Navigation Links
Researchers identify new drug target for treating jet lag and shift work disorders
Date:8/30/2013

ck. They identified one gene and its corresponding protein product, called SIK1, that limits the body clock's ability to adjust to changes in the daily patterns of light and dark. In one particular experiment, when the researchers blocked the activity of SIK1 in laboratory mice, the mice adjusted faster to changes in the light-dark cycle that mimic a time zone change. The study proposes that the light-stimulated production of SIK1 in turn switches off the molecular pathway that feeds into the clock mechanism, thereby halting the shifting response of the biological clock.

"Our key contribution to the project was to manipulate the SIK1 protein pharmacologically, and we revealed that such blockage of the protein's activity in combination with exposure to a natural clock resetting agent, such as light, enhanced the clock shifting response," Duffield said. "For example, a one hour shift of the clock became two hours. We also showed this effect in both peripheral tissues as well as in the clock in the brain.

"It would appear that SIK1 plays a common role in our circadian clocks found throughout our body, and working as a hand-brake on our ability to shift our biorhythms and adjust to new time zones, whether these are real or artificial, such as those produced during shift work schedules."

In addition to the inconvenience of jet lag, disruptions in the circadian system, such as produced during shift work, have been linked to many diseases including diabetes, heart disease and cancer. Disturbances of the circadian clock have even been linked to mental disorders, such as schizophrenia, bipolar disease and seasonal affective disorder, also known as winter depression. It is important to note that approximately 16 percent of the U.S. and European workforces undertake some form of shift work.

"Having such a hand-break on the circadian clock systems makes sense so as to prevent excessive responses to environmental change, and that it is only in our modern 24-h
'/>"/>

Contact: Giles Duffield
Giles.E.Dufield.2@nd.edu
574-631-1834
University of Notre Dame
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 2014 In recognition of Veteran’s Day, ... Hero Reward, a local organization that provides services to ... , Located on a couple hundred acres in the ... lodging, world class fishing, hunting, hiking, horseback riding, 4-wheeling, ... several years ago to support U.S. Service men and ...
(Date:12/22/2014)... 22, 2014 TheHardwareCity.com now stocks MagnoGrip ... many useful features. Customers of the large online tool ... new gloves delivered to their home or workplace with ... tools that incorporate heavy duty magnets, which make work ... workers to store metal parts on the back of ...
(Date:12/22/2014)... 21, 2014 A substantial percentage ... computed tomography (CT) to evaluate abnormal findings on ... cancer, according to a new study published online ... the findings show that radiologist recommendations for additional ... to patient care. , RAIs, which have grown ...
(Date:12/21/2014)... 22, 2014 Recently, BambooFlooringChina.com, a famous ... woven bamboo flooring collection , and launched a bamboo ... promotion is valid until Jan. 30, 2015. , According ... is the hardest bamboo flooring available today; it has ... of traditional teak hardwoods. Strand woven bamboo is made ...
(Date:12/21/2014)... 21, 2014 AngelWeddingDress.com’s new collection of ... a total of 1,000 new designs in this collection, ... spring 2015. , AngelWeddingDress.com promises to provide ... with wardrobe essentials while many fashion trends come and ... customer service team at AngelWeddingDress.com is ready to assist. ...
Breaking Medicine News(10 mins):Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:MagnoGrip Pro Utility Magnetic Gloves on Sale at TheHardwareCity.com 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 3Health News:BambooFlooringChina.com Announced Its Durable Strand Woven Bamboo Flooring Collection 2Health News:2015 Spring Wedding Dresses From AngelWeddingDress Just Released 2
... Hopkins University, men who keep up playing tennis throughout ... those who are less active. They have been following a ... //They asked them about participation in tennis, golf, football, baseball ... were the most likely of all to still be physically ...
... researchers, that three years on, a group of kidney ... thanks to a new procedure. Researchers at the University ... cancer, called interventional-MRI renal cryosurgery. //The procedure relies on ... removing cancerous tissue. So high-tech is this procedure, that ...
... tips regarding splitting a pill and ways of taking care your ... whole one. one might be neglecting off a medication, or be ... you may need to split a pill into two or more ... advice on how to go about pill splitting. First, you need ...
... care centre felt that, everyone should be aware of ... Sepsis occurs when the body over-reacts to an infection. ... cancer but it can attack anyone.// In fact sepsis ... cancer together, and is the leading cause of death ...
... after menopause. Specific exercises to strengthen the back have ... is common after the menopause and involves a reduction ... of disabling bone fractures. Doctors at the University of ... exercises is very effective in reducing this fracture risk. ...
... a recent study, a combined scan identifies unstable areas of ... attack in the future. Fatty deposits, known as plaque, set ... - atherosclerosis - begins many years before any symptoms occur.// ... formation of a clot which will then cause a heart ...
Cached Medicine News:
(Date:12/17/2014)...  Northstar Global Business Services, Inc. (OTCPink:MDIN) today ... made their final decision and has determined to ... effective December 15, 2014, and has resumed accepting ... book entry transfer services. All deposit restrictions have been ... fully "DTC Eligible", and has resumed electronic trading ...
(Date:12/17/2014)... , The new Dompé website ... concerning the biopharmaceutical Group,s national and international clinical research activities ... recently launched institutional website that is receiving accolades from all ... new chapter in the fascinating story of Drug Discovery   ... hub on the world of clinical research, ranging from information ...
(Date:12/17/2014)... , Dec. 17, 2014  RXi Pharmaceuticals Corporation ... focused on discovering, developing and commercializing innovative therapies ... today announced completion of enrollment in its first Phase ... 3-month observations confirmed the 1-month findings that were ... Logo - http://photos.prnewswire.com/prnh/20130917/NE80755LOGO , ...
Breaking Medicine Technology:Northstar announces that the DTC chill on MDIN has been officially lifted 2Northstar announces that the DTC chill on MDIN has been officially lifted 3Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 4RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 5
... Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL ) today reported ... September 30, 2009. , For the third quarter of 2009, ... per share, compared to a net loss of $37.7 million, ... Weighted average shares outstanding for the third quarters of 2009 ...
... 2 The owner and operator of a Houston-area ... defrauding the Medicare program, announced Assistant Attorney General of ... Johnson of the Southern District of Texas and Daniel ... & Human Services (HHS). , Noel Wayne Jhagroo, 47, ...
Cached Medicine Technology:Rigel Announces Third Quarter 2009 Financial Results 2Rigel Announces Third Quarter 2009 Financial Results 3Rigel Announces Third Quarter 2009 Financial Results 4Rigel Announces Third Quarter 2009 Financial Results 5Medical Equipment Company Owner Pleads Guilty to Fraud Scheme Involving Nutritional Supplies and "Arthritis Kits" 2Medical Equipment Company Owner Pleads Guilty to Fraud Scheme Involving Nutritional Supplies and "Arthritis Kits" 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: