Navigation Links
Scientists map elusive 3-D structure of telomerase enzyme, key actor in cancer, aging
Date:4/12/2013

Like finally seeing all the gears of a watch and how they work together, researchers from UCLA and UC Berkeley have, for the first time ever, solved the puzzle of how the various components of an entire telomerase enzyme complex fit together and function in a three-dimensional structure.

The creation of the first complete visual map of the telomerase enzyme, which is known to play a significant role in aging and most cancers, represents a breakthrough that could open up a host of new approaches to fighting disease, the researchers said.

"Everyone in the field wants to know what telomerase looks like, and there it was. I was so excited, I could hardly breathe," said Juli Feigon, a UCLA professor of chemistry and biochemistry and a senior author of the study. "We were the first to see it."

The scientists report the positions of each component of the enzyme relative to one another and the complete organization of the enzyme's active site. In addition, they demonstrate how the different components contribute to the enzyme's activity, uniquely correlating structure with biochemical function.

The research appears April 11 in the print edition of the journal Nature and is available online.

"We combined every single possible method we could get our hands on to solve this structure and used cutting-edge technological advances," said co-first author Jiansen Jiang, a researcher who works with Feigon and the study's co-senior author, Z. Hong Zhou, director of the Electron Imaging Center for Nanomachines at the California NanoSystems Institute at UCLA and a professor of microbiology, immunology and molecular genetics. "This breakthrough would not have been possible five years ago."

"We really had to figure out how everything fit together, like a puzzle," said co-first author Edward Miracco, a National Institutes of Health postdoctoral fellow in Feigon's laboratory. "When we started fitting in the high-re
'/>"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists discover gene mutation that causes children to be born without spleen
2. Unusual suspect: Hopkins scientists find second fiddle proteins role in Type 2 diabetes
3. Polio eradication is achievable by 2018 and urgent, declare 400+ global scientists
4. Scientists create phantom sensations in non-amputees
5. Scientists Map Genome for Dutch Elm Disease Fungus
6. Could Scientists Peek Into Your Dreams?
7. CWRU-led scientists build material that mimics squid beak
8. Singapore clinician-scientists identify new type of deadly lymphoma
9. Kessler Foundation scientists receive Consortium of MS Centers grant to study emotional processing
10. Scientists identify brains molecular memory switch
11. Dana-Farber Scientists find potential loophole in pancreatic cancer defenses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... 01, 2015 , ... USA Medical Card, a leading distributor ... coincide with back-to-school and the start of “sick season” for many households across ... children are sick an average of 8 to 12 times each school year. ...
(Date:9/1/2015)... ... September 01, 2015 , ... AdvantagePlusCaregivers.com® provides information on defining ... what to look for and expect when searching for resources, as well as ... Canoga Park, CA by CEO, Richard Weatherman and Co-Founder Piroska Zalkadi, AdvantagePlusCaregivers.com® grew ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... communications archiving solution integrated with Alfresco‘s enterprise content management system. PRO Archiver ... save millions of dollars in printing costs by digitizing vast amounts of ...
(Date:9/1/2015)... ... 01, 2015 , ... Elizabeth Callahan, MD, founder and medical director of ... to offer RADIESSE® filler treatment for volume loss in the hands. RADIESSE provides an ... in the hands, delivering smooth, natural-looking results that can last up to one year ...
(Date:9/1/2015)... ... September 01, 2015 , ... A new episode of “Voices ... take a look at the topic of arthritis. There are over 100 different types ... interesting arthritis types and statistics in an effort to shed light on this important ...
Breaking Medicine News(10 mins):Health News:USA Medical Card Launches New FAQ Video During Back-to-School 2Health News:AdvantagePlusCaregivers.com® Launches New Website for Corporate and Franchisee Locations in 3 States 2Health News:Introducing Next-Generation Archiving Solution PRO Archiver for Alfresco® 2Health News:Introducing Next-Generation Archiving Solution PRO Archiver for Alfresco® 3Health News:SkinSmart Dermatology in Sarasota is Now Offering RADIESSE to Rejuvenate Hands 2Health News:SkinSmart Dermatology in Sarasota is Now Offering RADIESSE to Rejuvenate Hands 3
... an issue than youngsters, tastes, studies find, , , MONDAY, April ... issue of supply than demand in the poorest parts of ... children in these rural areas are open to eating more ... not readily available and could become even less so if ...
... published in the April issue of the Journal ... large numbers of physician assistants and nurse practitioners ... hired by general surgery residency programs in the last ... these professionals continue to be in demand. Most have ...
... of Fit by Sara and Susan G. Komen for the Cure, ... DIEGO, April 20 Word is spreading about YOGA 4 THE ... have gathered together to stretch, deep breathe and meditate. Along ... $1,000 in donations for breast cancer. Susan G. Komen for the ...
... 20 The 7th annual FedEx/St. ... 16, 2009 at 7:00 p.m. at the InterContinental Miami Hotel ... premier pediatric cancer research centers. This year,s event will honor ... Thalia , for their generous support of children in need ...
... PAUL, Minn., April 20 More than 2,000 letter carriers ... Out Hunger on May 9, 2009 in an effort ... by the recession. Stamp Out Hunger is the ... locally supports Second Harvest Heartland, the Upper Midwest,s largest hunger-relief ...
... Australia and Israel has identified a genetic variation that ... The finding is published in the latest edition of ... Helen Leonard, who heads the Australian Rett Syndrome Study ... the finding was exciting in that it identifies a ...
Cached Medicine News:Health News:Kids and Veggies: Offer Them and They Will Eat 2Health News:Surgical education programs have demand for physician assistants and nurse practitioners 2Health News:YOGA 4 THE CURE Raises $1,000 for Breast Cancer 2Health News:YOGA 4 THE CURE Raises $1,000 for Breast Cancer 3Health News:7th Annual FedEx/St. Jude Angels & Stars Gala Announces 2009 Honorees Tommy Mottola & Thalia 2Health News:7th Annual FedEx/St. Jude Angels & Stars Gala Announces 2009 Honorees Tommy Mottola & Thalia 3Health News:7th Annual FedEx/St. Jude Angels & Stars Gala Announces 2009 Honorees Tommy Mottola & Thalia 4Health News:Letter Carriers to Deliver Hope for Those Impacted by Economy 2Health News:Letter Carriers to Deliver Hope for Those Impacted by Economy 3Health News:New insight into Rett syndrome severity 2
(Date:9/1/2015)... Belgium , Sept. 1, 2015 VolitionRx ... on developing blood-based diagnostic tests for a broad range of ... Executive Officer, Cameron Reynolds , is scheduled to attend ... is being held September 9-10, 2015 in Boston, ... on September 10. Wells Fargo Securities Research ...
(Date:9/1/2015)... , Sept. 1, 2015 Sargas ... Management (CCM) and Drug Adherence m Health applications ... automate the process of non face-to-face monitoring of ... this new release of our apps, doctors are ... services along with our ONCHIT certified Physician, Pharmacy ...
(Date:9/1/2015)... Sept. 1, 2015   Ivenix Inc. , ... management system, closed on a $42M round of ... Ventures. Cardinal Partners, CICA, Inc., Easterly Capital, Fidelity ... the round. This financing will support the company,s ... Leerink Partners LLC acted as the exclusive placement ...
Breaking Medicine Technology:VolitionRx to Attend 10th Annual Wells Fargo Healthcare Conference on September 9-10, 2015 2VolitionRx to Attend 10th Annual Wells Fargo Healthcare Conference on September 9-10, 2015 3VolitionRx to Attend 10th Annual Wells Fargo Healthcare Conference on September 9-10, 2015 4SPAC International's Drug Adherence and Chronic Care Management App Now available at Apple App and Google Play stores 2Ivenix Inc. Secures $42 Million in Funding 2Ivenix Inc. Secures $42 Million in Funding 3
... telangiectasia-like disease and Nijmegen breakage syndrome offer ... and cancer vulnerability in people carrying the ... Scientists at St. Jude Children,s Research Hospital ... two related neurological diseases--ataxia telangiectasia-like disease (ATLD) ...
... MannKind Corporation (Nasdaq: MNKD ) ... equivalence of its commercial inhaler to the version of ... deliver AFRESA(TM), MannKind,s ultra rapid acting insulin that recently ... Bioequivalence of Clinical and Commercial Scale Inhalers Study 138 ...
Cached Medicine Technology:Study Shows How Defective DNA Repair Triggers Two Neurological Diseases 2Study Shows How Defective DNA Repair Triggers Two Neurological Diseases 3MannKind Reports Successful Completion of Device Bioequivalence Trial 2MannKind Reports Successful Completion of Device Bioequivalence Trial 3
... Chamber Lenses: The Bausch & Lomb PMMA Posterior ... for primary implantation for the visual correction of ... older where a cataractous lens has been removed ... to be placed in the ciliary sulcus or ...
... are manufactured using the highest ... CQ UV PMMA material is ... single piece lenses. Unioptic lens ... nonphaco and phaco styles. All ...
... STAARVISC II is a sterile nonpyrogenic, ... hyaluronate. STAARVISC II contains 12 mg/ml of ... daltons) sodium hyaluronate dissolved in physiological saline. ... the viscosity is 105,000 cps (105 Pa ...
... viscoelastic agent for the surgeon who performs ... Amvisc possesses sufficient viscosity for excellent chamber ... cohesive so that complete removal at the ... quickly accomplished. Amvisc is priced to compete ...
Medicine Products: