Navigation Links
Scientists find way to target cells resistant to chemo
Date:4/24/2014

Scientists from The University of Manchester have identified a way to sensitise cancer cells to chemotherapy - making them more open to treatment.

The study published today in Cell Reports, could pave the way for the development of drugs to target cells that have become resistant to treatment.

The research team made the discovery whilst exploring the possible mechanisms behind resistance to chemotherapy drugs like Paclitaxel, often used to treat breast and colon cancer.

Dr Andrew Gilmore, who led the research team at The University of Manchester, is part of both the Wellcome Trust Centre for Cell-Matrix Research and also the Manchester Cancer Research Centre.

He said: "Cells replicate and divide through a process known as mitosis. This process is carefully controlled and if any mistake is made during normal division then the cell undergoes apoptosis otherwise known as controlled cell death.

"Failure of cells to complete mitosis correctly can be the start of cancer. We wanted to understand how this failure delay of cell division - activates apoptosis, and why some cancer cells may be able to avoid being killed."

Cancer cells replicate rapidly, and chemotherapy drugs such as paclitaxel target mitosis as a way to kill these quickly dividing cells. But cancer cells can develop resistance to the drugs.

The researchers found a particular protein known as 'Bid' in colon cancer cells, and looked at what happened when Bid was switched on.

Their results show that Bid is turned on as cells prepare to divide. This primes the cells to die if cell division takes too long. Cancer cells that were resistant to chemotherapy still turned Bid on, but went through mitosis too quickly for it to kill the cell. However, these resistant cells could be made to die by directly targeting the part of the cell where Bid works.

"Our findings demonstrate that Bid plays a central role in mitosis-related cell death. This opens up new areas of research into drugs that might be able to kill cancer cells that have become resistant to chemotherapy. This could eventually be of huge benefit in a clinical setting and help patients who suffer from advanced stages of colon cancer," added Dr Gilmore.


'/>"/>

Contact: Kath Paddison
kath.paddison@manchester.ac.uk
01-612-755-2111
University of Manchester
Source:Eurekalert

Related medicine news :

1. Scientists identify cancer specific cell for potential treatment of gastric cancer
2. Scientists pinpoint protein that could improve small cell lung cancer therapies
3. AMP publishes curriculum recommendations for medical laboratory scientists
4. Scientists alter fat metabolism in animals to prevent most common type of heart disease
5. Scientists discover a new way to enhance nerve growth following injury
6. Scientists find key steps linking dietary fats and colon cancer tumor growth
7. Stanford scientists identify source of most cases of invasive bladder cancer
8. Scientists discover brains anti-distraction system
9. Scientists find new way to fight malaria drug resistance
10. Stanford scientists develop playbook for reverse engineering tissue
11. Scientists unlock secrets of protein produced by disease-causing fungus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... ... August 22, 2017 , ... Nurses at Apple Rehab Watch Hill , ... received training and certification in Closed Pulse Irrigation™ (CPI) for wound care. ... from the Centers for Medicare and Medicaid Services, to have a CPI machine that ...
(Date:8/22/2017)... ... August 22, 2017 , ... “To Walk Away”: a ... B17 bomber named Edward Koontz. “To Walk Away” is the creation of published author, ... published over two hundred manuscripts in chemistry and religion, as well as four novels. ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Without Love’s Beauty and Pleasures ... the struggles faced while hoping for a better life. “Without Love’s Beauty and ... Bernewitz, who spent 13 years working with deprived/neglected adolescents and almost 20 years ...
(Date:8/22/2017)... ... , ... “Glimpses Of Light”: is a unique and thought inspiring guide ... creation of published author, J.M. Shepherd, a writer, teacher, traveler, and metaphysician, the author ... , Shepherd shares, “Love is one of the least understood and yet most sought-after ...
(Date:8/22/2017)... Overland Park, KS (PRWEB) , ... August 22, 2017 , ... ... sellers of products to fight Fatigue . , As the stress of modern ... to keep up the pace. Constant use of artificial stimulants can trap people in ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), a ... of Directors has approved the payment of a quarterly cash ... The cash dividend of $0.24 ... 2017 to stockholders of record as of the close of ... subject to approval of the Board of Directors and may ...
(Date:8/4/2017)... -- The search for test results that can be ... long been the goal of healthcare providers and the ... largest meeting of lab professionals and IVD firms this ... Kalorama Information.  The firm said scores of companies with ... and software were at the American Association for Clinical ...
(Date:8/2/2017)... and BENTON, Ky. , Aug. 2, 2017   Marshall County Hospital ... environmental services (ES) team to proactively reduce the risk of hospital-acquired infections (HAIs). The new ... robot that uses UVC light energy to kill deadly pathogens such as C. diff ... Tru-D SmartUVC ... Tru-D in action in a ...
Breaking Medicine Technology: