Navigation Links
Resisting the flu
Date:1/15/2014

McGill researchers, led by Dr. Maya Saleh of the Department of Medicine, have identified an enzyme, cIAP2 that helps the lungs protect themselves from the flu by giving them the ability to resist tissue damage. "It's a discovery that offers exciting new avenues for controlling influenza, since until now attempts to target the virus itself have proven challenging, especially in the face of emerging new strains of the virus," says Saleh, who is also a researcher at the Research Institute of the McGill University Health Centre (RI-MUHC). "The results from our study now suggest that one effective way of countering influenza infections may instead be offered by enhancing the body's resistance to the virus."

Like many other battles, fighting the flu is a combination of both control and defence. On the one hand, on the control end of the process, our immune system comes into play to prevent the virus from replicating inside our cells, and attacking with increasing strength. At the same time, on the defensive side, our bodies need to actively resist the destruction and harmful cell death that is caused by the virus.

By investigating the role played by cIAP2 in mice with the H1N1 influenza A virus, what Saleh and her team discovered was that the enzyme is necessary to control the nature of cell death during influenza infection. They found that cIAP2, which functions by modifying and activating survival factors in the cell, steers the body away from an inflammatory and auto-destructive process known as necrotic death. The enzyme is, in effect, a gatekeeper of cell death.

In its absence, the same factors that depend on cIAP2 to keep the cell alive, reveal a destructive side and induce a harmful form of cell death. cIAP2 therefore not only protects the infected cells from dying in such a manner, but also protects uninfected neighbouring cells in the same tissue. By doing so, this enzyme increases the resistance of the lung to influenza infecti
'/>"/>

Contact: Katherine Gombay
katherine.gombay@mcgill.ca
McGill University
Source:Eurekalert  

Page: 1 2

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Resisting the flu
(Date:4/14/2014)... Doctors at Henry Ford Hospital reached a medical ... replacement using a novel way to access the heart. ... United States performing the unique procedure called transcaval valve ... blood vessels. , Northern Michigan resident Viola Waller, 80, ...
(Date:4/14/2014)... Penicillin, one of the scientific marvels of the 20th ... once won against bacterial infections. But scientists at the ... approach to restoring its combat effectiveness, even against so-called ... power of the penicillin family of drugs since their ...
(Date:4/14/2014)... their radiation treatment decisions leaves cancer patients feeling more ... distress around the experience, researchers from the Perelman ... report in the journal Cancer . , In ... Neha Vapiwala, MD , an associate professor in the ...
(Date:4/14/2014)... 14, 2014 Popular web information on colorectal cancer ... and doesn,t address the appropriate risks to and concerns ... gastroenterologists suggests. , In a review of a dozen ... for colorectal cancer screening were written beyond the recommended ...
(Date:4/14/2014)... Scientists found that the molecule, called microRNA 135b, is ... to drive the growth of bowel cancers. , Drugs ... of multiple cancer-causing mutations at once, while tests for ... the researchers believe. , The research was carried out ...
Breaking Medicine News(10 mins):Health News:Henry Ford Hospital hits new heart valve surgery milestone 2Health News:Penicillin redux: Rearming proven warriors for the 21st century 2Health News:Penicillin redux: Rearming proven warriors for the 21st century 3Health News:Shared decision making during radiation therapy improves patient satisfaction 2Health News:Shared decision making during radiation therapy improves patient satisfaction 3Health News:Website information on colon cancer too complex, fails to address key concerns 2Health News:Website information on colon cancer too complex, fails to address key concerns 3Health News:'MicroRNA' could be key target for bowel cancer treatment 2
... a grant of 1.6 million Euro from the Stichting ... of diabetes. The grant will make it possible to ... insulin is regulated in living organisms and this ... against diabetes. , Diabetes is an extremely common condition, ...
... University and Texas Children,s Hospital have turned stem cells from ... offers hope that such stem cells may be used to ... to come up with technology to replace defective tissue with ... the infant into the amniotic fluid," said Rice bioengineer Jeffrey ...
... Ariz. Feb. 5, 2012 The Translational Genomics ... Feb. 6-8 at the Hotel Valley Ho in Scottsdale, ... clinicians and foundations to promote the exchange of information ... The causes of childhood cancers are largely unknown ...
... not only shed its stigma, it has surpassed all ... meeting through friends, according to a new analysis of ... digital revolution in romance is a boon to lonely-hearters, ... reports the team of psychological scientists who prepared the ...
... did not decrease breast cancer cell proliferation in a ... Cancer Prevention Research , a journal of the ... A. Khan, M.D., professor of surgery at the Robert ... the results of this study are consistent with the ...
... Scientists from The Scripps Research Institute, Scripps ... the effectiveness of an advanced blood test for ... from patients, solid tumorsfrom cancer patients. The findings, ... highly sensitive blood analysis provides information that may ...
Cached Medicine News:Health News:Donation opens new opportunities for more effective diabetes treatment 2Health News:Scientists make strides toward fixing infant hearts 2Health News:Scientists make strides toward fixing infant hearts 3Health News:TGen hosts international conference for leading pediatric cancer researchers, foundations 2Health News:TGen hosts international conference for leading pediatric cancer researchers, foundations 3Health News:TGen hosts international conference for leading pediatric cancer researchers, foundations 4Health News:Online dating research shows cupid's arrow is turning digital 2Health News:Online dating research shows cupid's arrow is turning digital 3Health News:Scripps research scientists demonstrate effective new 'biopsy in a blood test' to detect cancer 2Health News:Scripps research scientists demonstrate effective new 'biopsy in a blood test' to detect cancer 3Health News:Scripps research scientists demonstrate effective new 'biopsy in a blood test' to detect cancer 4
(Date:1/15/2014)... DUBLIN , Jan. 15, 2014  Research and Markets ... "Dental Consumables Market - Global Industry Analysis, Size, ... report to their offering. (Logo: ... products which are used on patients in order to ...
(Date:1/15/2014)... , Jan. 15, 2014  Novation, the leading health ... several new IT value-added reseller (VAR) national contracts that ... goods and services at lower costs. These include manufacturer ... such as initiative assistance and ongoing IT consulting support. ...
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces that ... to the announced tender offer for all of the outstanding shares ... of the waiver, the transaction is no longer conditional on OFT ... 24, 2014 following the currently scheduled expiration time, subject to the ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3
Shafts angled 45 degrees, 10 mm from tip to bend. 1 x 2 teeth. Serrated handle with polished finish. Most popular size or model....
Straight shafts with 5.5 mm tying platform and 1 mm crisscross serrated tips. Wide serrated handle with polished finish....
Serrated tips, straight platforms....
Curved shafts with fine pointed tips. Smooth handle with dull finish....
Medicine Products: