Navigation Links
Researchers identify novel biomarker for diabetes risk
Date:9/16/2013

Researchers at the Vanderbilt Heart and Vascular Institute and Massachusetts General Hospital have identified a biomarker that can predict diabetes risk up to 10 years before onset of the disease.

Thomas J. Wang, M.D., director of the Division of Cardiology at Vanderbilt, along with colleagues at Massachusetts General Hospital, report their findings in the October issue of The Journal of Clinical Investigation.

The researchers conducted a study of 188 individuals who developed type 2 diabetes mellitus and 188 individuals without diabetes who were followed for 12 years as participants in the Framingham Heart Study.

"From the baseline blood samples, we identified a novel biomarker, 2-aminoadipic acid (2-AAA), that was higher in people who went on to develop diabetes than in those who did not," Wang said. "That information was above and beyond knowing their blood sugar at baseline, knowing whether they were obese, or had other characteristics that put them at risk."

Individuals who had 2-AAA concentrations in the top quartile had up to a fourfold risk of developing diabetes during the 12-year follow-up period compared with people in the lowest quartile.

"The caveat with these new biomarkers is that they require further evaluation in other populations and further work to determine how this information might be used clinically," Wang said.

The researchers also conducted laboratory studies to understand why this biomarker is elevated so well in advance of the onset of diabetes. They found that giving 2-AAA to mice alters the way they metabolize glucose. These molecules seem to influence the function of the pancreas, which is responsible for making insulin, the hormone that tells the body to take up blood sugar.

"2-AAA appears to be more than a passive marker. It actually seems to play a role in glucose metabolism," Wang said. "It is still a bit early to understand the biological implications of that role, but these experimental data are intriguing in that this molecule could be contributing in some manner to the development of the disease itself."

Future laboratory studies may determine exactly how 2-AAA regulates function of the pancreatic cells and how and when the body makes this molecule. On the clinical side, researchers might study whether the administration of these metabolites to humans causes similar effects to those observed in animal models.

"The value of markers like these, which are metabolites, is that they can be given to people as nutritional supplements. These are amino acid derivatives that are byproducts of metabolism. Studies in humans can be done to see if there are similar patterns to what is seen experimentally," Wang said.

Type 2 diabetes is present in 5 to 10 percent of adults in the United States and is more prevalent among obese and overweight individuals, who comprise two-thirds of adults.

"Diabetes is common and the prevalence will only rise in coming years fueled by the rise of obesity. Understanding why diabetes occurs and how it might be prevented is a very intense area of investigation because of the serious consequences of having the disease," Wang said. "It is certainly a focus of many research groups to understand how we might develop strategies to detect diabetes risk at an earlier stage and intervene."


'/>"/>

Contact: Kathy Whitney
kathy.f.whitney@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Related medicine news :

1. Tufts researchers identify how Yersinia spreads within infected organs
2. Approved cancer drug potentially could help treat diabetes, Stanford researchers find
3. Mount Sinai Researchers Show Stem Cells Are Wired for Cooperation, Down to the DNA
4. Virginia Tech Carilion researchers find surprising relationships in brain signaling
5. Researchers to identify genetic biomarkers for aggressive breast cancer
6. Researchers link obesity and the bodys production of fructose
7. Researchers find whats missing in teen health programs
8. UCLA researchers describe new form of irritable bowel syndrome
9. Researchers study survival in African American versus Caucasian lung cancer patients
10. Researchers develop specific tests to identify cancer biomarkers in dermatomyositis
11. Medical Researchers Say They Have Made a Breakthrough That Could Lead to a Potential Cure for AIDS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, affiliated ... Weintraub as a prominent plastic surgeon and the network’s newest partner. , ... most handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th Annual ... Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised funds ... been wounded in battle and their families. Venture Construction Group is a 2016 Silver ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... innovative inhaled drugs, announced today that it was added ... reconstituted its comprehensive set of U.S. and global ... is an important milestone for Pulmatrix," said Chief Executive ... awareness of our progress in developing drugs for crucial ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on the ... announced that patient enrollment in its ongoing randomized ... has exceeded 50% of its 24-patient target. Capricor ... the third quarter of 2016, and to report ...
Breaking Medicine Technology: