Navigation Links
Scientists map elusive 3-D structure of telomerase enzyme, key actor in cancer, aging
Date:4/12/2013

Like finally seeing all the gears of a watch and how they work together, researchers from UCLA and UC Berkeley have, for the first time ever, solved the puzzle of how the various components of an entire telomerase enzyme complex fit together and function in a three-dimensional structure.

The creation of the first complete visual map of the telomerase enzyme, which is known to play a significant role in aging and most cancers, represents a breakthrough that could open up a host of new approaches to fighting disease, the researchers said.

"Everyone in the field wants to know what telomerase looks like, and there it was. I was so excited, I could hardly breathe," said Juli Feigon, a UCLA professor of chemistry and biochemistry and a senior author of the study. "We were the first to see it."

The scientists report the positions of each component of the enzyme relative to one another and the complete organization of the enzyme's active site. In addition, they demonstrate how the different components contribute to the enzyme's activity, uniquely correlating structure with biochemical function.

The research appears April 11 in the print edition of the journal Nature and is available online.

"We combined every single possible method we could get our hands on to solve this structure and used cutting-edge technological advances," said co-first author Jiansen Jiang, a researcher who works with Feigon and the study's co-senior author, Z. Hong Zhou, director of the Electron Imaging Center for Nanomachines at the California NanoSystems Institute at UCLA and a professor of microbiology, immunology and molecular genetics. "This breakthrough would not have been possible five years ago."

"We really had to figure out how everything fit together, like a puzzle," said co-first author Edward Miracco, a National Institutes of Health postdoctoral fellow in Feigon's laboratory. "When we started fitting in the high-re
'/>"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists discover gene mutation that causes children to be born without spleen
2. Unusual suspect: Hopkins scientists find second fiddle proteins role in Type 2 diabetes
3. Polio eradication is achievable by 2018 and urgent, declare 400+ global scientists
4. Scientists create phantom sensations in non-amputees
5. Scientists Map Genome for Dutch Elm Disease Fungus
6. Could Scientists Peek Into Your Dreams?
7. CWRU-led scientists build material that mimics squid beak
8. Singapore clinician-scientists identify new type of deadly lymphoma
9. Kessler Foundation scientists receive Consortium of MS Centers grant to study emotional processing
10. Scientists identify brains molecular memory switch
11. Dana-Farber Scientists find potential loophole in pancreatic cancer defenses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2015)... Pasadena porcelain veneers dentist, Dr. ... cosmetic treatments. Cosmetic dentistry is becoming increasingly popular in ... are committed to providing you with the highest level ... and a smile of a lifetime … We work ... to change your life,” explains Dr. Martirosyan’s team. “Giving ...
(Date:5/26/2015)... May 26, 2015 Indosoft, Inc ... upgrade of the DMi Partners contact center ... the first in Indosoft's contact center ACD system to ... screen support for such trunk features as diversion headers, ... management, and included upgrades to warm transfers ...
(Date:5/26/2015)... May 26, 2015 National Prevention Week ... year. It is supported by the Substance Abuse ... raising public awareness of, and action about, substance abuse ... organizations and coalitions are encouraged to join in promoting ... and related issues, and in building community partnerships. , ...
(Date:5/26/2015)... i2i Systems, the leader in integrated Population ... years, has earned 2014 Patient Centered Medical Home prevalidation ... for its flagship product i2iTracks , the company ... we have done to create healthier populations for so ... NCQA once again,” said Janice Nicholson, co-founder and CEO ...
(Date:5/26/2015)... Award-winning travel photographer and life coach Raul Espinoza creates ... connect viewers to the beauty of the world while making ... Raul has traveled the world documenting lives, and then shared ... bounded by our circumstances. , “KAWSAY” means “life” ... The photo gallery show by the same name will support ...
Breaking Medicine News(10 mins):Health News:Pasadena Porcelain Veneers Expert, Marine Martirosyan DDS, is Now Offering Complimentary Dental Cleaning with Cosmetic Treatments 2Health News:DMi Partners Upgrades to Indosoft Q-Suite 5.8 2Health News:DMi Partners Upgrades to Indosoft Q-Suite 5.8 3Health News:Narconon Arrowhead Takes Part in National Prevention Week 2Health News:Narconon Arrowhead Takes Part in National Prevention Week 3Health News:i2iTracks Earns NCQA 2014 PCMH Prevalidation 2Health News:i2iTracks Earns NCQA 2014 PCMH Prevalidation 3Health News:A Photographer & Two Educational Organiazations Join to Make a Difference in Our Youth 2
... Life Sciences has submitted an application with the Drug ... phase-1 clinical trials of its new drug Suvn-502 for ... ,'Treatment for Alzheimer's disease and Schizophrenia is ... to discover drugs that address significant unmet medical needs,' ...
... Nepalese doctors has developed a drug that is more ... reported Friday . ,The drug also costs ... Organization (WHO), reported The Himalayan Times daily.Doctors at the ... typhoid patients. ,,The team compared the effectiveness ...
... 1,763 food shipments from India, 1,480 from Mexico and 1,368 ... year . ,Some of India's spices, seeds and ... found too filthy to eat. Chinese products like seafood, bean ... has reported. ,,But the FDA did not reveal the ...
... for the high-tech dental lasers used mainly to prepare cavities ... conducted by researchers in Austria, these advanced dental lasers can ... study credits the progress of miniaturized, flexible fiber tips for ... treatment. ,Dr. Ulrich Schoop and a team of ...
... on the Yamuna River that flows past India's capital, it's easy ... surface by rotting sewage -- and that's after at least ... ,Now, with New Delhi to host the Commonwealth Games in ... built on the stinking river's banks, India must do in three ...
... the end of the last century death rates from breast ... Long waiting lists, resulting in delayed diagnosis and treatment, were ... is failing breast cancer patients and needs to be reviewed ... brought in the 2 week wait rule which stipulated that ...
Cached Medicine News:Health News:US Rejects More Food from India Than from Any Other Country 2Health News:Millions Spent, but the Indian Capital's River Still Stinks 2Health News:Millions Spent, but the Indian Capital's River Still Stinks 3Health News:Two Week Wait Rule Not Working With Breast Cancer Patients 2
(Date:5/26/2015)... Research and Markets ... of the "North American Computerized Physician ... Physician Order Entry, Standalone Computerized Physician Order ... Forecast to 2019 " report to ... , The North American computerized ...
(Date:5/26/2015)... May 26, 2015  EndoChoice today announced the launch ... its common stock, which will represent 25.6% of its ... Delaware corporation in connection with the ... to be between $15 and $17 per share. The ... option to purchase up to an additional 937,500 shares ...
(Date:5/26/2015)... May 26, 2015  Advanzeon Solutions, Inc. (OTC:BB: ... Management Solutions, Inc. ("PVMS"), (sometimes, collectively referred to ... Mr. Matt Capps has joined the ... to the Company,s Community Outreach Programs.  Mr. Capps ... This engagement provides for Mr. Capps to form ...
Breaking Medicine Technology:North American Computerized Physician Order Entry Market 2015-2019 2EndoChoice Announces Launch of Its Initial Public Offering 2Advanzeon Solutions, Inc. And Its Wholly-Owned Subsidiary, Pharmacy Value Management Solutions, Inc., Welcome Major League Baseball Great Matt Capps As Senior Public Relations Consultant 2Advanzeon Solutions, Inc. And Its Wholly-Owned Subsidiary, Pharmacy Value Management Solutions, Inc., Welcome Major League Baseball Great Matt Capps As Senior Public Relations Consultant 3Advanzeon Solutions, Inc. And Its Wholly-Owned Subsidiary, Pharmacy Value Management Solutions, Inc., Welcome Major League Baseball Great Matt Capps As Senior Public Relations Consultant 4
... June 22 The SCOOTER Store today announced a major milestone, ... delivery of a power wheelchair to Earvin Thompson of ... from the nation,s leading provider of power mobility equipment, will enjoy more ... , , ...
... GRONINGEN, The Netherlands , ... the Netherlands , announced this week that in ... it has obtained outstanding,results for the treatment of inhalation ... be achieved with extended time to treatment (48h post,infection) ...
Cached Medicine Technology:The SCOOTER Store Marks Half-Millionth Life Changed 2The SCOOTER Store Marks Half-Millionth Life Changed 3The SCOOTER Store Marks Half-Millionth Life Changed 4Survival Rate Up to 100% for Late Stage Treatment of Anthrax Infections 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: