Navigation Links
Scientists Spot Real 'Smoking Gun' in Prostate Cancer
Date:5/21/2010

Gene fusion may be behind disease, not androgen receptors, study suggests

FRIDAY, May 21 (HealthDay News) -- The primary cause of prostate cancer could be the fusion of two genes and the subsequent abnormal prostate cell growth that results when receptors for the hormone androgen get blocked, a new study reveals.

The implication is that standard efforts to treat the disease by targeting the androgen receptors might be missing the real "smoking gun," a University of Michigan Comprehensive Cancer Center team suggests.

"We need to begin to think about targeting prostate cancer by targeting the gene fusion, and not confining our approaches to androgen receptors," study author Dr. Arul Chinnaiyan, director of the Michigan Center for Translational Pathology, said in a news release. "If we're going to find a more durable therapy, we need to get at the gene fusion."

Chinnaiyan and his colleagues report their findings in the May 18 issue of Cancer Cell.

The authors note that typical prostate cancer treatments focus on drugs that attempt to slow production of androgen, the male hormone that regulates healthy prostate growth. However, such efforts usually become less effective over time as cancer cell resistance mounts, making recurrent cancer much less amenable to similar treatments.

But having earlier identified a so-called "on switch" for prostate cancer development in the form of the initial fusion of a prostate gene with a cancer-causing gene, Chinnaiyan and colleagues now have launched a new investigation into what happens post-fusion.

By using high-tech genetic mapping techniques, the research team found that once fusion takes place, androgen receptors get blocked, in turn cutting off normal prostate cell growth while permitting cancer to spread.

"Our study shows the underlying problem in prostate cancer is the presence of a gene fusion, not the androgen receptor," Chinnai
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Scientists discover the molecular heart of collective behavior
2. Scientists Map Genetic Codes of Human Microbes
3. Scientists find protein spurs spread of prostate cancer
4. What to Read on World Ocean Day: Scientists and Non Profits Herald New Eco-Thriller Eye of the Whale
5. Clue to switch of bladder cancer from locally contained to invasive found by Jefferson scientists
6. Wistar scientists explain the persistence of melanoma through dynamic stemness
7. Mass. Eye and Ear receives NEI grant renewal for growing clinical/scientists
8. Scientists Map Neanderthal Genome
9. Genome breakthrough allows scientists to identify and profile tumor cells from very small samples
10. Scientists Unravel Secret of HIV Resistance
11. A century-old puzzle comes together: Scientists ID potential protein trigger in lung disease sarcoidosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/6/2015)... 2015 Johnson & Johnson and Ethicon ... March 5, 2015 in Superior Court in the State ... a jury of 12 awarded Mrs. Perry $700,000 in ... with an Ethicon TVT Abbrevo plastic sling for stress ... women also awarded $5 million in punitive damages. , ...
(Date:3/6/2015)... 06, 2015 Jvion, the Atlanta-based ... of a Clostridium Difficile (C Diff) predictive use ... Diff use case is the latest in a ... acquired infections, chronic conditions, and individual illnesses. Using ... Diff solution flags at risk individuals to help ...
(Date:3/6/2015)... March 06, 2015 In a new study ... mesothelioma patients reported that shoulder pain was their first mesothelioma ... its website. Click here to read it now. ... the medical records of 49 mesothelioma patients between ... that it was shoulder pain that first prompted them to ...
(Date:3/6/2015)... (PRWEB) March 06, 2015 FCPX developers ... from Pixel Film Studios. , “Pro3rd Hue is a lower ... Austin, CEO of Pixel Film Studios. “Blurring the line between ... , Pro3rd Hue is a set of 30 customizable lower ... X. With Pro3rd Hue, FCPX users can complement any design ...
(Date:3/6/2015)... 2015 Fluid Running® Owner, Jennifer Conroyd, ... the Fluid Running® method 3 years ago ... marathon. She hit upon the trifecta of combining matched-bpm ... a maximum-resistance, deep water running technique. She not only ... water running workout that made the experience both enjoyable ...
Breaking Medicine News(10 mins):Health News:Johnson & Johnson Hit with $5.7 Million Verdict in Pelvic Mesh Trial Announces Matthews & Associates Law Firm 2Health News:Johnson & Johnson Hit with $5.7 Million Verdict in Pelvic Mesh Trial Announces Matthews & Associates Law Firm 3Health News:Jvion Predicts Patients at Risk of C Difficile Infection to Reduce Risk and Save Lives 2Health News:New Report Reveals Shoulder Pain Could Signal Early Mesothelioma, According to Surviving Mesothelioma 2Health News:A New Plugin Entitled Pro3rd Hue was Released Today from Pixel Film Studios Exclusively for FCPX 2Health News:Fluid Running®, the Revolutionary, No-Impact Running Workout, Expands Nationally with New Training Workshop 2Health News:Fluid Running®, the Revolutionary, No-Impact Running Workout, Expands Nationally with New Training Workshop 3
... Jan. 14 Nephros, Inc. (Amex: NEP ... the prestigious 2009 Frost & Sullivan Medical Device Patient ... its rapid growth, progressive technology, and strategic product development. ... that meet market demands. Nephros,s breakthrough hemodiafiltration technology ...
... ,must book-mark site,BETHESDA, Md., Jan. 14 The American ... Web site -- www.cff.org -- the top ... "Best of the Web" review of 2008, the American ... cystic fibrosis. , , "This is ...
... /PRNewswire/ -- Scarguard Labs, LLC, a closely ... other dermatological problems through the use of multi-technology drugs ... has appointed Richard E. Pino as Chief Financial Officer. ... and treasury functions and will report to Chief Executive ...
... new treatments for aggressive form of childhood disease, study ... say they may have identified a subtype of T-lymphoblastic ... standard intensive chemotherapy. , Approximately 20 percent ... chemotherapy treatments that cure others with the disease, and ...
... Lagan, a provider of enterprise case management solutions that ... announced a new Lagan Human Services Call Center ... agencies in North America. The new solution is ... a range of functions depending on the programs administered, ...
... the Pearl of Wisdom(TM) as Worldwide Symbol for ... Cancer Awareness Month in the United States, a ... healthcare providers and others is partnering with their ... to prevent cervical cancer worldwide. The Pearl ...
Cached Medicine News:Health News:Nephros, Inc. Receives the 2009 Frost & Sullivan Medical Device Patient Care Company of the Year Award 2Health News:Nephros, Inc. Receives the 2009 Frost & Sullivan Medical Device Patient Care Company of the Year Award 3Health News:Nephros, Inc. Receives the 2009 Frost & Sullivan Medical Device Patient Care Company of the Year Award 4Health News:Nephros, Inc. Receives the 2009 Frost & Sullivan Medical Device Patient Care Company of the Year Award 5Health News:Nephros, Inc. Receives the 2009 Frost & Sullivan Medical Device Patient Care Company of the Year Award 6Health News:Cystic Fibrosis Foundation Web Site Rated 'Best of the Web' 2Health News:Scarguard Labs, LLC Appoints Richard E. Pino as CFO 2Health News:Hard-to-Treat Leukemia Cell Subtype Identified 2Health News:Lagan Unveils Human Services Call Center Solution for North America 2Health News:U.S. and European Advocacy Groups Launch United, Global Campaign to Prevent Cervical Cancer 2Health News:U.S. and European Advocacy Groups Launch United, Global Campaign to Prevent Cervical Cancer 3Health News:U.S. and European Advocacy Groups Launch United, Global Campaign to Prevent Cervical Cancer 4
(Date:3/6/2015)... CHICAGO, Ill. , March 6, 2015  AbbVie ... Barclays Global Health Care Conference on Thursday, March 12, ... executive officer, will participate in a question and answer ... live audio webcast of the presentation will be accessible ... .  An archived edition of the session will be ...
(Date:3/6/2015)... , March 6, 2015  Par Pharmaceutical Companies, ... conference call on Friday, March 13, 2015 at ... operations for the fourth quarter and full year ... and currently makes certain financial information available to ... and Exchange Commission and will make certain other ...
(Date:3/6/2015)... Mar. 06, 2015 Research and Markets ... "European Patient Handling Equipment Market by Product, by ... Forecast to 2019" report to their offering. ... expected to grow at a double-digit CAGR of 11.4% ... Factors such as rising geriatric population, increasing incidences of ...
Breaking Medicine Technology:European Patient Handling Equipment (Wheelchair, Scooters, Bathroom Safety Supply, Mechanical, Ambulatory) Market 2015-2019 2European Patient Handling Equipment (Wheelchair, Scooters, Bathroom Safety Supply, Mechanical, Ambulatory) Market 2015-2019 3
... 17 deCODE genetics, Inc. (Nasdaq: DCGN ) today ... under Chapter 11 of the United States Bankruptcy Code with ... to facilitate the sale of substantially all of its assets. ... properties as a debtor-in-possession pursuant to Sections 1107 and 1108 ...
... , FREMONT, Calif., Nov. 16 Vermillion, Inc. (Pink ... will be presenting at the Lazard Capital Markets Sixth Annual ... scheduled for Tuesday, November 17, 2009 at 5:10 p.m. Eastern ... OVA1 Test is a qualitative serum test that combines the ...
Cached Medicine Technology:deCODE genetics, Inc. Files Voluntary Chapter 11 Petition to Facilitate Sale of Assets 2deCODE genetics, Inc. Files Voluntary Chapter 11 Petition to Facilitate Sale of Assets 3deCODE genetics, Inc. Files Voluntary Chapter 11 Petition to Facilitate Sale of Assets 4
Bravo Vacuum Pump Accessories Kit (One canister, one lid, one "O" ring tube, one tubing set)...
Bravo pH capsule with delivery system....
Buffer solution is needed to calibrate pH catheters. The specific chloride ion concentration in the Medtronic buffers is required for proper function of your Medtronic pH measurement system. Buffer s...
Buffer solution is needed to calibrate pH catheters. The specific chloride ion concentration in the Medtronic buffers is required for proper function of your Medtronic pH measurement system. Buffer s...
Medicine Products: