Navigation Links
Scientists identify proteins that help bacteria put up a fight
Date:2/25/2008

COLUMBUS, Ohio Scientists have identified the role of two proteins that contribute to disease-causing bacteria cells versatility in resisting certain classes of antibiotics.

The finding is a step toward development of drug therapies that could target bacterial resistance at its cellular source. Before researchers can design such drugs, they must understand all of the activities at play in the conflict between bacteria and the agents that kill them.

This finding by Ohio State University microbiologists extends the understanding of how bacteria cells resist antibiotics through the activities of two genetically distinct forms of what are called MprFs, or multiple peptide resistance factors. The proteins they studied are MprF1 and MprF2.

These proteins were found to be key to the mechanism allowing bacteria cells to change the electrical charge of their membrane, which is how the cells develop their resistance to certain antimicrobial agents and, more generally, how they adapt their membrane to new environmental conditions, such as those provided by their host organism.

Both of these proteins are potentially very good drug targets because in theory, if you can target them and inhibit their action, you can make bacteria strains more susceptible to existing antibiotics, said Michael Ibba, associate professor of microbiology at Ohio State and a coauthor of the study.

The findings are described online in this weeks issue of Proceedings of the National Academy of Sciences.

Scientists have already observed that the cell membranes of many disease-causing bacteria develop resistance by changing their electrical charge from negative to positive. Many antibiotics work because they carry a positive charge that attracts them to negatively charged bacteria cells. The opposite charges allow antibiotics to penetrate and kill bacteria. But by changing their naturally occurring negative charge to positive, some bacteria cell
'/>"/>

Contact: Michael Ibba
Ibba.1@osu.edu
614-292-2120
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. CSHL scientists discover new details of a gene-regulatory network governing metabolism
2. Scientists make first map of emerging-disease hotpsots
3. Scientists shed light on long-distance signaling in developing neurons
4. Scientists explore consciousness
5. Scientists using laser light to detect potential diseases via breath samples, says new study
6. Scientists move towards stem cell therapy trials to mend shattered bones
7. U-M scientists develop tool to probe role of oxidative stress in aging, disease
8. Scientists Show Stem Cells Dont Cause Cancer
9. Microbial cheaters help scientists ID social genes
10. Scientists solve structure of gene regulator that plays key role in cancer
11. VEGF Neutralization Can Damage Brain Vessels, Say Schepens Eye Research Institute Scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... 2014 The Truth about Six Pack Abs ... reveal to users some shocking foods that can burn belly ... modeling looks, as well as some motivation secrets for successful ... there is one unique trick that can help users reduce ... what many people might think, cardio exercise routines are not ...
(Date:8/30/2014)... (PRWEB) August 31, 2014 Recently, Skmen.com, ... 2014 long casual dresses . Before the middle ... can enjoy a discounted price, from 15 to 30 ... all the company’s long casual outfits are carefully made ... a graceful look for the wearers. Skmen.com is popular ...
(Date:8/30/2014)... Dayton, OH (PRWEB) August 30, 2014 United ... school’s first fully online degree, the Master of Theological Studies ... completed in 2-3 years, is designed for students who wish ... deepen their understanding and capacity to serve the Church and ... this degree, but now they can attend classes from any ...
(Date:8/30/2014)... 2014 Daily Gossip reveals in its review ... Desire You program, who shows a unique formula to get ... this method says that the program goes beyond mere attraction ... Desire You review indicates that the program was created by ... his great techniques to make a man feel emotionally addicted. ...
(Date:8/30/2014)... The Plastic Surgery Group (PSG) is one ... in the U.S. to provide clients with Vanquish, a ... waists with deep-tissue heating. , Unlike Cryotherapy which kills ... more inclusive to target large sections of desired weight ... about one inch away from their body while the ...
Breaking Medicine News(10 mins):Health News:Truth about Six Pack Abs Review Reveals Unique Method to Eliminate Stubborn Stomach Fat 2Health News:Huge Deals On 2014 Long Casual Dresses Unveiled By Skmen.com 2Health News:United Theological Seminary Announces First Fully Online Degree 2Health News:Make Him Desire You Review Reveals Powerful Formula to Make a Man Emotionally Addicted 2Health News:NJ Top Docs Presents, The Plastic Surgery Group 2
... Israel, Nov. 21 Shamir,Optical Industry Ltd. (Nasdaq: ... earnings results on Tuesday, November 27, 2007, and has,scheduled ... A.M. EST that,morning., The conference call will be ... go to http://www.kcsa.com approximately five minutes before,the ...
... 2007 Full-Year Financial Outlook, WOODCLIFF LAKE, N.J., Nov. ... today filed with the U.S.,Securities and Exchange Commission (SEC) ... 2007. The filing of Par,s Form 10-Qs for these ... restating its consolidated,financial statements for certain prior periods, which ...
... Open access online journal,AZoJono* (The AZo Journal ... research edition in conjunction with DESYGN-IT*, an ... investigating the design,synthesis, growth and application of ... URL for special edition,[ http://www.azonano.com/nanotechnology%20journal.asp ...
... 20 CHF,International has been selected as the ... Fund) new Principal Recipient (PR) for,HIV/AIDS prevention, treatment ... awarded an HIV proposal in Round 3 programming., ... years, CHF will be directly responsible for,managing Honduras, ...
... S.C., Nov. 20 BlueCross BlueShield of ... awarded Case Management,Accreditation from URAC, a Washington, ... standards for the health care,industry. URAC,s ... a process to assess, plan and implement ...
... 20 2007 Vase or face" When presented with the well ... the faces of two people, what we observe depends on the ... , In this example, whether you see faces or vases depends ... always stays exactly the same, said John Serences, a UC Irvine ...
Cached Medicine News:Health News:Shamir Optical Industry Ltd. to Host Conference Call Announcing Third Quarter 2007 Earnings Results 2Health News:Par Pharmaceutical Files Form 10-Qs for First and Second Quarters of 2007 2Health News:Par Pharmaceutical Files Form 10-Qs for First and Second Quarters of 2007 3Health News:Par Pharmaceutical Files Form 10-Qs for First and Second Quarters of 2007 4Health News:Par Pharmaceutical Files Form 10-Qs for First and Second Quarters of 2007 5Health News:Par Pharmaceutical Files Form 10-Qs for First and Second Quarters of 2007 6Health News:Par Pharmaceutical Files Form 10-Qs for First and Second Quarters of 2007 7Health News:Par Pharmaceutical Files Form 10-Qs for First and Second Quarters of 2007 8Health News:Par Pharmaceutical Files Form 10-Qs for First and Second Quarters of 2007 9Health News:Par Pharmaceutical Files Form 10-Qs for First and Second Quarters of 2007 10Health News:Par Pharmaceutical Files Form 10-Qs for First and Second Quarters of 2007 11Health News:Par Pharmaceutical Files Form 10-Qs for First and Second Quarters of 2007 12Health News:Par Pharmaceutical Files Form 10-Qs for First and Second Quarters of 2007 13Health News:Par Pharmaceutical Files Form 10-Qs for First and Second Quarters of 2007 14Health News:Par Pharmaceutical Files Form 10-Qs for First and Second Quarters of 2007 15Health News:Major EU Funded Nanotube Research Group, DESYGN-IT, Publish in AZoJono - The Open Access Online Nanotech Journal 2Health News:CHF International Named Global Fund Principal Recipient in Honduras 2Health News:S.C. BlueCross BlueShield Receives URAC Case Management Accreditation 2Health News:Scientists uncover how the brain controls what the eyes see 2
(Date:8/29/2014)... Aug. 29, 2014 Does your doctor know what ... doctors have recommended marijuana to the over 112,000 currently registered ... the majority of the other roughly 20,300+ active physicians listed ... little about it – even though a poll in February ... say they have tried it. "With marijuana ...
(Date:8/29/2014)... 29, 2014  United Therapeutics Corporation (NASDAQ: ... for the District of New Jersey ... case against Sandoz, Inc. regarding United Therapeutics, Remodulin ® ... ruled that U.S. Patent No. 6,765,117 is both valid ... marketing its generic product until the expiration of that ...
(Date:8/29/2014)... According to the new ... (Equipment, Reagent, Primer, Probe, Custom Oligos), End-User (Research, ... Synthesis, NGS, DNA, RNAi) - Global Forecast to ... Market is expected to reach $1,712.1 Million by ... a CAGR of 9.8% from 2014 to 2019.. ...
Breaking Medicine Technology:Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4District Court Decision Received In Remodulin Patent Case 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4
... Spherix Incorporated (NASDAQ: SPEX ) -- an ... and atherosclerosis, and providers of technical and regulatory consulting ... today announced that Dr. Claire Kruger, Chief Executive Officer, ... corporate overview at the Rodman & Renshaw 13th Annual ...
... ® Technologies, Inc., a world leader in personal and ... receive the coveted Orange Innovation Award in the 10th annual ... innovative approach to the design, development and manufacture of ... Sudden Cardiac Arrest . The Orange Innovation ...
Cached Medicine Technology:Spherix Incorporated to Present at the Rodman & Renshaw 13th Annual Healthcare Conference 2HeartSine® Technologies Named One of the Most Innovative Businesses in the United Kingdom 2
... WideBiter Punch series facilitates fast and effective ... smooth, anatomically shaped meniscal rim. The flat, ... to access even the tightest joint spaces. ... Inc., 20 years of engineering experience in ...
... The WideBiter Punch series facilitates fast ... recreating a smooth, anatomically shaped meniscal rim. ... low profile to access even the tightest ... Arthrex California, Inc., 20 years of engineering ...
... series facilitates fast and effective resection of ... shaped meniscal rim. The flat, crescent-shaped tip ... even the tightest joint spaces. Made in ... years of engineering experience in arthroscopy hand ...
... facilitates fast and effective resection of meniscal ... meniscal rim. The flat, crescent-shaped tip has ... the tightest joint spaces. Made in the ... of engineering experience in arthroscopy hand instrument ...
Medicine Products: