Navigation Links
Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
Date:5/14/2012

rs coming to Singapore to work in NCCS laboratories.

Professor Teh said the study will pave the way for a better understanding of the roles that newly identified genes play in the development of bile duct cancer.

"This discovery adds depth to what we currently know about bile duct cancer," said Teh. "More important is that we are now aware of new genes and their effects on bile duct cancer, and we now need to further examine their biological aspects to determine how they bring about the onset of Cholangiocarcinoma."

Using state of the art DNA sequencing, the researchers analysed eight bile duct cancers and normal tissues from Thai patients, and discovered mutations in 187 genes. The team then selected 15 genes that were frequently mutated for further analysis in an additional 46 cases. Many of these genes, such as MLL3, ROBO2 and GNAS, have not been previously implicated in bile duct cancers.

"With this finding we now know much more about the molecular mechanisms of the disease and we can draw up additional measures that can be taken while we identify the most appropriate treatment protocols. We are talking about the potential to save many lives in Thailand," said Professor Vajarabhongsa Bhudhisawasdi, Director of the Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University of Thailand. "Also, this study shows that we can work closely with our counterparts in other countries and share our expertise and experience to improve the lot for the people."

The researchers also compared the bile duct cancers to other related cancers of the liver and pancreas. Surprisingly, they found that the bile ducts cancers shared certain similarities with pancreatic cancer.

"This research provides a strong direction for future studies," said Associate Professor Patrick Tan, faculty member of the Cancer and Stem Cell Biology Programme at the Duke-NUS. "Cholangiocarcinoma and Pancreatic Duct Adenocarcinoma appear to
'/>"/>

Contact: Tim Hawkins
tim.hawkins@vai.org
616-234-5519
Van Andel Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... are able to grow well in infertile land, and ... reason for this is because most legumes have a ... nitrogen in the air and then supply the host ... plants create symbiotic organs called nodules in their roots. ... will adversely affect the growth of the plants, because ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 Lifeinsure.biz ... life insurance riders that can be purchased without medical ... values up and make a life insurance policy more ... to find more about extra options available for a ... insurance without medical examinations required is simple to purchase, ...
(Date:9/19/2014)... York, NY (PRWEB) September 19, 2014 ... Stevie Wonder tickets for his 2014 concert tour. ... In the music business, there are a handful of artists ... Stevie Wonder. Born in Saginaw, MichIgan, Wonder has been a ... During his time in the music business, he has released ...
(Date:9/19/2014)... September 19, 2014 Dr. John Paul ... Periodontal Treatment to their Miami practice. Routinely at ... and Dr. Lamas are one of the first ... health’ approach for diagnosing and treating periodontal disease. ... most under-diagnosed and under-treated diseases in the world. ...
(Date:9/19/2014)... Steven Reinberg HealthDay Reporter ... half of all Americans got a flu shot last year, ... months and older get vaccinated for the coming flu season. ... getting the protection from flu they could get," said Dr. ... and Prevention, during a morning news conference. The result ...
Breaking Medicine News(10 mins):Health News:Long-distance communication from leaves to roots 2Health News:No Medical Exam Life Insurance - Lifeinsure.biz Presents 5 Important Riders! 2Health News:Stevie Wonder Tickets: Ticket Down Slashes Ticket Prices in Seattle, Boston, New York, Atlanta, Chicago, Detroit, Philadelphia, Toronto, Las Vegas & Oakland 2Health News:Stevie Wonder Tickets: Ticket Down Slashes Ticket Prices in Seattle, Boston, New York, Atlanta, Chicago, Detroit, Philadelphia, Toronto, Las Vegas & Oakland 3Health News:Gallardo & Lamas Periodontics & Implant Dentistry Therapeutic Periodontal Treatment Shown to Improve Patient’s Overall Health 2Health News:Gallardo & Lamas Periodontics & Implant Dentistry Therapeutic Periodontal Treatment Shown to Improve Patient’s Overall Health 3Health News:Almost Everyone Needs a Flu Shot: CDC 2Health News:Almost Everyone Needs a Flu Shot: CDC 3
... disease characterized by difficultly in breathing and the ... in these patients. Earlier research has shown that ... and endurance of respiratory muscles of COPD patients, ... found that this intense training// is difficult for ...
... of Texas has found a gene mutation in people with ... too much calcium. They reported on six gene mutations which ... much calcium absorption - a condition known as absorptive hypercalciuria ... a greater risk// for osteoporosis because of deficiencies in the ...
... hospitals to overcome illness. However, very often, patients land ... infections that they contract during their stay. Sanjay Saint, ... born infections are common, costly and harmful, but they ... which can be prevented by new and simple// changes. ...
... Chronic Obstructive Pulmonary Disease - including chronic bronchitis and ... blockage of the bronchial tubes. Asthma is a chronic ... resulting in episodes of airflow obstruction, which has been ... death and affects nearly 16 million people in the ...
... in the United States have found that the practice ... the past 14 years. However, they suggested that patients ... Helicobacter Pylori(H.Pylori) infection rather than receiving treatment for the ... more appropriate option// than empiric treatment in patients with ...
... with heart disease has shown that doctors are under-using ... these women even though the medications have been shown ... Though this study did not look at how often ... shown that men and women alike are under-treated for ...
Cached Medicine News:Health News:Adult COPD or asthma could be effectively treated with Xopenex 2Health News:Heart disease in women being under-treated 2
(Date:9/19/2014)... Sept. 19, 2014  PCI is pleased to ... Biotec is a leading provider of Clinical Trial ... Bridgend, Wales in the ... significantly expands PCI,s presence in the UK/EU to ... adding packaging, storage and distribution capacity, as well ...
(Date:9/18/2014)... 18, 2014  Low T Center endorses the ... Hyattsville, Maryland earlier this ... proper patient population for testosterone therapy (TRT), as ... with TRT. Examining recent claims from studies that TRT ... epidemiological studies do not provide convincing evidence that ...
(Date:9/18/2014)... , September 18, 2014 ... Markets ( http://www.researchandmarkets.com/research/f9nkkh/sugar_alcohols ) has announced the addition ... Business Report"  report to their offering.  ... analyzes the worldwide markets for Sugar Alcohols ... Segments: Food & Confectionery, Pharmaceuticals, Cosmetics, Oral-Care ...
Breaking Medicine Technology:PCI Announces Acquisition Of Biotec 2PCI Announces Acquisition Of Biotec 3PCI Announces Acquisition Of Biotec 4PCI Announces Acquisition Of Biotec 5PCI Announces Acquisition Of Biotec 6Low T Center Endorses The Joint FDA Committee Meeting on Testosterone 2Sugar Alcohols - Global Strategic Business Report 201 2Sugar Alcohols - Global Strategic Business Report 201 3
... Vascular Disrupting Agent and,Tubulin Inhibitor , SALT ... Inc.,(NASDAQ: MYGN) (<a target="_blank" href=,"http://www.myriad.com/">www.myriad.com ) announced ... mode of action of its,investigational new drug, ... annual meeting of the American Association for ...
... 18, 2007 - Gemin,X today announced the presentation ... lead compound, GX15-070 (obatoclax), in infant,acute lymphoblastic leukemia ... at the Annual Meeting of the American Association,for ... potent single agent activity against ALL blast cells,and ...
Cached Medicine Technology:Myriad Genetics Presents Azixa's Mode of Action at AACR 2Myriad Genetics Presents Azixa's Mode of Action at AACR 3Gemin X Presents Positive Preclinical Data of GX15-070 in Infant,ALL at AACR Meeting 2Gemin X Presents Positive Preclinical Data of GX15-070 in Infant,ALL at AACR Meeting 3
... Utilized for capsulotomies, nucleus ... Formed (bent) cystitomes are angled ... of the lens, providing easier ... while reducing the potential for ...
23 gauge thin wall irrigation. 25 gauge thin wall aspiration. Angled 30 degree shaft 8 mm from tip to bend. Irrigation tip set 0.5 mm behind aspiration tip. Dual hub construction. Polished finish. Ov...
U tip irrigation-aspiration cannual designed for manual removal of 12 oclock cortex. 23 gauge thin wall irrigation and aspiration lines for maximum aspiration capabilities. Polished finish. Overall l...
This specially designed 23 gauge spoon-shaped cannula is connected to a balanced salt solution bottle and with a low-flow of fluid, is designed to allow a controlled cleaning of the stromal interface...
Medicine Products: