Navigation Links
Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
Date:5/14/2012

rs coming to Singapore to work in NCCS laboratories.

Professor Teh said the study will pave the way for a better understanding of the roles that newly identified genes play in the development of bile duct cancer.

"This discovery adds depth to what we currently know about bile duct cancer," said Teh. "More important is that we are now aware of new genes and their effects on bile duct cancer, and we now need to further examine their biological aspects to determine how they bring about the onset of Cholangiocarcinoma."

Using state of the art DNA sequencing, the researchers analysed eight bile duct cancers and normal tissues from Thai patients, and discovered mutations in 187 genes. The team then selected 15 genes that were frequently mutated for further analysis in an additional 46 cases. Many of these genes, such as MLL3, ROBO2 and GNAS, have not been previously implicated in bile duct cancers.

"With this finding we now know much more about the molecular mechanisms of the disease and we can draw up additional measures that can be taken while we identify the most appropriate treatment protocols. We are talking about the potential to save many lives in Thailand," said Professor Vajarabhongsa Bhudhisawasdi, Director of the Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University of Thailand. "Also, this study shows that we can work closely with our counterparts in other countries and share our expertise and experience to improve the lot for the people."

The researchers also compared the bile duct cancers to other related cancers of the liver and pancreas. Surprisingly, they found that the bile ducts cancers shared certain similarities with pancreatic cancer.

"This research provides a strong direction for future studies," said Associate Professor Patrick Tan, faculty member of the Cancer and Stem Cell Biology Programme at the Duke-NUS. "Cholangiocarcinoma and Pancreatic Duct Adenocarcinoma appear to
'/>"/>

Contact: Tim Hawkins
tim.hawkins@vai.org
616-234-5519
Van Andel Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... (PRWEB) , ... July 27, 2015 , ... ... today, especially in wound center management. Earlier this year Wound Care Advantage ... education and training for WCA wound centers. Customized learning paths allow for ...
(Date:7/27/2015)... ... July 27, 2015 , ... In a piece published July ... of plastic surgery and explained why people should not shy away from their own ... excesses of the few and celebrate it for the modern wonder that it is.” ...
(Date:7/27/2015)... ... ... North Central Surgical Center Hospital will be holding twice-monthly joint wellness classes ... patients, along with their friends and family members, to attend. The classes take place ... 8 [Tue due to Labor Day], Oct 5, Nov 2, Dec 7) beginning at ...
(Date:7/27/2015)... ... ... A Harris County jury awarded a group of Texas and Canadian investors approximately ... on findings of fraud and violations of the Texas Securities Act. The verdict was ... 2010-09675; Jo Ann Schermerhorn, et al v. CenturyLink, Inc. and Robert Kubbernus, et al., ...
(Date:7/27/2015)... ... July 27, 2015 , ... ... To Reduce Hospital Readmissions." , The Centers for Medicare and Medicaid Services (CMS) ... as part of their penalty calculation. Known as the QualityNet Hospital-Specific Report (HSR), ...
Breaking Medicine News(10 mins):Health News:Wound Care Advantage Launches Luvo University An Online Hub For Wound Care Education and Training 2Health News:Wound Care Advantage Launches Luvo University An Online Hub For Wound Care Education and Training 3Health News:Recent Op-Ed Defending Plastic Surgery Highlights the Personal Side of Cosmetic Procedures, says Beverly Hills Physicians 2Health News:North Central Surgical Center Hospital to Hold Joint Wellness Classes 2Health News:Fryar Law Firm Announces: Jury Awards $19 Million to Investors in Houston Space Teleport 2Health News:Fryar Law Firm Announces: Jury Awards $19 Million to Investors in Houston Space Teleport 3Health News:Fryar Law Firm Announces: Jury Awards $19 Million to Investors in Houston Space Teleport 4Health News:Fryar Law Firm Announces: Jury Awards $19 Million to Investors in Houston Space Teleport 5Health News:Fryar Law Firm Announces: Jury Awards $19 Million to Investors in Houston Space Teleport 6Health News:BESLER Consulting Publishes E-book Focused on Reducing Hospital Readmissions 2
... On the eve of President Obama,s healthcare summit ... said today that expanding and updating Medicare to ... approach to achieving the goals and principles outlined ... Congress and budget proposal.While welcoming President Obama,s call ...
... University Baptist Medical Center, and colleagues, have identified a ... people with cystic fibrosis, a lethal genetic condition. The ... treatment, researchers say. , The study appeared online last ... . It is the first published study to search ...
... IDIX ) announced today that management will present ... Conference on Tuesday, March 10th at 1:30 p.m. ET at ... Company 29th Annual Healthcare Conference on Tuesday , March ... Marriott Copley Place.The live and archived webcasts of the presentations ...
... WXYZ is proud to announce that ... Nielsen , will now be seen exclusively on Channel ... 15 years Peter Nielsen has hosted the nationally syndicated ... author of numerous books and videos on health and fitness and is ...
... Genaera Corporation (Nasdaq: GENR ) today announced its financial ... net loss for the year ended December 31, 2008 was $16.0 ... a net loss of $15.7 million, or $(0.90) per share basic ... loss for the quarter ended December 31, 2008 was $3.6 million, ...
... percent increased chance of death, rehospitalization , , TUESDAY, March ... blood thinner Plavix, plus a proton pump inhibitor such ... of death or another heart attack, a new study ... help reduce the risk of another heart attack after ...
Cached Medicine News:Health News:Nation's RNs on the Healthcare Summit: Insurance-Based Reform Will Fail, and Undermine Public Trust, Only Medicare for All Can Achieve Administration's Goals 2Health News:Nation's RNs on the Healthcare Summit: Insurance-Based Reform Will Fail, and Undermine Public Trust, Only Medicare for All Can Achieve Administration's Goals 3Health News:Scientists find gene that modifies severity of cystic fibrosis lung disease 2Health News:Scientists find gene that modifies severity of cystic fibrosis lung disease 3Health News:Peter Nielsen Has a New Home on WXYZ-TV! 2Health News:Genaera Corporation Announces 2008 Financial Results 2Health News:Genaera Corporation Announces 2008 Financial Results 3Health News:Genaera Corporation Announces 2008 Financial Results 4Health News:Genaera Corporation Announces 2008 Financial Results 5Health News:Blood Thinner, Heartburn Drugs May Be Risky After Heart Attack 2Health News:Blood Thinner, Heartburn Drugs May Be Risky After Heart Attack 3
(Date:7/27/2015)... 27, 2015  Array BioPharma Inc. (Nasdaq: ... the fourth quarter and full year of ... to discuss those results on Monday, August ... will lead the call.  Date:Monday, ... 507-2598Pass Code: 68380312 Webcast, including Replay and ...
(Date:7/27/2015)... July 27, 2015 As per the ... - Global Industry Analysis, Size, Share, Growth, Trends and Forecast ... 7.96 billion in 2014, growing at a CAGR of 13.2% ... in 2021. The global bionics market is growing ... which is leading to paralysis or amputation of body parts. ...
(Date:7/27/2015)... , July 20, 2015 Research and ... the "Medical Device Regulation in Asia/Pacific Markets Seminar" ... that the European Medical Device market is well established, ... . China , together with other ... in the process of implementing, their own medical device ...
Breaking Medicine Technology:Global Bionics Market is Expected to Reach USD 20.49 Billion in 2021, Growing at CAGR of 13.2% From 2015 to 2021: Transparency Market Research 2Global Bionics Market is Expected to Reach USD 20.49 Billion in 2021, Growing at CAGR of 13.2% From 2015 to 2021: Transparency Market Research 3Global Bionics Market is Expected to Reach USD 20.49 Billion in 2021, Growing at CAGR of 13.2% From 2015 to 2021: Transparency Market Research 4Medical Device Regulation in Asia/Pacific Markets Seminar: London, UK - 21st, 22nd of September 2015 2
... Advances and Expands Internal Pipeline as DARA Program Enters ... Development and New SARM Program is Added, PRINCETON, ... for the quarter and nine months ended,September 30, 2007, ... corporate milestones achieved since the beginning,of the quarter. ...
... Laboratories, Inc.,(NYSE: FRX ) today announced ... trial, published in the November 2007 issue ... that nebivolol,significantly reduced sitting diastolic and systolic ... with stage I-II hypertension.,The study also found ...
Cached Medicine Technology:Pharmacopeia Announces Third Quarter 2007 Financial Results 2Pharmacopeia Announces Third Quarter 2007 Financial Results 3Pharmacopeia Announces Third Quarter 2007 Financial Results 4Pharmacopeia Announces Third Quarter 2007 Financial Results 5Pharmacopeia Announces Third Quarter 2007 Financial Results 6Pharmacopeia Announces Third Quarter 2007 Financial Results 7Pharmacopeia Announces Third Quarter 2007 Financial Results 8Pharmacopeia Announces Third Quarter 2007 Financial Results 9Pharmacopeia Announces Third Quarter 2007 Financial Results 10Pharmacopeia Announces Third Quarter 2007 Financial Results 11UPDATE: Nebivolol Lowers Blood Pressure in African Americans With Stage I-II Hypertension as Demonstrated in a Study Published in the Journal of Clinical Hypertension 2UPDATE: Nebivolol Lowers Blood Pressure in African Americans With Stage I-II Hypertension as Demonstrated in a Study Published in the Journal of Clinical Hypertension 3
CHEMICON's Advanced Tissue Arrayer with patent-pending technology allows you to create customized arrays of multiple tissu specimens on a single slide, saving time and money....
CO2 gas object holder and knife freezer for the 8000 Series Sliding Microtome...
Tilt Adapter for the 8000 Sliding Microtome to allow for orientation of the specimen....
... 5040 microtome is of rotary retracting, self-lubricating design ... cutting arm. Its robust construction makes it accurate ... hinges means that all lateral motion is controlled ... be experienced in other, lesser designs which can ...
Medicine Products: