Navigation Links
Scientists Spot Real 'Smoking Gun' in Prostate Cancer
Date:5/21/2010

Gene fusion may be behind disease, not androgen receptors, study suggests

FRIDAY, May 21 (HealthDay News) -- The primary cause of prostate cancer could be the fusion of two genes and the subsequent abnormal prostate cell growth that results when receptors for the hormone androgen get blocked, a new study reveals.

The implication is that standard efforts to treat the disease by targeting the androgen receptors might be missing the real "smoking gun," a University of Michigan Comprehensive Cancer Center team suggests.

"We need to begin to think about targeting prostate cancer by targeting the gene fusion, and not confining our approaches to androgen receptors," study author Dr. Arul Chinnaiyan, director of the Michigan Center for Translational Pathology, said in a news release. "If we're going to find a more durable therapy, we need to get at the gene fusion."

Chinnaiyan and his colleagues report their findings in the May 18 issue of Cancer Cell.

The authors note that typical prostate cancer treatments focus on drugs that attempt to slow production of androgen, the male hormone that regulates healthy prostate growth. However, such efforts usually become less effective over time as cancer cell resistance mounts, making recurrent cancer much less amenable to similar treatments.

But having earlier identified a so-called "on switch" for prostate cancer development in the form of the initial fusion of a prostate gene with a cancer-causing gene, Chinnaiyan and colleagues now have launched a new investigation into what happens post-fusion.

By using high-tech genetic mapping techniques, the research team found that once fusion takes place, androgen receptors get blocked, in turn cutting off normal prostate cell growth while permitting cancer to spread.

"Our study shows the underlying problem in prostate cancer is the presence of a gene fusion, not the androgen receptor," Chinnai
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Scientists discover the molecular heart of collective behavior
2. Scientists Map Genetic Codes of Human Microbes
3. Scientists find protein spurs spread of prostate cancer
4. What to Read on World Ocean Day: Scientists and Non Profits Herald New Eco-Thriller Eye of the Whale
5. Clue to switch of bladder cancer from locally contained to invasive found by Jefferson scientists
6. Wistar scientists explain the persistence of melanoma through dynamic stemness
7. Mass. Eye and Ear receives NEI grant renewal for growing clinical/scientists
8. Scientists Map Neanderthal Genome
9. Genome breakthrough allows scientists to identify and profile tumor cells from very small samples
10. Scientists Unravel Secret of HIV Resistance
11. A century-old puzzle comes together: Scientists ID potential protein trigger in lung disease sarcoidosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... Providenciales, Turks and Caicos Islands, BWI (PRWEB) April 25, ... Providenciales International Airport (PLS) has celebrated three months of ... since reopening on January 5, 2015. , As ... phases, the interior of Providenciales airport was completely redesigned ... area has quickened up the process of getting out ...
(Date:4/25/2015)... April 25, 2015 On Friday, April ... RFID Journal’s annual Best Implementation Award. This award ... the best use of RFID technology to improve its ... the company that best demonstrates how RFID is delivering ... at RFID Journal Live! 2015 in San Diego, the ...
(Date:4/24/2015)... AK (PRWEB) April 24, 2015 As ... (#MOTMC2015) and the unique sacrifices of these young men ... for Service members, Veterans and their Families” presents a ... training is designed to gain a better understanding of ... health and wellness. For those – civilian and military ...
(Date:4/24/2015)... The 1975 have had an intense ... globe to theaters, festivals and TV performances. Now that they’ve ... their label, Dirty Hit Records, to provide clean drinking water ... launched Cadence & Cause website, this four-piece has ... and a signed photo card. Entries from this sweepstakes ...
(Date:4/24/2015)... Anchor Health Administrators (Anchor), specialists in Long-Term ... their exclusive agreement with LTC Solutions for All LLC ... partner. , Anchor has more than 18 years of ... associations, and is currently the designated advocate for the ... Insurance member benefit. , “I am very pleased to ...
Breaking Medicine News(10 mins):Health News:The Tuscany on Grace Bay Celebrates Providenciales Airport Expansion With Summer Specials to Travelers! 2Health News:Seeonic’s Industry Leading Technology Powers Interstate Batteries to Winning Award 2Health News:Coalition Presents Resiliency Training to Raise Awareness during Month of the Military Child (#MOTMC2015) 2Health News:Internationally Recognized British Indie Rock Outfit The 1975 Partner with Cadence & Cause to Provide Clean Drinking Water to Those in Need 2
... simulation exhibition event ever held will feature top leaders from ... opening ceremonies of the Interservice/Industry Training, Simulation and Education Conference ... Army Training and Doctrine Command (TRADOC). Joining him will ... Martin Joint Strike Fighter Program. , ...
... Latina women who prefer speaking Spanish are more likely ... with their breast cancer treatment, according to a new ... Cancer Center. , Despite receiving similar treatment, Latina women ... report high levels of dissatisfaction and regret about their ...
... and healthcare information resource, today released the results ... increasing healthcare costs and more infrequent doctor visits. ... percent) indicated they are going to the doctor ... healthcare costs. In an additional question of 274 ...
... when given before birth, glucocorticoids tied to cognitive, motor ... News) -- Glucocorticoid drugs used to treat chronic lung ... and may cause cognitive and motor control problems even ... Washington University School of Medicine in St. Louis. , ...
... found little link between drinking and malignancies , , MONDAY, ... your chances of developing cancer after age 65, new ... lack of physical activity were among the usual suspects ... to the Duke University study. , The findings are ...
... a test would be especially useful for blacks, other high-risk ... someday be able to use five genetic markers to assess ... cancer, a new study suggests. , If reliable, these five ... patients, or men of any race with a family history ...
Cached Medicine News:Health News:Military, Industry Leaders to Speak at World's Largest Simulation Event 2Health News:Military, Industry Leaders to Speak at World's Largest Simulation Event 3Health News: More Than Half of Consumers Going to Doctors Less Due to Rising Healthcare Costs, According to checkMD Survey : 38 Percent Lack Adequate Employer Healthcare Coverage 2Health News: More Than Half of Consumers Going to Doctors Less Due to Rising Healthcare Costs, According to checkMD Survey : 38 Percent Lack Adequate Employer Healthcare Coverage 3Health News:Drugs to Treat Lung Damage in Preemies May Harm Brain 2Health News:Stay Upbeat, Exercise to Help Prevent Cancer in Old Age 2Health News:Gene Screen Might Predict Prostate Cancer 2
(Date:4/23/2015)... 23, 2015  Jazz Pharmaceuticals plc (Nasdaq: JAZZ ... first quarter financial results on Thursday, May 7, 2015, ... will host a live audio webcast immediately following the ... first quarter 2015 financial results and provide a business ... the live audio webcast via the Investors & Media ...
(Date:4/23/2015)... , April 23, 2015  Research Solutions, Inc. (OTCQB: ... and medical (STM) information for life science companies, academic ... to present at the 16 th Annual B. ... 12-14, 2015 at the Loews Hollywood Hotel ... Research Solutions management is scheduled to present on ...
(Date:4/23/2015)... 23, 2015  DanDrit Biotech A/S ("DanDrit Denmark"), ... , Inc. ("DanDrit"), (symbol : OTCQB:DDRT) a ... for the treatment of colorectal cancer, announced that ... signed a partnership agreement in Saudi ... advances DanDrit,s goal to deliver an innovative portfolio ...
Breaking Medicine Technology:Jazz Pharmaceuticals to Report 2015 First Quarter Financial Results on May 7, 2015 2Research Solutions to Present at the 16th Annual B. Riley & Co. Investor Conference on May 12, 2015 2Research Solutions to Present at the 16th Annual B. Riley & Co. Investor Conference on May 12, 2015 3DanDrit Biotech and Riyadh Pharma Sign Partnership Agreement 2
... of Beta Blockers May Have Long-Term BenefitsSAN FRANCISCO, ... a research breakthrough suggesting that, contrary to popular ... pressure may also bring relief to many asthma ... of the American Asthma Foundation (AAF), said, "Drugs ...
... VEGAS, Feb. 26 Tying a shoe, typing ... The mobility of our fingers and wrists can often be ... begins, and interferes with simple, everyday tasks. According to ... American Academy of Orthopaedic Surgeons (AAOS) ( http://www.aaos.org/ ...
Cached Medicine Technology:Research Finding Could Revolutionize Asthma Treatment 2Research Finding Could Revolutionize Asthma Treatment 3Research Finding Could Revolutionize Asthma Treatment 4Got Pain? 2Got Pain? 3Got Pain? 4
... Recently updated with a high ... the new Kowa Non Myd - ... quality, style and ease of use. ... comprehensive, easy to install VK-2 image ...
The quick access to diabetic screening, panoramic images of the retina including peripheral area are available by using easy, semi automatic guidance of peripheral fixation....
Measurement of progressive multi-focal lenses is fast and easy with the CLM-3100P auto-lensmeter. The data is represented in a simple to understand graphic display....
Autolensmeter with color 5.7 inch LCD screen and built in printer....
Medicine Products: