market research report is available ... http://www.reportlinker.com/p0324750/Virtual-Pharma.html ... in the pharmaceutical market has slowed – almost to a ... cutting costs in a faltering world economy. ...
... NEW YORK, Nov. 3, 2010 Pfizer Inc. (NYSE: ... public to view and listen to a webcast of ... Primary Care, at the 2010 Annual Credit Suisse Healthcare ... Mountain Standard Time. (Logo: http://photos.prnewswire.com/prnh/20100416/PFIZERLOGO) ...
Cached Medicine Technology:Reportlinker Adds Virtual Pharma 2Reportlinker Adds Virtual Pharma 3Reportlinker Adds Virtual Pharma 4Reportlinker Adds Virtual Pharma 5Reportlinker Adds Virtual Pharma 6
This blanket is ideal for warming the large child or small adult during upper body surgery....
The torso blanket is designed to affix to the lower abdominal area and cover the upper half of the body....
The fabric is antistatic and non-linting and is both oil and water repellent.These superior blankets are an environmental friendly alternative to disposable blankets....
The fabric is antistatic and non-linting and is both oil and water repellent.These superior blankets are an environmental friendly alternative to disposable blankets....
Medicine Products: