Navigation Links
Researchers pinpoint sources of fibrosis-promoting cells that ravage organs
Date:7/1/2013

at happens to it until it dies, Kalluri said.

This was particularly important because two of the four sources of myofibroblasts start out as another cell type and differentiate into the collagen-producing cells.

Their experiments showed:

  • Half of all myofibroblasts are produced by the proliferation of pre-existing resting fibroblasts.
  • Another 35 percent are produced by mesenchymal stem cells that originate in the bone marrow, migrate to the "wound" site, and then differentiate into myofibroblasts.
  • An additional 10 percent are the products of endothelial to mesenchymal transition (EndMT), in which blood vessel cells change into mesenchymal cells, then become myofibroblasts.
  • The final 5 percent come from epithelial to mesenchymal transition (EMT), in which functional cells of an organ sometimes behave like mesenchymal cells and myofibroblasts.

"These differentiation pathways provide leads for drug targets," Kalluri said.

"Combining an antiproliferation drug with therapies that block one or more differentiation pathways could provide a double hit to control fibrosis. We hope to synergize these pathways for the most effective therapeutic response."

Recruitment from the bone marrow, EMT and EndMT appear to rely on transforming growth factor beta 1 (TGF-B1) to differentiate into myofibroblasts.

Pericytes are not involved

Some earlier descriptive studies implicated pericytes connective, contractile cells that surround blood vessels in the creation of myofibroblasts. The researchers tested pericytes via fate-mapping and found that they're not involved in myofibroblast generation.

Deleting pericytes did not improve kidney fibrosis or change the recruitment of myofibroblasts.

While their research focused on kidney fibrosis, the scientists believe their findings will be applicable to other types of fibrosis.

"Recruitment of fibroblasts
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers use immunocytochemistry to determine ALK status
2. Researchers find 2 new methods to determine ALK status
3. CWRU researchers trace inner-city womens health issues to childhood traumas
4. Penn Medicine researchers discover link between fear and sound perception
5. UCI researchers awarded $2.27 million to create novel diabetes treatments
6. MS researchers determine that brain reserve independently protects against cognitive decline in MS
7. Notre Dame and Harper researchers developing novel method to test for HPV and oral cancers
8. PhD Thesis Writing Expands the Scope of its Services for Doctoral Researchers
9. Researchers Identify New Genes Linked to the Origins of Alzheimer’s, Says Cure Alzheimers Fund
10. Researchers identify master coordinator for aortic rupture
11. Fate of the heart: Researchers track cellular events leading to cardiac regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... York, NY (PRWEB) October 20, 2014 ... be introduced in the U.S., has a lot to celebrate ... when our country recognizes the achievements and contributions of Americans ... the anniversary for Punzoné, and today it shares its favorite ... take a trip to Italy - even if it is ...
(Date:10/20/2014)... 20, 2014 Do you ever feel ... comes a wonderful app Metassessor for teachers, specialists and ... helped its client “Intervention Development LLC” to launch ... is designed for iOS 4.3 or later and is ... is optimized for iPhone 5. It is now available ...
(Date:10/19/2014)... The leading review website, Top10BestSEOHosting.com, has recently announced ... the best Dedicated Server Hosting suppliers. Their websites ... buy high quality hosting and save money at ... Top10BestSEOHosting.com says, “We believe that iPage and GreenGeeks ... lot of the global clients enjoy using their ...
(Date:10/19/2014)... UNITED NATIONS, New York (PRWEB) October 19, 2014 ... the United Nations Population Fund, welcomes news of a ... release of the more than 200 girls who were ... Girls. "These girls have languished in captivity long enough, ... their families, schools and communities," stated Dr. Osotimehin. , ...
(Date:10/19/2014)... October 20, 2014 Having been working in ... good knowledge of customer needs. According to James, one of ... with dazzling sequins, or with high-low skirts that add beauty ... huge demand. Recently, LunaDress has unveiled its new selection of ... fact, the company’s brand new items are available in over ...
Breaking Medicine News(10 mins):Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 4Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2
... "Occlusions in the retinal vein could not only make you loose ... veins is so painful that the eye may have to be ... new instrument that uses a plasma to shoot tiny bullets ... vessels that supply blood to the retina drain into a single ...
... market is currently dominated by the Mumbai based ... company, is planning to enter the anti-AIDS drugs ... and west Asia, S D Kaul, the company ... Aabacavir and Indinavir products in the Indian market ...
... that can have Complication as its other name. Among the ... be the foot ulcer, as damage can be severe enough ... ulcer, a boon in disguise would be a new device ... //Such an electrical stimulation would help in the healing of ...
... procedure widely used on knees can also repair damaged ... best known for repairing knee injuries, but it is ... it is a minimally invasive surgical technique it is ... relieve different ankle problems, including ligament damage, bone chips ...
... basis. One of these latest laser techniques is helpful in ... This degenerative condition cause blood vessels to grow underneath the ... ,Eye specialists have come up with a new therapy ... of damaging the retinal tissue. ,This is a two-step ...
... active ingredient is Acetaminophen is found effective in the ... temperature in people who have had a stroke, according ... ,Rise in the body temperature during the first few ... fever, has been linked to poorer outcomes including an ...
Cached Medicine News:Health News:Blocked viens block eye sight 2Health News:Arthroscopy for Ankles 2
(Date:10/20/2014)...   Mary,s Medicinals today announced that its ... Sponsor of Operation Grow4Vets , a national, nonpartisan ... and services to assist them in living with injuries ... , An ever-increasing number of medical studies ... treatment for pain, Post-traumatic Stress Disorder (PTSD) and Traumatic ...
(Date:10/19/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces ... notified the Board of Directors of his decision to step down ... CFO of Severn Trent plc.  James will leave Shire at the ... for a new CFO immediately. Flemming Ornskov, Shire,s Chief ... a high-quality finance team at Shire. We are very grateful to ...
(Date:10/19/2014)... FRANKFURT , Deutschland, October 19, 2014 /PRNewswire/ ... echten CRT-Fallstudien gefragt. Das Problem dabei ... ihre Informationen mit der Kompetenz zu teilen. ... zusammenzustellen, und deshalb freuen wir uns umso mehr, ... Pharmafirmen gebeten, ihre Gepflogenheiten bei Kühlketten aufzuschreiben - ...
Breaking Medicine Technology:Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 2Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 3Interim Chief Financial Officer James Bowling to Step Down 2Interim Chief Financial Officer James Bowling to Step Down 3Interim Chief Financial Officer James Bowling to Step Down 4Vergleichsbericht zu Pharma-Kühlketten und CRT 2
... Dilon Diagnostics will introduce the latest advancement in molecular ... Nuclear Medicine (SNM) Meeting in San Antonio, Texas, with ... Camera system. To complement the already widely successful Dilon ... feature a much larger MBI detector which will make ...
... 2, 2011 Clovis Oncology, Inc. and Roche (SIX: ... entered into an agreement to develop an in ... test. The goal is to identify activating epidermal growth ... lung cancer (NSCLC), including the EGFR T790M mutation.   ...
Cached Medicine Technology:The World Leader in Molecular Breast Imaging to Premiere Largest Detector in the Industry 2Roche and Clovis Oncology to Co-Develop EGFR Companion Diagnostic 2Roche and Clovis Oncology to Co-Develop EGFR Companion Diagnostic 3
Made exclusively from LactoSorb® Resorbable Copolymer....
The Stryker Bioabsorbable Wedge Interference Screw is made of Poly-L Lactic Acid (PLLA). The patented wedge design makes it perfect for cruciate reconstruction and is indicated for BTB and soft tissu...
... The Stryker Conquest ... manual instruments that pierce ... retrieve suture through the ... stitch. The Conquest Retrievers ...
... for excising soft tissue more efficiently than a ... serrated edge on the straight scissor helps to ... the jaws for more efficient resection.,The curved scissors, ... the perfect tools for ACL stump removal, meniscectomies ...
Medicine Products: