Navigation Links
Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
Date:5/14/2012

rs coming to Singapore to work in NCCS laboratories.

Professor Teh said the study will pave the way for a better understanding of the roles that newly identified genes play in the development of bile duct cancer.

"This discovery adds depth to what we currently know about bile duct cancer," said Teh. "More important is that we are now aware of new genes and their effects on bile duct cancer, and we now need to further examine their biological aspects to determine how they bring about the onset of Cholangiocarcinoma."

Using state of the art DNA sequencing, the researchers analysed eight bile duct cancers and normal tissues from Thai patients, and discovered mutations in 187 genes. The team then selected 15 genes that were frequently mutated for further analysis in an additional 46 cases. Many of these genes, such as MLL3, ROBO2 and GNAS, have not been previously implicated in bile duct cancers.

"With this finding we now know much more about the molecular mechanisms of the disease and we can draw up additional measures that can be taken while we identify the most appropriate treatment protocols. We are talking about the potential to save many lives in Thailand," said Professor Vajarabhongsa Bhudhisawasdi, Director of the Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University of Thailand. "Also, this study shows that we can work closely with our counterparts in other countries and share our expertise and experience to improve the lot for the people."

The researchers also compared the bile duct cancers to other related cancers of the liver and pancreas. Surprisingly, they found that the bile ducts cancers shared certain similarities with pancreatic cancer.

"This research provides a strong direction for future studies," said Associate Professor Patrick Tan, faculty member of the Cancer and Stem Cell Biology Programme at the Duke-NUS. "Cholangiocarcinoma and Pancreatic Duct Adenocarcinoma appear to
'/>"/>

Contact: Tim Hawkins
tim.hawkins@vai.org
616-234-5519
Van Andel Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... 18, 2015 Carinsurancesavings.biz has released a ... are cheaper during Spring. , Spring can ... plan. Drivers should make sure they compare the newest ... Clients can learn more about Spring car insurance offers ... Auto insurance quotes are becoming more and more popular. ...
(Date:4/18/2015)... 18, 2015 Review of Ophthalmology magazine ... ‘Strategies for Success’ program for cataract surgeons attending the ... San Diego, where eye surgeon Jeffrey L. Martin, MD ... event. Dr. Martin is the Managing Partner of North ... chose Dr. Martin to lead this year’s discussion on ...
(Date:4/18/2015)... (PRWEB) April 18, 2015 Patients who ... of developing mesothelioma later in life, but the disease ... mesothelioma that is unrelated to radiation. Surviving Mesothelioma has ... its website. Click here to read it now. ... compared the cases of 45 patients who had both ...
(Date:4/18/2015)... 18, 2015 On April 14th, 2015, Symantec ... , which they say, “exposes a tactical shift by cyberattackers.” ... variants were introduced in 2014 - almost a million a ... threats to be identified and patched by prominent manufacturers – ... that doing business in a digital world can be fraught ...
(Date:4/18/2015)... 18, 2015 French physician and gastronome ... choices when he uttered, “Tell me what you eat, ... food to cope with stress or sadness has often ... indicates otherwise. Data collected from their Emotional ... to emotional eating, but for different reasons. , Collecting ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Plans Are Cheaper During Spring! 2Health News:Dr. Jeffrey Martin Invited to Share Latest Breakthroughs in Cataract Care During Roundtable Discussion at National 2015 ASCRS Meeting In San Diego 2Health News:New Study Examines Relationship Between Radiation for Hematologic Cancers and Development of Mesothelioma, According to Surviving Mesothelioma 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 4Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 5Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 2Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 3Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 4Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 5Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 6
... Reflecting the expanding,scope of chronic disease care and ... on health care systems and practices, DMAA: The,Care ... have renamed,the peer-reviewed journal of DMAA Population Health ... (formerly Disease Management) begins with,the August 2008 issue ...
... biologics during Psoriasis Awareness Month , , MONDAY, Aug. 25 (HealthDay ... of thick, inflamed skin covered with silvery scales form here ... knees, other parts of the legs, scalp, lower back, face, ... feel sore, and the more of the patches there are, ...
... Researchers may be closer to understanding why anti-cancer drugs ... immune cells, haven,t fared well in clinical trials. The ... ability of these drugs to shrink well-established tumors, will ... Journal of Experimental Medicine . , The immune system,s ...
... of developing cancers of the respiratory tract, according to a ... the first prospective investigation of incense and cancer risk, appears ... a peer-reviewed journal of the American Cancer Society. , Incense ... of Asia. Researchers have shown that burning incensewhich is made ...
... Newsweek previews,the Democratic National Convention. Editor Jon Meacham opens ... and often complex relationships,Obama has had with his father, ... into who he is today. Meacham writes that,while growing ... comfortable in his own,skin, reconciling his black and white ...
... engaged medical consumers is a long standing goal of ... a new consumer guide containing hundreds of facts, action ... in their quest for medical care that is safe ... immersed in our health care system as her late ...
Cached Medicine News:Health News:Disease Management Journal Changes Name and Expands Focus to Population Health Management 2Health News:After Fits and Starts, New Hope for Psoriasis Patients 2Health News:After Fits and Starts, New Hope for Psoriasis Patients 3Health News:Burning incense increases risk of respiratory tract cancers 2Health News:NEWSWEEK: Media Lead Sheet/September 1, 2008 Issue (on newsstands Monday, August 25, 2008). 2Health News:NEWSWEEK: Media Lead Sheet/September 1, 2008 Issue (on newsstands Monday, August 25, 2008). 3Health News:NEWSWEEK: Media Lead Sheet/September 1, 2008 Issue (on newsstands Monday, August 25, 2008). 4Health News:NEWSWEEK: Media Lead Sheet/September 1, 2008 Issue (on newsstands Monday, August 25, 2008). 5Health News:Mother of Child Cancer Victim Rallies Patient and Families to Guard Against Hidden Dangers in Today's Hospital Care 2Health News:Mother of Child Cancer Victim Rallies Patient and Families to Guard Against Hidden Dangers in Today's Hospital Care 3
(Date:4/17/2015)... -- CVS Health Corporation (NYSE: CVS ) will ... 2015, at 8:30 a.m. (EDT) with analysts and investors ... An audio webcast of the conference call will be ... CVS Health website for all interested parties. To access ... be archived and available on the web site for ...
(Date:4/17/2015)... and DETROIT , April 17, 2015 ... live in poverty, the infant mortality rate is two and ... per 1,000 live births. Nearly 6 of 10 infants that ... adequate prenatal care.  These are sobering statistics that Covenant Community ... people of Metro Detroit, is poised to change thanks to ...
(Date:4/17/2015)... Today, the Pharmaceutical Research and Manufacturers ... biopharmaceutical companies as "We Work For Health Champions" ... community service. Established in 2009, the ... by the biopharmaceutical industry to honor employees who ... have also shown an outstanding commitment to their ...
Breaking Medicine Technology:Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 2Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 3Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 4PhRMA Applauds 2015 We Work For Health Champion Award Winners 2PhRMA Applauds 2015 We Work For Health Champion Award Winners 3
... provider of bioanalytical accelerator mass spectrometry (AMS) services in ... measurement service at $99 per sample. GLP-compliant service is ... includes sample graphitization and AMS measurement services. Accium will ... at competitive rates. "This new pricing ...
... 19 The National Association of State Controlled ... grant from Purdue Pharma L.P. today at the ... The grant is part of Purdue Pharma,s ongoing ... of appropriately-designed state prescription drug monitoring programs, which ...
Cached Medicine Technology:Accium BioSciences Announces $99 Sample Pricing for Its Accelerator Mass Spectrometry (AMS) Measurement Service 2NASCSA Receives $200,000 Grant From Purdue Pharma L.P. to Support State Prescription Drug Monitoring Programs 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: