Navigation Links
Scientists Find Key to Hormone-Resistant Prostate Tumors
Date:3/10/2010

p>By studying prostate cancer in mice, the researchers figured out that, as the prostate tumor shrinks, the dying cancer cells apparently send off signals that activate the body's immune response.

"What we think is going on is, when you kill the tumor, the body doesn't know it's the tumor being killed," Karin said. "It responds to it like there is tissue injury, a wound or something like that."

White blood cells called B-cells infiltrate the tumor and release a substance called lymphotoxin, a protein that kills infected cells. The research team found that exposure to lymphotoxin promoted the development of cancer cells resistant to hormone therapy. Interfering with the inflammatory response delayed the development of castration-resistant cancer.

"It's somewhat counterintuitive, that the death of these androgen-resistant cells somehow contributes to androgen resistance," said Dr. Durado Brooks, director of prostate and colorectal cancer for the American Cancer Society.

The finding could be key in developing a means to delay or stop the development of therapy-resistant secondary tumors. Until now, research into this resistance has focused on the role that the cells' androgen receptors play in the process. But researchers now can also consider controlling inflammation as another way to delay resistance.

Don't expect anything useful for humans anytime soon. Researchers will have to first make sure that human prostate cancer responds in the same way that the cancer did in mice.

"There's going to have to be a lot more work done to clarify that the mechanisms in humans are the same as those they have identified in mouse prostate cancer," Brooks said. "It's going to be quite a while before this mouse model moves to the bedside and actual clinical practice, if it ever does."

But if the findings do transfer to humans, this new understanding of the role of inflammation in prostate cancer treatment could help
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. University of Michigan scientists discover bone marrow can harbor HIV-infected cells
2. MSU scientists develop more effective method of predicting lead-poisoning risk
3. Scientists Unravel Mysteries of Intelligence
4. Scientists Spot Genetic Fingerprints of Individual Cancers
5. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
6. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
7. Neuroscientists reveal new links that regulate brain electrical activity
8. Scientists find donut-shaped structure of enzyme involved in energy metabolism
9. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
10. Prevention Is Key Research Goal for Premature Babies, Scientists Say
11. Scientists Discover How HIV Is Transmitted Between Men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The City of West Hollywood hosted a news conference on ... anniversary of the Supreme Court decision Roe v. Wade, which legalized ... the Roe vs. Wade decision and the fight to protect a ... City of West Hollywood Councilmember Abbe Land. “We need to continue ...
(Date:1/22/2015)... TN (PRWEB) January 22, 2015 Gabe’s Chemo Duck ... Duck App, the first app ever created for kids with cancer. ... Apple phones and devices, is filled with enjoyable games to help ... and treatments. The free app helps to keep kids entertained, educated ...
(Date:1/22/2015)... January 23, 2015 VogueQueen is a seasoned ... prices and many designers are thrilled to have it lead ... announces its new collection of prom dresses for the global ... drive the strategic vision and he focuses on continuing the ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company offering many ... it on Facebook, Twitter, and Pinterest. The fans will have ... a lottery every week. , Moreover, the company has extended ... Angelweddingdress homepage for more information. , Angelweddingdress ...
(Date:1/22/2015)... 2015 AngelWeddingDress, the premier women’s dress ... wedding dresses. View website of AngelWeddingDress.com to ... maternity wedding dresses online for a bridal party. AngelWeddingDress ... quality for them. Its maternity wedding dresses are specially ...
Breaking Medicine News(10 mins):Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2
... , IRVINE, Calif., July 17 ... has reached a settlement with Respironics, Inc. of pending litigation under which ... the litigation between them in California Superior Court. As part of ... phase-out of the MARS oximetry technology. , , ...
... , , GLASGOW, Scotland, July 17 ... like to be the national emblem of England, beating Wimbledon favourite Strawberries ... survey commissioned by AXA PPP healthcare,s Nutrition and Fitness website: www.axappphealthcare.co.uk/healthyliving. , ... ban on the sale of ,misshapen, produce such as straight bananas on ...
... ... QHR client hospitals Littleton Regional Hospital (Littleton, N.H.), ... Vt.) and Trigg County Hospital (Cadiz, Kent.) were recently named ... healthcare quality improvement services. Avatar celebrated these hospitals for their ...
... , INDIANAPOLIS, July 17 HCC Medical ... 2009, MultiNational Underwriters, LLC (MNU) has adopted the HCC name to ... behalf of HCC Life Insurance Company and Lloyd,s Syndicate 4141. ... MultiNational Underwriters in 1998, MNU has been a recognized leader in ...
... say , THURSDAY, July 16 (HealthDay News) -- Circumcision ... women, says a study that included 922 HIV-infected men ... the start of the study, were randomly selected to ... study also included HIV-uninfected female partners of the men. ...
... , , NEWPORT BEACH, ... ) announced today that the Company will release its 2009 second quarter ... the New York Stock Exchange. The Company will host a webcast ... time (11:30 a.m. Eastern time) to discuss these results. , ...
Cached Medicine News:Health News:Masimo Announces Settlement of Lawsuit 2Health News:Masimo Announces Settlement of Lawsuit 3Health News:Potato Tops Poll To Be UK's National Veg 2Health News:QHR Client Hospitals Lauded for Consistently High Quality Standards, Exceeding Patient Expectations 2Health News:QHR Client Hospitals Lauded for Consistently High Quality Standards, Exceeding Patient Expectations 3Health News:MultiNational Underwriters Is Now HCC Medical Insurance Services 2Health News:Circumcision Doesn't Lessen HIV Transmission 2Health News:NHP Announces Second Quarter Earnings Release Date and Webcast/Conference Call 2
(Date:1/23/2015)...  Now available for sale, The Armor1 Ankle Roll Guard is ... sprains by cushioning the ankle from an inversion or ... outside of any shoe type and allows the user ... protection against sprains. With customers in physical therapy, podiatry, ...
(Date:1/23/2015)... , Jan. 23, 2015  CytoSorbents Corporation (NASDAQ ... its CytoSorb® extracorporeal cytokine adsorber to reduce deadly ... the receipt of $385,642, net of transaction costs, ... the Technology Business Tax Certificate Transfer Program sponsored ...
(Date:1/22/2015)... , Jan. 22, 2015  ViewRay™, a privately held ... into an exclusive distributor agreement with ITOCHU Corporation (Tokyo ... therapy system for the treatment of cancer in ... system, is the world,s first and only MRI-guided radiation ...
Breaking Medicine Technology:The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2
... The R4Mplus offers global companies a ... meet RFID compliance initiatives. With die-cast ... variety of connectivity options, and complex ... a super value. Plus, the fully ...
... Visitor Control System. A bar code-based nursery control ... verify identity of those people authorized to handle ... with all visitors and staff who have access ... It also helps to reduce the chance for ...
... H 2824-Z direct thermal printer ensures reliable ... and privacy. Generating clear bar codes, text, ... types, the H 2824-Z direct thermal printeravailable ... identification wristbands on demand. It can also ...
... global companies a cost-effective and dependable ... initiatives. With die-cast metal construction, centralized ... options, and complex multi-language font support, ... Plus, the fully integrated RFID reader/encoder ...
Medicine Products: