Navigation Links
Scientists map elusive 3-D structure of telomerase enzyme, key actor in cancer, aging
Date:4/12/2013

identified telomerase and telomeres, leading to the 2009 Nobel Prize in medicine or physiology. Research on Tetrahymena telomerase in the lab of co-senior author Kathleen Collins, a professor of molecular and cell biology at UC Berkeley, laid the genetic and biochemical groundwork for the structure to be solved.

"The success of this project was absolutely dependent on the collaboration among our research groups," said Feigon.

"At every step of this project, there were difficulties," she added. "We had so many technical hurdles to overcome, both in the electron microscopy and the biochemistry. Pretty much every problem we could have, we had, and yet at each stage these hurdles were overcome in an innovative way."

One of the biggest surprises, the researchers said, was the role of the protein p50, which acts as a hinge in Tetrahymena telomerase to allow dynamic movement within the complex; p50 was found to be an essential player in the enzyme's activity and in the recruitment of other proteins to join the complex.

"The beauty of this structure is that it opens up a whole new world of questions for us to answer," Feigon said. "The exact mechanism of how this complex interacts with the telomere is an active area of future research."

"The atmosphere and collaboration at UCLA really amazes me, and that is combined with some of the most advanced facilities around," Zhou said. "We have a highly advanced electron microscopy facility here at UCLA that even researchers without a strong background in electron microscopy can learn how to use and benefit from. This will be really useful as we move forward."


'/>"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists discover gene mutation that causes children to be born without spleen
2. Unusual suspect: Hopkins scientists find second fiddle proteins role in Type 2 diabetes
3. Polio eradication is achievable by 2018 and urgent, declare 400+ global scientists
4. Scientists create phantom sensations in non-amputees
5. Scientists Map Genome for Dutch Elm Disease Fungus
6. Could Scientists Peek Into Your Dreams?
7. CWRU-led scientists build material that mimics squid beak
8. Singapore clinician-scientists identify new type of deadly lymphoma
9. Kessler Foundation scientists receive Consortium of MS Centers grant to study emotional processing
10. Scientists identify brains molecular memory switch
11. Dana-Farber Scientists find potential loophole in pancreatic cancer defenses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Amy Norton HealthDay Reporter , ... on the three Ebola cases in Dallas. But, mental health ... to Americans. President Barack Obama on Friday appointed an ... which has infected two Dallas nurses who cared for a ... Health Presbyterian Hospital. But the U.S. cases are miniscule ...
(Date:10/22/2014)... With the Affordable Care Act (ACA) open enrollment period ... for Research (AIR) finds that three out of four Americans ... 42 percent say they are not likely or only somewhat ... coverage. , The AIR survey found wide gaps in Americans’ ... correctly how much they owe for a routine doctor’s visit. ...
(Date:10/22/2014)... 2014 Although there are only 24 hours in ... people who have trouble finding time within their busy schedules for ... long periods of time to get in shape. Here are five ... the go. , Change Up Your Commute , Consider riding ... add some exercise into your daily routine. If you must use ...
(Date:10/22/2014)... Maureen Salamon HealthDay ... Black women undergoing in vitro fertilization (IVF) are only about ... the popular assisted reproduction technique, new research indicates, and the ... In the study, about 31 percent of white patients became ... patients. Analyzing more than 4,000 IVF cycles over two ...
(Date:10/22/2014)... Dennis Thompson HealthDay Reporter , ... on Monday officially tightened guidelines for health workers treating Ebola ... and use of a respirator at all times. The ... the tougher rules after two Dallas nurses contracted Ebola while ... States, Liberian national Thomas Eric Duncan. Nina Pham is currently ...
Breaking Medicine News(10 mins):Health News:Ebola Anxiety: A Bigger Threat Now Than the Virus Itself 2Health News:Ebola Anxiety: A Bigger Threat Now Than the Virus Itself 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3
... variety', wrote the famous Dramatist and Poet, William Shakespeare in ... is quite an enigma and undoubtedly, there is more to ... sex' or the 'fair sex', they often find themselves at ... has endowed unique qualities in a man and woman, so ...
... simple way of cutting heart disease and stroke risk, ... by heart experts, folic acid could lower homocysteine concentrations ... be a cause of cardiovascular disease, reported Newswise wire. ... School of Medicine and Barts Hospital, London, examined all ...
... Researchers have cloned a gene from wild wheat that ... the grain, offering solutions to //nutritional deficiencies that affect ... California conducted the research along with Davis; the U.S. ... Israel and the results were published in the Nov. ...
... Health Canada has warned women strongly about the side effects ... off //the development of severe blood clots in the ... ethinyl estradiol is available in the U.S with more ... this birth control patch has been linked with a higher ...
... Kingdom of Saudi Arabia have taken a decision that all ... and vaccination status should receive at least one dose of ... decision was conveyed to the Ministry of Health and Family ... ,The Ministry of Health & Family Welfare has ...
... the first patient in the United States in a study ... type of brain// tumor. ,The international, multi-center trial ... the tumor, radiotherapy or chemotherapy -- to that treatment combined ... directly to the surface of the head. ,"This ...
Cached Medicine News:Health News:Men are from Mars and Women from Venus, but why on Earth are Women so Woefully Wronged? 2Health News:Men are from Mars and Women from Venus, but why on Earth are Women so Woefully Wronged? 3Health News:Newly Cloned Wheat Gene May Boosts Foods' Nutrient Contents – Says A Researc 2Health News:University Evaluates New Device To Treat Brain Tumors 2
(Date:10/20/2014)... Oct. 20, 2014 Valeritas, Inc., a leader ... patients with Type 2 diabetes, announced today that it ... Award. The award was presented October 16 th ... Columbus, Ohio . The Cardinal ... a variety of metrics specifically targeted at the importance ...
(Date:10/20/2014)... , Oct. 20, 2014  AnaptysBio, Inc., ... therapeutic antibodies, today announced the appointment of ... Dr. Londei will lead the preclinical and clinical ... "We are pleased to welcome Dr. Londei ... Suria , President and Chief Executive Officer of ...
(Date:10/20/2014)... 2014 Lpath, Inc. (NASDAQ: ... therapeutics, received official notification from the European Patent Office ... patent supporting its iSONEP™ and ASONEP™ programs. ... No. 2087002, claims compositions of matter related to ... compounds, iSONEP and ASONEP. Sonepcizumab is an antibody ...
Breaking Medicine Technology:Valeritas Receives 2014 Cardinal Health Supply Chain Excellence Award 2Valeritas Receives 2014 Cardinal Health Supply Chain Excellence Award 3AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 2Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 3Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 4
... Bio-Rad isotopic anemia ... and minimal ,pipetting steps ... information about the processes ... and the benefit to ...
... an enzyme-linked immunosorbent assay (ELISA) for the ... human serum. The presence of ANA can ... and other laboratory tests to aid in ... systemic lupus erythematosus, Sjgren's syndrome, scleroderma, and ...
... Screen ELISA test system is a qualitative screening ... human sera. When performed according to the directional ... all ANAs commonly tested for, such as those ... SSA, SSB, and Scl-70. The test is also ...
... change to the ELISA methodology for their ANA ... IFA and many user friendly features provide an ... currently on the market is capable of 100% ... been shown to be quite effective at detecting ...
Medicine Products: