Navigation Links
Resisting the flu
Date:1/15/2014

McGill researchers, led by Dr. Maya Saleh of the Department of Medicine, have identified an enzyme, cIAP2 that helps the lungs protect themselves from the flu by giving them the ability to resist tissue damage. "It's a discovery that offers exciting new avenues for controlling influenza, since until now attempts to target the virus itself have proven challenging, especially in the face of emerging new strains of the virus," says Saleh, who is also a researcher at the Research Institute of the McGill University Health Centre (RI-MUHC). "The results from our study now suggest that one effective way of countering influenza infections may instead be offered by enhancing the body's resistance to the virus."

Like many other battles, fighting the flu is a combination of both control and defence. On the one hand, on the control end of the process, our immune system comes into play to prevent the virus from replicating inside our cells, and attacking with increasing strength. At the same time, on the defensive side, our bodies need to actively resist the destruction and harmful cell death that is caused by the virus.

By investigating the role played by cIAP2 in mice with the H1N1 influenza A virus, what Saleh and her team discovered was that the enzyme is necessary to control the nature of cell death during influenza infection. They found that cIAP2, which functions by modifying and activating survival factors in the cell, steers the body away from an inflammatory and auto-destructive process known as necrotic death. The enzyme is, in effect, a gatekeeper of cell death.

In its absence, the same factors that depend on cIAP2 to keep the cell alive, reveal a destructive side and induce a harmful form of cell death. cIAP2 therefore not only protects the infected cells from dying in such a manner, but also protects uninfected neighbouring cells in the same tissue. By doing so, this enzyme increases the resistance of the lung to influenza infecti
'/>"/>

Contact: Katherine Gombay
katherine.gombay@mcgill.ca
McGill University
Source:Eurekalert  

Page: 1 2

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Resisting the flu
(Date:3/28/2015)... The California-based leading wig brand UniWigs has prepared ... UniWigs during the Easter Holidays from today until April ... April Fools’ Day. , As the winter fades and ... Easter Festival, with religious origins to countries in Europe ... Christmas. The best wig provider, UniWigs, would like to ...
(Date:3/28/2015)... An article in Fortune on Monday, ... critical to organizations that deal with PCI (Payment Card ... data security, is worsening . Using numbers from ... major category out of the twelve measured improved, barring ... the craziness that has gone on in the retail ...
(Date:3/28/2015)... One in three young athletes who ... today at the American Orthopaedic Society for Sports Medicine’s ... long term success of surgery for patients aged 18 ... from 242 patients who underwent ACL reconstruction between 1993 ... FRACS, from North Sydney Orthopaedic and Sports Medicine Centre. ...
(Date:3/28/2015)... Las Vegas, NV (PRWEB) March 28, 2015 ... option for patients with Type V AC joint injuries, ... The study, presented today at the American Orthopaedic Society ... military personnel returned to duty faster when surgery was ... 24 patients, with 7 receiving surgical treatment and 17 ...
(Date:3/28/2015)... Portland, OR (PRWEB) March 28, 2015 ... in the media regarding recent changes and proposals around ... TV , current and former collegiate student-athletes across a ... experiences and reflect on common challenges. The special panel ... the country in sports ranging from football, track and ...
Breaking Medicine News(10 mins):Health News:UniWigs Is Sending Out Mysterious Gifts During the Easter Holidays 2Health News:Businesses Dealing With PCI Falling Short On Regular Vulnerability Scans and Pen Testing 2Health News:Businesses Dealing With PCI Falling Short On Regular Vulnerability Scans and Pen Testing 3Health News:Businesses Dealing With PCI Falling Short On Regular Vulnerability Scans and Pen Testing 4Health News:Young Athletes at Greater Risk for Re-Injury after ACL Surgery 2Health News:For Type V AC Joint Injuries, Early Surgery May Not Be the Best Approach 2Health News:SCI TV Panel of Former College Athletes Discusses Student Athlete Experience 2Health News:SCI TV Panel of Former College Athletes Discusses Student Athlete Experience 3
... on a new survey, sales of nicotine replacement have increased ... replacement therapy (NRT)// over the counter, without having to consult ... a good move. Make NRT more accessible and more people ... ,Researchers at the University of California, San Fransisco have analysed ...
... the standard treatment for viral warts to be the ... remain the treatment of choice for this common medical condition. ... will usually clear up eventually on their own. Anyhow, warts ... for people because those are on such visible parts of ...
... helped the Communicable Diseases Centre (CDC) at Atlanta identify a ... and Japan early this year. The new cholera pathogen, transmitted ... for scientists across the world. // ,The reason behind ... Indians made the discovery. “We received calls from the US ...
... , it was observed that carbohydrates that originate in ... from Harvard Medical School and Brigham and Women's Hospital ... body that causes inflammation. While the cause of arthritis ... light on the origin of the crippling disease. ...
... Columbia University researchers, people who suffer from the most ... to have a lower body mass index than their ... unknown origins, but doctors believe it may be neurodegenerative ... time that can interfere with a person's daily activities, ...
... Mifipriston, the new high-tech abortion drug being freely sold ... an era of do-it-yourself-abortions,// experts fear. Already, the sale ... claim, and even as the pharmaceutical concerns treat the ... to “the revolutionary approach to medical abortion”, the tribe ...
Cached Medicine News:Health News:Abortion made easy pill causes alarm in state 2
(Date:3/27/2015)... CITY , March 27, 2015 Dynatronics Corporation ... Linder has been appointed to the Company,s Board of ... by the death in November 2014 of board member ... Rich Linder to our Board of Directors represents an ... Jr. , chairman and president of Dynatronics.  "Rich is a ...
(Date:3/27/2015)... VICTORIA, Texas , March 27, 2015  Victoria Vein ... removal services with the Astanza Duality laser in ... of vein disease as well as advanced laser treatments for ... are entering the tattoo industry to provide more services for ... Surgery has helped many Victoria residents ...
(Date:3/27/2015)... Zimmer Holdings, Inc. (NYSE and SIX: ZMH) is celebrating a key milestone ... Complete Knee System. ,   ... first introduced the NexGen knee system, with its innovative design ... implantations of the NexGen knee have taken place worldwide. ... demonstrates the importance of design innovation and component quality for surgeons and ...
Breaking Medicine Technology:Dynatronics Announces Appointment of Richard J. Linder to Board of Directors 2Victoria Vein And Surgery Clinic Uses Advanced Astanza Duality Tattoo Removal Technology 2Zimmer Celebrates Key Milestones For NexGen Complete Knee System 2
... - Dimebon Improved the Clinical Course of Alzheimer,s Disease; ... Activities of Daily Living, ... 17 Medivation, Inc.,(Nasdaq: MDVN ) today announced ... clinical trial of the investigational drug,Dimebon in the July ...
... Impliant, Inc., a developer of,novel spine arthroplasty alternatives ... first surgery in the United States using a,less-invasive ... device designed to treat spinal stenosis with or ... by Domagoj,Coric, MD, Neurosurgeon at the Charlotte Neurosurgery ...
Cached Medicine Technology:Medivation Announces Publication in The Lancet of Dimebon Pivotal Trial Results in Alzheimer's Disease 2Medivation Announces Publication in The Lancet of Dimebon Pivotal Trial Results in Alzheimer's Disease 3Medivation Announces Publication in The Lancet of Dimebon Pivotal Trial Results in Alzheimer's Disease 4Medivation Announces Publication in The Lancet of Dimebon Pivotal Trial Results in Alzheimer's Disease 5Impliant Launches Less-Invasive Version of Patented TOPS(TM) Spine System 2
circuitGuard™ Products are available in filter or filter/HME styles., ,High quality air cushion anesthesia masks may be packaged with any circuitGuard™ product....
... Since 1991 Intersurgical ... breathing filters, heat and ... oxygen therapy products, hand-held ... range of accessories and ...
... Intersurgical Incorporated manufactures high ... and moisture exchangers, ventilator ... hand-held nebulizers and an ... and connectors for anesthesia ...
... Since 1991 Intersurgical Incorporated ... filters, heat and moisture ... therapy products, hand-held nebulizers ... of accessories and connectors ...
Medicine Products: