Navigation Links
Researchers pinpoint sources of fibrosis-promoting cells that ravage organs
Date:7/1/2013

at happens to it until it dies, Kalluri said.

This was particularly important because two of the four sources of myofibroblasts start out as another cell type and differentiate into the collagen-producing cells.

Their experiments showed:

  • Half of all myofibroblasts are produced by the proliferation of pre-existing resting fibroblasts.
  • Another 35 percent are produced by mesenchymal stem cells that originate in the bone marrow, migrate to the "wound" site, and then differentiate into myofibroblasts.
  • An additional 10 percent are the products of endothelial to mesenchymal transition (EndMT), in which blood vessel cells change into mesenchymal cells, then become myofibroblasts.
  • The final 5 percent come from epithelial to mesenchymal transition (EMT), in which functional cells of an organ sometimes behave like mesenchymal cells and myofibroblasts.

"These differentiation pathways provide leads for drug targets," Kalluri said.

"Combining an antiproliferation drug with therapies that block one or more differentiation pathways could provide a double hit to control fibrosis. We hope to synergize these pathways for the most effective therapeutic response."

Recruitment from the bone marrow, EMT and EndMT appear to rely on transforming growth factor beta 1 (TGF-B1) to differentiate into myofibroblasts.

Pericytes are not involved

Some earlier descriptive studies implicated pericytes connective, contractile cells that surround blood vessels in the creation of myofibroblasts. The researchers tested pericytes via fate-mapping and found that they're not involved in myofibroblast generation.

Deleting pericytes did not improve kidney fibrosis or change the recruitment of myofibroblasts.

While their research focused on kidney fibrosis, the scientists believe their findings will be applicable to other types of fibrosis.

"Recruitment of fibroblasts
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers use immunocytochemistry to determine ALK status
2. Researchers find 2 new methods to determine ALK status
3. CWRU researchers trace inner-city womens health issues to childhood traumas
4. Penn Medicine researchers discover link between fear and sound perception
5. UCI researchers awarded $2.27 million to create novel diabetes treatments
6. MS researchers determine that brain reserve independently protects against cognitive decline in MS
7. Notre Dame and Harper researchers developing novel method to test for HPV and oral cancers
8. PhD Thesis Writing Expands the Scope of its Services for Doctoral Researchers
9. Researchers Identify New Genes Linked to the Origins of Alzheimer’s, Says Cure Alzheimers Fund
10. Researchers identify master coordinator for aortic rupture
11. Fate of the heart: Researchers track cellular events leading to cardiac regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2015)... California (PRWEB) February 28, 2015 Plugin ... of TransFold Volume 2. A fully customizable transition ... , “TransFold Volume 2 gives users total control over ... Christina Austin, CEO of Pixel Film Studios. “TransFold Volume ... X editor.” , TransFold Volume 2 from Pixel Film ...
(Date:2/28/2015)... My Shiney Hiney® LLC., the renowned brand ... Las Vegas, Nevada for the annual ASD Market Week tradeshow. ... leading consumer-goods tradeshows and My Shiney Hiney will be one ... Shiney Hiney can be found at booth number C1663. , ... at-home personal hygiene brush and cleansing system exclusively created to ...
(Date:2/27/2015)... February 27, 2015 Wireless Analytics, ... services, and one of the founders of ... for Bell Mobility within their CLEAN Platform™ (Communications ... Wireless Analytics’ newly developed Bell Mobility Data ... the Canadian wireless carrier’s business customers. , Wireless ...
(Date:2/27/2015)... Beverly Hills, CA (PRWEB) February 27, 2015 ... was in the air for those suffering from Sjögren’s ... had been discovered by researchers at the University of ... the next phase of research was to develop a ... to precisely detect the presence of new autoantibodies. Researchers ...
(Date:2/27/2015)... MD (PRWEB) February 27, 2015 ... (Meso Foundation) and the National Cancer Institute (NCI) ... Mesothelioma at the National Institutes of Health (NIH), ... one part is dedicated to medical professionals and ... is directed to the general public, including patients, ...
Breaking Medicine News(10 mins):Health News:Announcing a New TransFold Transition Pack from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:My Shiney Hiney® to Participate in ASD Market Week 2015 2Health News:Bell Mobility Gains Traction With Enterprises; Is Added to Wireless Analytics’ CLEAN Platform™ 2Health News:Bell Mobility Gains Traction With Enterprises; Is Added to Wireless Analytics’ CLEAN Platform™ 3Health News:Breakthrough Blood Test for Early Detection of Sjögren’s Syndrome Now Available 2Health News:Conference on Mesothelioma Co-Hosted with National Cancer Institute 2Health News:Conference on Mesothelioma Co-Hosted with National Cancer Institute 3
... (HealthDay News) -- Asthma and chronic obstructive pulmonary disease ... face a significantly higher relative risk for both the ... The warning stems from an analysis of data ... use was associated with a 34 percent increase in ...
... HealthDay Reporter , WEDNESDAY, Dec. 15 (HealthDay News) ... States has declined 28 percent since the late 1990s, but ... deaths, a new study finds. And the cost of ... or any other diagnostic group, an estimated $286 billion in ...
... Reinberg HealthDay Reporter , WEDNESDAY, Dec. 15 (HealthDay News) ... had both leukemia and AIDS no longer has any detectable HIV ... leukemia three years ago. But experts were quick to ... treatment of AIDS worldwide. As it turns out, the ...
... infected at some time in their lives with Epstein-Barr virus ... immune systems, such as people with organ transplants or HIV ... this virus. Scientists at the Duke Cancer Institute have ... EBV infections, a finding that has implications for understanding the ...
... received a 2010 Web Health Award for its patient-geared ... is a national competition that recognizes high-quality electronic health ... competition from a variety of health care professionals nationwide. ... electronic health information experts., This year, ASTRO received a ...
... , WEDNESDAY, Dec. 15 (HealthDay News) -- A group that ... to watch for attempted suicides in patients with no history ... by the Joint Commission, stresses that it,s not just psychiatric ... diagnosed with cancer who goes to an ER because the ...
Cached Medicine News:Health News:Inhalers Linked to Higher Odds of Diabetes in Asthma, COPD Patients 2Health News:Inhalers Linked to Higher Odds of Diabetes in Asthma, COPD Patients 3Health News:Death Rate From Heart Disease, Stroke Drops Off Over Decade 2Health News:Death Rate From Heart Disease, Stroke Drops Off Over Decade 3Health News:Docs Claim Transplant Cured Man of HIV, But Experts Urge Caution 2Health News:Docs Claim Transplant Cured Man of HIV, But Experts Urge Caution 3Health News:Scientists decode secrets of a very common virus that can cause cancer 2Health News:Severe Pain Can Trigger Suicide in Hospital ERs 2Health News:Severe Pain Can Trigger Suicide in Hospital ERs 3
(Date:2/26/2015)... DIEGO , Feb. 26, 2015  Tandem Diabetes ... device company and manufacturer of the t:slim® and t:flex™ ... public offering of 5,250,000 shares of its common stock ... share.  The net proceeds to Tandem from this offering ... discounts and commissions and other estimated offering expenses payable ...
(Date:2/26/2015)... 2015  Mobility Ventures LLC, an AM General Company, ... America (NYSE: BAC ) that will make ... the revolutionary MV-1 - - the world,s first and ... to provide safe and comfortable transportation for all passengers ... to purchase a new MV-1 vehicle at the over ...
(Date:2/26/2015)... , February 26, 2015 ... Outlook 2015: First -In- Class Innovations and Cost ... for Large Cap Pharmaceutical Companies research report to ... According to this Global Pharma US & ... as productivity measurements, divestment of non-core assets result ...
Breaking Medicine Technology:Tandem Diabetes Care Announces Pricing of Underwritten Public Offering of Common Stock 2Tandem Diabetes Care Announces Pricing of Underwritten Public Offering of Common Stock 3Mobility Ventures and Bank of America Announce New Agreement to Simplify Retail Consumer Financing for MV-1 Universally Accessible Vehicle 2Mobility Ventures and Bank of America Announce New Agreement to Simplify Retail Consumer Financing for MV-1 Universally Accessible Vehicle 3Global Pharma U.S. and EU Outlook 2015 Market Research Report 2Global Pharma U.S. and EU Outlook 2015 Market Research Report 3Global Pharma U.S. and EU Outlook 2015 Market Research Report 4
... Germany, January 18, 2012 Eppendorf AG ... to Bibby Scientific for use e.g. in their TC ... 7,074,367. Eppendorf utilizes the technology in its Eppendorf Mastercycler® ... models. Eppendorf AG, based in Hamburg, Germany, ...
... Takeda Pharmaceutical Company Limited ("Takeda", TSE: ... global workforce and consolidate site operations in order to ... than 70 countries, adapt to changing market conditions and ... as outlined in its 2011-2013 Mid-Range Plan (MRP). ...
Cached Medicine Technology:Takeda Announces Strategic Measures to Achieve Efficiencies for Long-Term Growth 2Takeda Announces Strategic Measures to Achieve Efficiencies for Long-Term Growth 3Takeda Announces Strategic Measures to Achieve Efficiencies for Long-Term Growth 4Takeda Announces Strategic Measures to Achieve Efficiencies for Long-Term Growth 5
... coded patient identification bracelets (wristbands) and/or ... at patient care areas throughout the ... identification and in creating a positive ... back to the patient through the ...
The IDENTI-PRINT II ID system functions as a complete, hospital wide patient identification system. It integrates the benefits of bedside labeling into a multipurpose ID band that consolidates admitt...
... Volks drive to provide ... to bring you a lens ... in a non-contact slit lamp ... true 3D viewing of the ...
... compact RFID printing solution that can encode ... the R2844-Z printer/encoder is one of the ... printing and encoding smart media such as ... the needs of applications requiring greater processing ...
Medicine Products: