Navigation Links
Scientists find way to target cells resistant to chemo
Date:4/24/2014

Scientists from The University of Manchester have identified a way to sensitise cancer cells to chemotherapy - making them more open to treatment.

The study published today in Cell Reports, could pave the way for the development of drugs to target cells that have become resistant to treatment.

The research team made the discovery whilst exploring the possible mechanisms behind resistance to chemotherapy drugs like Paclitaxel, often used to treat breast and colon cancer.

Dr Andrew Gilmore, who led the research team at The University of Manchester, is part of both the Wellcome Trust Centre for Cell-Matrix Research and also the Manchester Cancer Research Centre.

He said: "Cells replicate and divide through a process known as mitosis. This process is carefully controlled and if any mistake is made during normal division then the cell undergoes apoptosis otherwise known as controlled cell death.

"Failure of cells to complete mitosis correctly can be the start of cancer. We wanted to understand how this failure delay of cell division - activates apoptosis, and why some cancer cells may be able to avoid being killed."

Cancer cells replicate rapidly, and chemotherapy drugs such as paclitaxel target mitosis as a way to kill these quickly dividing cells. But cancer cells can develop resistance to the drugs.

The researchers found a particular protein known as 'Bid' in colon cancer cells, and looked at what happened when Bid was switched on.

Their results show that Bid is turned on as cells prepare to divide. This primes the cells to die if cell division takes too long. Cancer cells that were resistant to chemotherapy still turned Bid on, but went through mitosis too quickly for it to kill the cell. However, these resistant cells could be made to die by directly targeting the part of the cell where Bid works.

"Our findings demonstrate that Bid plays a central role in mitosis-relat
'/>"/>

Contact: Kath Paddison
kath.paddison@manchester.ac.uk
01-612-755-2111
University of Manchester
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists identify cancer specific cell for potential treatment of gastric cancer
2. Scientists pinpoint protein that could improve small cell lung cancer therapies
3. AMP publishes curriculum recommendations for medical laboratory scientists
4. Scientists alter fat metabolism in animals to prevent most common type of heart disease
5. Scientists discover a new way to enhance nerve growth following injury
6. Scientists find key steps linking dietary fats and colon cancer tumor growth
7. Stanford scientists identify source of most cases of invasive bladder cancer
8. Scientists discover brains anti-distraction system
9. Scientists find new way to fight malaria drug resistance
10. Stanford scientists develop playbook for reverse engineering tissue
11. Scientists unlock secrets of protein produced by disease-causing fungus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... (PRWEB) July 30, 2014 Good ... featured in an upcoming episode of Innovations with ... Discovery Channel. Dates and show times TBA. , ... Good Neighbor Community Services’ vision to redefine the ... individualized and dynamic services. Through passion, innovation, determination, ...
(Date:7/30/2014)... HealthDay Reporter WEDNESDAY, July ... States, at least 2,000 Americans die from extreme heat or ... waves, heat stroke or sun stroke caused nearly one-third of ... according to the U.S. Centers for Disease Control and Prevention. ... body heat -- accounted for 63 percent of those weather-related ...
(Date:7/30/2014)... HealthDay Reporter WEDNESDAY, July 30, 2014 (HealthDay ... excess pounds may want to team up with their child, ... a supervised behavioral modification program gained less weight than their ... average difference of about four pounds over two years). Their ... years, according to the study. "In a nutshell, we ...
(Date:7/30/2014)... happen in an instant: A small child pulls up on ... injured when the furniture tips over. "Every parent or ... and imagine what could tip over, fall off walls and ... a reality," Dr. Alex Rosenau, president of the American College ... Between 2009 and 2011, roughly 43,000 people ended up in ...
(Date:7/30/2014)... Volunteers from the Church of Scientology of Denmark have ... massive distribution of Truth About Drugs education ... Strøget, the famous Copenhagen walking street. Popular with ... ambiance, some quarter of a million people stroll down ... These activities are part of a coordinating effort by ...
Breaking Medicine News(10 mins):Health News:Good Neighbor Community Services to be Featured in an Upcoming Episode of Innovations With Ed Begley, Jr. 2Health News: Extreme Weather Kills 2,000 in U.S. Each Year: CDC 2Health News: Extreme Weather Kills 2,000 in U.S. Each Year: CDC 3Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 2Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 3Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 4Health News:Tip-Over Furniture Can Kill Kids 2
... Research Center Co. announced on Feb. 26 that the ... business cooperation agreement the same day to combine their ... China.SGS-CSTC, a unit of the SGS group, the world,s ... network of over 40 business offices and laboratories in ...
... Executive-level management from biopharma and device sponsors, CROs, consultants, and ... (DIA,s) Realizing Structural Change Management for Patient Recruitment Success Forum ... ... horsham, PA (Vocus) February 26, 2009 -- ...
... this years AmeriGlide Achiever Scholarship. This scholarship is available to full ... ... Raleigh, NC (PRWEB) February 26, 2009 -- AmeriGlide Stair Lifts ... Scholarship. The AmeriGlide Achiever Scholarship is available to full time college ...
... the retina that is responsible for maintaining the health of ... a living retina for the first time. , The ability ... the onset of many diseases of the eye long before ... of Investigative Ophthalmology and Visual Science ., "Our goal ...
... of Putting Money in the Hands of Beauty Corporations for ... or Counseling to Remain Youthful? Now one does not ... Before Published Secrets to Eternal Youth and Immortality, gives FREE ... that folks can attain and maintain the Age they Intend ...
... Goody who will be left behind without a motherHOLLYWOOD, ... "Chani" Christie who recently won the 2009 Martin Luther ... set to donate proceeds from her debut album "My ... Jade Goody. In addition, she also plans to fundraise ...
Cached Medicine News:Health News:QSAI & SGS-CSTC to Begin Joint Food Analysis Services in China 2Health News:DIA to host Patient Recruitment and Retention Forum April 20-21, 2009 2Health News:DIA to host Patient Recruitment and Retention Forum April 20-21, 2009 3Health News:AmeriGlide Announces Recipient of AmeriGlide Achiever Scholarship 2Health News:'Dark cells' of living retina imaged for the first time 2Health News:'Dark cells' of living retina imaged for the first time 3Health News:What the Billion Dollar Beauty Industry Does Not Want Leaked: That One Can Actually Reverse Aging for Free by Moving Only to the Right. We Smell a Nobel. 2Health News:Chantel 'Chani' Christie Will Donate Proceeds From Her Top-Selling Debut Album 'My Dream' to the Children of Terminally Ill TV Star Jade Goody 2
(Date:7/30/2014)... -- Hologic, Inc. (NASDAQ: HOLX ) today announced ... 28, 2014. Third Quarter Financial Highlights and ... million, reflecting operational growth of 0.5% and a positive ... in the prior year. , Revenues grew in ... revenues grew 3.5%. , GYN Surgical revenues grew ...
(Date:7/30/2014)... July 30, 2014  Cepheid (Nasdaq: ... contract with Premier will end on September 30, ... will be able to continue their relationship with ... MedAssets, Novation, and ROi, in addition to the ... Cepheid. "Cepheid has always recognized and ...
(Date:7/30/2014)... , July 30, 2014 CryoLife, Inc. (NYSE: ... focused on cardiac and vascular surgery, announced today that ... dividend for the third quarter 2014 of $0.03 per ... of $0.03 per share will be paid on September ... of September 12, 2014.  The ex-dividend date for the ...
Breaking Medicine Technology:Hologic Announces Third Quarter Fiscal 2014 Operating Results 2Hologic Announces Third Quarter Fiscal 2014 Operating Results 3Hologic Announces Third Quarter Fiscal 2014 Operating Results 4Hologic Announces Third Quarter Fiscal 2014 Operating Results 5Hologic Announces Third Quarter Fiscal 2014 Operating Results 6Hologic Announces Third Quarter Fiscal 2014 Operating Results 7Hologic Announces Third Quarter Fiscal 2014 Operating Results 8Hologic Announces Third Quarter Fiscal 2014 Operating Results 9Hologic Announces Third Quarter Fiscal 2014 Operating Results 10Hologic Announces Third Quarter Fiscal 2014 Operating Results 11Hologic Announces Third Quarter Fiscal 2014 Operating Results 12Hologic Announces Third Quarter Fiscal 2014 Operating Results 13Hologic Announces Third Quarter Fiscal 2014 Operating Results 14Hologic Announces Third Quarter Fiscal 2014 Operating Results 15Hologic Announces Third Quarter Fiscal 2014 Operating Results 16Hologic Announces Third Quarter Fiscal 2014 Operating Results 17Cepheid Updates Status Of Premier Group Purchasing Organization (GPO) Agreement 2Cepheid Updates Status Of Premier Group Purchasing Organization (GPO) Agreement 3CryoLife Announces Quarterly Cash Dividend for the Third Quarter 2014 2CryoLife Announces Quarterly Cash Dividend for the Third Quarter 2014 3
...  19, 2011 The Emergency Medicine Patient Safety ... upcoming 1st Annual Patient Safety Summit in Las Vegas, ... Safety in Emergency Care: Excellence in Outcomes, (Twitter ... on solving the patient safety challenges associated with providing ...
... 19, 2011 Medical Care Technologies Inc. ... industry, is pleased to announce that is has signed ... Limited ("OWII"), a private Hong Kong investment holding company ... opening and operating private pediatric clinics throughout China. ...
Cached Medicine Technology:National Leaders in Emergency Medicine and Patient Safety to Address Future Opportunities and Challenges in Emergency Care 2Medical Care Technologies Inc. Signs Letter of Intent for Joint Venture in China 2Medical Care Technologies Inc. Signs Letter of Intent for Joint Venture in China 3
BD Visitec IOL Manipulator (Fenzl), blunt tip angled 45, 12.0 mm from end, fits 0.20 mm diameter holes and larger (3/bx, 1 bx/ca). For positioning intraocular lenses. Sure grip handles hand ridge ind...
... IOL Manipulator (Jaffe-Maltzman), blunt tip, ... end, fits 0.20 mm diameter ... intraocular lenses, (3/bx, 1 bx/ca), ... Sure grip handles hand ridge ...
Sinskey lens manipulator, straight. Also available in titanium....
Straight, with guard. Ideal for multi-directional manipulation....
Medicine Products: