Navigation Links
Researchers pinpoint sources of fibrosis-promoting cells that ravage organs
Date:7/1/2013

at happens to it until it dies, Kalluri said.

This was particularly important because two of the four sources of myofibroblasts start out as another cell type and differentiate into the collagen-producing cells.

Their experiments showed:

  • Half of all myofibroblasts are produced by the proliferation of pre-existing resting fibroblasts.
  • Another 35 percent are produced by mesenchymal stem cells that originate in the bone marrow, migrate to the "wound" site, and then differentiate into myofibroblasts.
  • An additional 10 percent are the products of endothelial to mesenchymal transition (EndMT), in which blood vessel cells change into mesenchymal cells, then become myofibroblasts.
  • The final 5 percent come from epithelial to mesenchymal transition (EMT), in which functional cells of an organ sometimes behave like mesenchymal cells and myofibroblasts.

"These differentiation pathways provide leads for drug targets," Kalluri said.

"Combining an antiproliferation drug with therapies that block one or more differentiation pathways could provide a double hit to control fibrosis. We hope to synergize these pathways for the most effective therapeutic response."

Recruitment from the bone marrow, EMT and EndMT appear to rely on transforming growth factor beta 1 (TGF-B1) to differentiate into myofibroblasts.

Pericytes are not involved

Some earlier descriptive studies implicated pericytes connective, contractile cells that surround blood vessels in the creation of myofibroblasts. The researchers tested pericytes via fate-mapping and found that they're not involved in myofibroblast generation.

Deleting pericytes did not improve kidney fibrosis or change the recruitment of myofibroblasts.

While their research focused on kidney fibrosis, the scientists believe their findings will be applicable to other types of fibrosis.

"Recruitment of fibroblasts
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers use immunocytochemistry to determine ALK status
2. Researchers find 2 new methods to determine ALK status
3. CWRU researchers trace inner-city womens health issues to childhood traumas
4. Penn Medicine researchers discover link between fear and sound perception
5. UCI researchers awarded $2.27 million to create novel diabetes treatments
6. MS researchers determine that brain reserve independently protects against cognitive decline in MS
7. Notre Dame and Harper researchers developing novel method to test for HPV and oral cancers
8. PhD Thesis Writing Expands the Scope of its Services for Doctoral Researchers
9. Researchers Identify New Genes Linked to the Origins of Alzheimer’s, Says Cure Alzheimers Fund
10. Researchers identify master coordinator for aortic rupture
11. Fate of the heart: Researchers track cellular events leading to cardiac regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... 21, 2014 Originally approved by ... GSK’s Flovent (fluticasone propionate) is a synthetic ICS ... for the maintenance treatment of asthma prophylactically in ... two formulations, Diskus and HFA, which received the ... active ingredient, fluticasone propionate, can bind to glucocorticoid ...
(Date:9/21/2014)... An experienced review website in the global ... list and announced that FatCow ( http://www.top10bestseohosting.com/go/FatCow.com/ ), GoDaddy ... , There has been a boom in websites in ... an increase in the number of web hosting companies ... affordable prices. VPS (Virtual Private Server) is the method ...
(Date:9/21/2014)... OH (PRWEB) September 21, 2014 C8 ... District of Ohio as the list of 20 possible ... been narrowed down to six, reports Wright & Schulte ... chosen from the almost 2500 C8 lawsuits filed that ... or testicular cancer as a result of being exposed ...
(Date:9/20/2014)... Vegas, NV (PRWEB) September 21, 2014 ... by Dr. Kenneth Pullman that is helping thousands of ... their diabetes symptoms without shots, pills, or prescriptions has ... review. , “There are currently tens of millions ... both Type 1 and Type 2 diabetes, and unfortunately, ...
(Date:9/20/2014)... Baja, Mexico (PRWEB) September 20, 2014 ... announced the resort did not experience any damage in ... all amenities and activities available. , Hurricane Odile struck ... bringing intense wind, rain and powerful surf conditions. Located ... del Palmar Islands of Loreto experienced some heavy rain, ...
Breaking Medicine News(10 mins):Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 2Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 3Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 4Health News:Top10BestSEOHosting.com: FatCow, GoDaddy And Bluehost Are The Best VPS Hosting Suppliers 2Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 2Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 3Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 4Health News:Diabetes Protocol: Review Exposes Kenneth Pullman’s Breakthrough Discovery About Diabetes Management 2Health News:Villa del Palmar at the Islands of Loreto Fully Functioning After Hurricane 2Health News:Villa del Palmar at the Islands of Loreto Fully Functioning After Hurricane 3
... Logicalis Initiate Collaborative Sales Agreements Designed to ... Federal Healthcare IT Stimulus FundsCHICAGO, April 8 ... disparate healthcare IT systems, announced strategic partnerships ... Systems (SIS) and Micro Solutions. These collaborative ...
... allow you to care for eight patients at once," stated Julia ... ... OH (PRWEB) April 8, 2009 -- Western announces the launch in ... designed to help Medical Response Teams to care for multiple patients, ...
... remained relatively stable since January, 2009 (1 April, 09 Bloomberg Report); the ... decline of between 16 and 28 percent against the Euro and US ... for luxury property in the South Island. , ... Christchurch, New Zealand ...
... 13485 Certificate of Registration issued by NSAI (National Standards Authority of ... , ... Elgin, IL. (PRWEB) April 8, 2009 -- ... numerous medical devices, today announced that it had received an ...
... In results from the largest health policy study of ... 2003 has been found effective in reducing crippling health ... success of the Seguro Popular program, and arise from ... faculty member, in collaboration with researchers in Mexico. , ...
... ARBOR, Mich. Despite enduring more invasive tests and ... stage bladder cancer had no better survival than patients ... patients were more likely to undergo major surgery to ... from researchers at the University of Michigan Comprehensive Cancer ...
Cached Medicine News:Health News:Compressus Launches Partnerships With Two Avnet HealthPath(TM) Partners to Accelerate Access to Interoperability Solutions 2Health News:Compressus Launches Partnerships With Two Avnet HealthPath(TM) Partners to Accelerate Access to Interoperability Solutions 3Health News:Compressus Launches Partnerships With Two Avnet HealthPath(TM) Partners to Accelerate Access to Interoperability Solutions 4Health News:Octi-Flo2™ - 8 Patient Portable Oxygen Delivery System 2Health News:New Zealand Beach Front Property Offers Global Currency Rate Bargains 2Health News:TRICOR Systems Inc. Receives ISO 13485 Certification; Contract Manufacturer Achieves Another Significant Milestone in 32 Year History 2Health News:Mexican health care program successful at reducing crippling health care costs 2Health News:Mexican health care program successful at reducing crippling health care costs 3Health News:More intense bladder cancer treatment does not improve survival, U-M study finds 2
(Date:9/19/2014)... , September 19, 2014 ... ) has announced the addition of the ... report to their offering.      ... have been broadly classified into wide categories ... used for the treatment of different gynecological ...
(Date:9/19/2014)... Sept. 19, 2014  For Cloud Pharmaceuticals, Inc., ... and development, partnering is an integral part of ... design new drugs and identify early stage, preclinical, ... further their development. The company also partners with ... this business model, Cloud Pharmaceuticals will be participating ...
(Date:9/19/2014)... The American Association for Homecare (AAHomecare) is ... has joined the AAHomecare Corporate Partner Program. ... have been actively involved in AAHomecare for much of ... grown into a major global manufacturer of home medical ... to increase efforts on behalf of the HME sector ...
Breaking Medicine Technology:Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 2Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 3Cloud Pharmaceuticals Announces Partnering Sessions and Presentation Schedule 2Drive Medical Design & Manufacturing Joins AAHomecare Corporate Partner Program 2
... CAMBRIDGE, Mass. , Aug. 4 ... therapies to treat autoimmune diseases and cancer by modulating ... Antonin (Tony) de Fougerolles , Ph.D., as Chief Scientific ... provide leadership for the company’s research and early-stage product ...
... , THE WOODLANDS, Texas , Aug. 3 ... LXRX ), a biopharmaceutical company focused on discovering breakthrough ... its second quarter 2010 financial results on Monday, August ... will hold a conference call to discuss its clinical development ...
Cached Medicine Technology:Tolerx Appoints Antonin de Fougerolles, Ph.D., as Chief Scientific Officer 2Tolerx Appoints Antonin de Fougerolles, Ph.D., as Chief Scientific Officer 3Tolerx Appoints Antonin de Fougerolles, Ph.D., as Chief Scientific Officer 4Lexicon to Provide Clinical Pipeline Update and Report Second Quarter 2010 Financial Results 2
... Electronic Medical Record system. It stores patient chart ... and everything you would normally put in a ... Someone has to write them, file them, find ... Paper Charts get lost. They find their way ...
... precision demands absolute knowledge. Access ... Lomb Zyoptix Diagnostic Workstation, uniting ... Wavefront Aberrometer and Orbscan IIz ... they supply critically important data. ...
ZYMAR™ ophthalmic solution is an anti-infective prescription eye drop that your doctor may instruct you to use if you have an eye infection caused by bacteria. Bacterial conjunctivitis is the e...
LUMIGAN® is a powerful eye drop medication for lowering IOP. IOP is short for intraocular pressure or eye pressure. LUMIGAN® is the first in a new class of medication....
Medicine Products: