Navigation Links
Scientists slow brain tumor growth in mice
Date:5/13/2014

Much like using dimmer switches to brighten or darken rooms, biochemists have identified a protein that can be used to slow down or speed up the growth of brain tumors in mice.

Brain and other nervous system cancers are expected to claim 14,320 lives in the United States this year.

The results of the preclinical study led by Eric J. Wagner, Ph.D., and Ann-Bin Shyu, Ph.D., of The University of Texas Health Science Center at Houston (UTHealth) and Wei Li, Ph.D., of Baylor College of Medicine appear in the Advance Online Publication of the journal Nature.

"Our work could lead to the development of a novel therapeutic target that might slow down tumor progression," said Wagner, assistant professor in the Department of Biochemistry and Molecular Biology at the UTHealth Medical School.

Shyu, professor and holder of the Jesse H. Jones Chair in Molecular Biology at the UTHealth Medical School, added, "This link to brain tumors wasn't previously known."

"Its role in brain tumor progression was first found through big data computational analysis, then followed by animal-based testing. This is an unusual model for biomedical research, but is certainly more powerful, and may lead to the discovery of more drug targets," said Li, an associate professor in the Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology at Baylor.

Wagner, Shyu, Li and their colleagues discovered a way to slow tumor growth in a mouse model of brain cancer by altering the process by which genes are converted into proteins.

Appropriately called messenger RNA for short, these molecules take the information inside genes and use it to make body tissues. While it was known that the messenger RNA molecules associated with the cancerous cells were shorter than those with healthy cells, the mechanism by which this occurred was not understood.

The research team discovered that a protein called CFIm25 is cr
'/>"/>

Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. UBC scientists find new way to mobilize immune system against viruses
2. Dartmouth scientists identify genetic blueprint for cancerous tumors of the appendix
3. Scientists decode epigenetic mechanisms distinguishing stem cell function and blood cancer
4. Scientists identify new protein in the neurological disorder dystonia
5. Scientists awarded grant to develop diagnostics for cancer, rheumatoid arthritis, colitis
6. Norwegian neuroscientists elected to National Academy of Sciences
7. NIH scientists establish monkey model of hantavirus disease
8. Stanford scientists create circuit board modeled on the human brain
9. A civil war inside our cells: Scientists show how our bodies fight off jumping genes
10. Scientists find way to target cells resistant to chemo
11. Scientists identify cancer specific cell for potential treatment of gastric cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists slow brain tumor growth in mice
(Date:5/26/2015)... May 26, 2015 Hexagon Geospatial is ... Defence and Space in a new content-sharing program that ... for use in the development of smart applications. ... this partnership combines optical satellite data from Airbus Defence ... tear down the walls between geospatial content, software and ...
(Date:5/26/2015)... (PRWEB) May 26, 2015 i2i Systems, ... solutions for more than 15 years, has earned 2014 ... Committee for Quality Assurance (NCQA) for its flagship product ... are proud of the work we have done to ... grateful for the acknowledgement from NCQA once again,” said ...
(Date:5/26/2015)... 2015 Scientists at the University of ... help advanced mesothelioma patients benefit from immunotherapy; surgery may ... article on the new research. Click here to ... of thoracic surgery and pulmonology theorized that, because large ... system attack, immunotherapy drugs might work better if the ...
(Date:5/26/2015)... 2015 ProTrailer Network is a new ... Pro X . This Effect includes 30 all ... styled text. , ProTrailer Network allows users to ... can easily complement any form of media project. FCPX ... can make professional looking openers. , ProTrailer Network includes ...
(Date:5/26/2015)... 2015 Learning ZoneXpress is excited to ... Education Cards . These cards have been specifically designed ... simple, easy-to-read text, these new educational resources are extremely ... practical nutrition tips and suggestions to clients and provide ... , + MyPlate: Eat for a Healthy Baby Pregnancy ...
Breaking Medicine News(10 mins):Health News:Hexagon Geospatial and Airbus Defense Establish Partnership 2Health News:Hexagon Geospatial and Airbus Defense Establish Partnership 3Health News:i2iTracks Earns NCQA 2014 PCMH Prevalidation 2Health News:i2iTracks Earns NCQA 2014 PCMH Prevalidation 3Health News:Researchers Say Surgery May Restore Effectiveness of Immunotherapy for Mesothelioma, According to Surviving Mesothelioma 2Health News:Developers at Pixel Film Studios Release ProTrailer Network for Final Cut Pro X 2Health News:Learning ZoneXpress Introduces New Educational Resource for WIC, SNAP-Ed, and EFNEP 2
... a forewarning from severe periodontal disease than non-diabetic pregnant ... periodontology.// ,Researchers from the University of Iowa Colleges ... and 20 non-diabetic women in their 20-39th week of ... the control of diabetes. They found the diabetics flaunted ...
... men who eat up tomato products more than twice ... prostate cancer. Consuming cooked tomatoes was particularly beneficial, according ... sauce, ketchup and other tomato-based foods lowered the prostate ... ,Dr. Edward Giovannucci of Brigham and Women's Hospital and ...
... transplant patients contracted a dangerous parasitic disease from their ... women died, but only one recovered after antibiotic treatment.// ... Disease Control and Prevention turned up 26 bacterial infections ... in the United States. ,This shows that the ...
... medications than smokers, as the extra weight poses them ... the nation's principal cause of preventable deaths, the surgeon ... ,For a more precise look at the ... from two national health surveys to estimate inpatient and ...
... Getting cold out of doors condenses the blood and increases ... of University of Texas, it has been found that too ... - in Britain. He believes that cold temperatures alter the ... raises the risk of clotting and heart attack. ...
... gender were among the best indicators of how you might ... state-by-state study of prescription drug use, where you live also ... you use. // ,According to the study, the percentage ... ranged from a high of 71 percent in Kansas to ...
Cached Medicine News:Health News:Prescription Drug Use Varies Widely Between States 2
(Date:5/26/2015)... May 26, 2015 For the ... Quality of Life Throughout Europe, the Middle ... Astellas Pharma EMEA is celebrating its 10 ... through the historic merger of Japanese pharmaceutical companies Yamanouchi ... committed to turning science into value for patients through ...
(Date:5/22/2015)... May 22, 2015  Research and Benchmarking firm, ... Medical Affairs Roundtable on Thursday, May ... virtual roundtable to discuss "Medical Affairs, Role in ... Practices, Medical Affairs Consortium provides Medical Affairs leaders ... key challenges they face. The consortium has developed ...
(Date:5/22/2015)... OAKS, Calif. , May 22, 2015 ... announced the Company has commenced termination of ... of brodalumab with AstraZeneca (LON:AZN, STO:AZN and ... IL-17 inhibitor, is in development for patients ... axial spondyloarthritis.  The decision was based on ...
Breaking Medicine Technology:Astellas Pharma EMEA Celebrates Its 10th Anniversary 2Astellas Pharma EMEA Celebrates Its 10th Anniversary 3Astellas Pharma EMEA Celebrates Its 10th Anniversary 4Best Practices Sixth Medical Affairs Consortium Roundtable to Focus on Health Economics & Outcomes Research 2Amgen to terminate participation in co-development and commercialization of brodalumab 2Amgen to terminate participation in co-development and commercialization of brodalumab 3Amgen to terminate participation in co-development and commercialization of brodalumab 4Amgen to terminate participation in co-development and commercialization of brodalumab 5
... The Pittsburgh Life Sciences Greenhouse (PLSG), ... formation and business growth programs to the region,s ... President and Chief Executive Officer, John W. ... signing an agreement with Ortho-McNeil-Janssen Pharmaceuticals, a Johnson ...
... Pa. , June 22 TheraQuest Biosciences, Inc., a ... TheraQuest also announced the launch of its new corporate website at ... , ... a careful strategic review of our pipeline, we have realigned our ...
Cached Medicine Technology:The Pittsburgh Life Sciences Greenhouse Congratulates Diamyd Medical on Its Agreement with Ortho-McNeil-Janssen Pharmaceuticals to Develop Diabetes Therapy 2TheraQuest Unveils New Pain Management Product Pipeline 2TheraQuest Unveils New Pain Management Product Pipeline 3TheraQuest Unveils New Pain Management Product Pipeline 4TheraQuest Unveils New Pain Management Product Pipeline 5
Part of the Octopus System which includes both the Starfish & Octopus3. The Octopus3 Tissue Stabilizer is the pioneering and market-leading suction device....
... way to lift the heart - Guidant's ... 3. The XPOSE 3 is designed to ... surgery and to easily position and access ... both apical and non-apical placement on the ...
... The CLEARGLIDE Optical Vessel Dissector has application ... operative cavity in the extraperitoneal spaces such ... The device may be used in surgical ... EVH system enables harvesting of a quality ...
The MicroMed DeBakey VAD is a miniaturized heart pump designed to provide increased blood flow (up to 10L/min) from the left ventricle of the heart throughout the body for patients in end stage heart...
Medicine Products: