Navigation Links
Scientists Find Key to Hormone-Resistant Prostate Tumors
Date:3/10/2010

p>By studying prostate cancer in mice, the researchers figured out that, as the prostate tumor shrinks, the dying cancer cells apparently send off signals that activate the body's immune response.

"What we think is going on is, when you kill the tumor, the body doesn't know it's the tumor being killed," Karin said. "It responds to it like there is tissue injury, a wound or something like that."

White blood cells called B-cells infiltrate the tumor and release a substance called lymphotoxin, a protein that kills infected cells. The research team found that exposure to lymphotoxin promoted the development of cancer cells resistant to hormone therapy. Interfering with the inflammatory response delayed the development of castration-resistant cancer.

"It's somewhat counterintuitive, that the death of these androgen-resistant cells somehow contributes to androgen resistance," said Dr. Durado Brooks, director of prostate and colorectal cancer for the American Cancer Society.

The finding could be key in developing a means to delay or stop the development of therapy-resistant secondary tumors. Until now, research into this resistance has focused on the role that the cells' androgen receptors play in the process. But researchers now can also consider controlling inflammation as another way to delay resistance.

Don't expect anything useful for humans anytime soon. Researchers will have to first make sure that human prostate cancer responds in the same way that the cancer did in mice.

"There's going to have to be a lot more work done to clarify that the mechanisms in humans are the same as those they have identified in mouse prostate cancer," Brooks said. "It's going to be quite a while before this mouse model moves to the bedside and actual clinical practice, if it ever does."

But if the findings do transfer to humans, this new understanding of the role of inflammation in prostate cancer treatment could help
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. University of Michigan scientists discover bone marrow can harbor HIV-infected cells
2. MSU scientists develop more effective method of predicting lead-poisoning risk
3. Scientists Unravel Mysteries of Intelligence
4. Scientists Spot Genetic Fingerprints of Individual Cancers
5. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
6. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
7. Neuroscientists reveal new links that regulate brain electrical activity
8. Scientists find donut-shaped structure of enzyme involved in energy metabolism
9. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
10. Prevention Is Key Research Goal for Premature Babies, Scientists Say
11. Scientists Discover How HIV Is Transmitted Between Men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... 31, 2014 Monica Williams-Murphy MD ... all too well the chaos that can occur for ... “The vast majority of Americans who come into the ... are completely unprepared for the moment and so are ... can serve as a catalyst for a family to ...
(Date:10/31/2014)... With all the preparations families carry ... they may overlook one critical area – the potential ... school performance and even behavior. Typical children’s vision screenings ... progressive vision problems, and to address this challenge, Dr. ... initiative: The Awesome Eyes Student Vision Program. , ...
(Date:10/31/2014)... 2014 (HealthDay News) -- Surgery for low back pain ... the United States you live, a new report says. ... back pain at some point in their lives, and ... care for a spine problem," co-author Brook Martin, of ... said in a college news release. In spinal ...
(Date:10/31/2014)... of treatment and cost, patients with early stage ... irradiation (APBI) with proton therapy versus whole breast ... University of Texas MD Anderson Proton Therapy Center. ... based on typical patient characteristics, researchers used Medicare ... different types of partial and whole breast irradiation ...
(Date:10/31/2014)... a lab device to give cancer researchers an unprecedented ... cells spread through the body, causing more than 90 ... how tumor cells travel, the device could uncover new ... from the university,s Whiting School of Engineering and its ... their new system recently in the journal Cancer ...
Breaking Medicine News(10 mins):Health News:This Thanksgiving or Christmas Family Gathering, Use The New App ListStuffFast to Start "The Conversation" With a Parent That Has No Plan For End-of-Life 2Health News:This Thanksgiving or Christmas Family Gathering, Use The New App ListStuffFast to Start "The Conversation" With a Parent That Has No Plan For End-of-Life 3Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 2Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 3Health News:Spinal Surgery Varies by Region in U.S.: Study 2Health News:Proton therapy shown to be less costly than some alternative radiotherapy techniques 2Health News:Proton therapy shown to be less costly than some alternative radiotherapy techniques 3Health News:Viewing cancer on the move: New device yields close-up look at metastasis 2Health News:Viewing cancer on the move: New device yields close-up look at metastasis 3
... dose to the breast and lungs before deciding which CT ... new study cautions. The study compared organ doses to ... found a change in protocol could decrease breast radiation dose ... breast skin and parenchyma were found with our standard thoracic ...
... or anxiety states are often associated with disturbances ... are compounds that are released from the synapses ... of neighboring neurons. Thus, as their name suggests, ... serotonin transporter (SERT) is responsible for reuptake of ...
... PROVIDENCE, R.I. Peter J. Snyder, Ph.D., vice president ... 10 Ig Nobel Prize awards during the annual ceremony ... and colleagues from the University of Melbourne and Yale Medical ... acute urge to void the bladder can have the same ...
... at least on the healthy part. "Early to bed and early ... youths keep slimmer and more physically active than their night-owl peers, ... A study in the Oct. 1 issue of the journal ... participants, ages 9 to 16, and compared their weights and uses ...
... New America Media (NAM) have selected 16 reporters for ... in its second year. They represent a wide range of mainstream ... Arizona to Korea Daily Atlanta. The fellows will convene during ... to 22 in Boston and tap into over 500 presentations ...
... -- Working rotating shifts is not as potentially unhealthy ... research that suggests modern shift patterns may not carry ... shift schedules. "Recent research has suggested shift work ... mechanism responsible for this observation is still unknown," the ...
Cached Medicine News:Health News:Combating mood disorders 2Health News:Lifespan researcher wins Ig Nobel Prize 2Health News:Early to bed and early to rise -- study suggests it's keeping kids leaner 2Health News:Journalism fellows promise in-depth portrayal of aging in a diverse America 2Health News:Journalism fellows promise in-depth portrayal of aging in a diverse America 3Health News:Journalism fellows promise in-depth portrayal of aging in a diverse America 4Health News:Modern Shift Work Patterns May Be Less Harmful to Health 2
(Date:10/31/2014)... 31, 2014 Mast Therapeutics, Inc. (NYSE MKT: ... for the quarter ended September 30, 2014. ... said:  "The third quarter was productive for Mast. Consistent with ... MST-188 for sickle cell disease is on track to ... have opened 50 study sites in the U.S. and ...
(Date:10/31/2014)... October 31, 2014 Oramed ... pharmaceutical company focused on the development of oral ... host a conference call to discuss the clinical ... ORMD-0801, the company,s proprietary oral insulin capsules, to ... 2014 at 10:00 a.m. Eastern time. ...
(Date:10/31/2014)... Investor-Edge has initiated coverage on the following ... Pharmaceuticals Inc. (NASDAQ: ISIS ), Halozyme Therapeutics ... (NASDAQ: ACAD ), and Synta Pharmaceuticals Corporation ... be accessed at: http://investor-edge.com/register . On ... 4,566.14, up 0.37%, the Dow Jones Industrial Average advanced ...
Breaking Medicine Technology:Mast Therapeutics Reports Third Quarter 2014 Financial Results 2Mast Therapeutics Reports Third Quarter 2014 Financial Results 3Mast Therapeutics Reports Third Quarter 2014 Financial Results 4Mast Therapeutics Reports Third Quarter 2014 Financial Results 5Mast Therapeutics Reports Third Quarter 2014 Financial Results 6Mast Therapeutics Reports Third Quarter 2014 Financial Results 7Mast Therapeutics Reports Third Quarter 2014 Financial Results 8Oramed to Report Key Top Line Results from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 2Oramed to Report Key Top Line Results from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 3Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 2Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 3Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 4Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 5
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: