Navigation Links
Scientists identify proteins that help bacteria put up a fight
Date:2/25/2008

COLUMBUS, Ohio Scientists have identified the role of two proteins that contribute to disease-causing bacteria cells versatility in resisting certain classes of antibiotics.

The finding is a step toward development of drug therapies that could target bacterial resistance at its cellular source. Before researchers can design such drugs, they must understand all of the activities at play in the conflict between bacteria and the agents that kill them.

This finding by Ohio State University microbiologists extends the understanding of how bacteria cells resist antibiotics through the activities of two genetically distinct forms of what are called MprFs, or multiple peptide resistance factors. The proteins they studied are MprF1 and MprF2.

These proteins were found to be key to the mechanism allowing bacteria cells to change the electrical charge of their membrane, which is how the cells develop their resistance to certain antimicrobial agents and, more generally, how they adapt their membrane to new environmental conditions, such as those provided by their host organism.

Both of these proteins are potentially very good drug targets because in theory, if you can target them and inhibit their action, you can make bacteria strains more susceptible to existing antibiotics, said Michael Ibba, associate professor of microbiology at Ohio State and a coauthor of the study.

The findings are described online in this weeks issue of Proceedings of the National Academy of Sciences.

Scientists have already observed that the cell membranes of many disease-causing bacteria develop resistance by changing their electrical charge from negative to positive. Many antibiotics work because they carry a positive charge that attracts them to negatively charged bacteria cells. The opposite charges allow antibiotics to penetrate and kill bacteria. But by changing their naturally occurring negative charge to positive, some bacteria cell
'/>"/>

Contact: Michael Ibba
Ibba.1@osu.edu
614-292-2120
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. CSHL scientists discover new details of a gene-regulatory network governing metabolism
2. Scientists make first map of emerging-disease hotpsots
3. Scientists shed light on long-distance signaling in developing neurons
4. Scientists explore consciousness
5. Scientists using laser light to detect potential diseases via breath samples, says new study
6. Scientists move towards stem cell therapy trials to mend shattered bones
7. U-M scientists develop tool to probe role of oxidative stress in aging, disease
8. Scientists Show Stem Cells Dont Cause Cancer
9. Microbial cheaters help scientists ID social genes
10. Scientists solve structure of gene regulator that plays key role in cancer
11. VEGF Neutralization Can Damage Brain Vessels, Say Schepens Eye Research Institute Scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 2014 With a mere 19 days ... made a brief fundraising stop at the  Law ... Fresh from a debate last night with his opponent ... for the first seven minutes because Crist had an ... the incident in one word: "weird." , Before touching ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Women’s health ... in Obstetrics & Gynecology of Columbus, Inc., A Division ... healthcare services to more than 100,000 patients annually. Dr. ... all ages and stages of a women’s life. She ... locations in Westerville and Dublin. , Dr. Murphy ...
(Date:10/20/2014)... 2014 JZ Fitness, an independently operated ... wellness programming, authorship, international lecturing and community wellness, created ... the release of the JZ Fitness nutrition app, available ... coaching thousands of individuals on nutrition, Jenn Zerling (“JZ”) ... not require calorie counting or cumbersome food logging. ...
(Date:10/20/2014)... 20, 2014 Myoderm ... Assistant Director of their CentralSource service. ... the innovative turnkey drug sourcing, distribution, and management ... over 12 years of industry experience, in both ... the peak of their international success to help ...
(Date:10/20/2014)... October 20, 2014 National Teen Driver Safety ... the American Academy of Pediatrics (Ohio AAP, http://www.ohioaap.org ) ... encouraging parents of teen drivers to talk to their teens ... , Motor vehicle crashes are the leading cause of death ... involved in fatal crashes, and 859 (42%) of those teen ...
Breaking Medicine News(10 mins):Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3Health News:Myoderm Hires Matthew Voicheck to Lead Turnkey Drug Sourcing Service 2Health News:Ohio AAP Promotes National Teen Driver Safety Week 2
... ST. PETERS, Mo. , Feb. 18 The ... has donated $25,000 to Meds & Food for Kids ... saving the lives of Haiti ,s malnourished children and other ... ready-to-use therapeutic food (RUTF) – known in Haiti as ...
... Largest Ever One-Year Increase Illustrates Medicaid,s Role In Covering People During ... WASHINGTON , Feb. 18 With the country mired ... in state Medicaid programs in June 2009 compared to ... Family Foundation,s Commission on Medicaid and the Uninsured. It was the ...
... to DNA damage by ordering repairs or the suicide of ... response to oxidative damage outside of the nucleus, researchers report ... of the National Academy of Sciences . "This ... defective cells also has a second life out in the ...
... a medical tool. But the latest miniature ultrasound device created ... one day introduce a whole new level of home therapy ... sleek blue-and-white device slips into a pocket and sends ultrasound ... is the transducer, which converts electrical energy into ultrasound. ...
... Mich. Elderly people with visual disorders that are left ... the most common form of dementia, according to a University ... Medicare data and shows that those with poor vision who ... 64 percent less likely to develop dementia. The ...
... that headache frequency affects finances and overall health, , THURSDAY, ... a difference between people who have migraines a lot and ... are in worse health overall, poorer and more depressed. ... people with headaches that were labeled either episodic, if they ...
Cached Medicine News:Health News:MEMC Foundation Donates to Help Fight Malnourishment in Haiti 2Health News:MEMC Foundation Donates to Help Fight Malnourishment in Haiti 3Health News:Kaiser Analysis Finds Record Medicaid Enrollment Growth in 2009 2Health News:Kaiser Analysis Finds Record Medicaid Enrollment Growth in 2009 3Health News:Researchers discover second protective role for tumor-suppressor 2Health News:Clinical trial underway: Miniature ultrasound device could revolutionize pain relief 2Health News:Untreated poor vision in elderly linked to dementia, University of Michigan study shows 2
(Date:10/17/2014)... 2014  Amgen (NASDAQ: AMGN ) today ... M.D., president of Gladstone Institutes and Gladstone,s Robert W. ... "We are pleased to welcome Dr. Sandy Williams ... Bradway , chairman and chief executive officer of Amgen. ... and his direct experience in our industry will both ...
(Date:10/17/2014)... DALLAS , October 17, 2014 /PRNewswire/ ... research report "Optical Imaging Market by Technique (Optical ... System, Imaging software) & by Application (Ophthalmology, Neurology, Oncology, ... by MarketsandMarkets, this report studies the Optical Imaging ... The market was valued at $917.1 million ...
(Date:10/17/2014)... Md. , Oct. 17, 2014 ... for Medical Technology Policy: The Green ... the FDA, public and private payers, medical device ... clinicians, and other experts January 12, 2015 at ... and value of weight loss treatments.  Participants will ...
Breaking Medicine Technology:Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 3Optical Imaging Market Worth $1,669.2 Million by 2019 2Optical Imaging Market Worth $1,669.2 Million by 2019 3Optical Imaging Market Worth $1,669.2 Million by 2019 4Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2
... A new study by researchers from Children,s Mercy ... that rapid electronic review of children,s heart images by ... and treatment of potentially serious pediatric heart problems. The ... National Conference and Exhibition in San Francisco. ...
... LAKES, N.J., Oct. 4 Medco Health Solutions, ... announce its third-quarter 2010 financial results in a ... November 2, 2010.   (Logo: http://photos.prnewswire.com/prnh/20100609/MEDCOLOGO) ... release, management will hold a conference call at ...
Cached Medicine Technology:New Study Shows Telemedicine Works to Effectively Identify Heart Problems in Children Far from a Specialized Medical Center 2Medco Announces Date for Third-Quarter 2010 Financial Results 2
Marquette General Health System Reference Laboratory provides a full range of testing including, Chemistry, Hematology, Coagulation, Urinalysis, Microbiology, Cytology, Anatomic Pathology, Flow Cytom...
... The Johns Hopkins University Dermatology, ... Laboratory is a federally-(Clinical Laboratory Improvement ... that began operation in 1982. Its ... quality diagnostic allergy and immunology testing ...
... national reference laboratory and a laboratory ... an extensive test menu of highly ... clinical and anatomic pathology. Owned by ... clients include university teaching hospitals and ...
Sharp tipped scissors angled 135 from the shaft with a horizontal cutting action. For cutting in the plane parallel to the retina and cutting membranes adherent to the retinal surface (delamination)....
Medicine Products: