Navigation Links
Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
Date:5/14/2012

rs coming to Singapore to work in NCCS laboratories.

Professor Teh said the study will pave the way for a better understanding of the roles that newly identified genes play in the development of bile duct cancer.

"This discovery adds depth to what we currently know about bile duct cancer," said Teh. "More important is that we are now aware of new genes and their effects on bile duct cancer, and we now need to further examine their biological aspects to determine how they bring about the onset of Cholangiocarcinoma."

Using state of the art DNA sequencing, the researchers analysed eight bile duct cancers and normal tissues from Thai patients, and discovered mutations in 187 genes. The team then selected 15 genes that were frequently mutated for further analysis in an additional 46 cases. Many of these genes, such as MLL3, ROBO2 and GNAS, have not been previously implicated in bile duct cancers.

"With this finding we now know much more about the molecular mechanisms of the disease and we can draw up additional measures that can be taken while we identify the most appropriate treatment protocols. We are talking about the potential to save many lives in Thailand," said Professor Vajarabhongsa Bhudhisawasdi, Director of the Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University of Thailand. "Also, this study shows that we can work closely with our counterparts in other countries and share our expertise and experience to improve the lot for the people."

The researchers also compared the bile duct cancers to other related cancers of the liver and pancreas. Surprisingly, they found that the bile ducts cancers shared certain similarities with pancreatic cancer.

"This research provides a strong direction for future studies," said Associate Professor Patrick Tan, faculty member of the Cancer and Stem Cell Biology Programme at the Duke-NUS. "Cholangiocarcinoma and Pancreatic Duct Adenocarcinoma appear to
'/>"/>

Contact: Tim Hawkins
tim.hawkins@vai.org
616-234-5519
Van Andel Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... (PRWEB) March 31, 2015 St. Joseph ... growing network of leading healthcare systems, major physician groups ... information for the benefit of patients. The health information ... that supports well coordinated care throughout the continuum of ... a long tradition of providing services to a broad ...
(Date:3/31/2015)... Juvent Sports ( http://www.juventsports.com ) recently ... show in Orlando. At the show, former LPGA golf ... was interviewed and she shared the life-changing physical improvements ... began integrating the Juvent Pro Micro-Impact Platform™ into her ... instrumental to her chronic back pain recovery that it ...
(Date:3/31/2015)... (PRWEB) March 31, 2015 An individual’s ... most important ligaments in the leg providing stability, load ... their study at today’s Specialty Day meeting of the ... utilized MRI data to determine the potential for biologic ... currently understood about the healing of meniscus tears when ...
(Date:3/31/2015)... Bend, Indiana (PRWEB) March 31, 2015 ... Lee DeRose in Youngstown, Ohio in 1987. ... of the curve with not just customer satisfaction, ... has been added to the well-stocked arsenal of ... manufactured by American Green Technology® (AGT). The patented ...
(Date:3/31/2015)... Wis. (PRWEB) March 31, 2015 For ... patients and a faster return on their investment, ... composition analyzer at Obesity Medicine 2015, April 8-12 at ... busy weight loss centers and medical offices, Rice Lake’s ... a health assessment tool. Obesity Medicine 2015 delivers clinical ...
Breaking Medicine News(10 mins):Health News:St. Joseph Medical Center Joins Other Leading Healthcare Systems Participating in Greater Houston Healthconnect 2Health News:Former LPGA Tour Winner Maggie Will Discovers The Juvent Micro-Impact Platform as a Pain Relief Breakthrough and Performance Enhancer 2Health News:Former LPGA Tour Winner Maggie Will Discovers The Juvent Micro-Impact Platform as a Pain Relief Breakthrough and Performance Enhancer 3Health News:New Way to Evaluate Meniscus Tear Outcomes 2Health News:American Green Technology® Signs Exclusive Agreement to Distribute Health Risk Management System in Midwest 2Health News:Rice Lake Weighing Systems’ Body Composition Analyzer On Display at Obesity Medicine 2015 2
... (HealthDay News) -- A possible new risk factor for death ... The study of almost 1,300 people aged 65 and ... smoothly the heart rate returns to normal after a premature ... follow-up, abnormal heart rate turbulence was associated with an eight ...
... News) -- Americans living in parts of Appalachia and ... in their free time, according to federal government estimates ... likely to be physically active during leisure time are ... rates are 29.2 percent or greater for more than ...
... of regulatory T cells in the tumors of breast cancer ... long been unclear. Now new research at the ... regulatory T cells, whose job is to help mediate the ... and intensify the spread of breast cancer to distant organs ...
... is available in German . , ... and Efficiency in Health Care (IQWiG) published the results ... on coronary heart disease (CHD). The aim of the ... of high methodological quality that may be relevant for ...
... Hospital (MGH) study has identified a new role for an ... metastases. Published in the early edition of Proceedings ... how focal adhesion kinase (FAK) is involved in producing areas ... part of the premetastatic process and increases expression of ...
... in clinical trials expect that their personal information will ... Khaled El-Emam, Canada Research Chair in Electronic Health Information ... practices used to transfer and share sensitive files were ... Are Passwords Used to Protect Personal Health Information in ...
Cached Medicine News:Health News:Appalachia, the South Home to Least-Active Americans: CDC 2Health News:Key culprit identified in breast cancer metastasis 2Health News:DMP for coronary heart disease: Current guidelines indicate some need for revision 2Health News:DMP for coronary heart disease: Current guidelines indicate some need for revision 3Health News:Enzyme helps prepare lung tissue for metastatic development 2Health News:Study reveals security weaknesses in file-sharing methods used in clinical trials 2
(Date:3/31/2015)... N.C. , March 31, 2015 PGI ... capabilities in North America at ... facility. The anticipated plant expansion is centered ... a need for differentiated products for personal care product ... state-of-the-art printing capabilities with in-line slitting and packaging, will ...
(Date:3/31/2015)... Israel, March 31, 2015  Galmed Pharmaceuticals Ltd. ... company focused on the development and commercialization of ... liver diseases and cholesterol gallstones, today announced financial ... 2014. Fourth Quarter 2014 Highlights: ... a keynote address by Professor Rohit Loomba, MD, ...
(Date:3/31/2015)... , Mar. 27, 2015 Research and Markets ... addition of the "European Laboratory Information System ... by Type (Clinical Pathology Laboratory Information System, Anatomic ... report to their offering. The ... grow at a CAGR of 7.6% from 2014 ...
Breaking Medicine Technology:PGI Expands Manufacturing Capabilities At Mexico Plant 2Galmed Pharmaceuticals Reports Full Year 2014 Financial Results and Provides Business Update 2Galmed Pharmaceuticals Reports Full Year 2014 Financial Results and Provides Business Update 3Galmed Pharmaceuticals Reports Full Year 2014 Financial Results and Provides Business Update 4Galmed Pharmaceuticals Reports Full Year 2014 Financial Results and Provides Business Update 5Galmed Pharmaceuticals Reports Full Year 2014 Financial Results and Provides Business Update 6Galmed Pharmaceuticals Reports Full Year 2014 Financial Results and Provides Business Update 7Galmed Pharmaceuticals Reports Full Year 2014 Financial Results and Provides Business Update 8European Laboratory Information System Market Report 2015: Germany holds a larger share of the laboratory information systems market 2European Laboratory Information System Market Report 2015: Germany holds a larger share of the laboratory information systems market 3
... Vista Partners announced today that it has updated coverage ... PRWP ) ("the Company") and maintains its twelve month target ... stated, "DAVANAT®, the Company,s lead product candidate, could potentially enhance ... Avastin® , while also reducing the side effect profile of ...
... Tenn. and MERCER ISLAND, Wash., Dec. 22, 2010 Renal ... to form the third largest provider of dialysis services in ...  The transaction – terms of which were not disclosed – ... 5,300 employees serving more than 19,000 patients in 260 locations ...
Cached Medicine Technology:Vista Partners Updates Coverage on Pro-Pharmaceuticals, Inc.; Maintains Target Price of $2.10 2Renal Advantage and Liberty Dialysis Deal Completed 2Renal Advantage and Liberty Dialysis Deal Completed 3
... Cards. Insert the card and turn on the ... off after the programmed time. The Smart Card ... Simply provide your patient with the appropriate card ... the next visit.,The initial set of programmes covers ...
... ELPHA 4 Conti is a battery operated dual-channel ... of conditions described below. ELPHA 4 Conti also ... STRESS- and faecal incontinence ELPHA 4 Conti provokes ... the user can feel which muscles need exercising. ...
... template is designed for single-use ... the need for cleaning. The ... silicone molded over a metal ... placement while maintaining needle support ...
... The Reusable Template is designed ... a guidance system for prostate brachytherapy. ... on your software match the graphics ... with two pins protruding from lower ...
Medicine Products: