Navigation Links
Resisting the flu
Date:1/15/2014

McGill researchers, led by Dr. Maya Saleh of the Department of Medicine, have identified an enzyme, cIAP2 that helps the lungs protect themselves from the flu by giving them the ability to resist tissue damage. "It's a discovery that offers exciting new avenues for controlling influenza, since until now attempts to target the virus itself have proven challenging, especially in the face of emerging new strains of the virus," says Saleh, who is also a researcher at the Research Institute of the McGill University Health Centre (RI-MUHC). "The results from our study now suggest that one effective way of countering influenza infections may instead be offered by enhancing the body's resistance to the virus."

Like many other battles, fighting the flu is a combination of both control and defence. On the one hand, on the control end of the process, our immune system comes into play to prevent the virus from replicating inside our cells, and attacking with increasing strength. At the same time, on the defensive side, our bodies need to actively resist the destruction and harmful cell death that is caused by the virus.

By investigating the role played by cIAP2 in mice with the H1N1 influenza A virus, what Saleh and her team discovered was that the enzyme is necessary to control the nature of cell death during influenza infection. They found that cIAP2, which functions by modifying and activating survival factors in the cell, steers the body away from an inflammatory and auto-destructive process known as necrotic death. The enzyme is, in effect, a gatekeeper of cell death.

In its absence, the same factors that depend on cIAP2 to keep the cell alive, reveal a destructive side and induce a harmful form of cell death. cIAP2 therefore not only protects the infected cells from dying in such a manner, but also protects uninfected neighbouring cells in the same tissue. By doing so, this enzyme increases the resistance of the lung to influenza infection and associated pathology.

The researchers believe that the identification of this pathway of resistance to flu opens a number of avenues for future drug development. Ian Rodrigue-Gervais is a post-doctoral fellow in Prof. Saleh's lab and one of the authors on the paper. According to him, what is truly exciting about this discovery is that it suggests that it may be possible to suppress features of flu-inflicted tissue injury. "What we saw in this study is that if the enzyme cIAP2 is present, the host can better tolerate the infection and then reduce the illness."


'/>"/>
Contact: Katherine Gombay
katherine.gombay@mcgill.ca
McGill University
Source:Eurekalert  

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Resisting the flu
(Date:5/26/2017)... , ... May 26, 2017 , ... “When the Stars ... Home” is the creation of published author Laura Weigel Douglas, an avid reader who ... in a house that sometimes feels like Green Hills Adventure Camp. She couldn’t be ...
(Date:5/26/2017)... ... May 26, 2017 , ... “Cactus Jack: Against All ... so many others. “Cactus Jack: Against All Odds” is the creation of published ... D. Hubbard is married to Jack Carlisle’s third child Jane. Walter. Walter and ...
(Date:5/24/2017)... New York, New York (PRWEB) , ... May 24, 2017 , ... ... and general vascular surgery in New York City. He is known for ... his broad specialization in vascular surgery, Dr. Benvenisty holds sub-specialty training in treating renovascular ...
(Date:5/24/2017)... ... 24, 2017 , ... Dr. Manju R. Kejriwal, a leading Ohio dentist, is ... without a referral. Dr. Kejriwal understands the emotional and financial toll traditional orthodontics can ... OH. Patients no longer need to feel the esthetic effects of wires and brackets ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... ... recently completed Course II of the HP3 (High-Performance Periodontal Practice) continuing education (CE) ... learning the latest advancements in his field by attending numerous CE courses each ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... , May 5, 2017   Provista , a ... more than 200,000 customers, today announced Jim Cunniff ... wealth of executive and business experience to Provista, including most ... pharmacy in California . He assumed his ... "Jim is a great fit for Provista," says Jody ...
(Date:5/4/2017)... DIEGO , May 4, 2017 ... demonstrating its wireless, handheld ultrasound scanners this week ... Annual Scientific Meeting (ACOG) in San ... "Clarius is the perfect tool ... growth and heart rate, and evaluate pregnancy-related complications ...
(Date:5/3/2017)... ORANGE COUNTY, Calif. , May 3, 2017 ... vital aspect of any hospital or healthcare facility. ... of examination room is equipped with diagnostic imaging ... and arteries of the heart. In these spaces, ... coronary angiography, catheterization, balloon angioplasty, percutaneous coronary intervention, ...
Breaking Medicine Technology: